Article
Biology
Asako Ishii, Jianyu Shan, Xin Sheng, Eunchul Kim, Akimasa Watanabe, Makio Yokono, Chiyo Noda, Chihong Song, Kazuyoshi Murata, Zhenfeng Liu, Jun Minagawa, David M. Kramer
Summary: Under low light conditions, Ostreococcus tauri assembles its photosystem I (PSI) supercomplex with light-harvesting complexes I (LHCI) and a prasinophyte-specific light-harvesting complex (Lhcp), expanding its photon-absorbing capacity. The structure of the supercomplex exhibits hybrid features of plant-type and green algal-type PSI supercomplexes. The formation of this supercomplex is likely induced by changes in light intensity through phosphorylation.
Review
Plant Sciences
Luiza Lane de Barros Dantas, Bethany M. Eldridge, Jack Dorling, Richard Dekeya, Deirdre A. Lynch, Antony N. Dodd
Summary: Circadian regulation plays a crucial role in the metabolism of photosynthetic organisms, maximizing plant productivity through alignment with day-night cycles. Understanding the relationship between circadian regulation and metabolism is important for enhancing sustainable crop production.
Article
Biochemistry & Molecular Biology
Wanggang Tang, Minhao Wu, Na Qin, Li Liu, Rui Meng, Chengliang Wang, Peng Wang, Jianye Zang, Guoping Zhu
Summary: This study elucidated the crystal structures and catalytic mechanism of OtIDH, revealing its novel interactions with NAD+ and conserved substrate binding mode. The findings demonstrated that OtIDH could be evolutionary ancestors of eukaryotic NADP-IDHs in the type II subfamily.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Silvia Ezpeleta, Elvira Orduna-Hospital, Justiniano Aporta, Maria Jose Luesma, Isabel Pinilla, Ana Sanchez-Cano
Summary: The evaluation of both visual and nonvisual effects from the spectral power distribution of outdoor light is critical in lighting design. This article suggests that the best parameter is the melanopic versus photopic irradiance ratio, which achieves reliable results at simplifying and correlating calculations. The study establishes a simple method to determine the SPD of daylight and solar radiation over the skydome accurately accounting for the effects of both photopic and circadian levels around a location.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Gabriella M. Marino, Deanna M. Arble
Summary: Sleep and circadian disruption are linked to a higher risk of metabolic disease. Researchers propose that targeting groups of cells with functional relationships can provide a better understanding of the consequences of sleep and circadian disruption, especially for metabolic outcomes that involve multiple sites of action.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dmitry Popov, Lekha Jain, Mariam Alhilali, Nicola Dalbeth, Raewyn C. Poulsen
Summary: Gout is caused by monosodium urate (MSU) crystal deposition in joints, leading to inflammation driven by NLRP3 inflammasome activation. Recent evidence suggests circadian control of NLRP3 inflammasome. This study found that MSU crystals alter the expression of circadian clock components in macrophages, resulting in time-of-day differences in NLRP3 inflammasome activation and susceptibility to gout flares.
Article
Endocrinology & Metabolism
Lindsey S. Brown, Melissa A. St Hilaire, Andrew W. McHill, Andrew J. K. Phillips, Laura K. Barger, Akane Sano, Charles A. Czeisler, Francis J. Doyle, Elizabeth B. Klerman
Summary: The study found that algorithms for estimating DLMO are less successful in college students with irregular schedules, with mean errors around 1.5-1.6 hours. By reframing the problem as a classification issue and using neural networks, the researchers achieved a high classification accuracy of about 90% in determining whether an individual is before or after DLMO. However, when applied to forced desynchrony protocols, the overall classification accuracy dropped to 55%-65%, with accuracy highly dependent on the phase angle between DLMO and sleep onset, particularly for nighttime sleep.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jason R. Carter, Kristen L. Knutson, Babak Mokhlesi
Summary: In March 2022, the US Senate passed the Sunshine Protection Act to abolish the biannual clock change and permanently adopt daylight saving time. However, leading scientific and medical organizations suggest a permanent switch to standard time instead. This article summarizes their recommendations and highlights the potential cardiovascular implications of the legislative change.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Theresa M. Casey, Karen Plaut
Summary: Understanding the biology of circadian clocks is crucial for optimizing cow health and production efficiency. Circadian clocks regulate metabolic and reproductive systems, and disruption of these clocks can negatively affect mammary development and lactation in dairy cows. External and internal cues, such as light and nutrients, play a role in setting the timing of circadian rhythms.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Physics, Fluids & Plasmas
P. L. Garrido, P. I. Hurtado
Summary: This article reports on the onset of convective flow in a compressible hard disk fluid under a temperature gradient and gravitational field using numerical simulations. The study reveals a surprising two-step transition scenario with two different critical temperatures.
