Article
Biochemistry & Molecular Biology
Hyeri Im, In Gyoung Ju, Jin Hee Kim, Seungmin Lee, Myung Sook Oh
Summary: This study found that PNP001 can inhibit neuroinflammation and neurological deficits induced by LPS. In both in vitro and in vivo experiments, PNP001 reduced the release of inflammatory cytokines, alleviated microglial activation and synaptic loss. Furthermore, PNP001 significantly improved memory decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yebin Oh, Hak-Jun Jung, Seungwon Hong, Yerim Cho, Jiyeong Park, Daeho Cho, Tae Sung Kim
Summary: Activation of microglia by AIMP1 through the JNK and p38/NF-kappa B pathways induces neuroinflammation and polarization of microglial cells into the M1 state.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Meichen Yan, Xuena Bo, Xinchao Zhang, Jingdan Zhang, Yajin Liao, Haiyan Zhang, Yong Cheng, Junxia Guo, Jinbo Cheng
Summary: This study found that Mangiferin (MGF) can significantly alleviate PPD-like behaviors in a hormone-simulated pregnancy PPD mouse model and inhibit microglial activation and neuroinflammation. Furthermore, MGF treatment also suppressed the activation of mitogen-activated protein kinase (MAPK) signaling. These results provide insight into the potential therapeutic strategy for PPD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mingde Fan, Chao Wang, Xueying Zhao, Yang Jiang, Chengwei Wang
Summary: Parthenolide (PTL) treatment improved cognitive impairment in APP/PS1 mice by inhibiting neuroinflammation. PTL reduced intracellular reactive oxygen species and restored microglial phagocytosis via the AKT/MAPK/NF-kappa B signaling pathway. Additionally, PTL enhanced TRIM31 expression and attenuated the NLRP3 signaling, exerting anti-inflammatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Yoshika Iwata, Mariko Miyao, Akiko Hirotsu, Kenichiro Tatsumi, Tomonori Matsuyama, Nobuo Uetsuki, Tomoharu Tanaka
Summary: Overall, the study found that OGT exhibited dose-dependent inhibition of PGE2 production in BV-2 cells, potentially through a COX-independent mechanism, suggesting its potential therapeutic application in neuroinflammatory diseases.
Article
Immunology
Eric A. Woodcock, Ansel T. Hillmer, Christine M. Sandiego, Paul Maruff, Richard E. Carson, Kelly P. Cosgrove, Robert H. Pietrzak
Summary: This study found that LPS administration in healthy adults can impair memory processes, specifically affecting verbal learning and recall, hippocampal memory processes. Furthermore, LPS also leads to increased neuroinflammation, which is correlated with decreased performance in memory in the hippocampus, putamen, and thalamus. This experimental paradigm may be useful for investigating the mechanistic relationships between neuroinflammatory signaling and cognitive dysfunction in psychiatric and neurologic disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Dewei He, Guiqiu Hu, Ang Zhou, Yanting Liu, Bingxu Huang, Yingchun Su, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Shoupeng Fu, Dianfeng Liu
Summary: This study found that Echinocystic acid (EA) inhibits neuroinflammation by activating the PI3K/Akt pathway and inhibiting the NF-kappa B and MAPK pathways, and exhibits neuroprotective effects in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Hwi Cho, Dae Hyun Kim, Jong Suk Lee, Mi-Suk Seo, Mi Eun Kim, Jun Sik Lee
Summary: This study found that S. horneri has anti-neuroinflammatory effects on microglia cells by inhibiting neuroinflammatory factors and NF-kappa B signaling in vitro and in vivo.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng- Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang Li
Summary: In this study, the researchers investigated the effect of nordalbergin, a compound derived from Dalbergia sissoo wood bark, on inflammation in microglial cells. They found that nordalbergin could suppress the production of inflammatory molecules and reduce oxidative stress through inhibiting specific signaling pathways. These findings suggest that nordalbergin has the potential to inhibit the progression of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Na Li, Chun-Yan Yao, Jun Diao, Xiao-Ling Liu, En-Jie Tang, Qing-Song Huang, Yu-Meng Zhou, Yue-Gu Hu, Xiu-Kuan Li, Jin-Yun Long, Hua Xiao, Da-Wei Li, Ning Du, Ya-Fei Li, Peng Luo, Tong-Jian Cai
Summary: T-2 toxin induces neurotoxicity in mice by activating microglia, leading to behavioral abnormalities. This toxic effect may be mediated through the MAPK/NF-kappa B signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junjue Chen, Huimin Zhong, Huan Yu, Jun Sun, Bingqiao Shen, Xing Xu, Shouyue Huang, Ping Huang, Yisheng Zhong
Summary: IL-17A plays a significant role in the regulation of retinal immune response and retinal ganglion cell death in glaucoma by promoting retinal microglial activation via p38 MAPK signaling pathway. Suppression of IL-17A contributes to alleviate glaucoma neuropathy.
