Article
Mathematics, Interdisciplinary Applications
Adriane S. Reis, Kelly C. Iarosz, Fabiano A. S. Ferrari, Ibere L. Caldas, Antonio M. Batista, Ricardo L. Viana
Summary: The study explores bursting synchronization in a neuronal network model inspired by the human cerebral cortex, which can be partially or completely suppressed using an external signal based on time delay and signal intensity. The findings suggest that bursting synchronization in the network model can be related to pathological rhythms and targeted suppression techniques may have potential applications for mitigating such pathologies.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Mathematics, Applied
Lou Zonca, David Holcman
Summary: This study developed a bursting model based on synaptic dynamics to simulate the bursts and interburst intervals of neuronal networks. Bursting is defined by long deterministic excursions away from the attractor, while interburst intervals correspond to escape induced by random fluctuations.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Mathematical & Computational Biology
Umesh Kumar Verma, G. Ambika
Summary: The study demonstrates the emergence of various spatio temporal patterns among neurons connected in a multiplex framework, with different functional couplings on two layers. Patterns such as in-phase synchronized oscillations, amplitude death, and anti-phase mixed-mode oscillations are observed.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Florencia Fernandez-Chiappe, Lia Frenkel, Carina Celeste Colque, Ana Ricciuti, Bryan Hahm, Karina Cerredo, Nara Ines Muraro, Maria Fernanda Ceriani
Summary: Research on Drosophila has revealed that the electrical properties of clock neurons play a crucial role in the temporal coordination of circadian behaviors, with the Ih channel being essential for communication between neurons and behavioral effects.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Akira Terui, Seoghyun Kim, Christine L. Dolph, Taku Kadoya, Yusuke Miyazaki
Summary: The prevailing paradigm suggests that species richness increases with area in a decelerating way. However, in spatially complex ecosystems like river networks, biodiversity patterns may scale along two dimensions of ecosystem size and complexity. Ecosystem size dictates metacommunity size and habitat diversity, while ecosystem complexity, represented by branching in fractal systems, controls habitat heterogeneity and affects species richness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Mathematics, Interdisciplinary Applications
Shaohua Zhang, Cong Wang, Hongli Zhang, Ping Ma, Xinkai Li
Summary: In this paper, a bursting oscillation suppression method is proposed for fractional-order permanent magnet synchronous motor (FPMSM) systems. The mechanism of bursting oscillations is revealed through system modeling and analysis methods. An adaptive backstepping super-twisting sliding mode control method is introduced to ensure the stable operation of the system, and comparisons with other methods are conducted.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Multidisciplinary Sciences
Kazufumi Sakamoto, Yoshitsune Hondo, Naoki Takahashi, Yuhei Tanaka, Rikuto Sekine, Kenji Shimoda, Haruki Watanabe, Kenji Yasuda
Summary: The study found that synchronized beating intervals of cardiomyocyte clusters were longer than those of isolated single cells, contradicting conventional regulations. This suggests that emergent slower synchronous beating occurred as a community effect of spontaneously beating cells within homogeneous cardiomyocyte clusters.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tsvetomira Atanasova, Tiina Savonlehto, Tiina-Kaisa Kukko-Lukjanov, Zoia Kharybina, Wei-Chih Chang, Sari E. Lauri, Tomi Taira
Summary: Kainate receptors play an important role in the development and pathological synchronization of the hippocampal neural network. GluK1 KARs regulate functional connectivity between excitatory neurons, possibly through morphological changes in the glutamatergic circuit that affect the synchronization of neuronal populations.
Article
Engineering, Mechanical
I. B. Tagne Nkounga, F. M. Moukam Kakmeni, B. Camara, R. Yamapi
Summary: A birhythmic conductance-based neuronal model with fast and slow variables is proposed to generate and control the coexistence of two different attracting modes in amplitudes and frequencies. By varying a specific parameter, the system can switch between periodic and chaotic spiking, and periodic and chaotic bursting. The adaptation variable in the neuron system filters existing electrical processes and allows the system to adapt to multiple transition states.
