Article
Orthopedics
Dani M. Gaillard-Campbell, Thomas P. Gross
Summary: This study investigated the efficacy of the lymphocyte transformation test (LTT) in predicting adverse outcomes in patients after receiving a metal joint replacement. The results showed that LTT could not predict metal sensitivity.
INTERNATIONAL ORTHOPAEDICS
(2023)
Letter
Oncology
Gilbert T. Chua, Jaime S. Rosa Duque, Daniel Ka Leung Cheuk, Alex Wing Kwan Leung, Wilfred Hing Sang Wong, Anthony Pak Yin Liu, Pamela P. W. Lee, Shau Yin Ha, Alan Kwok Shing Chiang, Marco Hok Kung Ho, Wai Keung Chu, Yuk Sing Chan, Chun Wing Luk, Alvin Siu Cheung Ling, Mike Yat Wah Kwan, Oscar Kuen Fong Yiu, Ian Chi Kei Wong, Yu Lung Lau, Chi Kong Li, Wing Hang Leung, Godfrey Chi Fung Chan, Patrick Ip, Janette Kwok
Summary: A retrospective study on Chinese children with haematological malignancies found a significant association between HLA-B*46:01, DRB1*09:01 alleles and asparaginase hypersensitivity, even after adjusting for age, gender, and specific types of leukemia.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Filippo Migliorini, Marco Pilone, Andreas Bell, Ricarda Merfort, Riccardo Giorgino, Nicola Maffulli
Summary: This systematic review investigated the concentration of chromium and cobalt in serum in patients who have undergone total hip arthroplasty (THA). The study found that the concentration of these metals varied depending on the material combinations used and the implant configuration. Patient characteristics and the time elapsed from the surgery did not significantly affect the concentration of these metals in serum. The findings provide important information for understanding the potential risks associated with THA.
SCIENTIFIC REPORTS
(2023)
Review
Allergy
Shawn J. R. Goh, Johanna E. E. Tuomisto, Anthony W. Purcell, Nicole A. Mifsud, Patricia T. Illing
Summary: Penicillin, as a first-line treatment for infections, can induce immune-mediated adverse reactions including IgE-mediated and non-IgE-mediated reactions, manifesting as skin eruptions and liver injury. Studies have shown that the infiltration of T cells at the site of inflammation is dependent on the nature of the reaction.
Article
Pharmacology & Pharmacy
Mona Al-Ahmad, Jusufovic Edin, Fardous Musa, Tito Rodriguez-Bouza
Summary: The study analyzed data from a national drug allergy registry over a 12-year period, focusing on common drugs associated with clinical reactions, diagnostic methods used, and outcomes of allergic evaluations. Results showed that anti-inflammatory drugs, analgesics, and antibiotics, particularly beta-lactam antibiotics, were the major contributors to confirmed drug allergies. Skin tests and drug provocation tests were key diagnostic methods, with respiratory symptoms and urticaria being the most common presenting symptoms among patients with confirmed hypersensitivity reactions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Environmental Sciences
Ka Roach, Jr. Roberts
Summary: Allergic disease is a significant global public health crisis, with metals playing a major role as allergens. However, there is a lack of comprehensive review on the various disease variants of metal allergy in the current scientific literature. This review aims to provide an up-to-date reference document for researchers and clinicians, while also identifying knowledge gaps related to metal allergy.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Eleonora Anci, Camille Braun, Annalisa Marinosci, Frederique Rodieux, Elise Midun, Maria-Jose Torres, Jean-Christoph Caubet
Summary: Viruses may cause non-allergic drug skin reactions and also play important roles in drug-induced skin reactions, especially in DRESS syndrome. Understanding the mechanisms of virus- and drug-induced skin reactions is crucial for clinical reflection and patient care.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Tarek Boutefnouchet, Francis Vallieres, Josee Delisle, Mohamed Benderdour, Julio C. Fernandes
Summary: The prevalence of true hypersensitivity to at least one metal is just over 3% among patients scheduled for primary total knee arthroplasty (TKA), with certain prior exposure factors increasing susceptibility to metal hypersensitivity reactions.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Nutrition & Dietetics
Fumiko Okazaki, Hiroyuki Wakiguchi, Yuno Korenaga, Kazumasa Takahashi, Hiroki Yasudo, Ken Fukuda, Mototsugu Shimokawa, Shunji Hasegawa
Summary: Little is known about the clinical features of food protein-induced enterocolitis syndrome (FPIES) in patients with Down syndrome (DS). This study found that FPIES in DS patients is associated with greater severity and earlier onset of symptoms. Cow's milk formula and wheat were the main causative foods. The surgical history of colostomy and postoperative nutrition may contribute to the onset of FPIES. Therefore, the use of amino acid-based formula should be considered for DS children undergoing gastrointestinal surgeries, and FPIES should be considered when acute gastrointestinal disease is suspected in DS children.
