Article
Engineering, Biomedical
Charles Van Liew, Leland E. Dibble, K. Bo Foreman, Daniel S. Peterson
Summary: This study showed that individuals with MS can experience improvements in reactive balance performance on the first trial after one day of training, with an increase in margin of stability as a key indicator. This suggests that MS patients may benefit from short-term improvements through low-dose perturbation training.
CLINICAL BIOMECHANICS
(2021)
Article
Clinical Neurology
Zuhal Abasiyanik, Turhan Kahraman, Ozge Ertekin, Cavid Baba, Serkan Ozakbas
Summary: The study found that falls are a common issue for pwMS, even without clinical disability. Higher TUG and MSWS-12 scores were associated with increased risk of falls, while lower ABC scores were related to falls. The ABC scale, MSWS-12, and TUG test can be used to predict potential fallers in pwMS without clinical disability.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Adel Jawad, Baian A. Baattaiah, Mutasim D. Alharbi, Mohamed Faisal Chevidikunnan, Fayaz Khan
Summary: The aim of this study is to assess the factors affecting falls in people with multiple sclerosis (MS) and determine the most significant ones. The results showed that impaired balance, slower gait speeds, and higher levels of fatigue were the strongest predicting factors of falls in people with MS. Targeting balance and fatigue in rehabilitation interventions could decrease the incidence of falls among this population.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Charles Van Liew, Andrew S. Monaghan, Leland E. Dibble, K. Bo Foreman, David P. MacKinnon, Daniel S. Peterson
Summary: This study aimed to investigate whether improvements in protective stepping observed in people with multiple sclerosis after repeated support surface translations could generalize to a different balance challenge. Using multilevel mediation models, it was found that while there were no mediated effects for margin of stability or step latency, there was mediation for step length, indicating that participants increased step length throughout the treadmill trials and this generalized to tether-release trials.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Yaprak Ozum Unsal Bilgin, Asli Koskderelioglu, Muhtesem Gedizlioglu
Summary: This study aimed to determine the fall rate and risk factors in patients with multiple sclerosis (MS), and found that advanced age, lower education level, and cognitive dysfunction adversely affect gait speed and balance. Patients with cognitive impairment should be closely monitored for the risk of falling.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Yoshiro Okubo, Mohamed Suhair Bin Mohamed Suhaimy, Phu Hoang, Carly Chaplin, Cameron Hicks, Daina L. Sturnieks, Stephen R. Lord
Summary: This study examined the feasibility and efficacy of reactive balance training for improving stepping performance and reducing laboratory-induced falls in people with multiple sclerosis (MS). The results showed that reactive balance training improved trip-induced dynamic stability, limb support, trunk control, and reduced falls in people with MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Rehabilitation
Saeideh Monjezi, Farshad Molhemi, Mohammad-Jafar Shaterzadeh-Yazdi, Reza Salehi, Mohammad Mehravar, Davood Kashipazha, Saeed Hesam
Summary: Perturbation-based Balance Training is at least as effective as conventional balance training in improving proactive postural control in people with multiple sclerosis. It has superiority over conventional balance training in improving reactive postural control. Further research is needed to confirm the results.
DISABILITY AND REHABILITATION
(2023)
Article
Neurosciences
Charles Van Liew, Jessie M. Huisinga, Daniel S. Peterson
Summary: This study evaluated the impact of reactive postural control on fall rates in persons with multiple sclerosis (PwMS) and found that delays in automatic postural responses uniquely account for increased fall rates in PwMS. In addition to clinical and balance assessments, muscle onset latency after balance perturbations may be a valuable tool for predicting falls in PwMS.
Article
Neurosciences
Rotem Soll, Temima Greenberg, Mark Dolev, Alon Kalron
Summary: This study investigated the relationship between bladder dysfunction in women with MS and balance, falls, and fear of falling. The results indicate that bladder dysfunction is not directly associated with increased risk of falls, but rather with fear of falling.
