Review
Medicine, General & Internal
Maria Teresa Gentile, Gianluca Muto, Giacomo Lus, Karl-Olof Lovblad, Asa Fex Svenningsen, Luca Colucci-D'Amato
Summary: This article reviews the role of angiogenesis in the onset and development of multiple sclerosis, including the molecular mechanisms, current therapeutic approaches, and potential therapeutic strategies with natural compounds as multi-target drugs with neuroprotective and anti-angiogenic properties.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Computer Science, Artificial Intelligence
Nazik Zakari, Muna Al-Razgan, Amani Alsaadi, Haya Alshareef, Heba Al Saigh, Lamia Alashaikh, Mala Alharbi, Rana Alomar, Seham Alotaibi
Summary: Blockchain technology is being adopted in the pharmaceutical industry to address issues such as lack of transparency, product tracking difficulties, lack of trust, and shipment of expired products. This systematic review of literature explores the various applications of blockchain technology in pharmaceuticals, with counterfeit drug prevention being the most common category. Newer research areas include data governance, data quality, pharmaceutical turnover, and prescription drug monitoring.
PEERJ COMPUTER SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Carolina Sall, Upendra Argikar, Kari Fonseca, Constanze Hilgendorf, Filipe Lopes, Jens Riedel, Hilmar Schiller, Anders Sonesson, Kenichi Umehara, Kai Wang
Summary: Currently, there are no regulatory guidelines for drug-drug interaction (DDI) assessments specifically for therapeutic peptides. A cross-industry working group was formed to investigate DDI studies conducted by companies involved in peptide drug development and compile a database of relevant data. Significant gaps and uncertainties were identified, highlighting the need for harmonization of DDI approaches for therapeutic peptides.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Chemistry, Applied
Paridhi Agrawal, Katerina Wilkstein, Emily Guinn, McKensie Mason, Carolina I. Serrano Martinez, Jeremiah Saylae
Summary: Tangential flow filtration (TFF) is widely used in various industries for membrane separation and purification processes. In the pharmaceutical industry, TFF has become more popular due to the need for telescoped manufacturing and the synthesis of high-volume drugs. This review focuses on the development of TFF processes, its applications in producing pharmaceutically relevant molecules, and provides insights for future improvements.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Review
Pharmacology & Pharmacy
Thenrajan Raja Sekharan, Oly Katari, Syed Nazrin Ruhina Rahman, Datta Maroti Pawde, Abhinab Goswami, Rajappa Margret Chandira, Tamilvanan Shunmugaperumal
Summary: The utilization of traditional volatile organic compound-based extraction processes in the pharmaceutical industry is being questioned due to safety concerns, leading to an encouragement of neoteric solvents. This review provides an overview of four neoteric solvents in API extraction and pharmaceutical product development, highlighting the potential of solvent-free reactions as a replacement in future drug development.
DRUG DISCOVERY TODAY
(2021)
Article
Pharmacology & Pharmacy
Mueen Uddin
Summary: Counterfeit drugs pose a serious threat to the pharmaceutical industry, with approximately 10% of drugs produced in the least developing countries being counterfeit. The proposed blockchain-enabled Medledger system leverages smart contracts to securely and efficiently execute drug supply chain transactions, reducing the need for centralized authorities and intermediaries. Storing all activities and transactions on an immutable blockchain ledger ensures transparency and traceability while addressing ongoing challenges in implementing the hyperledger fabric platform.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Gan Fu, Zhao Zhao
Summary: Especially in the post-pandemic period, the operational risks of pharmaceutical supply chains are uncertain due to the increased risk of supply disruptions. Businesses are concerned about how to handle the risk of supply disruption and minimize losses. The three-tiered supply chain consists of pharmaceutical raw material suppliers, pharmaceutical manufacturers, and medical institutions.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Materials Science, Multidisciplinary
Rahul Upadhya, Ashish Punia, Mythili J. Kanagala, Lina Liu, Matthew Lamm, Timothy A. Rhodes, Adam J. Gormley
Summary: By utilizing an automated combinatorial library approach and rapid screening strategy, researchers successfully synthesized and screened polymer excipients for the model drug probucol, elucidating the relationship between polymer hydrophobicity, monomer hydrophobic side group geometry, and API dissolution performance.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Abdulrahman A. Halwani
Summary: Nanotechnology has a significant impact on medicine and drug delivery, addressing the limitations of conventional pharmaceutical agents. Many nanotechnology applications have been developed and nanotechnology-based medicines are now on the market. Nanotechnology attracts increasing investment worldwide. Pharmaceutical nanomedicine products are projected to play a major role in the global pharmaceutical market and healthcare system.