Article
Microbiology
Sunish Shah, Lloyd G. Clarke, Kathleen K. Adams
Summary: Results from a large multicenter study suggest that patients with confirmed hypersensitivity reactions to ciprofloxacin, moxifloxacin, or levofloxacin are likely to tolerate other fluoroquinolones. Avoiding different fluoroquinolones in patients with labeled allergies to ciprofloxacin, moxifloxacin, or levofloxacin may not always be necessary.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Orthopedics
Mattia Loppini, Alessandro Pisano, Marco Di Maio, Francesco La Camera, Maddalena Casana, Guido Grappiolo
Summary: The incidence of unexpected PJIs in presumed aseptic revision of THAs and TKAs has been previously underestimated. The infection-free implant survival rate at the one year follow-up in patients with unexpected PJIs was not significantly lower compared with patients undergoing aseptic revision.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Engineering, Mechanical
Shu Yang, Jian Pu, Xiaogang Zhang, Yali Zhang, Wen Cui, Fengbao Xie, Weiping Lu, Qin Tan, Zhongmin Jin
Summary: This study investigates the biotribocorrosion mechanism at the taper/trunnion interface of total hip replacement during long-term walking gait cycles. Experimental results show that the interface dominates the corrosion, with cyclic variations in open circuit potential attributed to the adsorbed protein layer. Surface and chemical analyses reveal the formation of a tribolayer on the worn surface, with different adhesion force and corrosion resistance compared to the protein layer. The observations provide insights into preventing complications in total hip replacement.
Review
Allergy
Federico Spataro, Palma Carlucci, Teresa Loverre, Luigi Macchia, Danilo Di Bona
Summary: Lysosomal storage diseases (LSDs) are rare genetic metabolic disorders characterized by the accumulation of glycosaminoglycans in lysosomes. Enzyme replacement therapy (ERT) is the standard treatment, but hypersensitivity reactions may occur. Desensitization procedures have been successful in restoring ERT in patients with previous hypersensitivity reactions. Standardized testing is necessary to estimate the risk and develop safe individualized desensitization protocols.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Federico Spataro, Palma Carlucci, Teresa Loverre, Luigi Macchia, Danilo Di Bona
Summary: Lysosomal storage diseases (LSDs) are rare genetic metabolic disorders characterized by the accumulation of glycosaminoglycans in lysosomes due to enzyme deficiency or reduced function. Enzyme replacement therapy (ERT) is the gold standard treatment, but hypersensitivity reactions can occur. Desensitization procedures have been successfully performed to restore ERT in patients with previous hypersensitivity reactions. Standardized testing is necessary to estimate the risk of the procedure and find the safest desensitization protocol.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Orthopedics
Dongmei Wu, Rohan M. Bhalekar, Jordan S. Marsh, David J. Langton, Alan J. Stewart
Summary: Implants made of cobalt-chromium alloy in joint replacement surgeries can lead to a complication called ALVAL, characterized by metal debris and metal ions causing hypersensitivity response. Current diagnostic tests and guidelines for ALVAL are not standardized.
EFORT OPEN REVIEWS
(2022)