Article
Biology
Peter H. Chipman, Chi Chung Alan Fung, Alejandra Pazo Fernandez, Abhilash Sawant, Angelo Tedoldi, Atsushi Kawai, Sunita Ghimire Gautam, Mizuki Kurosawa, Manabu Abe, Kenji Sakimura, Tomoki Fukai, Yukiko Goda
Summary: The study reveals a circuit function for GluN2C NMDAR, which is highly expressed in astrocytes in mouse hippocampus, in tuning synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity affects the range of presynaptic strength distribution in specific inputs without altering the mean presynaptic strength. Mathematical modeling suggests that the narrowing of the width of presynaptic release probability distribution compromises long-term synaptic plasticity.
Article
Cell Biology
Xiaofang Shi, Qi Zhang, Jie Li, Xingyu Liu, Yi Zhang, Minhua Huang, Weiqing Fang, Junyu Xu, Tifei Yuan, Lin Xiao, Yi-Quan Tang, Xiao-Dong Wang, Jianhong Luo, Wei Yang
Summary: Phosphorylation levels of GluN2B-Y1070 in the mPFC are linked to depressive behaviors, blocking its phosphorylation can have antidepressant-like effects without affecting cognitive or anxiety-related behaviors in mice. Additionally, the Y1070F mutation helps increase excitatory synapse numbers, but only in the layer 5 pyramidal neurons of the mPFC.
Article
Neurosciences
Sebi Rolotti, Heike Blockus, Fraser T. Sparks, James B. Priestley, Attila Losonczy
Summary: The hippocampus plays a critical role in memory consolidation, particularly during sharp-wave ripple (SWR) events. This study investigated the relationship between network state and information processing in dendrites, the primary sites of synaptic input integration and plasticity. The researchers found that immobility led to increased dendritic activity, which was concentrated during SWR events. Concurrent dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. Somatic-dendritic coupling and SWR recruitment also varied based on cells' tuning distance to reward location during a goal-learning task.
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Review
Neurosciences
Ayland C. Letsinger, Zhenglin Gu, Jerrel L. Yakel
Summary: This review discusses the significance of the alpha 7 nicotinic acetylcholine receptor (nAChR) in the hippocampus and its association with cognitive dysfunction, as well as highlighting approaches to improve therapeutic development.
TRENDS IN NEUROSCIENCES
(2022)
Article
Neurosciences
Erwan Leprince, Robin F. Dard, Salome Mortet, Caroline Filippi, Marie Giorgi-Kurz, Romain Bourboulou, Pierre-Pascal Lenck-Santini, Michel A. Picardo, Marco Bocchio, Agnes Baude, Rosa Cossart
Summary: The adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. Neonatal CA1, on the other hand, is tightly linked to externally generated sensorimotor activity, but the circuit mechanisms underlying early synchronous activity in CA1 remain unclear. In this study, researchers use a combination of in vivo and ex vivo circuit mapping, calcium imaging, and electrophysiological recordings in mouse pups to investigate the dynamics in the ventro-intermediate CA1. They find that these dynamics are influenced by both the entorhinal (EC) and thalamic (VMT) inputs, but movement-related population bursts are exclusively driven by the EC. The differential effects reflect the different intrahippocampal targets of these inputs, suggesting distinct contributions to the development of the hippocampal microcircuit and related cognitive maps.
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Neurosciences
Hongshen He, Roman Boehringer, Arthur J. Y. Huang, Eric T. N. Overton, Denis Polygalov, Kazuo Okanoya, Thomas J. McHugh
Summary: Research suggests that CA2 activity plays a crucial role in the fidelity of experience-dependent hippocampal replay. By temporarily silencing CA2 pyramidal cells, it was observed that the reactivation of CA1 pyramidal cell ensembles within sharp-wave ripples events lost both temporal and informational precision.
Article
Biochemistry & Molecular Biology
Solenn Percelay, Jean-Marie Billard, Thomas Freret, Annie Andrieux, Michel Boulouard, Valentine Bouet
Summary: The study revealed dysregulations of functional properties and plasticity in hippocampal networks of 3-hit mice, potentially contributing to the pathophysiology of schizophrenia. Additionally, differences between males and females were observed, supporting the sexual dimorphism seen in the disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zi-Fan Mai, Zhi-Ping Cao, Shu-Yi Huang, Wen-Wen Yan, Jun-Ni Huang, Bao-Yan Wu, Chu-Hua Li
Summary: Cordycepin may modulate metaplasticity in the hippocampal CA1 area of rats through adenosine A(1) receptors, affecting the induction of LTP and LTD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Patrycja Brzdak, Katarzyna Lebida, Marcin Wyroslak, Jerzy W. Mozrzymas
Summary: GABAergic transmission onto pyramidal neurons shows different forms of plasticity, and plasticity at inhibitory interneurons remains largely unknown. This study investigated the impact of integrins on the long-term plasticity of GABAergic synapses on specific inhibitory interneurons. The results revealed interneuron-specific plasticity and differences in the underlying integrin-dependent mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Jan Voldrich, Marika Matousova, Marketa Smidkova, Barbora Slavikova, Hana Chodounska, Eva Kudova, Helena Mertlikova-Kaiserova
Summary: The goal of this study was to evaluate the efficacy of mixed cortical and hippocampal primary rat postnatal neuronal culture for identifying NMDAR antagonists. The authors found that this model is comparable to other commonly used primary rat neuronal models and is a convenient and robust tool for NMDAR antagonist screening.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Chad R. Camp, Anna Vlachos, Chiara Kloeckner, Ilona Krey, Tue G. Banke, Nima Shariatzadeh, Sarah M. Ruggiero, Peter Galer, Kristen L. Park, Adam Caccavano, Sarah Kimmel, Xiaoqing Yuan, Hongjie Yuan, Ingo Helbig, Tim A. Benke, Johannes R. Lemke, Kenneth A. Pelkey, Chris J. McBain, Stephen F. Traynelis
Summary: N-methyl-D-aspartate receptors (NMDARs) are receptors that mediate calcium-permeable excitatory neurotransmission. Genetic variants in the GRIN2A gene are associated with NMDAR diseases, and individuals with null GRIN2A variants experience transient seizure susceptibility during infancy. Studies on mice show increased circuit excitability and delayed electrophysiological maturation of inhibitory interneurons in CA1 in relation to Grin2a gene dosage.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Niccolo P. Pampaloni, Irene Riva, Anna L. Carbone, Andrew J. R. Plested
Summary: The study shows that in addition to the previously known fast-acting AMPA receptors, slow AMPA receptors with prolonged activity are also expressed in the hippocampal CA1 region. These slow AMPA receptors may play a significant role in synaptic transmission, short-term potentiation, and triggering of action potentials.
Article
Chemistry, Multidisciplinary
Farah Arshad, Amjad Ali, Gauhar Rehman, Sobia Ahsan Halim, Muhammad Waqas, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al-Harrasi
Summary: Leukemia is a proliferative disorder of myeloid and lymphoid cells with different types caused by genetic and environmental factors. The Philadelphia chromosome mutation BCR-ABL1 is responsible for the uncontrolled proliferation of leukocytes in various types of leukemia. qPCR was used to evaluate the expression levels of BCR-ABL1 in patients with different types of leukemia.