Article
Multidisciplinary Sciences
Linxuan Li, Tingting Zhu, Yun Song, Li Feng, Philip James Kear, Rooallah Saberi Riseh, Mahmoud Sitohy, Raju Datla, Maozhi Ren
Summary: This study explored the potential mechanisms of salicylic acid (SA) as a biofungicide by using the highly pathogenic Fusarium oxysporum as a model system. The results showed that SA could inhibit key targets of the pathogen, modify the metabolic activity within pathogen cells, and induce pathogen cell death. This research provides insights into the application of SA in controlling various fungal diseases by targeting the SNF1-TORC1 pathway of pathogens.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Cell Biology
Zi-Qian Cheng, Jie Fan, Fang-Yi Zhao, Jing-Yun Su, Qi-Han Sun, Ran-Ji Cui, Bing-Jin Li
Summary: Recent studies have found that a 9-hour fast in mice reduces immobility time in the forced swimming test. This study aimed to investigate the therapeutic effects of 9-hour fasting in female mice with depressive symptoms. The results showed that fasting alleviated depressive symptoms in ovariectomized mice, suggesting its potential as a treatment for depression.
NEURAL REGENERATION RESEARCH
(2023)
Article
Physiology
Bahetiyaer Huwatibieke, Wenzhen Yin, Lingchao Liu, Yuxin Jin, Xinxin Xiang, Jingyan Han, Weizhen Zhang, Yin Li
Summary: The study demonstrates that the mTOR signaling pathway affects the transformation of adipocytes by regulating mitochondrial quality control in brown adipocytes. Activation of mTOR signaling inhibits the mitochondrial quality control and promotes the transformation from brown to white adipocytes, while inhibition of mTOR signaling enhances mitochondrial quality control and inhibits the phenotypic shift.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald
Summary: The study demonstrates that mTORC1 and p70S6K are required for reconsolidation of cocaine contextual memory, showing their essential roles in the process through mechanisms such as protein phosphorylation and changes in transcriptional levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aigli G. Vakrakou, Anastasia Alexaki, Maria-Evgenia Brinia, Maria Anagnostouli, Leonidas Stefanis, Panos Stathopoulos
Summary: This article summarizes the evidence on the role of mammalian targets of rapamycin (mTOR) complex pathways in multiple sclerosis (MS), including autophagy, inflammasome activation, immune responses, and neuronal toxicity. There is robust evidence that mTOR inhibitors, such as rapamycin, improve the clinical course of MS animal models. New research highlights the effects of mTOR on T cells and myeloid cells, providing insight into MS pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nastaran Daneshgar, Peter S. Rabinovitch, Dao-Fu Dai
Summary: mTOR signaling plays a crucial role in regulating cellular metabolism and aging by controlling key cellular processes such as protein synthesis, autophagy, and mitochondrial function. Dysregulation of mTOR signaling has been associated with various age-related pathologies, including heart failure and age-related cardiac dysfunction.
Review
Medicine, General & Internal
Zhe Zhang, Yunhan Tan, Canhua Huang, Xiawei Wei
Summary: DTP cells are a type of cells that can survive after exposure to anticancer drugs, and they enhance adaptive mutation by altering DNA repair mechanisms, resulting in the emergence of drug-resistant mutations. DTP cells maintain cellular homeostasis through metabolic reprogramming that promotes mitochondrial oxidative respiration and a robust antioxidant process, and they can resume proliferation after treatment withdrawal, leading to cancer relapse. Disrupting redox homeostasis by intervening with redox signaling is considered a promising therapeutic strategy. This review provides a comprehensive overview of the characteristics of DTP cells and the underlying mechanisms involved in redox signaling, aiming to offer a unique perspective on potential therapeutic applications based on their vulnerabilities to redox regulation.
Article
Biochemistry & Molecular Biology
Ning Liu, Ying Yang, Xuemeng Si, Hai Jia, Yunchang Zhang, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: L-proline plays a crucial role in embryogenesis, placental development, and fetal growth. This study revealed that proline enhances cell viability, activates the mTORC1 signaling pathway, and modulates the intracellular redox environment. Proline regulates the expression of proline transporters and enzymes involved in redox balance, indicating its potential therapeutic benefits in various developmental processes.
Article
Cell & Tissue Engineering
Ming Fang, Xingwu Wang, Yongli Wei, Wuliang Yu, Jianmeng Lu
Summary: This study found that Tanshinone IIA can promote fracture healing by regulating osteoblast differentiation through the mTORC1 signaling pathway, accelerating bone healing.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Cell Biology
Kevin M. Keary III, Qin-Hua Gu, Jiji Chen, Zheng Li
Summary: The mechanism of long-term depression (LTD) is extensively studied in Schaffer collateral (SC) synapses, and inhibition of autophagy is identified as a key factor. Here, it is demonstrated that the temporoammonic pathway (TAP) and SC synapses have a shared LTD mechanism reliant on NMDA receptors, caspase-3, and autophagy inhibition. The distribution of autophagosomes in dendrites and distinct LTD induction at SC and TAP synapses suggest a model where autophagosomes gate LTD inducibility.
Article
Agriculture, Dairy & Animal Science
Guo Yan Wang, Sen Lin Qin, Yi Ning Zheng, Hui Jun Geng, Lei Chen, Jun Hu Yao, Lu Deng
Summary: This study found that propionate enhances the gluconeogenic capacity of calf hepatocytes by regulating the activity of the mTOR pathway, and it counteracts the inhibitory effect of palmitic acid on gluconeogenesis.
Review
Biochemistry & Molecular Biology
Yipin Wang, Nicholas Siu Kay Fung, Wai-Ching Lam, Amy Cheuk Yin Lo
Summary: Recent advances in research have highlighted the importance of the mTOR signaling pathway in the treatment of ocular degenerative diseases. This pathway is regulated by oxidative stress, and understanding the complex relationship between mTOR and oxidative stress is crucial. Additionally, the role of mTOR-mediated autophagy in ocular degenerative diseases should not be overlooked.
Review
Biochemistry & Molecular Biology
Graham M. Burkart, Federica Brandizzi
Summary: Organisms must sense and process information about the availability of nutrients, energy status, and environmental cues to identify the appropriate times for growth and development. The TOR complex in plants has evolved specific functional and mechanistic features, serving as a central hub for integrating external and internal metabolic cues.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Review
Behavioral Sciences
Wei Zhao, Cong Xie, Xu Zhang, Ju Liu, Jinzhi Liu, Zhangyong Xia
Summary: Epilepsy is a common and serious brain syndrome that has adverse effects on a patient's wellbeing and quality of life. The dysregulation of the mTOR pathway is believed to play a significant role in the development and progression of epilepsy. This review discusses the role of the mTOR signaling pathway in epilepsy pathogenesis and the potential use of mTOR inhibitors for treatment.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Linxuan Li, Tingting Zhu, Lele Huang, Maozhi Ren
Summary: This study identified and analyzed a Chlorella sorokiniana DP-1 strain and found a conserved CsTOR protein in its genome. The study also showed that CsTOR plays an important role in photosynthesis and cellular metabolism. Pharmacological assays revealed that Chlorella sorokiniana DP-1 is insensitive to rapamycin, Torin1, and KU0063794, but can be significantly inhibited by AZD8055. RNA-seq analysis further demonstrated that CsTOR regulates various metabolic processes and signal transduction pathways in Chlorella sorokiniana DP-1 treated with AZD8055.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)