Article
Respiratory System
Martine Remy-Jardin, Christopher J. Ryerson, Mark L. Schiebler, Ann N. C. Leung, James M. Wild, Marius M. Hoeper, Philip O. Alderson, Lawrence R. Goodman, John Mayo, Linda B. Haramati, Yoshiharu Ohno, Patricia Thistlethwaite, Edwin J. R. van Beek, Shandra Lee Knight, David A. Lynch, Geoffrey D. Rubin, Marc Humbert
Summary: Pulmonary hypertension (PH) is characterized by a mean pulmonary artery pressure greater than 20 mmHg and classified into five groups with similar pathophysiologic mechanisms. Radiologists play a key role in the multidisciplinary assessment and management of PH, utilizing CT, MRI, and nuclear medicine to evaluate and treat the condition effectively.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chi Wan Koo, James M. Williams, Grace Liu, Ananya Panda, Parth P. Patel, Livia Maria M. Frota Lima, Ronald A. Karwoski, Teng Moua, Nicholas B. Larson, Alex Bratt
Summary: QCT features and QCT feature-based ML models successfully differentiate interstitial lung diseases (ILDs). The performance of QCT-ML models outperforms a DL model in ILD classification. Further investigations are needed to determine the superior approach for ILD classification.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jooae Choe, Eun Jin Chae, Yeon Joo Kim, Kyung-Hyun Do, Joon Seon Song, Jin Woo Song
Summary: In patients with chronic hypersensitivity pneumonitis, fibrotic progression and acute exacerbation were common, with baseline fibrosis score and CT pattern of usual interstitial pneumonia/probable UIP being independent risk factors for predicting progression and exacerbation.
EUROPEAN RADIOLOGY
(2021)
Correction
Pharmacology & Pharmacy
Yvette N. Lamb
Summary: A correction for this paper has been published and can be accessed at the provided link.
Article
Radiology, Nuclear Medicine & Medical Imaging
Takeshi Johkoh, Kyung Soo Lee, Mizuki Nishino, William D. Travis, Jay H. Ryu, Ho Yun Lee, Christopher J. Ryerson, Tomas Franquet, Alexander A. Bankier, Kevin K. Brown, Jin Mo Goo, Hans-Ulrich Kauczor, David A. Lynch, Andrew G. Nicholson, Luca Richeldi, Cornelia M. Schaefer-Prokop, Johny Verschakelen, Suhail Raoof, Geoffrey D. Rubin, Charles Powell, Yoshikazu Inoue, Hiroto Hatabu
Summary: The frequency and broad spectrum of lung toxicity have increased with the use of molecular targeting agents and immune checkpoint inhibitors (ICIs), particularly in cancer patients. Diagnosis of drug-related pneumonitis (DRP) involves excluding other causes, and awareness of its incidence and risk factors is crucial. The severity of DRP symptoms can range from mild to life-threatening, requiring accurate diagnosis and prompt treatment.
Article
Critical Care Medicine
Takeshi Johkoh, Kyung Soo Lee, Mizuki Nishino, William D. Travis, Jay H. Ryu, Ho Yun Lee, Christopher J. Ryerson, Tomas Franquet, Alexander A. Bankier, Kevin K. Brown, Jin Mo Goo, Hans-Ulrich Kauczor, David A. Lynch, Andrew G. Nicholson, Luca Richeldi, Cornelia M. Schaefer-Prokop, Johny Verschakelen, Suhail Raoof, Geoffrey D. Rubin, Charles Powell, Yoshikazu Inoue, Hiroto Hatabu
Summary: Diagnosis and management of drug-related pneumonitis requires excluding other potential causes, understanding the incidence and risk factors, and evaluating imaging features based on the distribution of lung parenchymal abnormalities.
