Article
Biochemistry & Molecular Biology
Mouna Ghorbel, Kaouthar Feki, Sana Tounsi, Najla Haddaji, Moez Hanin, Faical Brini
Summary: The catalytic activity of durum wheat catalase 1 (TdCAT1) is enhanced by various divalent cations and CaM in a Ca-dependent manner, which may play a crucial role in cellular response to oxidative stress.
Article
Engineering, Biomedical
Jonah S. Peter, Jan Schuemann, Kathryn D. Held, Aimee L. McNamara
Summary: In this study, a computational modeling approach was used to investigate the effects of galactic cosmic ray irradiation on neuronal function at the nano-scale level. The results showed that neuronal absorption of radiation dose can lead to ionization events, which may have implications for neuronal function.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Plant Sciences
Zhan Li, Jeffrey F. Harper, Chrystle Weigand, Jian Hua
Summary: Calmodulin-regulated Ca2+ pumps play a crucial role in maintaining basal cytosol Ca2+ levels, which are important for biotic and abiotic stress responses in Arabidopsis. The resting cytosol Ca2+ levels have an impact on plant survival under chilling and heat-stress conditions, and the regulation of these levels is critical for plant immune activation and environmental responses. Loss-of-function mutants of the calmodulin-regulated Ca2+ pumps exhibited elevated resting cytosol Ca2+ levels and increased susceptibility to chilling and heat stress, indicating the importance of these pumps in plant stress tolerance.
Article
Multidisciplinary Sciences
Biraj B. Kayastha, Aya Kubo, Jacob Burch-Konda, Rosalie L. Dohmen, Jacee L. McCoy, Rendi R. Rogers, Sergio Mares, Justin Bevere, Annalisa Huckaby, William Witt, Shuxia Peng, Bharat Chaudhary, Smita Mohanty, Mariette Barbier, Gabriel Cook, Junpeng Deng, Marianna A. Patrauchan
Summary: This study identified a calcium-binding protein EfhP that selectively binds calcium and showed that its structural changes are crucial for regulating the virulence of Pseudomonas aeruginosa.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Vibha Verma, Neelima Boora, Saraswati Nayar, Gulshan Kumar, Somesh Thapliyal, Ankur, Ridhi Khurana, Gautam Gawande, Meenu Kapoor, Sanjay Kapoor
Summary: OsMADS29 (M29) is a crucial regulator of seed development in rice and its expression is tightly regulated at transcriptional and post-transcriptional levels. This study reveals that calmodulin (CaM) interacts with M29 in a Ca2+-dependent manner, leading to localization of M29 in the cytoplasm. The interaction of CaM with M29 may also facilitate dimerization of two M29 monomers, suggesting a general regulatory mechanism for oligomerization and nuclear transport of MADS proteins.
Article
Neurosciences
Junjie Huang, Susu Liang, Longhui Li, Xingyi Li, Xiang Liao, Qianshuo Hu, Chunqing Zhang, Hongbo Jia, Xiaowei Chen, Meng Wang, Ruijie Li
Summary: Quantitative and mechanistic understanding of learning and long-term memory at the level of single neurons in living brains require highly demanding techniques, specifically the precise labeling of one cell and investigation of dendritic inputs through the learning process.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Genesis Mantilla, Maria C. Perez-Gordones, Soledad Cisneros-Montufar, Gustavo Benaim, Juan-Carlos Navarro, Marta Mendoza, Jose R. Ramirez-Iglesias
Summary: This study analyzed the CaMBD of multiple Ca2+-ATPases and identified specific patterns and amino acid selections in different species. The results demonstrated a conserved mechanism for maintaining calcium homeostasis across evolution and provided insights for detecting potential CaMBDs.
JOURNAL OF MEMBRANE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sanda Nastasia Moldovean, Vasile Chis
Summary: The study reveals that m-HTT proteins and CaM interact in the cerebral cortex, affecting intracellular calcium levels. The 9P(EM) model has the most significant impact on the structure and fluctuation rate of CaM, with lower interaction energies compared to the 45Qs-HTT mutant model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Goutham Kodakandla, Savannah J. West, Qiaochu Wang, Ritika Tewari, Michael X. Zhu, Askar M. Akimzhanov, Darren Boehning
Summary: Cell surface stimuli can induce the release of calcium from the endoplasmic reticulum to regulate cellular physiology. The S-acylation of Orai1 and STIM1 proteins plays a critical role in the assembly and function of CRAC channels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Kyung Min Chung, Hyunha Kim, Claudio Gouveia Roque, Ethan P. McCurdy, Trang T. T. Nguyen, Markus D. Siegelin, Jee-Yeon Huang, Ulrich Hengst
Summary: This study reveals a mechanism in which cells secrete a factor, TAILS, to enhance antioxidant signaling and mitochondrial function in neighboring neurons, providing protection against oxidative stress. This mechanism plays a critical role in preserving cognitive function in ischemic brain injury.