NONLINEAR DYNAMICS
(2022)
Article
Cell Biology
Saichiro Yagi, Hideyoshi Igata, Yuji Ikegaya, Takuya Sasaki
Summary: Learning new experiences leads to reorganization of hippocampal neuronal circuits, which is facilitated by coordinated reactivation patterns during offline states for memory consolidation. This study investigates the relationship between awake synchronous events during a novel run and post-run reactivation patterns. Disruption of awake sharp-wave ripples inhibits the contribution of neurons to post-experience synchronous events. Hippocampal place cells that participate more in awake synchronous events exhibit stronger reactivation during post-experience synchronous events. Awake synchronous neuronal patterns, in conjunction with place-selective firing patterns, determine the cell ensembles for subsequent synchronous reactivation, supporting memory consolidation.
Article
Mathematics, Interdisciplinary Applications
A. S. Reis, E. L. Brugnago, R. L. Viana, A. M. Batista, K. C. Iarosz, F. A. S. Ferrari, I. L. Caldas
Summary: In this study, a model of a clustered network formed by scale-free subnetworks is used to investigate the synchronization of neuronal activity. The spatial distribution of vertices in the cerebral cortex is simulated using the fitness model. The cortical connections in the network are established based on a human connectivity matrix obtained from experimental data. The results demonstrate that the fitness model and a three-stage switching control with time-delayed feedback are effective in suppressing synchronization in clustered networks.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Mathematics, Interdisciplinary Applications
Bo Lu, Huaguang Gu, Xianjun Wang, Hongtao Hua
Summary: This paper investigates paradoxical phenomena in bursting activity modulated by inhibitory autapse, revealing that with increased inhibitory autaptic conductance, burst duration widens or spike number per burst increases. Different bursting patterns are observed, and the paradoxical enhancement of bursting activity is explained by nonlinear dynamics.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Clinical Neurology
Miaoxian Yang, Shuixiang Deng, Junliang Jiang, Mi Tian, Lei Xiao, Ye Gong
Summary: This study investigates the role of oxytocin (OXT) in improving outcomes after intracerebral hemorrhage (ICH). The results show that endogenous OXT levels decrease while OXT receptor expression increases after ICH. Intranasal application of OXT improves neurological deficits, reduces neuronal pyroptosis and neuroinflammation, and decreases excessive mitochondrial fission and oxidative stress. These effects are mediated by the OXTR/p-PKA/DRP1 signaling pathway. Therefore, OXT administration may be a potential therapeutic strategy for ICH.
Article
Neurosciences
Ben Cao, Runxia Wang, Huaguang Gu, Yuye Li
Summary: This study explored the response of different bursting patterns to noise, the relationship between spike undershoot and subthreshold oscillations within bursts, and the impact of noise on information processing and bursting regularity. The characteristics of bursting patterns determine whether noise-induced coherence resonance occurs.
COGNITIVE NEURODYNAMICS
(2021)
Article
Mathematical & Computational Biology
Zilu Liu, Qingyun Wang, Fang Han
Summary: This study investigates the dynamics of synchronous theta oscillations using a hybrid E-I network as a conceptual model of the hippocampus. The results clarify the distinct role of synaptic connections in theta rhythm generation, facilitation of synchronization, and induction of burst activities. Counter-inhibition is found to be effective in modulating network synchronization, while having little effect on regulating network frequency.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Duncan J. MacGregor, Gareth Leng
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Shumsuzzaman Khan, Xinjiang Lu, Qingyao Huang, Jiawei Tang, Jian Weng, Zhi Yang, Minchao Lv, Xiaokang Xu, Fangyuan Xia, Mengchen Zhang, Yi Li, Shuangshuang Liu, Gareth Leng, Nicholas Spitzer, Jizeng Du, Xuequn Chen
Article
Endocrinology & Metabolism
Daichi Kayo, Yoshitaka Oka, Shinji Kanda
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Luis Paiva, Gareth Leng
