Article
Multidisciplinary Sciences
Linda M. Isbell, Sungha Kang, Gregory Barysky, Grace Quinn
Summary: Stigmatizing attitudes towards children with psychopathology pose a barrier to their treatment and well-being. This study examines the effects of medication treatment and genetic etiology on stigmatizing attitudes towards Disruptive Mood Dysregulation Disorder (DMDD). The results show that parents reported more stigma when the perceived appropriate treatment matched the etiology. The findings underscore the need to consider multiple factors and further investigate such nuances to inform anti-stigma interventions.
Article
Neurosciences
Hiroko Miyagishi, Minoru Tsuji, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Yasuhiro Kosuge, Kumiko Ishige, Hiroshi Takeda
Summary: The expression levels of 5-HT1A receptor were found to increase in the midbrain and hippocampus of stress-adaptive mice, while in the midbrain of stress-unadaptive mice, the expression levels of 5-HT1A receptor were increased, along with a decrease in the expression of Freud-1 and NUDR. These findings suggest that the increased expression of 5-HT1A receptor due to a decrease in the expression of Freud-1 and NUDR in the midbrain may play a critical role in the emotional abnormality of stress-unadaptive mice.
Article
Clinical Neurology
Darakhshan Jabeen Haleem
Summary: The global prevalence of depression is increasing, but the current treatment outcome is unsatisfactory. Stress-related epigenetic changes and the role of serotonin and 5-HT1A receptors in the pathogenesis and treatment of depression are important. Synthetic compounds targeting GC and 5-HT1A receptors may be better therapeutic agents for depression.
Article
Medicine, Research & Experimental
Kate Beecher, Joshua Wang, Fatemeh Chehrehasa, Ronan Depoortere, Mark A. Varney, Adrian Newman-Tancredi, Selena E. Bartlett, Arnauld Belmer
Summary: The consumption of high-sugar food has been linked to the increase in obesity prevalence. A recent study found that chronic sucrose consumption can alter the serotonergic neuroplasticity in the neural circuits involved in feeding control. Specifically, the 5-HT1A receptor subtype plays a role in the regulation of mood, anxiety, and appetite, and may be involved in reversing addiction to substances of abuse. Targeting the 5-HT1A autoreceptors could be an effective therapeutic strategy to combat obesity resulting from overconsumption of high-sugar diet.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Raghavan Pillai Raju, Alvin Terry
Summary: Gulf War Illness (GWI) affects a significant number of veterans from the first Persian Gulf War, with common symptoms including chronic neurological impairments and fatigue syndrome. Despite the lack of effective treatments, research on mitochondrial dysfunction and cellular energetics provides promising implications for developing therapeutic strategies. Further studies are needed to understand the underlying pathology and develop new treatment methods for GWI.
Article
Multidisciplinary Sciences
Amina Benhadda, Celia Delhaye, Imane Moutkine, Xavier Marques, Marion Russeau, Corentin Le Magueresse, Anne Roumier, Sabine Levi, Luc Maroteaux
Summary: Many psychiatric diseases are associated with dysfunction of serotonin (5-HT) neurons. This study shows that 5-HT1A and 5-HT2B receptors can form heterodimers and co-cluster at the plasma membrane of dendrites. Stimulation of these receptors prevents 5-HT1A receptor internalization and increases 5-HT2B receptor membrane clustering, regulating the excitability of serotonergic neurons.
Article
Biochemistry & Molecular Biology
Deepika Singh, Priya Singh, Pooja Srivastava, Dipti Kakkar, Mallika Pathak, Anjani Kumar Tiwari
Summary: Serotonin is an important neurotransmitter and hormone that affects mood, anxiety, depression, and sleep. It is one of the most desirable targets for medical chemists and pharmaceutical firms. The 5-HT1A and 5-HT7 receptors are related to psychological conditions such as anxiety, depression, and movement disorders, with the 5-HT7 receptor potentially being a beneficial target for depression treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Connar S. J. Westgate, Hannah F. Botfield, Zerin Alimajstorovic, Andreas Yiangou, Mark Walsh, Gabrielle Smith, Rishi Singhal, James L. Mitchell, Olivia Grech, Keira A. Markey, Daniel Hebenstreit, Daniel A. Tennant, Jeremy W. Tomlinson, Susan P. Mollan, Christian Ludwig, Ildem Akerman, Gareth G. Lavery, Alexandra J. Sinclair
Summary: This study found that idiopathic intracranial hypertension (IIH) is a metabolic disorder characterized by dysfunction of adipose tissue. Patients with IIH exhibit insulin and leptin resistance, along with other metabolic abnormalities such as preferential central adiposity.
Article
Chemistry, Multidisciplinary
Barbara A. Bricker, Chandrashekhar Voshavar, Edem K. Onyameh, Uma M. Gonela, Xinsong Lin, Tracy L. Swanson, Laura B. Kozell, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: In this study, we synthesized and separated the enantiomers of SYA0340, identified their absolute configurations, and evaluated their binding affinities and functional characteristics at the 5-HT1A and 5-HT7A receptors. The results showed that both enantiomers have similar agonist properties at the 5-HT1A receptor and antagonist properties at the 5-HT7A receptor, with SYA0340-P1 displaying higher potency as a 5-HT1A receptor antagonist. Therefore, SYA0340-P1 is considered the eutomer and these enantiomers may serve as new pharmacological probes for the 5-HT1A and 5-HT7A receptors.
Article
Multidisciplinary Sciences
Adam C. Powell, James W. Long, Garry Carneal, Kathryn J. Schormann, David P. Friedman
Summary: Contrary to previous findings on screening, anxiety and depression were associated with a greater likelihood of diagnostic imaging within the studied population.
