Article
Computer Science, Artificial Intelligence
Weixin Liang, Girmaw Abebe Tadesse, Daniel Ho, Fei-Fei Li, Matei Zaharia, Ce Zhang, James Zou
Summary: It is clear that creating, using, and maintaining high-quality annotated datasets for AI applications requires careful attention. This Perspective explores the challenges and best practices for different stages in the data-to-AI pipeline, aiming to promote a more data-centric approach. As AI moves from research to deployment, developing appropriate datasets and data pipelines for AI models becomes increasingly challenging. While publicly available AI model builders can achieve top performance, the design and curation of data for AI often rely on bespoke manual work, which significantly impacts the model's trustworthiness. This Perspective discusses key considerations from data design to evaluation, highlighting technical advancements for a more scalable and rigorous data-for-AI pipeline. Additionally, it explores the impact of recent data regulations and policies on AI.
NATURE MACHINE INTELLIGENCE
(2022)
Review
Cell & Tissue Engineering
Meng-Xue Xu, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng
Summary: Platelet transfusion is a standard clinical treatment to prevent bleeding, but the shortage of supply and challenges such as short shelf life and allogeneic immunity call for the development of alternative sources. Human pluripotent stem cells offer a potential unlimited source for regenerative medicine and research models for disease pathogenesis. Research efforts are focused on generating functional induced platelets from hPSCs and evaluating their production efficiency and safety concerns.
STEM CELLS INTERNATIONAL
(2021)
Article
Psychology, Multidisciplinary
Timothy Jung, Justin Cho, Dai-In Danny Han, Sun Joo (Grace) Ahn, Mansi Gupta, Gopal Das, Cindy Yoonjoung Heo, Sandra Maria Correia Loureiro, Marianna Sigala, Mariapina Trunfio, Alexandra Taylor, M. Claudia tom Dieck
Summary: Although the metaverse is still in its early stages, it has the potential to revolutionize the way businesses interact with customers. Service industries are already exploring ways to provide immersive customer experiences through the metaverse. This study examines the untapped potential of the metaverse in service industries, and identifies opportunities such as new experiences, inter-world interactions, and business-consumer relations, as well as challenges including technological limitations, health issues, and data privacy and legal concerns.
COMPUTERS IN HUMAN BEHAVIOR
(2024)
Article
Cell Biology
Marcin Orzechowski, Maximilian Schochow, Michael Kuehl, Florian Steger
Summary: There is a need to address specific ethical challenges related to induced pluripotent stem cell research, especially concerning informed consent practices. Research conducted at Ulm University from 2007 to 2019 showed that while general information was provided in iPSC studies, there were gaps in addressing individual consequences and potential future implications of the research. Updating the informed consent process with tailored information methods is important for effective communication and ethical considerations in iPSC research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Glyn N. Stacey, Jingyi Cao, Baoyang Hu, Qi Zhou
Summary: PSConf 2021 is a discussion forum aimed at promoting international communication and coordination in the field of pluripotent stem cell manufacturing. The conference addressed crucial topics in stem cell manufacturing and showcased various potential pluripotent stem cell-based medicines under development.
CELL PROLIFERATION
(2022)
Review
Cell Biology
Sara Guerreiro, Patricia Maciel
Summary: Neurodevelopmental disorders (NDDs) result from disruptions in brain development, leading to impaired sensory, motor, and/or cognitive functions. While rodent models have provided valuable insights, translating findings to clinical therapies remains challenging. Human-induced pluripotent stem cells (hIPSCs) have emerged as a promising tool for NDD research, allowing for the study of human neuronal development and disease-specific phenotypes. This review highlights the utility of hIPSCs in advancing NDD research and discusses the challenges and advances in hIPSC culture and neuronal differentiation protocols.
