☆ 4.6 Article

Local Function Conservation in Sequence and Structure Space

PLOS COMPUTATIONAL BIOLOGY (2008)

期刊

PLOS COMPUTATIONAL BIOLOGY

卷 4, 期 7, 页码 -

出版社

PUBLIC LIBRARY SCIENCE

DOI: 10.1371/journal.pcbi.1000105

关键词

-

类别

Biochemical Research Methods Mathematical & Computational Biology

资金

European Commission [LSHG-CT-2003-503265]

向作者/读者索取更多资源

Protocol

Reagent

摘要

We assess the variability of protein function in protein sequence and structure space. Various regions in this space exhibit considerable difference in the local conservation of molecular function. We analyze and capture local function conservation by means of logistic curves. Based on this analysis, we propose a method for predicting molecular function of a query protein with known structure but unknown function. The prediction method is rigorously assessed and compared with a previously published function predictor. Furthermore, we apply the method to 500 functionally unannotated PDB structures and discuss selected examples. The proposed approach provides a simple yet consistent statistical model for the complex relations between protein sequence, structure, and function. The GOdot method is available online (http://godot.bioinf.mpiinf.mpg.de).

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Genetics & Heredity

Ultraconserved enhancer function does not require perfect sequence conservation

Valentina Snetkova, Athena R. Ypsilanti, Jennifer A. Akiyama, Brandon J. Mannion, Ingrid Plajzer-Frick, Catherine S. Novak, Anne N. Harrington, Quan T. Pham, Momoe Kato, Yiwen Zhu, Janeth Godoy, Eman Meky, Riana D. Hunter, Marie Shi, Evgeny Z. Kvon, Veena Afzal, Stella Tran, John L. R. Rubenstein, Axel Visel, Len A. Pennacchio, Diane E. Dickel

Summary: Mutagenesis of 23 ultraconserved enhancers and examination of their activities in transgenic mouse reporter assays show that overall their regulatory properties are robust to mutation. Manipulation of endogenous loci in mice corroborates reporter assay data.

NATURE GENETICS (2021)

添加到收藏夹

Article Mathematics, Applied

A new local function and a new compatibility type in ideal topological spaces

Ferit Yalaz, Aynur Keskin Kaymakci

Summary: In this study, a new local function is defined and its properties are examined. The new local function is compared with the well-known local function and the local closure function. With the help of this new local function, the psi(& sigmaf;*gamma) operator is defined and topologies are obtained. Alternative answers are given to an open question found in the literature. psi(& sigmaf;*gamma)-compatibility is defined and its properties are examined. New spaces are defined and characterized.

AIMS MATHEMATICS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Local sequence-structure relationships in proteins

Tatjana Skrbic, Amos Maritan, Achille Giacometti, Jayanth R. Banavar

Summary: The study focuses on exploring how amino acid sequence relates to local protein structure, using two angles θ and μ to represent the structure of each C-alpha atom, organizing 20 amino acids into six groups to analyze their similarities, and observing that the correlation between sequence and structure is not very strong.

PROTEIN SCIENCE (2021)

添加到收藏夹

Article Mathematics

Representations of Rectifying Isotropic Curves and Their Centrodes in Complex 3-Space

Jinhua Qian, Pei Yin, Xueshan Fu, Hongzeng Wang

Summary: This work investigates rectifying isotropic curves in three-dimensional complex space C3, concluding that such curves are rectifying when their pseudo curvature is a linear function of their pseudo arc-length. The rectifying isotropic curves are explicitly expressed using Bessel functions, and the centrodes of these curves are explored in detail.

MATHEMATICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

PredictProtein - Predicting Protein Structure and Function for 29 Years

Michael Bernhofer, Christian Dallago, Tim Karl, Venkata Satagopam, Michael Heinzinger, Maria Littmann, Tobias Olenyi, Jiajun Qiu, Konstantin Schuetze, Guy Yachdav, Haim Ashkenazy, Nir Ben-Tal, Yana Bromberg, Tatyana Goldberg, Laszlo Kajan, Sean O'Donoghue, Chris Sander, Andrea Schafferhans, Avner Schlessinger, Gerrit Vriend, Milot Mirdita, Piotr Gawron, Wei Gu, Yohan Jarosz, Christophe Trefois, Martin Steinegger, Reinhard Schneider, Burkhard Rost