Article
Nutrition & Dietetics
Annabel Sandra Mueller-Stierlin, Scott B. Teasdale, Uemmueguelsuem Dinc, Sabrina Moerkl, Nicole Prinz, Thomas Becker, Reinhold Kilian
Summary: This study assessed the feasibility and effectiveness of three dietary assessment methods for individuals with serious mental illness. The photographic food record and food diary were found to be feasible and acceptable to participants, with further validation testing and clear guidance needed for optimal use.
Article
Multidisciplinary Sciences
Joshua I. Warrick, Margaret A. Knowles, Carolyn D. Hurst, Lauren Shuman, Jay D. Raman, Vonn Walter, Jeffrey Putt, Lars Dyrskjot, Clarice Groeneveld, Mauro A. A. Castro, A. Gordon Robertson, David J. DeGraff
Summary: In this study, a transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma (NIPUC) was identified. The activity of transcription factors in this network was associated with mutational burden, copy number instability, and other characteristics. The findings suggest that transcription factor activity plays a prominent role in driving cell cycle dysregulation in NIPUC.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sanchez-de-Diego, Jose Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa
Summary: Bone remodeling is a continuous process involving osteoblasts and osteoclasts, and imbalances can cause metabolic bone diseases like osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects cellular processes by regulating the ubiquitination of target proteins. Pathogenic variants in HERC1 have been associated with the neurodevelopmental disorder MDFPMR syndrome. This study shows that HERC1 regulates osteoblastogenesis and osteoclastogenesis, and its depletion increases gene expression of osteoblastic markers, leading to imbalanced bone homeostasis and osteopenia.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. Toure, Angela N. Koehler
Summary: Undermining transcriptional addiction is crucial for addressing cancers with high unmet clinical need. CDK9 has long been considered a therapeutic target for regulating transcription, but targeting it in the clinic has been challenging due to its essentiality across cell lineages and the cytotoxicity of first-generation pan-CDK inhibitors. However, the early-stage clinical evaluation of highly selective molecules offers renewed hope.
Article
Biochemistry & Molecular Biology
Kotaro Sugimoto, Naoki Ichikawa-Tomikawa, Keisuke Nishiura, Yasuto Kunii, Yasuteru Sano, Fumitaka Shimizu, Akiyoshi Kakita, Takashi Kanda, Tetsuya Imura, Hideki Chiba
Summary: Our research found that 5-HT1A receptors are expressed in brain microvascular endothelial cells and mural cells in the normal prefrontal cortex, and that PKA is aberrantly activated in both cell types in the schizophrenic PFC. Additionally, serotonin/5-HT1A signaling enhances endothelial CLDN5 expression in BMVECs under two-dimensional co-culture conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Paul R. Albert, Faranak Vahid-Ansari
Editorial Material
Neurosciences
Paul R. Albert
Editorial Material
Neurosciences
Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2020)
Article
Psychiatry
Amin Zahrai, Faranak Vahid-Ansari, Mireille Daigle, Paul R. Albert
TRANSLATIONAL PSYCHIATRY
(2020)
Review
Clinical Neurology
Shawn Hayley, Antoine M. Hakim, Paul R. Albert
Summary: Major depression may be a precursor to cognitive decline and dementia, with chronic stress and inflammation compromising brain function and leading to depression and mild cognitive impairment. Treating inflammatory changes in depression can reverse the condition, and anti-inflammatory and antidepressant treatments may reduce or prevent dementia in individuals with depression. Chronic stress and inflammation may increase brain permeability and cytokine production, eventually manifesting as depression, cognitive impairment, and potentially dementia.
Editorial Material
Neurosciences
Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Review
Psychiatry
Faranak Vahid-Ansari, Paul R. Albert
Summary: Serotonin plays key roles in wiring the developing brain and synaptic reorganization during adulthood, mediated by 14 different 5-HT receptors. The 5-HT system has the capacity to regrow and reinnervate brain regions following insults, often leading to depression, anxiety, and cognitive impairment. Chronic treatment with antidepressants can accelerate the rewiring processes and potentially improve recovery from injury-induced mental illness or cognitive impairment.
FRONTIERS IN PSYCHIATRY
(2021)
Editorial Material
Neurosciences
Paul R. Albert, Lena Palaniyappan, Patricia Boksa
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Neurosciences
S. Hayley, F. Vahid-Ansari, H. Sun, P. R. Albert
Summary: Parkinson's disease is a complex illness influenced by environmental factors and genetic vulnerability. Many studies focus on the disease's motor symptoms and overlook the debilitating non-motor features that occur early in the disease process. Comorbid psychiatric features, such as clinical depression, anxiety, and sleep disorders, are believed to emerge before prominent motor deficits. This review explores the prodromal stage of PD, the unfolding of early neuropsychiatric pathology, and later motor disturbances, as well as the complexity captured by animal models of PD.
NEUROBIOLOGY OF DISEASE
(2023)
Meeting Abstract
Neurosciences
Faranak Vahid-Ansari, Amin Zahrai, Mireille Daigle, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Meeting Abstract
Neurosciences
Min Zhang, Faranak Vahid-Ansari, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Meeting Abstract
Clinical Neurology
F. Vahid-Ansari, A. Zahrai, P. Albert
INTERNATIONAL JOURNAL OF STROKE
(2021)
Meeting Abstract
Clinical Neurology
Faranak Vahid-Ansari, Amin Zahrai, Paul Albert
INTERNATIONAL JOURNAL OF STROKE
(2019)
Meeting Abstract
Clinical Neurology
Min Zhang, Faranak Vahid-Ansari, Paul Albert
INTERNATIONAL JOURNAL OF STROKE
(2019)
Meeting Abstract
Neurosciences
Amin Zahrai, Faranak Vahid-Ansari, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)