Article
Immunology
Xinyue Yin, Xinming Rang, Xiangxiang Hong, Yinglian Zhou, Chaohan Xu, Jin Fu
Summary: In this study, target genes and target pathways for drug repositioning in multiple sclerosis (MS) were identified based on transcriptomic changes in MS immune cells. The study found that targeting both the PI3K-Akt signaling pathway and Chemokine signaling pathway, or using tyrosine kinase inhibitors may be potential therapies for the treatment of MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Chemistry, Medicinal
Maria Dichiara, Emanuele Amata
Summary: Integrating efforts from pharmacologists and biologists into sustained innovation from synthetic chemists is crucial for the progress of H2S research and the development of H2S therapeutics for clinical use.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Jianfeng Lin, Jiawei Zhou, Yan Xu
Summary: Lin et al. use Mendelian randomization analysis to identify potential drug targets for multiple sclerosis. They find that genetically determined levels of certain plasma and CSF proteins are associated with multiple sclerosis risk. These findings suggest promising drug targets for multiple sclerosis prevention.
Article
Information Science & Library Science
Yang Gao, Wenjing Duan, Huaxia Rui
Summary: This study investigates the impact of social media on the speed of product recalls, finding that more adverse drug reaction discussions on social media lead to a higher hazard rate of the drug being recalled and, thus, a shorter time to recall.
INFORMATION SYSTEMS RESEARCH
(2021)
Review
Engineering, Chemical
Outi M. H. Salo-Ahen, Ida Alanko, Rajendra Bhadane, Alexandre M. J. J. Bonvin, Rodrigo Vargas Honorato, Shakhawath Hossain, Andre H. Juffer, Aleksei Kabedev, Maija Lahtela-Kakkonen, Anders Stottrup Larsen, Eveline Lescrinier, Parthiban Marimuthu, Muhammad Usman Mirza, Ghulam Mustafa, Ariane Nunes-Alves, Tatu Pantsar, Atefeh Saadabadi, Kalaimathy Singaravelu, Michiel Vanmeert
Summary: This review provides a comprehensive overview of the current applications of MD in the drug development process, covering target validation, lead discovery, lead optimization, and pharmaceutical formulation development. The importance of MD in providing insights into drug targets, evaluating ligand-receptor interactions, and considering lipid bilayer environments in membrane protein simulations is highlighted. Additionally, the emerging role of MD in studying crystalline and amorphous solids, drug-polymer formulations, drug solubility, and nano-particle simulations is discussed.
Article
Clinical Neurology
Zahra Ghadimi Korka, Shohreh Noorizadeh Dehkordi, Soheil Mansour Sohani, Marzieh Yassin
Summary: The Trunk Impairment Scale (TIS) in Persian has been found to be a relevant and reliable tool for assessing trunk abnormalities in Persian-speaking people with multiple sclerosis (PWMS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Maddalena Sparaco, Elisabetta Maida, Floriana Bile, Renato Vele, Luigi Lavorgna, Giuseppina Miele, Simona Bonavita
Summary: The SDQ was translated into Italian and validated for use in pwMS to detect swallowing disturbances. The 14-item SDQ demonstrated high internal consistency, good accuracy, and reliability in pwMS, making it a readily applicable tool for investigating dysphagia in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Leticia Rodrigues Gomes, Benito Pereira Damasceno, Brunno Machado de Campos, Alfredo Damasceno
Summary: This study found that patients with multiple sclerosis (MS) have more frequent work restrictions and impairment in money management and driving abilities compared to controls. Cognitive function, physical disability, and MS lesion burden are strongly associated with work restrictions, and social cognition can influence financial capacity. Cognitive and brain reserve can help retain some of these daily occupations.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Kaitlin E. Riegler, John Beauvais, Lindsay O. Neto, Elizabeth S. Gromisch
Summary: This study examined the differences in resilience levels among individuals with multiple sclerosis (PwMS) who had sleep disorders, sleep problems, and no sleep disorders/problems. The results showed that PwMS with sleep disorders had significantly lower resilience, with the difference being driven by the support from family and friends. These findings highlight the connection between sleep and resilience in PwMS, emphasizing the importance of social support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
A. Maunula, S. Atula, Sm Laakso, Pj Tienari
Summary: This study aimed to investigate the frequency and risk factors of FTY rebound in a hospital district in Southern Finland. The results showed that 10.5% of patients experienced a rebound, and 28% of patients had relapses of any severity after discontinuing FTY. Younger age at diagnosis, longer exposure to FTY, lower lymphocyte count, and higher neutrophil to lymphocyte ratio after discontinuation were identified as risk factors for a rebound.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