Article
Immunology
Karen Krukowski, Amber Nolan, McKenna Becker, Katherine Picard, Nathalie Vernoux, Elma S. Frias, Xi Feng, Marie-Eve Tremblay, Susanna Rosi
Summary: The study revealed that one week after brain injury, microglia exhibit increased phagocytic activity, synaptic engulfment, and neuronal contact, which may contribute to cognitive deficits. By utilizing state-of-the-art techniques, novel microglia-mediated mechanisms that impact neuronal function after TBI were uncovered.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Jian-wei Ge, Shi-ji Deng, Zhi-wei Xue, Pin-yi Liu, Lin-jie Yu, Jiang-nan Li, Sheng-nan Xia, Yue Gu, Xin-yu Bao, Zhen Lan, Yun Xu, Xiao-lei Zhu
Summary: The research suggests that imperatorin can suppress neuroinflammation, alleviate ischemic injury, and exert protective effects by downregulating the MAPK and NF-kappa B signaling pathways.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Engineering, Chemical
Ji-Woong Park, Woong Kim, Chul Yung Choi, Seok-Jun Kim
Summary: The study found that RLE effectively suppressed the inflammatory response induced by LPS in BV-2 cells, suggesting its potential use as a preventive agent against diseases triggered by microglial inflammatory responses.
Article
Biochemistry & Molecular Biology
Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Hyo Jung Kang, Sujung Yoon, Suji Lee, Koeul Choi, Sihwan Seol, Shinwon Park, Eun Namgung, Tammy D. Kim, Yong-An Chung, Jungyoon Kim, Jung-Soo Han, In Kyoon Lyoo
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Yoonjeong Cho, Hongik Hwang, Md. Ataur Rahman, ChiHye Chung, Hyewhon Rhim
SCIENTIFIC REPORTS
(2020)
Article
Psychology, Biological
Dong-Hee Kim, Hye-A Kim, Ye Sun Han, Won Kyung Jeon, Jung-Soo Han
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Dong Bin Back, Bo-Ryoung Choi, Jung-Soo Han, Kyoung Ja Kwon, Dong-Hee Choi, Chan Young Shin, Jongmin Lee, Hahn Young Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Jung-Cheol Park, Yong-Jae Jeon, Jeansok J. Kim, Jeiwon Cho, Dong-Hee Choi, Jung-Soo Han
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Sang-Wook Shin, Dong-Hee Kim, Won Kyung Jeon, Jung-Soo Han
Article
Multidisciplinary Sciences
Hee-Ju Kang, Eun-Hye Lee, Ju-Wan Kim, Sung-Wan Kim, Il-Seon Shin, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho, Jung-Soo Han, In Kyoon Lyoo, Jae-Min Kim
Summary: The study found that high methylation of SLC6A4 and suicidal ideation within 2 weeks after stroke are both associated with worse long-term outcomes. Additionally, a significant interaction effect between SI and CpG 4 methylation status was identified, enhancing the association with long-term stroke outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jung-Cheol Park, Yong-Jae Jeon, Yoon-Sun Jang, Jeiwon Cho, Dong-Hee Choi, Jung-Soo Han
Summary: Down-regulation of SGK1 expression in the mPFC of rats can affect resistance to stress-induced cognitive impairment, while recognition memory remains intact in control rats following brief stress.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Dong-Hee Kim, Bo-Ryoung Choi, Yong-Jae Jeon, Yoon-Sun Jang, Jung-Soo Han
Summary: Research indicates that midbrain dopamine neurons and lateral habenula neurons play crucial roles in appetitive extinction. The study found higher activity levels of LHb neurons in the paired-CS-alone group, while VTA and SNc activity was significantly higher in the paired-paired group. Additionally, lesions in the LHb decelerated the decline in conditioned food-cup responses, highlighting the crucial role of LHb in appetitive extinction.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Woonhee Kim, ChiHye Chung
Summary: Mood disorders are more prevalent and severe in women, but the underlying mechanisms of this sexual prevalence remain unclear. A study comparing brain activation in male and female mice after acute stress exposure found sexually dimorphic activation in certain brain areas, though core stress responding mechanisms were largely shared between sexes. Stress strengthened intra-circuitries in the hippocampus, amygdala, and prefrontal cortex in female mice, while longer-range connections were highlighted in stressed male mice. This study provides a valuable neuroanatomical framework for investigating the circuit mechanism underlying the higher vulnerability to depression in women.
Article
Behavioral Sciences
Dong-Hee Kim, Bo-Ryoung Choi, In-Beom Jin, Jin-Ah Jeon, Sang-Pil Park, Jung-Soo Han
Summary: A previous study found that lateral habenula (LHb) lesions slowed down appetitive extinction. Therefore, we investigated whether LHb activation could accelerate appetitive extinction. In this study, rats underwent appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation expedited the decrease in conditioned food-cup responses during extinction. The present findings, along with previous LHb lesion studies, suggest that LHb mediates appetitive extinction.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
In-Beom Jin, Yong-Jae Jeon, Jeiwon Cho, Jung-Soo Han
Summary: Recent studies have shown that the LHb plays a critical role in mediating the association between CS and the absence of US. The LHb is involved in the conditioned inhibitory properties of CS acquired through explicit unpaired training, but preexposure to the same number of lights does not significantly retard the acquisition of subsequent excitatory associations.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Neurosciences
Hee-Ju Kang, Ju-Wan Kim, Sung-Wan Kim, Jung-Soo Han, In Kyoon Lyoo, Jae-Min Kim
Summary: Biomarkers, especially peripheral ones, can contribute to the development of preventive and intervention strategies for suicidal behavior. These biomarkers should be easily accessible, cost-effective, and minimally invasive. Several peripheral biomarkers are associated with suicidal behavior, such as decreased levels of peripheral interleukin-2 in suicide attempts and elevated levels of certain substances in cerebrospinal fluid related to suicide risk and suicide death. Combining multiple potential biomarkers may improve screening, diagnosis, and prediction of suicidal behavior.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Correction
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
NATURE COMMUNICATIONS
(2023)