Article
Clinical Neurology
Monika Angerer, Gerald Pichler, Birgit Angerer, Monika Scarpatetti, Manuel Schabus, Christine Blume
Summary: This study aimed to evaluate the effects of light therapy on circadian rhythms in post-comatose patients with disorders of consciousness (DOC). The results showed that dynamic daylight stimulation can entrain and stabilize circadian rhythms in these patients, highlighting the importance of adequate room lighting as an adjunct therapeutic approach for improving their rhythms.
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Article
Biochemistry & Molecular Biology
Marrit Putker, David C. S. Wong, Estere Seinkmane, Nina M. Rzechorzek, Aiwei Zeng, Nathaniel P. Hoyle, Johanna E. Chesham, Mathew D. Edwards, Kevin A. Feeney, Robin Fischer, Nicolai Peschel, Ko-Fan Chen, Michael Vanden Oever, Rachel S. Edgar, Christopher P. Selby, Aziz Sancar, John S. O'Neill
Summary: CRY proteins are considered essential components of the cellular clock mechanism, but studies show that circadian rhythms can still exist in the absence of CRY, albeit with variable expression and shorter periods. The classic circadian hallmarks like temperature compensation and period determination by specific activities are maintained even without CRY-mediated feedback repression. The sustained PER2 protein rhythms and circadian variation in protein stability suggest a post-translational core mechanism for biological clocks.
Article
Chemistry, Multidisciplinary
Ana Sanchez-Cano, Elvira Orduna-Hospital, Guisela Fernandez-Espinosa, Justiniano Aporta
Summary: This study aims to simplify a method to calculate circadian light reaching the retina based on photopic illuminance and the optical density of an aging crystalline lens. Calculations were performed with D65 and A standard illuminants, showing how the spectral power distribution is modified by the optical density of the lens. Selective wavelength absorptions of the aged lens lead to significant variations in the level of daylight equivalent melanopic illuminance in the retina. The results of this study will allow researchers to optimize lighting designs considering the optical density of an aging lens from both photometric and circadian perspectives.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Yun Jae Eo, Seohyeon Kim, Keyong Nam Lee, Dae Hwan Kim, Changwook Kim, Seung Min Lee, Young Rag Do
Summary: A simple circadian light meter was fabricated to assess the effects of light on the human circadian rhythm, and was found to show significant differences in light exposure levels between daytime and nighttime, which may impact melatonin levels. The developed light meter is a valuable tool for real world circadian lighting studies that require actual light dose to the eyes of the test subjects.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Meike Luck, Francisco Velazquez Escobar, Kathrin Glass, Mareike-Isabel Sabotke, Rolf Hagedorn, Florence Corellou, Friedrich Siebert, Peter Hildebrandt, Peter Hegemann
Article
Biochemistry & Molecular Biology
Marie Guilbert, Francois Anquez, Alexandra Pruvost, Quentin Thommen, Emmanuel Courtade
Article
Plant Sciences
Charlotte Degraeve-Guilbault, Rodrigo E. Gomez, Cecile Lemoigne, Nattiwong Pankansem, Soizic Morin, Karine Tuphile, Jerome Joubes, Juliette Jouhet, Julien Gronnier, Iwane Suzuki, Denis Coulon, Frederic Domergue, Florence Corellou
Article
Multidisciplinary Sciences
Julien Hurbain, Darka Labavic, Quentin Thommen, Benjamin Pfeuty
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Benjamin Pfeuty, Emmanuel Courtade, Quentin Thommen
Summary: The study developed a data-driven modeling framework to capture cell adaptation behaviors to heat stress, providing an effective tool for designing preconditioning and fractionation hyperthermia protocols for therapeutic purpose.