Article
Immunology
Songnan Qin, Bingxuan Jiao, Bing Kang, Haiou Li, Hongwu Liu, Congshan Ji, Shifeng Yang, Hongtao Yuan, Ximing Wang
Summary: This study developed a radiomics nomogram for patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) using the ILD-GAP index system. The nomogram showed favorable efficacy in predicting individual ILD-GAP stages and outperformed clinical factors and radiomics signature in terms of clinical usefulness.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Miriana D'Alessandro, Laura Bergantini, Paolo Cameli, Claudia Landi, Nicola Lanzarone, Anna Perrone, Valerio Alonzi, Felice Perillo, Francesco Bianchi, Rosa M. E. T. E. L. L. A. Refini, Maria Pieroni, Piersante Sestini, Elena Bargagli
Summary: Fibrotic hypersensitivity pneumonitis (fHP) is a challenging interstitial pneumonia to diagnose, as there is a lack of uniform diagnostic criteria. This review examined the recent literature on serum and BAL biomarkers and their clinical role in the diagnosis and management of fHP. Various biomarkers in serum (IgG antibodies, macrophage inflammatory proteins-1, epithelial cell proteins) and BAL (lymphocytes, T-cell mediators) were proposed, and further research is needed to validate and standardize them for diagnostic purposes.
Article
Dermatology
Laurent Misery, Christina Schut, Flora Balieva, Svetlana Bobko, Adam Reich, Francesca Sampogna, Ilknur Altunay, Florence Dalgard, Uwe Gieler, Joerg Kupfer, Andrey Lvov, Francoise Poot, Jacek C. Szepietowski, Lucia Tomas-Aragones, Nienke Vulink, Anna Zalewska-Janowska, Anthony Bewley
Summary: Psychodermatology is a subspecialty of dermatology that is gaining increasing attention from dermatologists and patients. The need for regional psychodermatology services across Europe has been proven, as these services provide better, faster, and more cost-efficient clinical outcomes for patients with psychodermatological conditions. However, such services are not uniformly available in Europe. Many countries have yet to establish dedicated psychodermatology services, while others are in the process of development. Even in countries with established psychodermatology units, the services are not accessible nationwide, especially for pediatric patients. Although most European states are keen to develop psychodermatology services, the progress is slow.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yann Gaillandre, Alain Duhamel, Thomas Flohr, Jean-Baptiste Faivre, Suonita Khung, Antoine Hutt, Paul Felloni, Jacques Remy, Martine Remy-Jardin
Summary: This study compared the impact of the ultra-high resolution (UHR) images of a photon-counting CT (PCCT) scanner with the high-resolution (HR) images of an energy-integrating detector CT (EID-CT) on lung parenchyma analysis. It found that using the UHR scanning mode improved the visibility and identification of ILD features, leading to the reclassification of ILD patterns, all while reducing radiation dose.
EUROPEAN RADIOLOGY
(2023)
Article
Respiratory System
Angela R. Shih, Chayanin Nitiwarangkul, Brent P. Little, Benjamin W. Roop, Sreyankar Nandy, Margit Szabari, Nathaniel Mercaldo, Sarah Mercaldo, Sydney B. Montesi, Ashok Muniappan, Sarita R. Berigei, David A. Lynch, Amita Sharma, Lida P. Hariri
Summary: According to the 2018 guidelines from ATS/ERS/JRS/ALAT and the Fleischner Society, CT UIP and Probable UIP have high specificity and positive predictive value for histopathologic UIP. Additional studies are needed to improve the classification performance based on the results.
RESPIRATORY RESEARCH
(2021)
Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martine Remy-Jardin, Christopher J. Ryerson, Mark L. Schiebler, Ann N. C. Leung, James M. Wild, Marius M. Hoeper, Philip O. Alderson, Lawrence R. Goodman, John Mayo, Linda B. Haramati, Yoshiharu Ohno, Patricia Thistlethwaite, Edwin J. R. van Beek, Shandra Lee Knight, David A. Lynch, Geoffrey D. Rubin, Marc Humbert
Summary: Pulmonary hypertension is a condition characterized by elevated mean pulmonary artery pressure, with radiologists playing a crucial role in its assessment and management. A working group was established to focus on the role of imaging techniques in diagnosing and managing PH, highlighting the importance of imaging in the recognition, work-up, treatment planning, and follow-up of PH.
