Article
Neurosciences
Zineb Soualah, Antoine Taly, Lucille Crespin, Ophelie Saulais, Daniel Henrion, Claire Legendre, Helene Tricoire-Leignel, Christian Legros, Cesar Mattei
Summary: Fipronil, a neurotoxic insecticide, inhibits GABA-induced currents on mammalian GABA(A) receptors by acting as a non-competitive antagonist. The subunit composition of the receptors plays a crucial role in determining the inhibitory effects of Fipronil, with complementary subunits affecting its interaction and localization within physiological synapses.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Julia Bukanova, Elena Solntseva, Rodion Kondratenko, Eva Kudova
Summary: Epi is a positive modulator of GABA-induced chloride current (I-GABA) with an EC50 of 5.7 μM in Purkinje cells and 9.3 μM in hippocampal neurons. The potentiation of I-GABA by Epi is more pronounced at low GABA concentrations.
Review
Cell Biology
Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli, Federico Sicca
Summary: Serotonergic dysfunction is believed to be a major cause of depression, although other dysfunctional mechanisms may also be involved. The astrocytic inward rectifier potassium channel 4.1 (Kir4.1) may play an important role in neuronal excitability and glutamate metabolism, with its dysfunction potentially related to depression.
Article
Medicine, Research & Experimental
Hossein Rezazadeh, Mohammad Reza Sharifi, Mohmmadreza Sharifi, Nepton Soltani
Summary: The study found that GABA or insulin therapy can effectively reduce blood glucose levels in type 2 diabetic patients and their offspring, while also increasing their insulin sensitivity. Additionally, GABA therapy is able to improve insulin resistance in patients by increasing the expression of GLUT4, IRS1, and Akt genes, indirectly reducing insulin resistance in their offspring.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Analytical
Taishi Tonooka, Toshihisa Osaki, Koji Sato, Ryuji Kawano, Shoji Takeuchi
Summary: Voltage-clamp fluorometry (VCF) combined with an embedded Ag/AgCl microelectrode in a picoliter-sized lipid bilayer chamber simplifies the equipment, improves precision, and expands the research scope, enabling molecular transport detection through a normal fluorescent microscope.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
David P. Richards, Rohit N. Patel, Ian R. Duce, Bhupinder P. S. Khambay, Michael A. Birkett, John A. Pickett, Ian R. Mellor
Summary: Ladybird beetles possess strong chemical defences, and recent studies have shown that their alkaloids can target receptors and act as antagonists. This study explored the actions of one particular alkaloid found in ladybirds on different types of receptors.
Article
Biochemistry & Molecular Biology
Dieter Janzen, Benedikt Slavik, Markus Zehe, Christoph Sotriffer, Helene M. Loos, Andrea Buettner, Carmen Villmann
Summary: This study analyzed the modulatory potential of 11 SQTs at GABA(A) receptors to characterize their potential neurotropic activity. The research found differences in receptor modulation by SQTs in HEK293 cells and neurons, with the presence of gamma(2) and delta subunits being important for SQT modulation. Additionally, the study provided insight into how nutritional digestion can affect the neurotropic potential of natural compounds.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ida C. Schiller, Kenneth A. Jacobson, Zhiwei Wen, Aparna Malisetty, Guenther Schmalzing, Fritz Markwardt
Summary: The study found limited efficacy in inhibiting the P2X5 receptor, but amlodipine may serve as a lead for future synthesis to increase its affinity for the receptor. A potential side effect of nimodipine therapy could be stimulation of inflammatory processes.
Article
Biochemistry & Molecular Biology
Julia V. Bukanova, Rodion V. Kondratenko, Elena I. Solntseva
Summary: This study investigates the interaction between positive allosteric modulators (PAMs) and competitive antagonists of GABA(A)Rs, demonstrating unblocking effects and revealing an allosteric relationship between these two types of compounds.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Na Wang, Jingjing Lian, Yanqing Cao, Alai Muheyati, Shanshan Yuan, Yujie Ma, Shuzhuo Zhang, Gang Yu, Ruibin Su
Summary: Benzodiazepines produce various pharmacological effects by positively modulating GABA(A) receptors. This study found that different concentrations of drugs have different effects on different GABA(A) receptors and vary in sensitivity to flumazenil. The results also support the existence of non-classical benzodiazepine binding sites on certain GABA(A) receptor subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Tony Barbay, Emilie Pecchi, Myriam Ducrocq, Nathalie Rouach, Frederic Brocard, Remi Bos
Summary: Neuronal oscillations in the spinal cord are regulated by astrocytic K+ homeostasis, which is mediated by the inward-rectifying K+ channel Kir4.1. Astrocytes display Ca2+ transients that precede and coincide with neighboring neuronal oscillations. Inhibition of astrocytic Ca2+ transients reduces K+ clearance through Kir4.1 channels, leading to disrupted neuronal oscillations and impaired locomotor performance.
