Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR

Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

(2009) Suman Verma et al.   BMC CANCER

Hybrid Scoring and Classification Approaches to Predict Human Pregnane X Receptor Activators

(2009) Sandhya Kortagere et al.   PHARMACEUTICAL RESEARCH

Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

(2009) Arunima Biswas et al.   PHARMACEUTICAL RESEARCH

The importance of discerning shape in molecular pharmacology

(2009) Sandhya Kortagere et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Evolution of pharmacologic specificity in the pregnane X receptor

(2008) Sean Ekins et al.   BMC EVOLUTIONARY BIOLOGY

Machine Learning Methods and Docking for Predicting Human Pregnane X Receptor Activation

(2008) Akash Khandelwal et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer

(2008) D. Gupta et al.   CLINICAL CANCER RESEARCH

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

(2008) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Critical Assessment of QSAR Models of Environmental Toxicity againstTetrahymena pyriformis:Focusing on Applicability Domain and Overfitting by Variable Selection

(2008) Igor V. Tetko et al.   Journal of Chemical Information and Modeling

Global Bayesian Models for the Prioritization of Antitubercular Agents

(2008) Philip Prathipati et al.   Journal of Chemical Information and Modeling

Pareto optimization in computational protein design with multiple objectives

(2008) María Suárez et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Intrinsic Disorder in Nuclear Hormone Receptors

(2008) Matthew D. Krasowski et al.   JOURNAL OF PROTEOME RESEARCH

Structural Basis of Human Pregnane X Receptor Activation by the Hops Constituent Colupulone

(2008) D. G. Teotico et al.   MOLECULAR PHARMACOLOGY

Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions

(2008) Denise G. Teotico et al.   PLoS Computational Biology

The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells

(2007) Jie Zhou et al.   MOLECULAR ENDOCRINOLOGY