Article
Environmental Sciences
Camila G. Dantas, Ailma O. da Paixao, Tassia L. G. M. Nunes, Italo J. F. Silva, Bruno dos S. Lima, Adriano A. S. Araujo, Ricardo L. C. de Albuquerque-Junior, Katia P. Gramacho, Francine F. Padilha, Luiz P. da Costa, Patricia Severino, Juliana C. Cardoso, Eliana B. Souto, Margarete Z. Gomes
Summary: This study evaluated the neuroprotective effects of Africanized bee venom (BV) on a mice model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA). The results showed that BV could counteract the symptoms caused by 6-OHDA, reduce cell death, and protect the striatum from damage. These findings suggest that Africanized bee venom may have potential as a novel therapeutic approach for Parkinson's disease.
Article
Multidisciplinary Sciences
Andrea Slezia, Panna Hegedus, Evgeniia Rusina, Katalin Lengyel, Nicola Solari, Attila Kaszas, Diana Balazsfi, Boris Botzanowski, Emma Acerbo, Florian Missey, Adam Williamson, Balazs Hangya
Summary: Studying animal models allows us to better understand the mechanisms of Parkinson's disease. However, current models mainly focus on late-stage symptoms, leaving a gap in our knowledge of early-stage changes. In this study, a graded-dose unilateral 6-OHDA model was established in mice, and the behavioral, neuronal, and ultrastructural features were analyzed within the first two weeks of lesion induction. The results showed that mild degeneration of dopaminergic neurons can lead to motor deficits shortly after striatal lesions, suggesting that this model can be used to study the early stages of Parkinson's disease in mice.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang
Summary: Acupuncture at HT7 acupoint can regulate the brain reward function of rats and elevate ICSS thresholds. However, it does not affect the threshold-lowering effects produced by cocaine, indicating that it only effectively regulates the ICSS thresholds in drug-naive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
F. Buehning, L. Miguel Telega, Y. Tong, J. Pereira, V. A. Coenen, M. D. Doeroessy
Summary: The study investigated the acute effects of MFB DBS on neuronal oscillations in different neuronal populations related to the pathophysiology of depression. MFB DBS differentially affected neuronal oscillations in the mPFC, NAc, and VTA across SD and FSL rats, with a significant increase in low gamma oscillations in the mPFC of FSL rats.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Victor Silva da Fonseca, Valeria de Cassia Goncalves, Mario Augusto Izidoro, Antonio-Carlos Guimaraes de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza
Summary: Parkinson's disease is an incurable neurodegenerative disease with an increasing global disability and mortality rate. Non-motor symptoms are the main cause of disability and decreased quality of life. This study used metabolomics to assess changes in cardiac metabolism in a PD model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Debora Masini, Carina Plewnia, Maelle Bertho, Nicolas Scalbert, Vittorio Caggiano, Gilberto Fisone
Summary: In Parkinson's disease, a wide range of symptoms affecting the peripheral and central nervous system appear before or simultaneously with the cardinal motor symptoms, requiring appropriate animal models for study. Injection of 6-OHDA in rodents can replicate several non-motor comorbidities associated with PD, but often leads to significant post-surgical mortality.
Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Ingrid Morales, Ricardo Puertas-Avendano, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate, Manuel Rodriguez
Summary: The study revealed the essential role of astrocytes in clearing axonal debris produced by the degeneration of dopaminergic axons, which can prevent the activation of microglia and hinder the progression of PD.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Cell Biology
Hai-Ying Zhang, Yong-Cheng Jiang, Jun-Rui Li, Jia-Nan Yan, Xin-Jue Wang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu
Summary: The neuroprotective effects of skin-derived precursor Schwann cells on the central nervous system are achieved through the release of insulin-like growth factor-2, which operates through the insulin-like growth factor-2 receptor/PI3K/AKT pathway.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Article
Neurosciences
Sara El Idrissi, Nada Fath, Hind Ibork, Khalid Taghzouti, Meryem Alamy, Oualid Abboussi
Summary: Activation of the apoptotic pathway may contribute to neuronal cell death in Parkinson's disease (PD), but the exact mechanisms remain unclear. This study investigated the impact of subchronic restraint stress on PD-related factors in a rat model. The results showed that stress worsened motor and anxiety symptoms, decreased dopamine levels, increased iron accumulation, and induced overexpression of pro-apoptotic factors. These findings suggest that stress may exacerbate apoptosis and contribute to the progression of PD.
