期刊
MRS COMMUNICATIONS
卷 8, 期 3, 页码 652-667出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrc.2018.148
关键词
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资金
- MEXT, Japan [S1101017]
- NIH, Foundation Edmund Rothschild, Paris, France
The inefficiencies of the current pipeline from discovery to clinical approval of drugs demand a surrogate method to indicate adverse drug reactions, e.g. liver damage. Organ-on-chip (OOC) models would be an ideal, rapid, and human-specific alternate, which would render animal testing obsolete. The ground-breaking ability of OOCs and Multi-OOC constructs is the accurate simulation of the in vivo conditions of human organs leading to precise drug screens for cytotoxicity and/or drug efficacy at a faster pace and lesser cost. Here we discuss the innovation, architecture, and the progress of OOCs towards human body-on-a-chip.
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