Review
Endocrinology & Metabolism
Melina Bailly, Audrey Boscaro, Bruno Pereira, Leonard Feasson, Yves Boirie, Natacha Germain, Bogdan Galusca, Daniel Courteix, David Thivel, Julien Verney
Summary: Constitutionally thin individuals have a lighter body weight but are not lacking in fat, with a higher fat-free mass to weight ratio compared to anorexic patients, indicating a higher metabolic fat-free mass. In contrast to anorexic patients, constitutionally thin people have normal levels of insulin-like growth factor 1, estradiol, growth hormone, follicle-stimulating hormone, and luteinizing hormone.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Physiology
Melina Bailly, Audrey Boscaro, Thierry Thomas, Leonard Feasson, Frederic Costes, Bruno Pereira, Jorg Hager, Bruno Estour, Bogdan Galusca, Lore Metz, Daniel Courteix, David Thivel, Julien Verney, Natacha Germain
Summary: Constitutionally thin individuals, especially men, have lower bone architecture, particularly in weight-supporting bones. However, compared to controls, there are many alterations in the associations between body weight or muscle and bone parameters in constitutionally thin individuals.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Prachi Singh, Naima Covassin, Fatima H. Sert-Kuniyoshi, Kara L. Marlatt, Abel Romero-Corral, Diane E. Davison, Ravinder J. Singh, Michael D. Jensen, Virend K. Somers
Summary: The study found that modest weight gain in males does not alter circulating gonadal hormones, but may increase the activity of testosterone and estrogen through decreases in SHBG. The results suggest a complex relationship between adipose tissue, gonadal hormones, and fat accumulation in males during overfeeding-induced modest weight gain.
PHYSIOLOGICAL REPORTS
(2021)
Article
Chemistry, Medicinal
Manendra Singh Tomar, Aditya Sharma, Fabrizio Araniti, Ankit Pateriya, Ashutosh Shrivastava, Akhilesh Kumar Tamrakar
Summary: High-fat-diet-induced obesity increases the risk of insulin resistance, which may lead to type 2 diabetes and related metabolic complications. Gas chromatography-tandem mass spectrometry analysis of serum samples from mice fed with high-fat-diet and chow diet revealed differences in metabolites and metabolic pathways. These findings provide potential metabolic biomarkers for diagnosing insulin resistance and clinical applications.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Mathematics, Applied
Dhouha Grissa, Blandine Comte, Melanie Petera, Estelle Pujos-Guillot, Amedeo Napoli
DISCRETE APPLIED MATHEMATICS
(2020)
Article
Oncology
Lucie Lecuyer, Celine Dalle, Sophie Lefevre-Arbogast, Pierre Micheau, Bernard Lyan, Adrien Rossary, Aicha Demidem, Melanie Petera, Marie Lagree, Delphine Centeno, Pilar Galan, Serge Hercberg, Cecilia Samieri, Nada Assi, Pietro Ferrari, Vivian Viallon, Melanie Deschasaux, Valentin Partula, Bernard Srour, Paule Latino-Martel, Emmanuelle Kesse-Guyot, Nathalie Druesne-Pecollo, Marie-Paule Vasson, Sephanie Durand, Estelle Pujos-Guillot, Claudine Manach, Mathilde Touvier
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Nutrition & Dietetics
Lucie Lecuyer, Celine Dalle, Pierre Micheau, Melanie Petera, Delphine Centeno, Bernard Lyan, Marie Lagree, Pilar Galan, Serge Hercberg, Adrien Rossary, Aicha Demidem, Marie-Paule Vasson, Valentin Partula, Melanie Deschasaux, Bernard Srour, Paule Latino-Martel, Nathalie Druesne-Pecollo, Emmanuelle Kesse-Guyot, Stephanie Durand, Estelle Pujos-Guillot, Claudine Manach, Mathilde Touvier
EUROPEAN JOURNAL OF NUTRITION
(2020)
Review
Biochemical Research Methods
Haiying Wang, Estelle Pujos-Guillot, Blandine Comte, Joao Luis de Miranda, Vojtech Spiwok, Ivan Chorbev, Filippo Castiglione, Paolo Tieri, Steven Watterson, Roisin McAllister, Tiago de Melo Malaquias, Massimiliano Zanin, Taranjit Singh Rai, Huiru Zheng
