Article
Cell Biology
Gang Wang, Li Ma, Bowen Wang, Fentang Gao, Jianfeng Li, Hongyi Cai, Juan Wang, Tiancheng Zhang, Hao Guo, Ping Xie, Yi Li
Summary: Tanshinone IIA can counteract radiation-induced myocardial injury by regulating the p38/p53 pathway, restoring cardiomyocyte proliferation and reducing cell apoptosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biology
Alejandra Escos, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego Gonzalez-Romero, Ana Risco, Jose Martin-Gomez, Eric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan Jose Sanz-Ezquerro, Steven C. Ley, Ana Cuenda
Summary: Evidence implicating p38? and p38d in inflammation is mainly based on experiments using Mapk12/Mapk13-deficient mice. A new mouse model, p38?/dKIKO, with specific depletion of p38? and p38d was generated to study their functions. The results showed reduced inflammation, susceptibility to septic shock, and Candida albicans infection in p38?/dKIKO mice compared to wild-type mice. Gene expression and phosphorylation analyses revealed the involvement of p38?/p38d in regulating innate immune responses through MEF2D phosphorylation and transcriptional activity.
Review
Biochemistry & Molecular Biology
Jie Chen, Lihan Wang, Meng Yuan
Summary: MAPK cascades in plants play critical roles in growth, stress responses, and hormone signaling. In rice, the cascades control growth, stress resistance, and signaling functions. Future research on the molecular mechanisms and functions of rice MAPK cascades requires attention to specific concerns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Xiaoshuang Wei, Shuang Liu, Cheng Sun, Guosheng Xie, Lingqiang Wang
Summary: This review summarizes the recent progress in understanding the cold stress response mechanisms of Arabidopsis and rice, highlighting both convergent and divergent mechanisms between the two species. Genetic engineering approaches for developing freezing tolerant Arabidopsis and chilling tolerant rice were discussed, along with future perspectives on cold stress signaling and tolerance in rice.
Article
Environmental Sciences
Muhammad Musa Khan, Dylan O'Neill Rothenberg, Shahfahad, Bao-Li Qiu, Zeng-Rong Zhu
Summary: This study analyzed the transcriptome data of Bemisia tabaci after exposure to UV-A radiation and identified 453 genes with significantly altered expression. Among them, 40 genes were up-regulated and 413 genes were down-regulated. Enrichment analysis revealed that these differentially expressed genes play important roles in antioxidation and detoxification, protein turnover, metabolism, developmental processes, and immunological response. The study demonstrated that UV-A stress suppresses immunity and affects the growth and biological parameters of B. tabaci through gene regulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Na-Na Li, Shan Jiang, Kun-Yu Lu, Ji-Sheng Hong, Yan-Bin Wang, Jin-Yang Yan, Jun-Bo Luan
Summary: This study reveals how insect sex affects the development of bacteriocytes through cellular and molecular mechanisms. In the whitefly Bemisia tabaci, bacteriocytes in females undergo cell division, while bacteriocytes in males degenerate through autophagy and apoptosis. A transcription factor called Adf-1 plays a crucial role in this process.
Review
Biochemistry & Molecular Biology
Min Jiang, Youze Zhang, Peng Li, Jinjing Jian, Changling Zhao, Guosong Wen
Summary: This review summarizes the research progress in recent years on the classification and functions of MAPK cascades in plants, with a focus on the research status and general methods available for identifying MAPK substrates, and provides suggestions for future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Litao Guo, Zhimin Li, Jianping Xu
Summary: Heavy metal contamination, especially cadmium, poses serious threats to the ecosystem and human health in China. This study investigated the effects of cadmium stress on the bacterial and fungal communities in whiteflies, revealing changes in community composition and diversity. The findings suggest that the whitefly microbiota may contribute to their adaptation and resistance to cadmium and could potentially be utilized for cadmium remediation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tongjun Sun, Yuelin Zhang
Summary: This review summarizes the functions of MAPK cascades in plant development and innate immunity, as well as recent findings on the molecular links connecting surface receptors to MAPK cascades and the mechanisms underlying MAPK signaling specificity.
Article
Food Science & Technology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: This study aimed to investigate the harmful effects of folpet on bovine mammary glands and milk production using MAC-T cells. The results showed that folpet exhibited cytotoxicity against MAC-T cells, causing apoptosis and cell death. Furthermore, folpet treatment induced oxidative stress and activated MAPK signaling pathways. This is the first report highlighting the detrimental impacts of folpet on bovine mammary glands and the dairy industry, providing insights into the intracellular mechanisms using MAC-T cells.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Cell Biology
Vanessa M. Ruscetta, Taj J. J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. D. Viirre, Marc J. J. Adler, Michael F. F. Olson
Summary: Cytoskeleton organization and dynamics are regulated by post-translational modifications of key target proteins, including the phosphorylation of myosin light chain proteins by MRCK kinases. Compared to ROCK kinases, the contributions of MRCK kinases are less characterized due to the late discovery of selective inhibitors. The recent development of selective MRCK inhibitors has expanded the tools to study MRCK function and shown therapeutic benefits in cancer studies.