Review
Cell Biology
Sreerama Shetty, Steven Idell
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no effective treatments. Lung transplantation is limited to a small number of patients, therefore, new therapies targeting caveolin-1 could provide a promising treatment option for IPF patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Manuel Roehrich, Dominik Leitz, Frederik M. Glatting, Annika K. Wefers, Oliver Weinheimer, Paul Flechsig, Nicolas Kahn, Marcus A. Mall, Frederik L. Giesel, Clemens Kratochwil, Peter E. Huber, Andreas von Deimling, Claus Peter Heussel, Hans Ulrich Kauczor, Michael Kreuter, Uwe Haberkorn
Summary: This study aimed to evaluate the imaging properties of static and dynamic fibroblast activation protein (FAP) inhibitor (FAPI) PET/CT in various types of fibrosing interstitial lung diseases (fILDs) and lung cancer (LC). The results showed that Ga-68-FAPI PET/CT imaging had high uptake and good imaging characteristics for fILD and LC.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Giacomo Sgalla, Mariachiara Flore, Matteo Siciliano, Luca Richeldi
EXPERT OPINION ON BIOLOGICAL THERAPY
(2020)
Article
Respiratory System
Luca Richeldi, Martin Kolb, Stephane Jouneau, Wim A. Wuyts, Birgit Schinzel, Susanne Stowasser, Manuel Quaresma, Ganesh Raghu
BMC PULMONARY MEDICINE
(2020)
Editorial Material
Clinical Neurology
Assunta Bianco, Pier-Valerio Mari, Anna Rita Larici, Matteo Lucchini, Viviana Nociti, Francesco Antonio Losavio, Chiara De Fino, Giuseppe Cicchetti, Daniele Coraci, Luca Richeldi, Massimiliano Mirabella
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Critical Care Medicine
Geoffrey D. Rubin, Christopher J. Ryerson, Linda B. Haramati, Nicola Sverzellati, Jeffrey P. Kanne, Suhail Raoof, Neil W. Schluger, Annalisa Volpi, Jae-Joon Yim, Ian B. K. Martin, Deverick J. Anderson, Christina Kong, Talissa Altes, Andrew Bush, Sujal R. Desai, Jonathan Goldin, Jin Mo Goo, Marc Humbert, Yoshikazu Inoue, Hans -Ulrich Kauczor, Fengming Luo, Peter J. Mazzone, Mathias Prokop, Martine Remy-Jardin, Luca Richeldi, Cornelia M. Schaefer-Prokop, Noriyuki Tomiyama, Athol U. Wells, Ann N. Leung
Article
Infectious Diseases
M. Bassetti, D. R. Giacobbe, S. Aliberti, E. Barisione, S. Centanni, F. G. De Rosa, F. Di Marco, A. Gori, G. Granata, M. Mikulska, N. Petrosillo, L. Richeldi, P. Santus, C. Tascini, A. Vena, P. Viale, F. Blasi
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Editorial Material
Pharmacology & Pharmacy
Giacomo Sgalla, Claudia Franciosa, Jacopo Simonetti, Luca Richeldi
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2020)
Article
Medicine, General & Internal
Elisabetta Cocconcelli, Roberto Tonelli, Gianluca Abbati, Alessandro Marchioni, Ivana Castaniere, Filippo Pelizzaro, Francesco Paolo Russo, Alberto Vegetti, Elisabetta Balestro, Antonello Pietrangelo, Luca Richeldi, Fabrizio Luppi, Paolo Spagnolo, Enrico Clini, Stefania Cerri
Summary: Data is lacking on subclinical fibrosis in multiple organs in patients with idiopathic lung fibrosis (IPF). This study found that more than one-third of IPF patients had concomitant subclinical liver fibrosis, which negatively affected overall survival. Higher levels of AST to platelet ratio index (APRI) were identified as an independent predictor of survival. Further investigation is needed to clarify the mechanisms of multiorgan fibrosis and its clinical implications in IPF patients.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Review
Respiratory System
Francesco Varone, Bruno Iovene, Giacomo Sgalla, Mariarosaria Calvello, Angelo Calabrese, Anna Rita Larici, Luca Richeldi