Summary: PredictProtein has been a one-stop online resource for protein sequence analysis since 1992, providing various predictions including protein structure, function, and binding. Recently, new prediction methods such as deep learning embeddings and prediction of protein and residues binding DNA, RNA, or other proteins have been added to enhance its usability for computational and experimental biologists.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

Nadine M. Shaban, Rui Yan, Ke Shi, Sofia N. Moraes, Adam Z. Cheng, Michael A. Carpenter, Jason S. McLellan, Zhiheng Yu, Reuben S. Harris

Summary: Viruses have evolved various mechanisms to evade immune responses. A recent study found that the Epstein-Barr virus (EBV) can neutralize the nuclear DNA cytosine deaminase APOBEC3B through its ribonucleotide reductase subunit BORF2. Cryo-EM studies of APOBEC3B-BORF2 complexes revealed a large binding surface that effectively blocks APOBEC3B's active site. This understanding of the pathogen-host interaction has the potential to inform the development of drugs that can disrupt this interaction and enhance the antiviral activity of APOBEC3B. Additionally, it may also have implications for the development of inhibitors targeting DNA deaminases, which are involved in cancer mutagenesis.

SCIENCE ADVANCES (2022)

添加到收藏夹

Review Environmental Sciences

Ecological time lags in biodiversity response to habitat changes

Xuejuan Chen, Qing Wang, Baoshan Cui, Guogui Chen, Tian Xie, Wenxin Yang

Summary: The decline of biodiversity can have significant time lags, posing challenges for biodiversity conservation. Our research examines the manifestations and impacts of ecological time lags, and proposes corresponding implications for conservation and management.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2023)

添加到收藏夹

Article Mathematics, Applied

A new regular infinite matrix defined by Jordan totient function and its matrix domain in lp

Merve Ilkhan, Necip Simsek, Emrah Evren Kara

Summary: This paper introduces a new regular matrix defined using the Jordan phi function and examines its matrix domain in the Banach space l(p). By computing the dual spaces of this new space, certain matrix mappings related to this space are characterized.

MATHEMATICAL METHODS IN THE APPLIED SCIENCES (2021)

添加到收藏夹

Article Computer Science, Artificial Intelligence

Navigating the amino acid sequence space between functional proteins using a deep learning framework

Tristan Bitard-Feildel

Summary: This study utilized an Adversarial Auto-Encoder (AAE) approach to generate new protein sequences, demonstrating high level of homogeneity and ability to produce meaningful biological sequences. The sampling strategies based on latent space interpolation and arithmetic successfully transferred protein sequence properties linked to function between different sub-families, showcasing the potential of deep learning frameworks in exploring biological complexity.

PEERJ COMPUTER SCIENCE (2021)

添加到收藏夹

Article Green & Sustainable Science & Technology

Making global targets local for freshwater protection

Rebecca L. L. Flitcroft, Robin Abell, Ian Harrison, Ivan Arismendi, Brooke E. E. Penaluna

Summary: Freshwaters require targeted policy considerations to achieve biodiversity conservation goals and to support ecosystem services that communities around the globe depend upon. Effective conservation requires creative solutions that build and expand upon conventional protected areas, contextualized for these diverse ecosystems.

NATURE SUSTAINABILITY (2023)

添加到收藏夹

Article Mathematics, Applied

Spaces of functions and sections with paracompact domain

Jaka Smrekar

Summary: We study spaces of continuous functions and sections with domain a paracompact Hausdorff k-space $X$ and range a nilpotent CW complex $Y$, with emphasis on localization at a set of primes. For $\mathop {\rm map}\nolimits _\phi (X,\,Y)$, the space of maps with prescribed restriction $\phi$ on a suitable subspace $A\subset X$, we construct a natural spectral sequence of groups that converges to $\pi _*(\mathop {\rm map}\nolimits _\phi (X,\,Y))$ and allows for detection of localization on the level of $E<^>2$. Our applications extend and unify the previously known results.

PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH SECTION A-MATHEMATICS (2023)

添加到收藏夹

Article Materials Science, Ceramics

Thermally-induced local structural transformations in Na0.5Bi0.5TiO3-KNbO3 ceramics

Ge Wang, Anton Goetzee-Barral, Zhilun Lu, Dean S. Keeble, David A. Hall

Summary: The local symmetry of (1-x)Na0.5Bi0.5TiO3-xKNbO3 (NBT-xKN, x = 0.01-0.07) ceramics was examined using high-energy synchrotron x-ray scattering and analysed with the pair distribution function (PDF) method. The structure of NBT-xKN ceramics was found to be best refined at room temperature with monoclinic C1c1 structures within the local range and rhombohedral R3c structures within the medium range.

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY (2021)

添加到收藏夹

Article Mathematics

Local theory for 2-microlocal Besov and Triebel-Lizorkin spaces of Jaffard type

Koichi Saka

Summary: In this paper, new 2-microlocal Besov and Triebel-Lizorkin spaces of Jaffard type are introduced, which include many classical functions. The local theory of these function spaces is established using the f-transform and the wavelet decomposition coefficients. Moreover, a characterization of these local spaces is given by a local polynomial approximation.

MATHEMATISCHE NACHRICHTEN (2023)

添加到收藏夹

Article Plant Sciences

High genetic diversity and low population differentiation of a medical plant Ficus hirta Vahl., uncovered by microsatellite loci: implications for conservation and breeding

Yi Lu, Jianling Chen, Bing Chen, Qianqian Liu, Hanlin Zhang, Liyuan Yang, Zhi Chao, Enwei Tian

Summary: This study provides a comprehensive investigation into the genetic diversity and population structure of F.hirta in southern China. The results reveal high genetic diversity and low population differentiation in this medicinal plant. The causes of the current genetic patterns are clarified, and insights are provided for the exploitation and conservation strategies of F.hirta.

BMC PLANT BIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Elliot Medina, Yathreb Easa, Daniel K. Lester, Eric K. Lau, David Sprinzak, Vincent C. Luca

Summary: Fat and Dachsous are key regulators of cell growth and animal development. They form heterophilic interactions to induce cell polarity within tissues. The co-crystal structure of the human homologs Fat4 and Dachsous1 (Dchs1) reveals the molecular basis for Fat-Dachsous interactions and the role of phosphorylation modifications in their binding.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Letter Psychology, Clinical

The silent danger of social distancing

Andre Aleman, Iris Sommer

PSYCHOLOGICAL MEDICINE (2022)

添加到收藏夹

Article Neurosciences

Greater male than female variability in regional brain structure across the lifespan

Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes

Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.

HUMAN BRAIN MAPPING (2022)

添加到收藏夹

Article Neurosciences

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou

Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.

HUMAN BRAIN MAPPING (2022)

添加到收藏夹

Article Psychology, Clinical

Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study

Marieke J. H. Begemann, Maya J. L. Schutte, Edwin van Dellen, Lucija Abramovic, Marco P. Boks, Neeltje E. M. van Haren, Rene C. W. Mandl, Christiaan H. Vinkers, Marc M. Bohlken, Iris E. C. Sommer

Summary: This study investigated the relationship between childhood trauma severity and gray matter volume. The findings suggest that childhood trauma is associated with reduced gray matter in the frontal lobe, regardless of psychiatric diagnoses. These results indicate that childhood trauma contributes significantly to neurobiological changes observed in various psychiatric disorders.

PSYCHOLOGICAL MEDICINE (2023)

添加到收藏夹

Article Psychology, Clinical

Acoustic speech markers for schizophrenia-spectrum disorders: a diagnostic and symptom-recognition tool

J. N. de Boer, A. E. Voppel, S. G. Brederoo, H. G. Schnack, K. P. Truong, F. N. K. Wijnen, I. E. C. Sommer

Summary: This study assessed the diagnostic value of acoustic speech parameters in schizophrenia-spectrum disorders and found that automatically extracted speech parameters can accurately classify patients and controls, as well as differentiate between different symptom subtypes. This suggests that speech technology has high potential for clinical applications in diagnosis and differentiation.

PSYCHOLOGICAL MEDICINE (2023)

添加到收藏夹

Article Psychiatry

Negative content in auditory verbal hallucinations: a natural language processing approach

J. N. de Boer, H. Corona Hernandez, F. Gerritse, S. G. Brederoo, F. N. K. Wijnen, I. E. Sommer

Summary: This study found that patients' auditory verbal hallucinations (AVH) have more negative linguistic content, which is closely associated with their experienced distress. Patients perceive their voices as more negative, and objective analyses confirm this.