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Yan Tang, Diego Benusiglio, Arthur Lefevre, Louis Hilfiger, Ferdinand Althammer, Anna Bludau, Daisuke Hagiwara, Angel Baudon, Pascal Darbon, Jonas Schimmer, Matthew K. Kirchner, Ranjan K. Roy, Shiyi Wang, Marina Eliava, Shlomo Wagner, Martina Oberhuber, Karl K. Conzelmann, Martin Schwarz, Javier E. Stern, Gareth Leng, Inga D. Neumann, Alexandre Charlet, Valery Grinevich
NATURE NEUROSCIENCE
(2020)
Article
Physiology
Yoichi Kasahara, Masataka Narukawa, Yoshiro Ishimaru, Shinji Kanda, Chie Umatani, Yasunori Takayama, Makoto Tominaga, Yoshitaka Oka, Kaori Kondo, Takashi Kondo, Ayako Takeuchi, Takumi Misaka, Keiko Abe, Tomiko Asakura
Summary: The study reveals that TMC4 acts as a chloride channel responding to high-concentration NaCl in the oral cavity, facilitating the permeation of organic anions and showing a weaker glossopharyngeal nerve response in Tmc4-deficient mice compared to wild-type littermates.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Soma Tomihara, Yoshitaka Oka, Shinji Kanda
Summary: Behavioral analysis plays a crucial role in biological studies, but manual behavioral recordings are laborious and prone to human-errors. By establishing an open-source behavioral recording system using Raspberry Pi, automated video-recording and file-sorting are achieved, reducing human errors significantly. Additionally, with the development of an Excel macro, behavioral annotation becomes easier and more efficient.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Chie Umatani, Nagisa Yoshida, Eri Yamamoto, Yasuhisa Akazome, Yasutaka Mori, Shinji Kanda, Kataaki Okubo, Yoshitaka Oka
Summary: Animals use multiple sensory cues to perform sexual behaviors, but the neural mechanisms behind integrating these cues and regulating motivation for sexual behaviors are not well understood. This study focuses on TN-GnRH neurons, which co-express NPFF and GnRH3, and demonstrates their role in modulating certain neuronal circuits for controlling behavioral motivation. Specifically, NPFF activates neurons in the preoptic area, leading to an increase in motivation for male sexual behaviors. These findings contribute to our understanding of the functional significance of peptidergic neuromodulation in response to sensory information from the external environments.
Article
Endocrinology & Metabolism
Kana Ikegami, Sho Kajihara, Chie Umatani, Mikoto Nakajo, Shinji Kanda, Yoshitaka Oka
Summary: Using a non-mammalian model of medaka, it was found that 17 beta-estradiol could promote the upregulation of GnRH1 neuronal activity, triggering the GnRH surge, and the combined action of estrogen and time signals is crucial for triggering ovulation at the appropriate time.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Satoshi Ogawa, Naoyuki Yamamoto, Hanako Hagio, Yoshitaka Oka, Ishwar S. Parhar
Summary: Three paralogous genes for GnRH and GnRH receptors exist in non-mammalian vertebrates. The migration of GnRH neurons in the brain is evolutionally conserved across different species. Each GnRH system has distinctive anatomical and physiological characteristics, and functions differently based on their origin and expression patterns.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Physics, Fluids & Plasmas
Giovanni Montani, Nakia Carlevaro, Brunello Tirozzi
Summary: This study constructs a model to analyze the turbulence near the X-point of a Tokamak device and obtains a closed equation for the electric field potential fluctuations. The analysis reveals that under certain operating conditions, the turbulence near the X-point is dominated by the enstrophy cascade from large to smaller spatial scales.
Article
Physics, Multidisciplinary
Brunello Tirozzi, Paolo Buratti
Summary: In this paper, a theory of force-free magnetic field useful for explaining the formation of convex closed sets, bounded by a magnetic separatrix in the plasma, is developed. The theory utilizes an analytic method based on a first-order expansion of the poloidal magnetic flux function, and solves the Grad-Shafranov equation to obtain an analytic expression for the solution. This work is important for understanding the application of force-free magnetic fields in laboratory and astrophysical plasmas.
Article
Physics, Multidisciplinary
Brunello Tirozzi
Article
Physics, Multidisciplinary
Masha Shcherbina, Brunello Tirozzi, Camillo Tassi
Article
Physics, Fluids & Plasmas
Paolo Buratti, Brunello Tirozzi, Franco Alladio, Paolo Micozzi