Article
Multidisciplinary Sciences
Rong-quan Xiao, Ting Ran, Qi-xuan Huang, Guo-sheng Hua, Da-meng Fan, Jia Yi, Wen Liu
Summary: JMJD6 is a potential therapeutic target in cancer treatment, and iJMJD6, a specific inhibitor of JMJD6, has been found to effectively suppress cancer cell proliferation, migration, and invasion. It represses oncogene expression and exhibits synergistic effects in combination with other drugs, providing a new avenue for cancer therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Francesca Vallese, Lorenzo Maso, Flavia Giamogante, Elena Poggio, Lucia Barazzuol, Andrea Salmaso, Raffaele Lopreiato, Laura Cendron, Lorella Navazio, Ginevra Zanni, Yvonne Weber, Tatjana Kovacevic-Preradovic, Boris Keren, Alessandra Torraco, Rosalba Carrozzo, Francesco Peretto, Caterina Peggion, Stefania Ferro, Oriano Marin, Giuseppe Zanotti, Tito Cali, Marisa Brini, Ernesto Carafoli
Summary: Precise regulation of calcium concentration is crucial for neuronal activity and dysregulation can lead to neurodegenerative processes. Mutations in ATP2B3 gene have been found to impair calcium pumping activity and are associated with hearing loss, cerebellar ataxia, and neurodevelopmental delay.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Alexander G. Stepchenko, Tatiana N. Portseva, Ivan A. Glukhov, Alina P. Kotnova, Bella M. Lyanova, Sofia G. Georgieva, Elizaveta Pankratova
Summary: The emergence of new primate-specific genes plays a crucial role in human and primate brain development. The Oct-1Z transcript, unique to primates, is mainly expressed in the human brain cortex and is involved in responding to stress conditions by activating genes related to neural cell differentiation and organ formation. This primate-specific genomic element, the Oct-1Z isoform of the POU2F1/Oct-1 transcription factor, contributes to brain development and cellular stress defense.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Xingyue Guan, Cheng Tan, Wenfei Li, Wei Wang, D. Thirumalai
Summary: This study reveals the crucial role of water-bridged interactions in metal ion coupled protein allostery, which reduces the ruggedness of ligand exchange landscape and facilitates allosteric communication. The asymmetric response of symmetrically arranged EF-hands upon Ca2+ binding is also highlighted as essential for efficient allosteric communication.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenzhong Yang, Xueyan Zhou, Helena R. Zimmermann, Tao Ma
Summary: Through the study of selectively suppressing brain AMPKα2 isoform, it was shown that impairment in cognition and hippocampal long-term potentiation can be induced, with the damage mediated by PERK-induced eIF2α phosphorylation, providing evidence for the molecular mechanism linking metabolism, protein synthesis, and cognition.
MOLECULAR PSYCHIATRY
(2021)
Article
Biophysics
Laurel Hoffman, Xu Wang, Hugo Sanabria, Margaret S. Cheung, John A. Putkey, M. Neal Waxham
BIOPHYSICAL JOURNAL
(2015)
Article
Biochemistry & Molecular Biology
Swarnendu Tripathi, Qian Wang, Pengzhi Zhang, Laurel Hoffman, M. Neal Waxham, Margaret S. Cheung
JOURNAL OF MOLECULAR RECOGNITION
(2015)
Article
Neurosciences
M. M. Farley, M. T. Swulius, M. N. Waxham
Article
Multidisciplinary Sciences
Swarnendu Tripathi, M. Neal Waxham, Margaret S. Cheung, Yin Liu
SCIENTIFIC REPORTS
(2015)
Article
Chemistry, Physical
Xubo Lin, Joseph H. Lorent, Allison D. Skinlde, Kandice R. Levental, M. Neal Waxham, Alemayehu A. Gorfe, Ilya Levental
JOURNAL OF PHYSICAL CHEMISTRY B
(2016)
Article
Cell Biology
Karolina Tulodziecka, Barbara B. Diaz-Rohrer, Madeline M. Farley, Robin B. Chan, Gilbert Di Paolo, Kandice R. Levental, M. Neal Waxham, Ilya Levental
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Chemistry, Multidisciplinary
Suparna Sarkar-Banerjee, Abdallah Sayyed-Ahmad, Priyanka Prakash, Kwang-Jin Cho, M. Neal Waxham, John F. Hancock, Alemayehu A. Gorfe
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Oncology
Monica Gireud-Goss, Sahily Reyes, Marenda Wilson, Madeline Farley, Kimiya Memarzadeh, Saipraveen Srinivasan, Natalie Sirisaengtaksin, Shinji Yamashita, Susan Tsunoda, Frederick F. Lang, M. Neal Waxham, Andrew J. Bean
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Tara D. Fischer, Pramod K. Dash, Jun Liu, M. Neal Waxham
Article
Biology
Donghyun Park, Maria Lara-Tejero, M. Neal Waxham, Wenwei Li, Bo Hu, Jorge E. Galan, Jun Liu
Article
Biophysics
Haden L. Scott, Allison Skinkle, Elizabeth G. Kelley, M. Neal Waxham, Ilya Levental, Frederick A. Heberle
BIOPHYSICAL JOURNAL
(2019)
Article
Multidisciplinary Sciences
Qian Wang, Mingchen Chen, Nicholas P. Schafer, Carlos Bueno, Sarah S. Song, Andy Hudmon, Peter G. Wolynes, M. Neal Waxham, Margaret S. Cheung
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Mark E. Maynard, John B. Redell, Nobuhide Kobori, Erica L. Underwood, Tara D. Fischer, Kimberly N. Hood, Vincent LaRoche, M. Neal Waxham, Anthony N. Moore, Pramod K. Dash
EXPERIMENTAL NEUROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Laurel Hoffman, Lin Li, Emil Alexov, Hugo Sanabria, M. Neal Waxham
Article
Neurosciences
Tara D. Fischer, Michael J. Hylin, Jing Zhao, Anthony N. Moore, M. Neal Waxharni, Pramod K. Dash
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2016)