Article
Plant Sciences
Charlotte Degraeve-Guilbault, Nattiwong Pankasem, Maurean Gueirrero, Cecile Lemoigne, Frederic Domergue, Tomonori Kotajima, Iwane Suzuki, Jerome Joubes, Florence Corellou
Summary: This study reveals the mechanism of fatty acid unsaturation in response to temperature changes, identifies the important role of desaturases in this process, and elucidates the regulatory relationship of specific fatty acids in different lineages.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Marie Guilbert, Emmanuel Courtade, Quentin Thommen
Summary: The cellular environment has an impact on cellular phenotypes, particularly the stress response phenotype. This study investigates the influence of collagen type I on the phenotypic heterogeneity of cellular response, and explains the observed changes through mathematical modeling. The experimental results are consistent with the predictions of the mathematical model, demonstrating a new approach to studying phenotypic heterogeneity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Alan Vandenberghe, Marc Lefranc, Alessandro Furlan
Summary: This review discusses the links between an altered circadian clock and the rise of pathologies, and emphasizes the importance of integrating circadian clock considerations in healthcare, medicine, and pharmacotherapy.
Article
Multidisciplinary Sciences
Julien Hurbain, Quentin Thommen, Francois Anquez, Benjamin Pfeuty
Summary: Living cells utilize signaling and regulatory mechanisms to adapt to environmental stresses, including oxidative stress. Research on adaptation to oxidative stress has shown that carbon flux rerouting into the pentose phosphate pathway involves the upregulation of G6PD activity, a decreased NADPH/NADP(+) ratio, and differential control of glycolytic fluxes. These regulatory feedback mechanisms promote efficient detoxification and homeostasis response.
Article
Biotechnology & Applied Microbiology
Quentin Thommen, Julien Hurbain, Benjamin Pfeuty
Summary: In this study, a stochastic simulation algorithm (SSA) derived from the chemical master equation of the isotope labeling system is proposed. The algorithm can compute the time evolution of isotopomer concentrations in non-stationary conditions without being influenced by the number of isotopomers. It is well-suited for comprehensive dataset including parallel labeling experiments and can serve as an alternative approach for metabolic flux analysis.
METABOLIC ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Majid Layachi, Anthony Treizebre, Laurent Hay, David Gilbert, Jean Pesez, Quentin D'Acremont, Kevin Braeckmans, Quentin Thommen, Emmanuel Courtade
Summary: An optofluidic method has been developed to bring gold nanoparticles close to cells for efficient photoporation, which can be used for producing genetically engineered therapeutic cells. This approach holds promise for clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Meteorology & Atmospheric Sciences
Faustine Mascaut, Olivier Pujol, Jerome Brioude, Andrew Jensen, Marc Lefranc, Stephanie Evan, Suzanne Crumeyrolle
Summary: In this paper, a non-linear bulk model based on species competition dynamics is proposed to describe the physics of water vapor-aerosol-cloud-rain interactions. The model is able to efficiently reproduce the macro features of clouds, such as cloud occurrences, cloud water content magnitudes, and cloud-rain links, based on comparisons with in situ measurements and observations. It can be adjusted to different spatiotemporal resolutions and used in various regions as long as implementation data is available.
ATMOSPHERIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Pfeuty, Julien Hurbain, Quentin Thommen
Summary: This article proposes a sampling-based metabolic control analysis framework to investigate the modes of regulatory interplay in metabolic functions. Using NADPH homeostasis as an example, the framework characterizes the respective and combined effects of regulations, distinguishing between synergistic and complementary modes of regulatory crosstalk. The results show that these cooperative effects significantly improve metabolic flux response to support NADPH homeostasis, providing a rationale for the complex feedback regulation pattern at work.
Article
Oncology
D. Labavic, M. T. Ladjimi, E. Courtade, B. Pfeuty, Q. Thommen
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)
Article
Oncology
M. T. Ladjimi, D. Labavic, M. Guilbert, F. Anquez, A. Pruvost, E. Courtade, B. Pfeuty, Q. Thommen
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)