期刊
PLOS BIOLOGY
卷 7, 期 4, 页码 747-755出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1000063
关键词
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资金
- National Insitutes of Health (NIH) National Research Service Award (NRSA) [1 F31 NS054519-01]
- Chapman Foundation
- Helen Hay Whitney Foundation
- Burroughs Wellcome Fund Career Award
- Deutscher Akademischer Austausch Dienst (DAAD)
- National Science Foundation (NSF) [DGE-033451, PHY-0417175]
- McKnight Foundation
- NIH [EY017992]
In the visual system, large ensembles of neurons collectively sample visual space with receptive fields (RFs). A puzzling problem is how neural ensembles provide a uniform, high-resolution visual representation in spite of irregularities in the RFs of individual cells. This problem was approached by simultaneously mapping the RFs of hundreds of primate retinal ganglion cells. As observed in previous studies, RFs exhibited irregular shapes that deviated from standard Gaussian models. Surprisingly, these irregularities were coordinated at a fine spatial scale: RFs interlocked with their neighbors, filling in gaps and avoiding large variations in overlap. RF shapes were coordinated with high spatial precision: the observed uniformity was degraded by angular perturbations as small as 158, and the observed populations sampled visual space with more than 50% of the theoretical ideal uniformity. These results show that the primate retina encodes light with an exquisitely coordinated array of RF shapes, illustrating a higher degree of functional precision in the neural circuitry than previously appreciated.
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