Article
Respiratory System
Giacomo Malipiero, Giovanni Paoletti, Francesco Blasi, Pierluigi Paggiaro, Gianenrico Senna, Manuela Latorre, Marco Caminati, Giovanna Elisiana Carpagnano, Nunzio Crimi, Antonio Spanevello, Stefano Aliberti, Giorgio Walter Canonica, Enrico Heffler, M. Bonavia, C. Bucca, M. F. Caiaffa, C. Calabrese, G. Camiciottoli, C. Caruso, S. Centanni, M. E. Conte, A. G. Corsico, L. Cosmi, M. T. Costantino, S. D'Alo, M. D'Amato, S. Del Giacco, A. Farsi, E. Favero, B. M. P. Foschino, G. Guarnieri, G. Guida, S. Lo Cicero, C. Lombardi, L. Macchia, F. Mazza, F. Menzella, M. Milanese, P. Montuschi, M. Montagni, E. Nucera, R. Parente, G. Passalacqua, V Patella, G. Pelaia, L. Pini, L. Ricciardi, F. L. M. Ricciardolo, L. Richeldi, E. Ridolo, G. Rolla, P. Santus, N. Scichilone, P. Solidoro, G. Spadaro, A. Vianello, V. Viviano, M. R. Yacoub, M. C. Zappa
Summary: Bronchiectasis is a common comorbidity in severe asthma patients, with associations with worse asthma control, quality of life, lung function, and higher rate of exacerbations. Proper assessment and management of bronchiectasis are crucial in severe asthmatic patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Review
Allergy
Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi, Andrea Rossi
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Enrico De Lorenzis, Silvia Laura Bosello, Francesco Varone, Giacomo Sgalla, Lucio Calandriello, Gerlando Natalello, Bruno Iovene, Giuseppe Cicchetti, Laura Gigante, Lucrezia Verardi, Elisa Gremese, Luca Richeldi, Anna Rita Larici
Review
Pharmacology & Pharmacy
Giacomo Sgalla, Marialessia Lerede, Luca Richeldi
Summary: Over the past two decades, there has been an increase in well-designed late-phase trials for Idiopathic Pulmonary Fibrosis (IPF) patients, resulting in the approval of the first effective therapies like pirfenidone and nintedanib. Currently, novel potential treatments for IPF are undergoing phase III trials, which could potentially bring a new breakthrough in IPF management.
EXPERT OPINION ON ORPHAN DRUGS
(2021)
Article
Critical Care Medicine
Ganesh Raghu, Martine Remy-Jardin, Luca Richeldi, Carey C. Thomson, Yoshikazu Inoue, Takeshi Johkoh, Michael Kreuter, David A. Lynch, Toby M. Maher, Fernando J. Martinez, Maria Molina-Molina, Jeffrey L. Myers, Andrew G. Nicholson, Christopher J. Ryerson, Mary E. Strek, Lauren K. Troy, Marlies Wijsenbeek, Manoj J. Mammen, Tanzib Hossain, Brittany D. Bissell, Derrick D. Herman, Stephanie M. Hon, Fayez Kheir, Yet H. Khor, Madalina Macrea, Katerina M. Antoniou, Demosthenes Bouros, Ivette Buendia-Roldan, Fabian Caro, Bruno Crestani, Lawrence Ho, Julie Morisset, Amy L. Olson, Anna Podolanczuk, Venerino Poletti, Moises Selman, Thomas Ewing, Stephen Jones, Shandra L. Knight, Marya Ghazipura, Kevin C. Wilson
Summary: This article provides updates on the guidelines for idiopathic pulmonary fibrosis (IPF) and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. The recommendations are based on consensus and systematic reviews, aiming to provide evidence-based guidance for clinicians.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
John S. Kim, Sydney B. Montesi, Ayodeji Adegunsoye, Stephen M. Humphries, Margaret L. Salisbury, Lida P. Hariri, Jonathan A. Kropski, Luca Richeldi, Athol U. Wells, Simon Walsh, R. Gisli Jenkins, Ivan Rosas, Imre Noth, Gary M. Hunninghake, Fernando J. Martinez, Anna J. Podolanczuk
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Editorial Material
Respiratory System
Giacomo Sgalla, Luca Richeldi
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2020)