Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Christina Tatsi, Megan Neely, Chelsi Flippo, Maria-Eleni Bompou, Meg Keil, Constantine A. Stratakis
Summary: The recovery of adrenal function in pediatric patients with CD after TSS may not be influenced by most clinical and biochemical factors, except for an increase in urinary free cortisol which may prolong the recovery time. Patients who recover adrenal function earlier are at a higher risk for CD recurrence, highlighting the importance of close follow-up and counseling for these patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Psychology, Multidisciplinary
Isabel Crespo-Sanmiguel, Mariola Zapater-Fajari, Matias M. Pulopulos, Vanesa Hidalgo, Alicia Salvador
Summary: The study found that early life stress (ELS) is associated with perceived stress, but not with HPA axis functioning. Loneliness mediates the relationship between ELS and perceived stress, but not between ELS and HPA axis functioning.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Agnes Martin, Josiane Castells, Valentine Allibert, Andrea Emerit, Cindy Zolotoff, Victoire Cardot-Ruffino, Yann S. Gallot, Barbara Vernus, Veronique Chauvet, Laurent Bartholin, Laurent Schaeffer, Anne-Cecile Durieux, Christophe Hourde, Francois B. Favier, Laetitia Mazelin, Damien Freyssenet
Summary: This study found that the hypothalamic-pituitary-adrenal-glucocorticoid pathway plays an important role in the transcriptional regulation of skeletal muscle catabolism and hepatic metabolism during cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Aleksandra S. S. Stojiljkovic, Zeljko Cupic, Stevan Macesic, Ana Ivanovic-Sasic, Ljiljana Kolar-Anic
Summary: This study investigates the mechanisms underlying the effects of arginine vasopressin (AVP) on the Hypothalamic-Pituitary-Adrenal (HPA) axis and reveals the influence of the synergistic action between AVP and corticotrophin-releasing hormone (CRH) on the ultradian dynamics of the HPA axis. The extended nonlinear network reaction model incorporates AVP into the HPA axis model and explores the conditions under which the HPA system transitions between oscillatory and stable states. The results demonstrate the importance of the synergy reaction rate constant and highlight the superior stimulatory effect of CRH compared to AVP on ACTH secretion in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian
Summary: The study demonstrated that electroacupuncture can normalize HPA axis dysfunction by reducing the transcription and synthesis of SCGN, thus facilitating recovery from surgical trauma.
Article
Endocrinology & Metabolism
Annamaria De Bellis, Giuseppe Bellastella, Vlenia Pernice, Paolo Cirillo, Miriam Longo, Antonietta Maio, Lorenzo Scappaticcio, Maria Ida Maiorino, Antonio Bellastella, Katherine Esposito, Jose G. Montoya
Summary: This study found that high titers of antihypothalamic (AHA) and/or antipituitary (APA) antibodies were associated with hypothalamic/pituitary dysfunction in ME/CFS patients, indicating the potential important role of hypothalamic/pituitary autoimmunity in the manifestations of ME/CFS, especially in its severe forms.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)