Article
Neurosciences
Michael Gray, Joseph M. Santin
Summary: Whole-cell patch clamp is a useful technique for studying voltage-gated ion channels in central neurons, but voltage errors caused by electrode resistance limit its application to small ionic currents. The commonly used Ohm's law-based correction for voltage errors was found to overestimate the actual errors in this study, leading to erroneous current-voltage relationships.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Thao Nguyen Thi Phuong, Seon Hui Jang, Santosh Rijal, Woo Kwon Jung, Junghyun Kim, Soo Joung Park, Seong Kyu Han
Summary: The study examined how linalool acted on SG neurons of the Vc in mice, revealing that linalool exhibits GABA- and glycine-mimetic effects. This suggests that linalool can be a promising target molecule for orofacial pain management by activating inhibitory neurotransmission in the SG area of the Vc.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Food Science & Technology
Shinhui Lee, Sanung Eom, Jung Hee Song, Hye Duck Yeom, Eun Ji Choi, Moeun Lee, Junho H. Lee, Ji Yoon Chang
Summary: This study reveals that the PKD2L1 sour taste receptor can be affected by mannitol in a concentration-dependent and pH-sensitive manner. The production of mannitol during the fermentation of kimchi contributes to the sweet and sour tastes, which may explain the unique taste associated with fermented kimchi.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Baofeng Ma, Richard Buckalew, Yixing Du, Conrad M. Kiyoshi, Catherine C. Alford, Wei Wang, Dana M. McTigue, John J. Enyeart, David Terman, Min Zhou
Article
Neurosciences
Yixing Du, Baofeng Ma, Conrad M. Kiyoshi, Catherine C. Alford, Wei Wang, Min Zhou
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Neurosciences
Michelle L. Olsen, Baljit S. Khakh, Serguei N. Skatchkov, Min Zhou, C. Justin Lee, Nathalie Rouach
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Wei Wang, Conrad M. Kiyoshi, Yixing Du, Baofeng Ma, Catherine C. Alford, Haijun Chen, Min Zhou
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Yixing Du, Conrad M. Kiyoshi, Qi Wang, Wei Wang, Baofeng Ma, Catherine C. Alford, Shiying Zhong, Qi Wan, Haijun Chen, Eric E. Lloyd, Robert M. Bryan, Min Zhou
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Neurosciences
Shiying Zhong, Yixing Du, Conrad M. Kiyoshi, Baofeng Ma, Catherine C. Alford, Qi Wang, Yongjie Yang, Xueyuan Liu, Min Zhou
Article
Neurosciences
Dongchuan Zuo, Kuihao Chen, Min Zhou, Zheng Liu, Haijun Chen
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Neurosciences
Yixing Du, Wei Wang, Anthony D. Lutton, Conrad M. Kiyoshi, Baofeng Ma, Anne T. Taylor, John W. Olesik, Dana M. Mctigue, Candice C. Askwith, Min Zhou
EXPERIMENTAL NEUROLOGY
(2018)
Article
Neurosciences
Conrad M. Kiyoshi, Yixing Du, Shiying Zhong, Wei Wang, Anne T. Taylor, Bangyan Xiong, Baofeng Ma, David Terman, Min Zhou
Article
Neurosciences
Wei Wang, Conrad M. Kiyoshi, Yixing Du, Anne T. Taylor, Erica R. Sheehan, Xiao Wu, Min Zhou
MOLECULAR NEUROBIOLOGY
(2020)
Article
Neurosciences
Qi Wang, Wei Wang, Sydney Aten, Conrad M. Kiyoshi, Yixing Du, Min Zhou
Review
Neurosciences
Min Zhou, Yixing Du, Sydney Aten, David Terman
Summary: The predominant expression of leak-type K+ channels in astrocytes allows for high membrane permeability to K+ ions and hyperpolarized membrane potential, which are crucial for astrocyte function in brain homeostasis. The passive behavior of astrocyte conductance is influenced by both the intrinsic properties of K+ channels and gap junctional coupling, which together create a unique membrane K+ conductance lacking voltage-dependent rectification.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Neurosciences
Monica M. Gaudier-Diaz, Ning Zhang, Adam H. Haines, Surbhi, Min Zhou, A. Courtney DeVries