NEUROTOXICITY RESEARCH
(2023)
Article
Biology
Molly C. Craig, Larissa O. Silva, Steven J. Swoap
Summary: The study found that fasted mice tend to prefer warmer ambient temperatures when given the choice, especially in a selective environment. Additionally, fasted mice are more likely to maintain a higher body temperature in warm environments, which is beneficial for metabolism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Summary: This study established a rat model of Parkinson's disease (PD) using 6-hydroxydopamine (6-OHDA) and analyzed the lipid profile in cerebrospinal fluid (CSF) using lipidomic approaches. The results showed significant effects of 6-OHDA on behavior, dopaminergic neurons, and lipid composition in CSF. Specific lipid families and species exhibited fluctuations during the progression of Parkinson's disease and were correlated with behavioral and pathological changes in the midbrain.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neuroimaging
Tobias Bracht, Nicolas Mertse, Sebastian Walther, Karin Luedi, Sigrid Breit, Andrea Federspiel, Roland Wiest, Niklaus Denier
Summary: This study aimed to explore the associations between structural connectivity of the medial forebrain bundle (MFB), functional connectivity (FC) of the ventral tegmental area (VTA), anhedonia, and depression severity in patients with depression. The results showed reduced tract volume and number in the left supero-lateral branch (slMFB) in depression patients. Additionally, there was an increase in FC between the VTA and right medial prefrontal cortex (PFC) in these patients, and depression severity was associated with reduced tract volume and number in the left slMFB. Furthermore, reduced hedonic tone was associated with reduced tract volume and increased FC between the VTA and the PFC.
NEUROIMAGE-CLINICAL
(2022)
Article
Cell Biology
Rolando Lara-Rodarte, Daniel Cortes, Karla Soriano, Francia Carmona, Luisa Rocha, Enrique Estudillo, Adolfo Lopez-Ornelas, Ivan Velasco
Summary: This study engineered mouse ESCs to produce human GDNF, showing that overexpression of GDNF contributes to enhanced midbrain differentiation and increased survival of DaNs after grafting into the striatum.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Marta Llansola, Carmina Montoliu, Jordi Boix, Vicente Felipo
CHEMICAL RESEARCH IN TOXICOLOGY
(2010)
Article
Chemistry, Medicinal
Patrick De Boever, Britt Wens, Jordi Boix, Vicente Felipo, Greet Schoeters
CHEMICAL RESEARCH IN TOXICOLOGY
(2013)
Article
Gastroenterology & Hepatology
Omar Cauli, Pilar Lopez-Larrubia, Regina Rodrigo, Ana Agusti, Jordi Boix, Laura Nieto-Charques, Sebastian Cerdan, Vicente Felipo
Article
Biochemistry & Molecular Biology
Nisrin ElMlili, Jordi Boix, Hanan Ahabrach, Regina Rodrigo, Mohammed Errami, Vicente Felipo
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Endocrinology & Metabolism
Carmina Montoliu, Regina Rodrigo, Pilar Monfort, Marta Llansola, Omar Cauli, Jordi Boix, Nisrin ElMlili, Ana Agusti, Vicente Felipo
METABOLIC BRAIN DISEASE
(2010)
Article
Endocrinology & Metabolism
Laura Brunelli, Roberta Campagna, Luisa Airoldi, Omar Cauli, Marta Llansola, Jordi Boix, Vicente Felipo, Roberta Pastorelli
METABOLIC BRAIN DISEASE
(2012)
Article
Biochemistry & Molecular Biology
Jordi Boix, Marta Llansola, Andrea Cabrera-Pastor, Vicente Felipo
NEUROCHEMISTRY INTERNATIONAL
(2011)
Article
Biochemistry & Molecular Biology
Jordi Boix, Omar Cauli, Heather Leslie, Vicente Felipo
NEUROCHEMISTRY INTERNATIONAL
(2011)
Review
Biochemistry & Molecular Biology
Jordi Boix, Omar Cauli
NEUROCHEMISTRY INTERNATIONAL
(2012)
Article
Biochemistry & Molecular Biology
Andrea Cabrera-Pastor, Marta Llansola, Vitaliy Reznikov, Jordi Boix, Vicente Felipo
NEUROCHEMISTRY INTERNATIONAL
(2012)
Article
Toxicology
Roberta Campagna, Laura Brunelli, Luisa Airoldi, Roberto Fanelli, Helen Hakansson, Rachel A. Heimeier, Patrick De Boever, Jordi Boix, Marta Llansola, Vicente Felipo, Roberta Pastorelli
TOXICOLOGICAL SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Christopher P. Hedges, Jordi Boix, Jagdish K. Jaiswal, Bhoopika Shetty, Peter R. Shepherd, Troy L. Merry
Summary: BYL719 delivered through diet effectively suppresses insulin signaling and maintains long-term efficacy without affecting food intake and other physiological indicators.
Article
Biochemistry & Molecular Biology
Min Shin, Madhavi Pandya, Kristan Espinosa, Ravindra Telang, Jordi Boix, Peter R. Thorne, Srdjan M. Vlajkovic
Summary: The study found that weekly injections of istradefylline in middle-aged C57BL/6 mice can attenuate the progression of ARHL and improve cochlear development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ilknur Ozen, Jordi Boix, Gesine Paul
CLINICAL AND TRANSLATIONAL MEDICINE
(2012)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)