Article
Rehabilitation
Tobia Zanotto, Irina Galperin, Anat Mirelman, Shahar Yehezkiyahu, John Estes, Lingjun Chen, Keren Regev, Arnon Karni, Tanja Schmitz-Hubsch, Friedemann Paul, Sharon G. Lynch, Abiodun E. Akinwuntan, Hannes Devos, Jeffrey M. Hausdorff, Jacob J. Sosnoff
Summary: Frailty is significantly associated with a history of falls in people with multiple sclerosis (MS), independent of age, sex, and disease severity.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Rehabilitation
Temima Greenberg, Rotem Soll, Mark Dolev, Alon Kalron
Summary: This study aimed to evaluate the test-retest reproducibility and convergent validity of the sitting-rising test in people with multiple sclerosis. The results showed a strong correlation between the SRT and other functional tests, supporting its validity and reproducibility in this population.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Engineering, Biomedical
Tyler VanDyk, Brett Meyer, Paolo DePetrillo, Nicole Donahue, Aisling O'Leary, Sam Fox, Nick Cheney, Melissa Ceruolo, Andrew J. Solomon, Ryan S. McGinnis
Summary: Impairment in persons with multiple sclerosis (PwMS) is often caused by motor instability and fatigue. Wearable devices have been used to improve the objectivity and temporal resolution of assessment. This study extends the application of standing transition quantification to longitudinal home monitoring of symptoms. The results show that this method can distinguish fallers from non-fallers and characterize symptoms at daily and sub-daily resolutions.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Rehabilitation
Gillian Quinn, Laura Comber, Chris McGuigan, Ailish Hannigan, Rose Galvin, Susan Coote
Summary: The study confirmed the high incidence of falls for people with Multiple Sclerosis and provided a risk prediction model including fall history, problems with bladder control, not having visual problems, and a slower Timed Up and Go speed. This model can be used to identify those at greater risk and in need of tailored falls prevention intervention.
CLINICAL REHABILITATION
(2021)
Article
Multidisciplinary Sciences
Aaron N. N. Best, Amy R. R. Wu
Summary: Healthy humans can maintain stability when facing diverse walking conditions, and this proficiency is achieved through control strategies that are yet to be fully understood. Laboratory-based research previously suggested that corrective stepping is the primary strategy, but its applicability in everyday obstacles outside the laboratory is uncertain. This study investigated changes in gait stability behavior during outdoor walking in different seasons and found that winter conditions did not hinder stepping as hypothesized. Instead, the stepping strategy was modified to enhance stability through increasing the anterior-posterior margin of stability, without additional compensation from ankle or trunk strategies.
SCIENTIFIC REPORTS
(2023)
Review
Environmental Sciences
Ana Castellano-Aguilera, Gemma Bivia-Roig, Ferran Cuenca-Martinez, Luis Suso-Marti, Joaquin Calatayud, Maria Blanco-Diaz, Jose Casana
Summary: Virtual reality interventions in neurorehabilitation for people with multiple sclerosis have shown positive effects on balance training and fall risk, but with very low certainty of evidence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Rehabilitation
Brian J. Loyd, Jane Saviers-Steiger, Annie Fangman, Serene S. Paul, Peter C. Fino, Mark E. Lester, Leland E. Dibble
Summary: The study aimed to quantify the control of linear accelerations at the head and trunk during gait in individuals with unilateral vestibular loss using clinically available inertial measurement units. Participants who underwent vestibular schwannoma resection surgery showed greater impairment in controlling accelerations at the head and trunk without visual sensory information compared to vestibular healthy participants. These impairments were detectable using clinically available inertial measurement units.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Peter C. Fino, Margaret M. Weightman, Leland E. Dibble, Mark E. Lester, Carrie W. Hoppes, Lucy Parrington, Jorge Arango, Alicia Souvignier, Holly Roberts, Laurie A. King
Summary: This study aims to evaluate the diagnostic accuracy, predictive capacity, and responsiveness to rehabilitation of objective dual-task turning measures within an mTBI population. Through two phases, the researchers will explore the potential new guidance and tools these measures can provide for clinical decisions in individuals with mTBI.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Clinical Neurology
Leland E. Dibble, Theresa D. Ellis
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Amanda Morris, Tallie Casucci, Mary M. McFarland, Benjamin Cassidy, Ryan Pelo, Nicholas Kreter, Leland E. Dibble, Peter C. Fino
Summary: This scoping review examines the research on reactive postural responses in individuals post-mTBI and finds a significant lack of investigation in this area. The author recommends incorporating all three classes of postural control in future research.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Clinical Neurology
Lucy Parrington, Laurie A. King, Carrie W. Hoppes, Maxwell J. Klaiman, Patrick Michielutti, Peter C. Fino, Leland E. Dibble, Mark E. Lester, Margaret M. Weightman
Summary: This study aimed to explore the differences in vestibular ocular motor screening (VOMS) symptoms between healthy adults and adults with persistent symptoms after mild traumatic brain injury (mTBI), and to investigate the relationships between VOMS symptoms and other measures. The results showed that the mTBI group had more VOMS symptoms and a further near point of convergence (NPC) distance compared to healthy controls. Self-reported symptoms on the Dizziness Handicap Inventory (DHI) were strongly associated with VOMS symptom scores. No significant relationships were found between VOMS symptoms and other measures. These findings support the relevance of VOMS for mTBI and its ability to capture vestibular complaints in this population.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Rehabilitation
Amanda Morris, Nora F. Fino, Ryan Pelo, Nicholas Kreter, Benjamin Cassidy, Leland E. Dibble, Peter C. Fino
Summary: The study evaluated the interadministrator reliability of objective outcomes from an instrumented, modified version of the P&R test. Results showed varying levels of consistency between raters in different directions with regard to step latency, time to stability, and step length.