COGNITIVE NEUROPSYCHIATRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades, Igor Nenadic, Tilo Kircher, Axel Krug, Tina Meller, Dominik Grotegerd, Alex Fornito, Aurina Arnatkeviciute, Mark A. Bellgrove, Jeggan Tiego, Udo Dannlowski, Katharina Koch, Carina Huelsmann, Harald Kugel, Verena Enneking, Melissa Klug, Elisabeth J. Leehr, Joscha Boehnlein, Marius Gruber, David Mehler, Pamela DeRosse, Ashley Moyett, Bernhard T. Baune, Melissa Green, Yann Quide, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbane, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom J. Spencer, Paul Fletcher, Wulf Roessler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme R. P. Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Petya Kozhuharova, Jan-Bernard Marsman, Irina Lebedeva, Alexander Tomyshev, Anna Mukhorina, Stefan Kaiser, Anne-Kathrin Fett, Iris Sommer, Sanne Schuite-Koops, Casey Paquola, Sara Lariviere, Boris Bernhardt, Alain Dagher, Phillip Grant, Theo G. M. van Erp, Jessica A. Turner, Paul M. Thompson, Andre Aleman, Gemma Modinos

Summary: Neuroanatomical abnormalities have been reported to be present from high schizotypy to chronic psychosis. A study conducted a large-scale meta-analysis of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, revealing thicker right medial orbitofrontal/ventromedial prefrontal cortex associated with higher schizotypy scores. The cortical thickness profile in schizotypy showed positive correlation with abnormalities in schizophrenia, while the subcortical volume pattern demonstrated negative correlation with abnormalities in schizophrenia, bipolar disorder, and major depression.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Article Psychology, Clinical

Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis

Priscilla P. Oomen, Marieke J. H. Begemann, Bodyl A. Brand, Lieuwe de Haan, Wim Veling, Sanne Koops, Jim van Os, Filip Smit, P. Roberto Bakker, Nico van Beveren, Nynke Boonstra, Sinan Guloksuz, Martijn Kikkert, Joran Lokkerbol, Machteld Marcelis, Bram-Sieben Rosema, Franciska de Beer, Shiral S. Gangadin, Chris N. W. Geraets, Erna van't Hag, Yudith Haveman, Inge van der Heijden, Alban E. Voppel, Elske Willemse, Therese van Amelsvoort, Maarten Bak, Albert Batalla, Agaath Been, Marinte van den Bosch, Truus van den Brink, Gunnar Faber, Koen P. Grootens, Martin de Jonge, Rikus Knegtering, Jorg Kurkamp, Amrita Mahabir, Gerdina H. M. Pijnenborg, Tonnie Staring, Natalie Veen, Selene Veerman, Sybren Wiersma, Ellen Graveland, Joelle Hoornaar, Iris E. C. Sommer

Summary: This study identified three distinct cognitive subgroups in first-episode psychosis (FEP) and found that patients with severely impaired cognition had more severe clinical symptoms and lower general functioning compared to patients with preserved cognition. However, there were no significant differences in self-reported functional outcomes. Early identification of cognitive profiles can offer valuable information about clinical outcomes.

PSYCHOLOGICAL MEDICINE (2023)

添加到收藏夹

Review Psychology, Clinical

Antipsychotic medication for women with schizophrenia spectrum disorders

Bodyl A. Brand, Yudith R. A. Haveman, Franciska de Beer, Janna N. de Boer, Paola Dazzan, Iris E. C. Sommer

Summary: There are significant differences between men and women in the efficacy and tolerability of antipsychotic drugs. Women have slower drug absorption, metabolism, and excretion, leading to higher plasma levels and increased risk for side-effects. Current treatment guidelines are based on studies predominantly conducted in men, which may result in overmedication of women. Women also have higher dopamine receptor occupancy compared to men, necessitating dose adjustments at different hormonal phases.

