Article
Polymer Science
Maciej Plonczak, Monika Wasyleczko, Tomasz Jakutowicz, Andrzej Chwojnowski, Jaroslaw Czubak
Summary: This study presents Autologous Chondrocyte Implantation (ACI) on two different scaffolds, Chondro-Gide made of collagen type I/III and a polyethersulfone (PES) synthetic membrane, for the treatment of lesions in hyaline cartilage in rabbits. The use of PES membranes with desirable features for chondrocyte cultivation is the revolutionary idea in this study.
Review
Biochemistry & Molecular Biology
Juan Antonio Rojas-Murillo, Mario A. Simental-Mendia, Nidia K. Moncada-Saucedo, Paulina Delgado-Gonzalez, Jose Francisco Islas, Jorge A. Roacho-Perez, Elsa N. Garza-Trevino
Summary: Cartilage tissue engineering is a promising alternative for chondral defect repair, using cells, scaffolds, and signaling factors to mimic natural tissue structure and improve tissue function. Fibrin, a biocompatible biomaterial, can enhance damaged cartilage regeneration when combined with other materials or biological components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fernando Canonici, Cristiano Cocumelli, Antonella Cersini, Daniele Marcoccia, Alessia Zepparoni, Annalisa Altigeri, Daniela Caciolo, Cristina Roncoroni, Valentina Monteleone, Elisa Innocenzi, Cristian Alimonti, Paola Ghisellini, Cristina Rando, Eugenia Pechkova, Roberto Eggenhoeffner, Maria Teresa Scicluna, Katia Barbaro
Summary: Cartilage injuries in animals and humans can lead to the progression of osteoarthritis and joint deterioration. A new experimental protocol for treating osteochondral lesions involves isolating chondrocytes from equine hyaline cartilage and using them to repair equine joint cartilage injuries. The chondrocytes, taken from autologous tracheal cartilage, are grown in a laboratory and implanted arthroscopically into the injured joint. Histological and immunohistochemical evaluation of the treated cartilage after 8 and 13 months shows progressive maturation, with tissue comparable to native articular cartilage detected after 24 months.
Review
Biotechnology & Applied Microbiology
Marcin Szustak, Edyta Gendaszewska-Darmach
Summary: Nanocellulose is a promising biocompatible biomaterial with good mechanical properties for use as a scaffold in cartilage tissue engineering. The limited regenerative capacity of cartilage due to its lack of vascularization and sparsely distributed chondrocytes poses challenges for cell infiltration, making nanocellulose scaffolds a potential solution. The scaffolds have been shown to induce stem cell differentiation into chondrocyte phenotypes, offering opportunities for cartilage tissue development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Liang Lu, Xifu Shang, Bin Liu, Weijian Chen, Yu Zhang, Shuyun Liu, Xiang Sui, Aiyuan Wang, Quanyi Guo
Summary: This paper explores the application value of tissue engineering in vitro for the construction of artificial cartilage. By seeding healthy porcine chondrocytes on articular cartilage extracellular matrix (ACECM) scaffolds, it was found that the cells performed well in terms of adhesion and growth on the scaffolds, and they secreted collagen type II. Moreover, the porcine ACECM scaffolds showed good biocompatibility and could be used for xenotransplantation without significant immune inflammatory response. Therefore, ACECM-oriented scaffold is an ideal natural biomaterial for cartilage tissue engineering.
Article
Pharmacology & Pharmacy
Maciej Baranowski, Monika Wasyleczko, Anna Kosowska, Andrzej Plichta, Sebastian Kowalczyk, Andrzej Chwojnowski, Wojciech Bielecki, Jaroslaw Czubak
Summary: The study demonstrates that different membranes implanted in rabbit articular cartilage defects support the regeneration process and degrade at an appropriate rate, aiding in cartilage regeneration.
Review
Cell Biology
Inga Urlic, Alan Ivkovic
Summary: Cell-based therapy is a promising strategy for treating cartilage defects, but the choice of the optimal cell source is complex. Research is currently focusing on different types of cells to objectively assess their advantages and disadvantages in repairing damaged articular cartilage.