Article
Medicine, Research & Experimental
Eric Jiang, Arjun Dinesh, Sohan Jadhav, Richard A. Miller, Gonzalo G. Garcia
Summary: Long-lived mouse models and certain treatments like Rapamycin, acarbose and 17α-estradiol, which extend lifespan, reduce mTORC1 and ERK1-2 signaling pathways. Canagliflozin, a drug that only extends lifespan in male mice, was found to have the same effect. This suggests a common mechanism in genetic and pharmacological models of slowed aging in mice, as well as a sexual dimorphism in the ERK1-2 pathway.
Article
Agriculture, Multidisciplinary
Hu Xue, Buli Fu, Mingjiao Huang, Chao He, Jinjin Liang, Jing Yang, Xuegao Wei, Shaonan Liu, Tianhua Du, Yao Ji, Cheng Yin, Peipan Gong, JinYu Hu, He Du, Rong Zhang, Chao Wang, Jahangir Khajehali, Qi Su, Xin Yang, Youjun Zhang
Summary: In this study, it was found that the increased resistance of whitefly to imidacloprid is associated with the overexpression of CYP6DW3 and CYP6DW5v1 genes, and knockdown of these genes weakened the resistance. Moreover, it was shown that the CYP6DW3 protein can metabolize 14.11% of imidacloprid in vitro. These findings enhance our understanding of insect resistance mechanisms and contribute to the development of integrated pest management frameworks.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Physiology
Shun-Xia Ji, Xiao-Di Wang, Ze-Kai Lin, Fang-Hao Wan, Zhi-Chuang Lue, Wan-Xue Liu
Summary: This study analyzed the molecular characteristics and gene expression of chromatin remodelers in invasive and native populations of Bemisia tabaci, and identified potential key roles of these remodelers in temperature adaptation. The results showed that certain genes in the invasive population had higher expression levels during heat stress compared to the native population, indicating a potential link to their temperature tolerance ability.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Cheng Chi, Xuechen Xu, Mengqi Wang, Hui Zhang, Pingping Fang, Jie Zhou, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jingquan Yu
Summary: The study demonstrates that strigolactones positively regulate tomato heat and cold tolerance by inducing the expression of ABA, HSP70, CBF1, and antioxidant-related genes. Deficiency in ABA biosynthesis can compromise the effects of synthetic strigolactone analog on heat and cold stresses, highlighting the importance of ABA in this process.
HORTICULTURE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hehong Zhang, Lulu Li, Yuqing He, Qingqing Qin, Changhai Chen, Zhongyan Wei, Xiaoxiang Tan, Kaili Xie, Ruifang Zhang, Gaojie Hong, Jing Li, Junmin Li, Chengqi Yan, Fei Yan, Yi Li, Jianping Chen, Zongtao Sun
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Entomology
Hai-Jian Huang, Zhuang-Xin Ye, Gang Lu, Chuan-Xi Zhang, Jian-Ping Chen, Jun-Min Li
Summary: The study characterized the gene/protein repertoires of whiteflyBemisia tabaci salivary glands and secreted saliva, finding similarities with other arthropods but also unique proteins specific to B. tabaci. Differential regulation of salivary proteins on different hosts indicates potential applications in future functional studies and pest management.
Article
Biochemistry & Molecular Biology
Linying Li, Yuqing He, Xueying Zhang, Hehong Zhang, Zongtao Sun, Junmin Li, Gaojie Hong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Yuqing He, Gaojie Hong, Hehong Zhang, Xiaoxiang Tan, Lulu Li, Yaze Kong, Tian Sang, Kaili Xie, Jia Wei, Junmin Li, Fei Yan, Pengcheng Wang, Hongning Tong, Chengcai Chu, Jianping Chen, Zongtao Sun
Article
Virology
Gang Lu, Zhuang-Xin Ye, Yu-Juan He, Yan Zhang, Xin Wang, Hai-Jian Huang, Ji-Chong Zhuo, Zong-Tao Sun, Fei Yan, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Article
Plant Sciences
Kelei Han, Haijian Huang, Hongying Zheng, Mengfei Ji, Quan Yuan, Weijun Cui, Hehong Zhang, Jiejun Peng, Yuwen Lu, Shaofei Rao, Guanwei Wu, Lin Lin, Xuemei Song, Zongtao Sun, Junmin Li, Chuanxi Zhang, Yonggen Lou, Jianping Chen, Fei Yan
MOLECULAR PLANT PATHOLOGY
(2020)
Article
Microbiology
Binghua Chen, Lin Lin, Yuwen Lu, Jiejun Peng, Hongying Zheng, Qiankun Yang, Shaofei Rao, Guanwei Wu, Junmin Li, Zhuo Chen, Baoan Song, Jianping Chen, Fei Yan
Article
Plant Sciences
Yuqing He, Xueying Zhang, Linying Li, Zongtao Sun, Junmin Li, Xiaoya Chen, Gaojie Hong
Summary: Phosphate is the plant-accessible form of phosphorus, and its deficiency limits plant growth. Studies show that phosphate deficiency can lead to over-accumulation of anthocyanins in plants, and SPX4 plays a role in transmitting the phosphate starvation signal to anthocyanin biosynthesis pathways.