PSYCHOLOGICAL MEDICINE (2022)

添加到收藏夹

Article Behavioral Sciences

Negative valence of hallucinatory voices as predictor of cortical glutamatergic metabolite levels in schizophrenia patients

Helene Hjelmervik, Alexander R. Craven, Erik Johnsen, Kristiina Kompus, Josef J. Bless, Igne Sinkeviciute, Rune A. Kroken, Else-Marie Loberg, Lars Ersland, Renate Gruner, Iris E. Sommer, Kenneth Hugdahl

Summary: Negative emotional valence of auditory verbal hallucinations in schizophrenia is associated with reduced glutamate levels in multiple brain regions, indicating aberrant glutamatergic signaling. Specifically, voices that evoke emotional resistance rather than behavioral resistance are predictive of lower glutamate levels, supporting the glutamate hypothesis of schizophrenia.

BRAIN AND BEHAVIOR (2022)

添加到收藏夹

Article Neurosciences

Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Jurjen J. Luykx, Dore Loef, Bochao Lin, Linda van Diermen, Jasper O. Nuninga, Eric van Exel, Mardien L. Oudega, Didi Rhebergen, Sigfried N. T. M. Schouws, Philip van Eijndhoven, Esmee Verwijk, Didier Schrijvers, Tom K. Birkenhager, Karen M. Ryan, Baer Arts, Suzanne C. van Bronswijk, Gunter Kenis, Geert Schurgers, Bernhard T. Baune, Martijn Arns, Edwin E. van Dellen, Metten Somers, Iris E. C. Sommer, Marco P. Boks, Sinan Guloksuz, Declan M. McLoughlin, Annemiek Dols, Bart P. F. Rutten

Summary: This study revealed a linear association between PRS-SCZ and ECT outcome, which strengthens the relevance of PRS-SCZ to treatment response in psychiatry.

BIOLOGICAL PSYCHIATRY (2022)

添加到收藏夹

Review Psychiatry

Brain vasculature disturbance in schizophrenia

Sofia Puvogel, Veronica Palma, Iris E. C. Sommer

Summary: The review discusses the vascular hypothesis of schizophrenia and provides recent evidence for and against this hypothesis. Increased blood-brain barrier permeability is observed in a consistent proportion of schizophrenia patients and is associated with inflammation and cognitive deficiencies. Gender also interacts with blood-brain barrier integrity and permeability in schizophrenia. The strongest independent genetic association with schizophrenia has been identified in the FZD1 gene. There is evidence of alterations in brain perfusion in schizophrenia, although medication may play a role. The review encourages further investigation into the dynamic context of gene expression and performance of human brain endothelium in relation to schizophrenia.

CURRENT OPINION IN PSYCHIATRY (2022)

添加到收藏夹

Review Psychology, Clinical

Role of the gut microbiome in three major psychiatric disorders

Jenny Borkent, Magdalini Ioannou, Jon D. Laman, Bartholomeus C. M. Haarman, Iris E. C. Sommer

Summary: Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia-spectrum disorders (SSD) are heterogeneous psychiatric disorders that have a significant impact on the well-being and global health of patients. Disruptions in the gut microbiome may contribute to the development of these disorders. Current research suggests that patients with psychiatric disorders tend to have higher levels of Streptococcus, Lactobacillus, and Eggerthella bacteria, and lower levels of Faecalibacterium, a bacteria that produces butyrate. However, further studies are needed to account for confounding factors such as medication use and lifestyle choices, and the effectiveness of probiotics and fecal microbiota transplantation (FMT) in treating these disorders remains inconclusive.

PSYCHOLOGICAL MEDICINE (2022)

添加到收藏夹

Article Psychiatry

A data-driven linguistic characterization of hallucinated voices in clinical and non-clinical voice-hearers

H. Corona-Hernandez, S. G. Brederoo, J. N. de Boer, I. E. C. Sommer

Summary: This study found that linguistic features can distinguish AVHs subtypes and are associated with phenomenology and clinical status. Clinical voice-hearers often experience negative, compact voices, while non-clinical voice-hearers experience expanded voices.

SCHIZOPHRENIA RESEARCH (2022)

添加到收藏夹

Article Psychiatry

The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders

P. P. Oomen, S. S. Gangadin, M. J. H. Begemann, E. Visser, R. C. W. Mandl, I. E. C. Sommer

Summary: This study aimed to identify cognitive subtypes in patients with early-phase schizophrenia-spectrum disorders (SSD) and evaluate their differences in clinical and brain volumetric measures. The results revealed three distinct cognitive clusters, characterized by differences in cortical regional brain volume and cortical thickness.

SCHIZOPHRENIA RESEARCH (2022)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.