Article
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Obesity is associated with increased risks of comorbidities, postoperative infections, and nosocomial infections. The pharmacokinetics and pharmacodynamics of antibiotics are affected by obesity, leading to increased risks of antibiotic therapy failure and toxicity. Precision dosing of antibiotics using therapeutic drug monitoring may improve the management of critically ill obese patients with infections.
Editorial Material
Medicine, General & Internal
Leslie L. Chang
Summary: This article discusses the management of hyperglycemia in non-critically ill adults, presenting two approaches: continuing metformin and initiating insulin therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Byunghyuk Yu, Ryoung-Eun Ko, Keesang Yoo, Eunmi Gil, Kyoung-Jin Choi, Chi-Min Park
Summary: In critically ill patients, a SOFA score >8 upon admission to the ICU, ICU admission for medical problems, and abdominal pain at diagnosis are associated with increased mortality among patients with NOMI.
Article
Obstetrics & Gynecology
Luis D. Pacheco, Antonio F. Saad, George R. Saade
Summary: In recent years, new antimicrobials that are safer and more effective have become available in obstetrics, emphasizing the importance of early and adequate antibiotic coverage for managing severe infections in pregnant individuals. Poor initial antibiotic selection can lead to higher mortality and significant side effects in critically ill pregnant patients with life-threatening infections. This guide aims to assist clinicians in selecting appropriate empirical antibiotic regimens for common severe infections affecting pregnant individuals.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Immunology
Wandong Hong, Qin Chen, Songzan Qian, Zarrin Basharat, Vincent Zimmer, Yumin Wang, Maddalena Zippi, Jingye Pan
Summary: This study investigated clinical features and laboratory findings between critically ill and non-critically ill COVID-19 pneumonia patients. It was found that older patients with higher interleukin-6 levels were more likely to develop critical illness. Interleukin-6 was identified as a superior predictor of disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Infectious Diseases
Kelly L. Maguigan, Mohammad H. Al-Shaer, Charles A. Peloquin
Summary: Beta-lactam antibiotics are the cornerstone for treating Gram-negative infections in critically ill patients, however, dosing adjustments may be necessary due to the unique physiology and increasing resistance rates in the ICU setting. Continuous infusions are often required to achieve desired pharmacokinetic/pharmacodynamic targets, especially when dealing with less-susceptible pathogens such as Pseudomonas aeruginosa.
Article
Medicine, General & Internal
Tong Li, Dawei Zhou, Dong Zhao, Qing Lin, Dijia Wang, Chao Wang, Rongli Zhang
Summary: This study evaluated the impact of oxygen saturation on mortality in critically ill patients with mechanical ventilation, and found that oxygen saturation below 88% and within the range of 89-93% were associated with higher risk of mortality for non-obese patients, while oxygen saturation of 99-100% was associated with increased risk of mortality for obese patients.
FRONTIERS IN MEDICINE
(2022)
Review
Critical Care Medicine
Swarna Rajagopalan, Aarti Sarwal
Summary: Critically ill patients are at high risk of acute brain injury. Bedside neuromonitoring techniques can provide early detection of neurologic deterioration before clinically manifest signs occur. Neuromonitoring provides measurable parameters of brain injury that can be used as a target for investigating therapeutic interventions, monitoring treatment responses, and testing clinical paradigms to improve clinical outcomes.
CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ioannis Ilias, Aristidis Diamantopoulos, Efthymia Botoula, Nikolaos Athanasiou, Alexandros Zacharis, Stamatios Tsipilis, Edison Jahaj, Alice G. Vassiliou, Dimitra A. Vassiliadi, Anastasia Kotanidou, Stylianos Tsagarakis, Ioanna Dimopoulou
Summary: The study aimed to measure IGF1 and GH in critically and non-critically ill Covid-19 patients. Results showed that IGF-1 levels were higher in survivors compared to non-survivors, suggesting a potential association between low IGF1 and poor outcomes in Covid-19 patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Erin F. Barreto, Jack Chang, Andrew D. Rule, Kristin C. Mara, Laurie A. Meade, Johar Paul, Paul J. Jannetto, Arjun P. Athreya, Marc H. Scheetz, BLOOM Study Group
Summary: A population pharmacokinetic model for cefepime was developed and validated for critically ill patients. The study highlighted the importance of using cystatin C in predicting cefepime clearance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Xiangru Luo, Shiyi Wang, Dong Li, Jun Wen, Na Sun, Guangjun Fan
Summary: The study aimed to develop a pharmacokinetic model for tigecycline in critically ill patients and optimize dosing regimens. Results showed that APACHEII score and age significantly influenced the drug's clearance and distribution volume. The standard dose regimen often failed to achieve satisfactory therapeutic effects for critically ill patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Alison L. Blackman, Praneeth Jarugula, David P. Nicolau, Sai Ho Chui, Manjari Joshi, Emily L. Heil, Mathangi Gopalakrishnan
Summary: This study demonstrates that standard linezolid doses may not be adequate for all patients, especially for noncirrhotic patients weighing over 140 kg with minimum inhibitory concentrations of >= 2mg/liter, as target attainment of >= 90% is not achieved in this population.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Agustin Clemente-Moragon, Juan Martinez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernandez, Lorena Rodriguez-Gonzalez, Cristina Serrano del Castillo, Ana-Maria Ioan, Maria Lopez-Alvarez, Sandra Gomez-Talavera, Carlos Galan-Arriola, Valentin Fuster, Cesar Perez-Calvo, Borja Ibanez
Summary: In this study, metoprolol treatment in patients with COVID-19-associated ARDS was shown to be safe and effective in reducing lung inflammation and improving oxygenation, resulting in fewer days on invasive mechanical ventilation. Repurposing metoprolol for COVID-19-associated ARDS could be a cost-effective strategy to alleviate the burden of the pandemic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Anthony C. Gordon, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Ahi Beane, Wilma Van Bentum-Puijk, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Allen C. Cheng, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas E. Hills, Christopher M. Horvat, Francois Lamontagne, Patrick R. Lawler, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, Elizabeth Lorenzi, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettill, Emma Rademaker, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy L. Sligl, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Steve A. Webb, Lennie P. G. Derde
Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Ewan C. Goligher, Charlotte A. Bradbury, Bryan J. McVerry, Patrick R. Lawler, Jeffrey S. Berger, Michelle N. Gong, Marc Carrier, Harmony R. Reynolds, Anand Kumar, Alexis F. Turgeon, Lucy Z. Kornblith, Susan R. Kahn, John C. Marshall, Keri S. Kim, Brett L. Houston, Lennie P. G. Derde, Mary Cushman, Tobias Tritschler, Derek C. Angus, Lucas C. Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E. Farkouh, Maria M. Brooks, Roger J. Lewis, Lindsay R. Berry, Elizabeth Lorenzi, Anthony C. Gordon, Scott M. Berry, Colin J. McArthur, Matthew D. Neal, Judith S. Hochman, Steven A. Webb, Ryan Zarychanski, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W. Costantini, Sophie de Brouwer, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Heather F. Eng, Jorge Escobedo, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Joshua D. Froess, Zhuxuan Fu, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Timothy D. Girard, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Rashan Haniffa, Sheila M. Hegde, Carolyn M. Hendrickson, Alisa M. Higgins, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, David T. Huang, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J. King, Aaron E. Kornblith, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A. Lother, Nicole Marten, Andrea Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Jose C. Nicolau, Brenda Nunez-Garcia, John J. Park, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Mauricio Pompilio, John G. Quigley, Robert S. Rosenson, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler O. Santos, Lewis Satterwhite, Christina T. Saunders, Jake Schreiber, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Aneesh B. Singhal, Arthur S. Slutsky, Dayna Solvason, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Yongqi Zhong
Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Letter
Medicine, General & Internal
Pieter Vermeersch, Frederic Cotton, Dieter De Smet, Geert Martens, Matthijs Oyaert, Etienne Cavalier
ACTA CLINICA BELGICA
(2022)
Letter
Medicine, General & Internal
Charlotte Vanhomwegen, Ioannis Veliziotis, Stefano Malinverni, Deborah Konopnicki, Philippe Dechamps, Marc Claus, Alain Roman, Frederic Cotton, Nicolas Dauby
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Francois Lersy, Mathieu Anheim, Thibault Willaume, Agathe Chammas, Jean-Christophe Brisset, Francois Cotton, Stephane Kremer
Summary: This study investigated intracranial vessel wall changes in COVID-19 patients with neurologic manifestations using brain MRI, revealing neuroimaging findings suggestive of cerebral vasculitis in some patients. The study suggests that medium-sized vessel cerebral vasculitis may be one of the mechanisms contributing to brain damage related to COVID-19.
JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Sandra Vukusic, Iuliana Ionescu, Catherine Cornu, Nadine Bossard, Francoise Durand-Dubief, Francois Cotton, Luca Durelli, Romain Marignier, Laurence Gignoux, David-Axel Laplaud, Thibault Moreau, Pierre Clavelou, Jerome De Seze, Marc Debouverie, David Brassat, Jean Pelletier, Christine Lebrun-Frenay, Emmanuelle Le Page, Giovanni Castelnovo, Eric Berger, Patrick Hautecoeur, Olivier Heinzlef, Maria Trojano, Francesco Patti, Etienne-Emile Baulieu, Laurent Remontet, Martine El-Etr
Summary: The POPARTMUS trial aimed to compare the annualized relapse rate in women treated with NOMAc and E2 after childbirth, but recruitment was prematurely stopped due to slow inclusions. The results showed that the combination did not have efficacy in preventing post-partum relapses.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Delphine Maucort-Boulch, Francois Cotton, Sandra Vukusic, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: Longitudinal analysis of T1-weighted images in multiple sclerosis patients over 4 years showed no significant signal intensity increases in the dentate nuclei and subcortical gray matter structures with cumulative administration of the macrocyclic gadolinium-based contrast agent, gadoterate meglumine.
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Axelle Gilles, Sebastian Vermeersch, Pieter Vermeersch, Fleur Wolff, Frederic Cotton, Sebastien Tilleux, David Cassiman
Summary: Acute hepatic porphyrias are a group of rare and severe diseases with limited treatment options, impacting an estimated 11-34 patients in Belgium. An expert consensus statement on the current status of AHP in Belgium was drafted by EPNet centers in collaboration with Alnylam Pharmaceuticals. This statement provides an overview of AHP pathophysiology, clinical manifestations, burden of disease, epidemiology, treatments, and proposed organization of care.
ACTA CLINICA BELGICA
(2022)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Berardino Barile, Francois Cotton, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: The study aimed to determine if T1/T2 ratio measurements can accurately detect cerebral white matter microstructural damage in RRMS patients compared to healthy controls. Results showed significant differences between RRMS and HC in both DTI and T1/T2 ratio measurements, highlighting the potential clinical use of T1/T2 ratio in evaluating WM abnormalities in the brain.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Alexandre Bani-Sadr, Marie-Camille Ruitton-Allinieu, Jean-Christophe Brisset, Francois Ducray, Bastien Joubert, Geraldine Picard, Francois Cotton
Summary: This study aimed to determine whether diffusion-weighted imaging (DWI) can help distinguish early-stage autoimmune (AI) encephalitis from herpes simplex virus (HSV) encephalitis. By comparing the MRIs of patients from a multi-center cohort of AI encephalitis and a single-center of HSV encephalitis, it was found that restricted diffusion lesions in the medial temporal lobe are a characteristic of HSV encephalitis and can aid in distinguishing it from early-stage AI encephalitis.
JOURNAL OF NEURORADIOLOGY
(2023)
Letter
Hematology
Anne-Sophie Adam, Melanie Vaes, Frederic Cotton, Beatrice Gulbis
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Letter
Rehabilitation
Shams Ribault, Ahmed Adham, Francois Cotton, Lisette Arsenault, Ludovic Delporte, Nicolas Chatron, Gaetan Lesca, Patrick Edery, Gilles Rode
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Valentine Wargnier-Dauchelle, Thomas Grenier, Francoise Durand-Dubief, Francois Cotton, Michael Sdika
Summary: The lack of interpretability of deep learning hinders its use in critical fields like medicine. This paper proposes a new weakly supervised method for interpretable healthy vs pathological classification and anomaly detection, which includes a new loss function and constrained training to reveal pathological structures and provide more accurate classification and anomaly detection.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Clinical Neurology
Florent Cluse, Tanguy Fenouil, Sandra Vukusic, Francois Ducray, Francois Cotton, Romain Marignier, Francoise Durand-Dubief
Summary: This study described the clinical, radiological, pathological, and follow-up characteristics of 13 pseudocystic inflammatory demyelinating lesions (PIDLs) in 9 MS patients. PIDLs often occurred at first event, were often asymptomatic, and showed distinctive MRI features. Biopsies revealed classical features of active MS except for unusual edema. The easily recognizable MRI features of PIDLs could help avoid biopsy.
MULTIPLE SCLEROSIS JOURNAL
(2023)