Article
Psychology, Multidisciplinary
Marie P. Wissing
Summary: Positive psychology is facing challenges to its initial identity and is evolving into a more comprehensive and interdisciplinary domain of well-being studies. Future research in well-being needs to focus on metatheoretical assumptions, develop more holistic theories, and implement methodological reforms to bridge conceptual fragmentation in the field. Opportunities exist to contribute to the discourse on the development of scientific knowledge in both positive psychology and the post-disciplinary domain of well-being studies.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Pradeep Kumar Sahu, Lisa A. Benjamin, Gunjan Singh Aswal, Arlene Williams-Persad
Summary: This article reviews the impact of ChatGPT on research and health professions education, identifying challenges and opportunities in these fields. Ethical concerns and limitations need to be addressed, and further research can explore effective ways of implementing ChatGPT in healthcare education.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Yan Hong, Qian Yang, Hongjun Song, Guo-li Ming
Summary: Neuropsychiatric disorders affect a large portion of the population and there is a need for better understanding and treatments for these disorders. Human induced pluripotent stem cells (hiPSCs) have provided a platform for studying psychiatric disorders at multiple levels. They allow investigation of the molecular, cellular, and structural aspects of psychiatric disorders. Moreover, hiPSCs derived from patients provide an opportunity to recapitulate disease pathogenesis and explore potential treatments. Genome-editing technologies have further expanded the potential of hiPSCs for studying the genetic basis of psychiatric disorders. This review highlights the opportunities and limitations of using hiPSC-derived models for studying psychiatric disorders.
MOLECULAR PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Chiara Villa, Romina Combi, Donatella Conconi, Marialuisa Lavitrano
Summary: Autism spectrum disorder is a group of neurodevelopmental diseases with complex etiology, limited by a lack of relevant human disease models. The development of iPSCs technology provides a promising cellular tool for disease modeling and development of novel drug treatments.
Review
Oncology
Yu-Ping Yang, Teresa M. Giret, Richard J. Cote
Summary: Circulating tumor cells (CTCs) are rare in blood, but play a crucial role in metastasis and have potential as a biomarker for cancer diagnosis, prognosis, and treatment monitoring. Advancements in CTC isolation techniques have improved detection sensitivity and accuracy, leading to increased focus on molecular characterization and understanding interactions between CTCs and associated cells for precision medicine. Challenges and opportunities in clinical utilization of CTCs are being addressed for future advancements in cancer research.
Review
Psychology, Multidisciplinary
Thomas M. Brinthaupt, Alain Morin
Summary: This review discusses the challenges in measuring and studying self-talk, including assessment of frequency, studying in natural context, personal pronoun usage, experiential sampling methods, and experimental manipulation. It highlights new research opportunities and discusses recent advances such as brain imaging studies, use of self-talk by robots, and measurement in aphasic patients.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Geosciences, Multidisciplinary
Seyedabdolhossein Mehvar, Kathelijne Wijnberg, Bas Borsje, Norman Kerle, Jan Maarten Schraagen, Joanne Vinke-de Kruijf, Karst Geurs, Andreas Hartmann, Rick Hogeboom, Suzanne Hulscher
Summary: Infrastructure systems are crucial in providing vital services to societies, and resilience in design can enhance community preparedness for hazards. However, the analysis of resilience in infrastructure systems within a cross-sectoral and interdisciplinary perspective is currently limited and fragmented. Key challenges include conceptual tensions, engineering and non-engineering measures, and future research directions, with a focus on integrating social, ecological, and technical resilience and developing new technologies for identifying recovery factors.
NATURAL HAZARDS AND EARTH SYSTEM SCIENCES
(2021)
Article
Orthopedics
Abdulaziz Z. Alomar
Summary: The study found that the majority of orthopedic residents were able to obtain informed consent independently for emergency, trauma, primary, and revision cases; only 33.5% of residents received formal training on obtaining informed consent; only 4.2% of residents routinely disclosed all essential information to patients; lack of knowledge and communication barriers were the most reported difficulties; receiving formal training, being at a senior level, and frequently being involved in obtaining informed consent were correlated with increased confidence level.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Computer Science, Information Systems
Oladayo Bello, Sherali Zeadally
Summary: This article discusses optimization issues in underwater Internet of Things communication and the impact of underwater environments on communication.