Article
Immunology
Yu-Juan He, Gang Lu, Yu-Hua Qi, Yan Zhang, Xiao-Di Zhang, Hai-Jian Huang, Ji-Chong Zhuo, Zong-Tao Sun, Fei Yan, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Summary: The Toll pathway in insect vectors is activated by plant virus infection, leading to upregulation of key genes and increased mortality in infected insects. The activation of Toll pathway is initiated by the direct interaction between Toll receptor and a protein encoded by the plant virus, indicating that it is an important defense mechanism against plant virus infection in insect vectors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Hai-Jian Huang, Xiao-Tian Yan, Xin Wang, Yu-Hua Qi, Gang Lu, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Summary: This study reveals the mechanism of persistent plant virus RSV multiplication within insect vectors, focusing on the HF area. Proteomic analysis identified two proteins (esf2 and ZFP36L1) that have different effects on RSV proliferation, providing valuable insights for virus-insect interaction research.
JOURNAL OF PROTEOMICS
(2021)
Article
Multidisciplinary Sciences
Lulu Li, Hehong Zhang, Changhai Chen, Haijian Huang, Xiaoxiang Tan, Zhongyan Wei, Junmin Li, Fei Yan, Chuanxi Zhang, Jianping Chen, Zongtao Sun
Summary: Plant viruses use transcriptional repressors to interfere with the jasmonic acid signaling pathway in plants, promoting infection and increasing feeding by insect vectors. These strategies have independently evolved in different plant RNA viruses, revealing a common feature of plant viruses in favoring viral pathogenicity and transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Yu-Hua Qi, Liao-Yuan Xu, Jing Zhai, Zhuang-Xin Ye, Gang Lu, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Summary: This study identified a novel nege-like virus, tentatively named Indomegoura nege-like virus 1 (INLV1), in aphids of the genus Indomegoura. INLV1 possessed typical features of negeviruses, including three open reading frames and multiple conserved domains. Phylogenetic analysis placed INLV1 in a distinct clade within the proposed Centivirus group.
Article
Biotechnology & Applied Microbiology
Hai-Jian Huang, Zhuang-Xin Ye, Xin Wang, Xiao-Tian Yan, Yan Zhang, Yu-Juan He, Yu-Hua Qi, Xiao-Di Zhang, Ji-Chong Zhuo, Gang Lu, Jia-Bao Lu, Qian-Zhuo Mao, Zong-Tao Sun, Fei Yan, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Summary: This study comprehensively analyzed the viromes of different cryptic species of the whitefly Bemisia tabaci, identifying 20 novel insect-specific viruses (ISVs) and revealing potential cross-infection between different cryptic species. Additionally, it was found that some ISVs can successfully replicate in the whitefly and the antiviral RNAi pathway of B. tabaci plays an active role in response to ISV infections.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Virology
Chulang Yu, Runpu Miao, Zhuangxin Ye, Stuart MacFarlane, Yuwen Lu, Junmin Li, Jian Yang, Fei Yan, Liangying Dai, Jianping Chen
Summary: By utilizing a potato virus X (PVX)-based expression vector, the expression mechanism of P3N-PIPO in turnip mosaic virus and wheat yellow mosaic virus was successfully investigated. Mass spectrometry identified the peptides spanning the slippery site of P3N-PIPO for the first time, providing direct evidence of the frameshift expression. Mutagenesis analysis revealed the importance of the Hexa-adenosine site for frameshift expression. The PVX-based expression vector proved to be a valuable tool for studying the expression mechanism of P3N-PIPO in Potyviridae.
Article
Virology
Zhuang-Xin Ye, Yue-Hong Li, Jian-Ping Chen, Chuan-Xi Zhang, Jun-Min Li
Summary: A novel virus, ALIV1, belonging to the genus Iflavirus and identified in A. lewisii, was reported in this study. It is the first virus discovered in both A. lewisii and the genus Aulacophora. Phylogenetic analysis showed that ALIV1 is closely related to Dinocampus coccinellae paralysis virus.
ARCHIVES OF VIROLOGY
(2021)