Summary: Systems medicine utilizes deep learning to extract relevant features from complex data for improved understanding, prevention, and treatment of diseases. This review paper discusses the developments and challenges of applying deep learning in systems medicine, highlighting its importance in predictive, preventive, and precision medicine. Promising prototypical examples showcase the potential impact of incorporating deep learning in systems medicine research.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Sport Sciences
Robin Pla, Estelle Pujos-Guillot, Stephanie Durand, Marion Brandolini-Bunlon, Delphine Centeno, David B. Pyne, Jean-Francois Toussaint, Philippe Hellard
Summary: The study found that metabolic responses differed between the polarised training group and threshold training group during high-intensity threshold training loads, with the threshold group showing higher glycogenic depletion and inflammation levels, while the polarised group exhibited lower levels of these reactions.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Julia Keller, Sylvie Chevolleau, Maria-Helena Noguer-Meireles, Estelle Pujos-Guillot, Mylene Delosiere, Celine Chantelauze, Charlotte Joly, Florence Blas-y-Estrada, Isabelle Jouanin, Denys Durand, Fabrice Pierre, Laurent Debrauwer, Vassilia Theodorou, Francoise Gueraud
Article
Endocrinology & Metabolism
Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R. Ahmed, Sanjay Purkayastha, Matthew R. Lewis, Stephen Bloom, Jia Li, Tricia M. Tan
Summary: The metabolic effects of a combined infusion of glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptideYY (PYY) (tripeptide GOP) were compared to a placebo infusion, Roux-en-Y gastric bypass (RYGB) surgery, and a very low-calorie diet (VLCD). The results showed that, compared to VLCD and RYGB, the tripeptide GOP had minimal effects on metabolites.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Blandine Comte, Stephanie Monnerie, Marion Brandolini-Bunlon, Cecile Canlet, Florence Castelli, Emeline Chu-Van, Benoit Colsch, Francois Fenaille, Charlotte Joly, Fabien Jourdan, Natacha Lenuzza, Bernard Lyan, Jean-Francois Martin, Carole Migne, Jose A. Morais, Melanie Petera, Nathalie Poupin, Florence Vinson, Etienne Thevenot, Christophe Junot, Pierrette Gaudreau, Estelle Pujos-Guillot
Summary: The study used a multiplatform metabolomics and lipidomics untargeted strategy to characterize metabolic perturbations in MetS, identifying significant changes and defining a comprehensive MetS signature for future clinical applications. This approach provides insights into the systemic alterations of metabolism in MetS, contributing to better diagnostic methods for the syndrome.
Review
Nutrition & Dietetics
Francesco Maria Calabrese, Annalisa Porrelli, Mirco Vacca, Blandine Comte, Katharina Nimptsch, Mariona Pinart, Tobias Pischon, Estelle Pujos-Guillot, Maria De Angelis
Summary: Low-grade inflammatory diseases have been found to be associated with metabolic disturbances, such as gut microbiota dysbiosis. Metaproteomics has been used in the past decade to investigate protein composition in specific healthy and pathological conditions. This review applied a rigorous protocol to select 10 metaproteomics studies aiming at investigating obesity and diabetes, providing insights into microbial and human metaproteome alterations and metabolic patterns in individuals affected by diabetes and obesity. However, the lack of metaproteomic data limits objective considerations, and the establishment of specific databases and standardized analysis protocols is needed to further enhance our knowledge on these prevalent diseases.