JOURNAL OF SPORT REHABILITATION
(2022)
Article
Clinical Neurology
Peter C. Fino, Leland E. Dibble, Elisabeth A. Wilde, Nora F. Fino, Paula Johnson, Melissa M. Cortez, Colby R. Hansen, Susanne M. van der Veen, Karen M. Skop, J. Kent Werner, David F. Tate, Harvey S. Levin, Mary Jo Pugh, William C. Walker
Summary: This study aimed to investigate chronic balance deficits in individuals with mTBI and compare sensory phenotypes between individuals with and without mTBI, finding that different sensory phenotypes have varying impacts on clinical characteristics, symptom severity, and physical and cognitive functioning.
Article
Chemistry, Analytical
Angela R. Weston, Brian J. Loyd, Carolyn Taylor, Carrie Hoppes, Leland E. Dibble
Summary: This study aimed to determine the ability of wearable sensors and data processing algorithms to discern motion restrictions during daily living activities. The results showed that wearable sensors accurately captured significant differences in head and trunk kinematics, including rotational velocity, amplitude, and head-trunk coupling, between restricted and non-restricted conditions. These findings support the ecological validity of using wearable sensors to quantify movement alterations during real-world scenarios.
Article
Neurosciences
W. Michael King, Andrew R. Wagner, Colin R. Grove, Brian J. Loyd, Leland E. Dibble, Michael C. Schubert
Summary: This study compared the effectiveness of compensatory saccades (CS) between individuals with peripheral and central vestibular dysfunction. The results showed that CS recruited by persons with central vestibular pathology were not uniformly deficient and could compensate for reductions in the vestibulo-ocular reflex (VOR) gain. On the other hand, individuals with central lesions exhibited greater variability in the amplitude of overt CS relative to gaze position error (GPE).
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Colin R. Grove, Andrew Wagner, Brian J. Loyd, Leland E. Dibble, Michael C. Schubert
Summary: The study found that the compensatory oculomotor behavior characteristics in PLW-MS depend on the extent of residual VOR gain. This is crucial for understanding and intervening in vestibular ocular control in patients with multiple sclerosis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. McKee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malu Gamez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. McFarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni, Kenneth Marek, Anna Naito, Codrin Lungu, Daniel M. Corcos
Summary: This article introduces a research study on the effects of high-intensity endurance exercise on the progression of Parkinson's disease. The study aims to explore whether high-intensity endurance training can slow down the progression of the disease, thus improving the quality of life for patients.
Article
Neurosciences
Colin R. Grove, Andrew Wagner, Victor B. Yang, Brian J. Loyd, Leland E. Dibble, Michael C. Schubert
Summary: This study found that the vestibular function and compensatory oculomotor behaviors in multiple sclerosis (MS) patients may vary depending on the level of disability. Worse disability was associated with poorer vestibular function and compensatory oculomotor function.
Review
Clinical Neurology
Ryan Pelo, Erin Suttman, Peter C. Fino, Mary M. McFarland, Leland E. Dibble, Melissa M. Cortez
Summary: The purpose of this review was to summarize the relationship between exercise intolerance and autonomic dysfunction, and to highlight key findings for future investigation.
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Chemistry, Analytical
Rebecca A. Martin, George Fulk, Lee Dibble, Ali Boolani, Edgar R. Vieira, Jennifer Canbek
Summary: This study aimed to investigate the impact of three different types of explicit cues on postural sway during transfers in people with Parkinson's disease. The results showed that modeling during sit to stand transfers may safely reduce sway more than other common cues in this patient population.
Article
Clinical Neurology
Brian J. Loyd, Annie Fangman, Daniel S. Peterson, Eduard Gappmaier, Anne Thackeray, Michael C. Schubert, Leland E. Dibble
Summary: This study compared the efficacy of gaze and postural stability (GPS) retraining intervention to strength and endurance (SAE) intervention in individuals with multiple sclerosis (PwMS) who experienced dizziness or imbalance. The results showed that both GPS and SAE interventions resulted in significant improvements in dizziness handicap and balance from baseline to 6 weeks, with no significant difference between the two groups.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)