Article
Psychology, Multidisciplinary
Adewale Adekiya
Summary: This study examined the impact of perceived job insecurity on task performance and found that it has a significant negative effect. Both quantitative and qualitative job insecurity also have significant negative effects, with qualitative job insecurity having a stronger impact. The study suggests that organizations should focus on the antecedents of job insecurity and managers should prioritize resources for employees experiencing qualitative job insecurity.
CURRENT PSYCHOLOGY
(2023)
Article
Biochemical Research Methods
Miao Guo, Yan Zhang, Lehao Wu, Ye Sheng, Jiaqi Zhao, Zeyuan Wang, Huiyu Wang, Lu Zhang, Hua Xiao
Summary: In this study, a quantitative phosphoproteomics approach was used to investigate the signal transductions upon intracellular BRS3 activation. The results revealed that BRS3 activation downregulates the Hippo signaling pathway, leading to cell migration.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jessica E. Besaw, Jorg Reichenwallner, Paolo De Guzman, Andrejs Tucs, Anling Kuo, Takefumi Morizumi, Koji Tsuda, Adnan Sljoka, R. J. Dwayne Miller, Oliver P. Ernst
Summary: In this study, the crystal structure of Thermoplasmatales archaeon SG8-52-1 heliorhodopsin (TaHeR) was determined under low pH conditions. The structure revealed the accommodation of a chloride anion in the hydrophilic Schiff base cavity (SBC), stabilizing the protonated retinal Schiff base. Computational studies further supported an intramolecular signaling transduction pathway, with allosteric network changes propagating from the perturbed SBC to the intracellular and extracellular space. These findings suggest the potential sensory role of TaHeR as a rhodopsin.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Vidyasiri Vemulapalli, Lily A. Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J. LaMarche, Michael G. Acker, Peter K. Sorger, Steven P. Gygi, Stephen C. Blacklow
Summary: The protein SHP2, often mutated in human cancer, potentiates intracellular signaling but can also have distinct effects when inhibited, as shown through phosphoproteome dynamics in breast cancer cells responding to EGF. Inhibiting SHP2 can lead to altered phosphorylation levels at specific tyrosine residues and highlight its dual roles as a scaffolding and catalytic protein in transmembrane signaling responses.
Review
Cell Biology
Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei
Summary: Lck and nuclear factor-kappa B play crucial roles in the development and progression of autoimmune diseases and malignancies, and understanding their signaling pathways may lead to the identification of new therapeutic targets and approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Julia Barison, Isabela Tiemy Pereira, Anny Waloski Robert, Bruno Dallagiovanna
Summary: Understanding cell differentiation involves characterizing signaling and regulatory pathways, with cellular metabolism playing a key role in gene expression. Analyzing mRNA associated with polysomes during cardiac differentiation of human embryonic stem cells reveals the importance of energy metabolism and lipid homeostasis in cardiomyogenesis. This study highlights the critical relevance of retinoic X receptor (RXR) heterodimers and their relationship with thyroid hormone signaling in regulating metabolism during cardiac differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wiwin Is Effendi, Tatsuya Nagano
Summary: The hedgehog pathway is important for cell specification and proliferation, and can be reactivated in adulthood to contribute to tissue-injury-associated diseases such as IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paula Dlugosz, Magdalena Teufl, Maximilian Schwab, Katharina Eva Kohl, Johannes Nimpf
Summary: Dab1 functions as an adapter protein for VLDLR and ApoER2 in the Reelin pathway, orchestrating neuronal layering in embryonic brain development. In addition, Dab1 can also act as an adaptor for EGFR and be phosphorylated by EGF, constituting a signaling pathway independent of Reelin and its receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Man-Ling Zhang, Yong Jin, Li-Hua Zhao, Jia Zhang, Meng Zhou, Mei-Shuang Li, Zhi-Bao Yin, Zi-Xin Wang, Li-Xia Zhao, Xi-He Li, Rong-Feng Li
Summary: Researchers have successfully derived porcine XEN cells through a novel method, showing positive XEN markers in vivo and retaining the ability to undergo VE and PE differentiation in vitro. These cells can be stably passaged and are significant for studying porcine embryo development and differentiation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. T. Lindenmeyer, Viji Nair, Sydney E. E. Gies, Guochao Wu, Robert G. G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. D. Cohen, Denis Delic, Christian F. F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. B. Huber
Summary: This study provides a comprehensive understanding of the cellular and molecular basis of early diabetic nephropathy (DN) through single-cell and bulk RNA sequencing of renal cells in type 2 diabetes mice. The activation of mechanosensitive signaling pathway MRTF-SRF in mesangial cells was identified as a key mechanism in DN. Importantly, the activation of MRTF-SRF pathway was also observed in DN glomeruli in patients.
Article
Oncology
Tamar Evron, Michal Caspi, Michal Kazelnik, Yarden Shor-Nareznoy, Shir Armoza-Eilat, Revital Kariv, Zohar Manber, Ran Elkon, Ella H. Sklan, Rina Rosin-Arbesfeld
Summary: The Wnt signaling pathways are crucial in development and adult homeostasis, with aberrant activation implicated in diseases such as cancer. A genome-scale CRISPR-Cas9 knockout screen identified potential Wnt signaling inhibitors, with DHX29 shown to regulate the pathway's activity. These findings suggest DHX29 may act as a novel canonical Wnt signaling tumor suppressor and showcase the utility of this screening approach in identifying new Wnt signaling modulators.
Article
Food Science & Technology
Si-Juan Huang, Meng-Ting Zuo, Xue-Jia Qi, Chong-Yin Huang, Zhao-Ying Liu
Summary: Using phosphoproteomics, this study found that gelsenicine mainly affected protein phosphorylation levels in the hippocampus and identified NMDA receptor-mediated excitotoxicity as a key signaling pathway in gelsenicine toxicity. These findings were confirmed through molecular docking and rescue experiments, highlighting the impact of gelsenicine on neurotransmitter release and receptor function.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Microbiology
Megan E. Garber, Vered Frank, Alexey E. Kazakov, Matthew R. Incha, Alberto A. Nava, Hanqiao Zhang, Luis E. Valencia, Jay D. Keasling, Lara Rajeev, Aindrila Mukhopadhyay
Summary: This report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance. Within-gene recombination can switch effector domains and change the regulatory context of duplicated response regulator proteins, leading to functional divergence. The study also suggests that recombined response regulators and their parents can sense and respond to different carboxylic acids.
Article
Biochemistry & Molecular Biology
Jihyun Kim, Changyong Lee, Sang Gyun Noh, Seungwoo Kim, Hae Young Chung, Haeseung Lee, Jeon-Ok Moon
Summary: This study investigates the transcriptomic signatures of three liver fibrosis models and the p53 signaling pathway in a rat liver fibrosis model induced by DMN. It finds significant changes in gene expression linked to liver fibrosis characteristics, with a correlation to the burn-wound-healing pathway. Additionally, it demonstrates the potential therapeutic effect of oligonol, a polyphenol derived from lychee, on inhibiting the overexpression of apoptotic genes in these fibrotic models, suggesting a potential treatment approach for liver fibrosis.
Article
Biochemistry & Molecular Biology
Jun Lu, Yi Zhang, Huiyue Dong, Jingjing Sun, Ling Zhu, Pengyang Liu, Fuli Wen, Rong Lin
Summary: Triptolide activates the cGAS-STING signaling pathway in kidney tubular cells, leading to renal injury. Inhibiting over-activation of the cGAS-STING pathway may be a new strategy to alleviate triptolide-induced nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