Article
Biotechnology & Applied Microbiology
Plansky Hoang, Nathaniel Huebsch, Shin Hyuk Bang, Brian A. Siemons, Bruce R. Conklin, Kevin E. Healy, Zhen Ma, Sabir Jacquir
BIOTECHNOLOGY AND BIOENGINEERING
(2018)
Article
Biochemical Research Methods
Plansky Hoang, Jason Wang, Bruce R. Conklin, Kevin E. Healy, Zhen Ma
Article
Engineering, Biomedical
Zhen Ma, Nathaniel Huebsch, Sangmo Koo, Mohammad A. Mandegar, Brian Siemons, Steven Boggess, Bruce R. Conklin, Costas P. Grigoropoulos, Kevin E. Healy
NATURE BIOMEDICAL ENGINEERING
(2018)
Article
Developmental Biology
Tilde V. Eskildsen, Sohrab Ayoubi, Mads Thomassen, Mark Burton, Mohammed A. Mandegar, Bruce R. Conklin, Charlotte H. Jensen, Ditte C. Andersen, Soren P. Sheikh
DEVELOPMENTAL BIOLOGY
(2019)
Editorial Material
Multidisciplinary Sciences
Bruce R. Conklin
Article
Genetics & Heredity
Michael Song, Xiaoyu Yang, Xingjie Ren, Lenka Maliskova, Bingkun Li, Ian R. Jones, Chao Wang, Fadi Jacob, Kenneth Wu, Michela Traglia, Tsz Wai Tam, Kirsty Jamieson, Si-Yao Lu, Guo-Li Ming, Yun Li, Jun Yao, Lauren A. Weiss, Jesse R. Dixon, Luke M. Judge, Bruce R. Conklin, Hongjun Song, Li Gan, Yin Shen
Article
Cell & Tissue Engineering
Daisuke Yoshinaga, Shiro Baba, Takeru Makiyama, Hirofumi Shibata, Takuya Hirata, Kentaro Akagi, Koichi Matsuda, I. Hirohiko Kohjitani, Yimin Wuriyanghai, Katsutsugu Umeda, Yuta Yamamoto, Bruce R. Conklin, Minoru Horie, Junko Takita, Toshio Heike
Article
Biochemistry & Molecular Biology
Ashley R. G. Libby, Demarcus Briers, Iman Haghighi, David A. Joy, Bruce R. Conklin, Calin Belta, Todd C. McDevitt
Article
Engineering, Biomedical
Chenyan Wang, Sangmo Koo, Minok Park, Zacharias Vangelatos, Plansky Hoang, Bruce R. Conklin, Costas P. Grigoropoulos, Kevin E. Healy, Zhen Ma
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Biochemical Research Methods
Beeke Wienert, Stacia K. Wyman, Charles D. Yeh, Bruce R. Conklin, Jacob E. Corn
Article
Multidisciplinary Sciences
Beeke Wienert, David N. Nguyen, Alexis Guenther, Sharon J. Feng, Melissa N. Locke, Stacia K. Wyman, Jiyung Shin, Katelynn R. Kazane, Georgia L. Gregory, Matthew A. M. Carter, Francis Wright, Bruce R. Conklin, Alex Marson, Chris D. Richardson, Jacob E. Corn
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Kazutoshi Takahashi, Daeun Jeong, Songnan Wang, Megumi Narita, Xuemei Jin, Mio Iwasaki, Samuel D. Perli, Bruce R. Conklin, Shinya Yamanaka
Article
Multidisciplinary Sciences
Hannah L. Watry, Carissa M. Feliciano, Ketrin Gjoni, Gou Takahashi, Yuichiro Miyaoka, Bruce R. Conklin, Luke M. Judge
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Kathleen C. Keough, Svetlana Lyalina, Michael P. Olvera, Sean Whalen, Bruce R. Conklin, Katherine S. Pollard
Article
Multidisciplinary Sciences
Beeke Wienert, Stacia K. Wyman, Christopher D. Richardson, Charles D. Yeh, Pinar Akcakaya, Michelle J. Porritt, Michaela Morlock, Jonathan T. Vu, Katelynn R. Kazane, Hannah L. Watry, Luke M. Judge, Bruce R. Conklin, Marcello Maresca, Jacob E. Corn