Article
Polymer Science
Clement Toullec, Jean Le Bideau, Valerie Geoffroy, Boris Halgand, Nela Buchtova, Rodolfo Molina-Pena, Emmanuel Garcion, Sylvie Avril, Laurence Sindji, Admire Dube, Frank Boury, Christine Jerome
Summary: The combination of chitosan and curdlan polysaccharides in an electrospun scaffold shows great potential for bone tissue engineering, with good biodegradability, swelling behavior, and non-cytotoxicity in vitro. Incorporating curdlan in the scaffold was shown to enhance cell migration, demonstrating its immunomodulatory properties. These innovative electrospun curdlan-chitosan scaffolds have high promise for bone tissue regeneration.
Review
Chemistry, Applied
Farnoush Sadat Rezaei, Fariborz Sharifianjazi, Amirhossein Esmaeilkhanian, Ehsan Salehi
Summary: Chitosan has shown unparalleled characteristics for regenerative medicine applications, offering biocompatibility, biodegradability, and film-forming capabilities. Recent advances in chitosan films and scaffolds in tissue engineering, wound healing, and drug delivery fields have been surveyed and discussed.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Sunena Dhania, Manju Bernela, Ruma Rani, Minakshi Parsad, Sapna Grewal, Santosh Kumari, Rajesh Thakur
Summary: Tissue engineering technology utilizes biopolymer materials like polyhydroxyalkanoates to mimic and replace damaged tissues, with excellent biocompatibility and biodegradability. This technology has vast potential applications in areas such as bone grafts, cardiovascular repair, and nerve regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
R. Olmos-Juste, G. Larranaga-Jaurrieta, I. Larraza, S. Ramos-Diez, S. Camarero-Espinosa, N. Gabilondo, A. Eceiza
Summary: In this study, functional alginate and waterborne polyurethane scaffolds were developed for articular cartilage regeneration using 3D bioprinting technology. It was found that scaffolds with a higher alginate content showed better 3D printing performance, structural integrity, and cell viability. After 28 days of experiments, these scaffolds were capable of maintaining cell numbers and synthesizing glycosaminoglycans, indicating their potential application for in vitro regeneration of articular cartilage tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Endocrinology & Metabolism
Maria Heim, Ian J. Nixon, Elaine Emmerson, Anthony Callanan
Summary: Primary hypothyroidism significantly impacts patient's quality of life. Current standard treatment has limitations, and combination therapy is an alternative. Tissue engineering and regenerative medicine techniques have potential to restore thyroid function, but more research and clinical translation are needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Mario Ledda, Miriam Merco, Antonio Sciortino, Elisa Scatena, Annalisa Convertino, Antonella Lisi, Costantino Del Gaudio
Summary: The scaffold plays a crucial role in tissue engineering, especially in addressing large defects or replacements of pathological tissues or organs. The interaction between cells and scaffold, as well as the integration with the surrounding biological tissue, is key to the expected outcome. Mimicking the natural extracellular matrix (ECM) of the tissue being healed can further optimize the healing process and minimize morphological mismatch. Using 3D printing technology, bioinspired scaffolds with microstructures resembling trabecular architecture were fabricated for bone tissue engineering. These scaffolds showed excellent adhesion, growth, and differentiation of osteoblast-like cells, indicating their potential in bone tissue engineering and regenerative medicine applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Green & Sustainable Science & Technology
Mano Govindharaj, Noura Sayed Al Hashemi, Soja Saghar Soman, Sanjairaj Vijayavenkataraman
Summary: This study successfully identified an environmentally destructive tunicate species and proposed sustainable utilization of tunicate tunics as wound-dressing materials, decellularized extracellular matrix (dECM) scaffolds, and bioinks. The tunics showed excellent biocompatibility and tensile modulus. The findings of this work contribute to the preservation of marine ecosystems and the reduction of costs associated with tunicate management.
JOURNAL OF CLEANER PRODUCTION
(2022)