Article
Nutrition & Dietetics
Valeria Agamennone, Peter M. Abuja, Marijana Basic, Maria De Angelis, Andre Gessner, Bart Keijser, Martin Larsen, Mariona Pinart, Katharina Nimptsch, Estelle Pujos-Guillot, Kristina Schlicht, Itai Sharon, Eva Untersmayr, Matthias Laudes, Tobias Pischon, Jildau Bouwman
Summary: Studies show that the intestinal microbiota has an influence on general metabolic processes and the risk of chronic diseases in humans. Dietary factors also play a role and affect the composition and function of the gut microbiota. The HDHL-INTIMIC knowledge platform aims to foster research on the microbiota, nutrition, and health by assembling available knowledge and sharing information with the scientific community.
Review
Food Science & Technology
Dragan Milenkovic, Frederic Capel, Lydie Combaret, Blandine Comte, Dominique Dardevet, Bertrand Evrard, Christelle Guillet, Laurent-Emmanuel Monfoulet, Alexandre Pinel, Sergio Polakof, Estelle Pujos-Guillot, Didier Remond, Yohann Wittrant, Isabelle Savary-Auzeloux
Summary: Impairment of gut function is a mechanism for the decline in health status in the elderly, involving declines in digestive physiology, metabolism, and immune status. This is associated with changes in the composition and function of the gut microbiota. These alterations can be targeted through nutritional strategies to prevent or delay the occurrence of age-related pathologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Marion Brandolini-Bunlon, Benoit Jaillais, Veronique Cariou, Blandine Comte, Estelle Pujos-Guillot, Evelyne Vigneau
Summary: In nutrition and health research, untargeted metabolomics is analyzed together with clinical data to improve prediction and understanding of pathological status. This can be modeled using a multiblock supervised model, where different input data blocks are potential predictors of the outcome. Path diagrams can also be used to represent this configuration, allowing for accounting of block effects.
Meeting Abstract
Gastroenterology & Hepatology
Benjamin Buchard, Natali Abeywickrama Samarakoon, Estelle Pujos-Guillot, Stephanie Durand, Melanie Petera, Delphine Centeno, Juliette Joubert, Aicha Demidem, Armand Abergel
JOURNAL OF HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
Nils Paulhe, Cecile Canlet, Annelaure Damont, Lindsay Peyriga, Stephanie Durand, Catherine Deborde, Sandra Alves, Stephane Bernillon, Thierry Berton, Raphael Bir, Alyssa Bouville, Edern Cahoreau, Delphine Centeno, Robin Costantino, Laurent Debrauwer, Alexis Delabriere, Christophe Duperier, Sylvain Emery, Amelie Flandin, Ulli Hohenester, Daniel Jacob, Charlotte Joly, Cyril Jousse, Marie Lagree, Nadia Lamari, Marie Lefebvre, Claire Lopez-Piffet, Bernard Lyan, Mickael Maucourt, Carole Migne, Marie-Francoise Olivier, Estelle Rathahao-Paris, Pierre Petriacq, Julie Pinelli, Lea Roch, Pierrick Roger, Simon Roques, Jean-Claude Tabet, Marie Tremblay-Franco, Mounir Traikia, Anna Warnet, Vanessa Zhendre, Dominique Rolin, Fabien Jourdan, Etienne Thevenot, Annick Moing, Emilien Jamin, Francois Fenaille, Christophe Junot, Estelle Pujos-Guillot, Franck Giacomoni
Summary: A comprehensive resource, PeakForest addresses the technical bottleneck in annotating large-scale spectral data and identifying metabolites in metabolomics laboratories. It provides a structured database with tools for data curation and browsing, facilitating the sharing and integration of spectral data across laboratories.
Article
Gastroenterology & Hepatology
Teresa Tavella, Simone Rampelli, Giulia Guidarelli, Alberto Bazzocchi, Chiara Gasperini, Estelle Pujos-Guillot, Blandine Comte, Monica Barone, Elena Biagi, Marco Candela, Claudio Nicoletti, Fawzi Kadi, Giuseppe Battista, Stefano Salvioli, Paul W. O'Toole, Claudio Franceschi, Patrizia Brigidi, Silvia Turroni, Aurelia Santoro
Summary: The study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles, and cardio-metabolic risk factors.