Article
Neurosciences
Benjamin Owen, Edyta Bichler, Morris Benveniste
Summary: This study investigates changes in synaptic transmission with progression of chronic epilepsy, finding that rats treated with pilocarpine show alterations in synaptic characteristics at different time points, possibly related to depletion of neurotransmitter vesicles.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Christine Grienberger, Jeffrey C. Magee
Summary: This study reveals that learning-related changes in the hippocampus are produced by synaptic plasticity directed by an instructive signal from the entorhinal cortex layer 3 that seems to be specifically adapted to the behaviorally relevant features of the environment.
Article
Neurosciences
Qian Sun, Eric W. Buss, Yu-Qiu Jiang, Bina Santoro, David H. Brann, Daniel A. Nicholson, Steven A. Siegelbaum
Summary: Entorhinal cortex neurons establish monosynaptic connections onto distal apical dendrites of CA1 and CA2 pyramidal neurons through the perforant path. The efficacy of the perforant path inputs varies substantially as a function of presynaptic firing rate, with CA2 showing stronger excitation compared to CA1. Blockade of NMDARs significantly reduces temporal summation in CA1, while having little impact on CA2 responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Neurosciences
Renee Chasse, Alexey Malyshev, Roslyn Holly Fitch, Maxim Volgushev
Summary: Theoretical and modeling studies suggest that heterosynaptic plasticity enhances discriminative learning and repetitive learning in Hebbian-type systems. Experimental manipulation of adenosine A1 receptors (A1Rs) to impair heterosynaptic plasticity resulted in impaired synaptic plasticity and deficits in visual discrimination learning in A1R KO mice. These results provide experimental evidence for the role of heterosynaptic plasticity in organism-level learning and suggest it as a potential target for interventions to enhance new learning.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Erine Craey, Fabian Hulpia, Jeroen Spanoghe, Simona Manzella, Lars E. Larsen, Mathieu Sprengers, Dimitri De Bundel, Ilse Smolders, Evelien Carrette, Jean Delbeke, Kristl Vonck, Paul Boon, Serge Van Calenbergh, Wytse J. Wadman, Robrecht Raedt
Summary: This study reports the design, synthesis, and validation of a novel compound that can precisely release adenosine A1 receptor agonist using light. By monitoring the strength of neurotransmission and controlling the release of light, the study achieved regulation of neurotransmission. This research method is of great significance for the treatment of diseases associated with neuronal hyperexcitability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zi-Fan Mai, Zhi-Ping Cao, Shu-Yi Huang, Wen-Wen Yan, Jun-Ni Huang, Bao-Yan Wu, Chu-Hua Li
Summary: Cordycepin may modulate metaplasticity in the hippocampal CA1 area of rats through adenosine A(1) receptors, affecting the induction of LTP and LTD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Natalia V. Gulyaeva
Summary: The study demonstrates that brain ischemia does not elicit transient adenosine release in the CA1 hippocampal area, potentially contributing to hippocampal vulnerability. While ischemia increases spontaneous adenosine release in the caudate putamen, the CA1 area of the hippocampus fails to respond rapidly with adenosine release, suggesting an insufficiency of this neuroprotective mechanism.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Jinxiu Wang, Yanchun Gong, Haoyuan Tan, Wenxi Li, Baiyi Yan, Chunfang Cheng, Juan Wan, Wei Sun, Chunhua Yuan, Li-Hua Yao
Summary: Through electrophysiological experiments, it was found that cordycepin significantly reduces the frequency of glutamatergic and GABAergic postsynaptic currents in hippocampal CA1 pyramidal neurons, and this inhibitory effect is primarily mediated through the A1 adenosine receptor.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
B. K. B. Murthy, S. Somatakis, A. F. Ulivi, H. Klimmt, T. P. Castello-Waldow, N. Haynes, R. E. Huettl, A. Chen, Alessio Attardo
Summary: Subpopulations of neurons with increased activity during memory encoding are considered as cellular engrams. Correlated synaptic activity between these engram neurons is thought to strengthen their connections, increasing the likelihood of recalling neural activity patterns. Labeling synaptic engrams using a transsynaptic GFP reconstitution system can highlight the synaptic connections between engram neurons.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Biology
Peter H. Chipman, Chi Chung Alan Fung, Alejandra Pazo Fernandez, Abhilash Sawant, Angelo Tedoldi, Atsushi Kawai, Sunita Ghimire Gautam, Mizuki Kurosawa, Manabu Abe, Kenji Sakimura, Tomoki Fukai, Yukiko Goda
Summary: The study reveals a circuit function for GluN2C NMDAR, which is highly expressed in astrocytes in mouse hippocampus, in tuning synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity affects the range of presynaptic strength distribution in specific inputs without altering the mean presynaptic strength. Mathematical modeling suggests that the narrowing of the width of presynaptic release probability distribution compromises long-term synaptic plasticity.
Article
Neurosciences
Daniela Madeira, Catia R. Lopes, Ana P. Simoes, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study found that silencing the A(2A)R gene in astrocytes leads to deficits in hippocampal synaptic plasticity and memory. Astrocytic A(2A)R control astrocytic morphology and influence hippocampal synaptic plasticity and memory in adult mice.
Article
Multidisciplinary Sciences
Anurag Singh, Shruthi Sateesh, Owen D. Jones, Wickliffe C. Abraham
Summary: The study revealed a pathway specificity for the heterodendritic metaplasticity in CA1, where Schaffer collateral/commissural synapses in the stratum radiatum were particularly sensitive to the inhibitory effects of high-frequency priming stimulation mediated by tumor necrosis factor (TNF). The metaplasticity effects were absent in TNFR1 knock-out mice, indicating a dependence on TNF regulation. This suggests an important control of information processing in this pathway, along with potential implications for neuroinflammation sensitivity under disease conditions.
SCIENTIFIC REPORTS
(2022)
