Article
Engineering, Multidisciplinary
Qi-Chen Zhang, Wang Ding, Sheng-Long Ding, Qing-Bing Meng, Di-Han Su, Tai-Wei Zhang, Qing Chen, Rui-Xian Lian, Ming-Dong Zhao, Bao-Qing Yu, Xi-Lei Li, Yu-Lin li, Li-Bo Jiang
Summary: Resorbable and bioactive regenerated silk fibroin/ gelatin (RSF/G) screws with dual physically and chemically crosslinked networks were fabricated in this study. The RSF/G screws showed controlled release of RGD peptide, better bioactivity, and promoted bone fracture healing compared to pure RSF screws and commercial devices.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Dentistry, Oral Surgery & Medicine
Wenyu Chuo, Guangqi Yan, Ran Zhang, Qing Zhou, Mingliang Yang
Summary: The study aimed to improve the accuracy of fracture reduction in condylar fractures by using a three-dimensional prototype and bioresorbable plates. Results showed that patients in the experimental group treated with the 3D-prototype approach achieved accurate reduction, while some patients in the control group did not. Using 3D prototype for bending the bioresorbable plate was found to be an effective method for accurate treatment of condylar fracture.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Orthopedics
Kai-xuan Yuan, Fan Yang, Kai Fu, Dao-yu Zhu, Chen-yi Jiang, Dong-xu Jin, Ze-hao Wang, Xiao-yuan Peng, You-Shui Gao, Peng-bo Luo
Summary: This study investigated the effectiveness of fully threaded cannulated compression screws (FTCCS) in treating femoral neck fractures (FNF). The results showed that the screw fixation method with FTCCS provided encouraging clinical results and may be a rational choice for the treatment of fresh FNF. Displaced fractures and unstable fractures were associated with a higher incidence of complications.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Polymer Science
Sybele Saska, Livia Pilatti, Alberto Blay, Jamil Awad Shibli
Summary: 3D printing is valuable in tissue engineering, but the structures produced are static. 4D printing is a new technology that uses smart materials to enable dynamic changes in printed structures, allowing engineered tissues to undergo planned morphological changes.
Article
Biochemistry & Molecular Biology
Paula Calvo, Antonia Costa-Bauza, Felix Grases
Summary: This study evaluated the effect of phytate on the crystallization of calcium oxalate, hydroxyapatite and brushite in artificial urine. The results showed that all lower InsPs seemed to inhibit the crystallization of calcium salts, especially InsP6 and InsP5 for calcium oxalate, and InsP5 and InsP4 for brushite. However, phytate had weak effects on the crystallization of hydroxyapatite in vitro, indicating a different mechanism for its in vivo crystallization.
Article
Biochemistry & Molecular Biology
Marta Trzaskowska, Vladyslav Vivcharenko, Wojciech Franus, Tomasz Goryczka, Adrian Barylski, Agata Przekora
Summary: The aim of this research was to optimize the concentration of individual components of polymer-ceramic nanocomposite granules for application in orthopedics and maxillofacial surgery. Two types of granules were made using nanohydroxyapatite and chitosan-based matrix, and different concentrations of the components were tested. The results showed slight differences among the resulting granules with respect to their microstructural, mechanical, and biological properties.
Article
Biochemistry & Molecular Biology
Kasper Dienel, Ahmed Abu-Shahba, Roman Kornilov, Roy Bjorkstrand, Bas van Bochove, Johanna Snall, Tommy Wilkman, Karri Mesimaki, Anna Meller, Jere Linden, Anu Lappalainen, Jouni Partanen, Riitta Seppanen-Kaijansinkko, Jukka Seppala, Bettina Mannerstrom
Summary: A major challenge in extensive craniomaxillofacial bone reconstruction is the limited availability of donor sites. This study tested patient-specific composite bioimplants in an animal model and found that they can induce bone growth but also have issues with resorption and infection.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Bu-fang Ren, Gang Li, Quan-ping Ma, Xin Lv, Jian Sun
Summary: This study compared a novel guide device with a conventional technique for the internal fixation of femoral neck fractures using cannulated screws. The results showed that the guide-device-assisted group had shorter fluoroscopy numbers and operation time, as well as fewer drilling attempts. Additionally, the guide-device-assisted group had better screw parallelism and greater spread than the conventional group.
ADVANCES IN THERAPY
(2023)
Article
Engineering, Biomedical
Kenda Sabouni, Yetkin Ozturk, Erkan Kacar, Hasan Serdar Mutlu, Seyhun Solakoglu, Gamze Torun Kose, Fatma Nese Kok, Muhammet Kursat Kazmanli, Kamil Mustafa Urgen, Sakip Onder
Summary: The study found that the (Ti,Mg)N coated titanium plates and screws in a rabbit model demonstrated enhanced bone regeneration compared to the standard TiN coated ones, with the (Ti,Mg)N coating promoting secondary bone regeneration. The presence of magnesium in the coating accelerated bone repair at the fracture site, indicating potential value in improving the efficiency of bone fixation devices.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Review
Agriculture, Dairy & Animal Science
Tofuko A. Woyengo, Jan V. Norgaard, Marleen E. van der Heide, Tina S. Nielsen
Summary: This study reviewed the digestibility of P and Ca in rock-derived and bone-derived calcium phosphates for pigs and poultry. The nutritive value of bone-derived calcium phosphates for poultry is greater than that of rock-derived calcium phosphates.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2022)
Article
Orthopedics
Lin Liu, Donggui Zeng, Shicai Fan, Yongxing Peng, Hui Song, Dadi Jin, Letian Zeng
Summary: Minimally-invasive surgery for Tile C pelvic fractures is challenging and a hot topic in orthopedic trauma research. In this study, using an anterior internal fixator combined with sacroiliac screws effectively stabilized Tile C3 pelvic fractures, with stability increasing as the number of screws in the internal fixator increased.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Daniel J. Hutchinson, Viktor Granskog, Johanna von Kieseritzky, Henrik Alfort, Patrik Stenlund, Yuning Zhang, Marianne Arner, Joakim Hakansson, Michael Malkoch
Summary: A new surgical method called AdhFix combines screws with polymer composites for rapid in situ fixation of bone fractures. Experimental results demonstrate that AdhFix provides strong and stable fixation for severe fractures without causing soft-tissue adhesions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Orthopedics
Felix G. E. Dyrna, Daniel M. Avery, Ryu Yoshida, David Lam, Simon Oeckenpoehler, Mark P. Cote, Elifho Obopilwe, Craig M. Rodner, Augustus D. Mazzocca
Summary: The study compared the stability of fracture fixation with intramedullary headless compression screws to other common forms of rigid fixation in metacarpal shaft fractures. Results showed that headless compression screws provided higher stiffness and peak load to failure, making it an excellent biomechanically stable option for treating these fractures.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Jing Wang, Wei Han, Yonggang Su, Junqiang Wang, Xieyuan Jiang
Summary: This retrospective study compared the outcomes of robot-assisted percutaneous screw fixation with traditional open reduction and internal fixation (ORIF) in treating Sander II and III calcaneal fractures. The results showed that the robot-assisted surgery group had significantly shorter operation time, preoperative waiting time, and length of postoperative hospital stay compared to the ORIF group. The fixation rate of the sustentaculum tali was significantly superior in the robot-assisted surgery group.
ORTHOPAEDIC SURGERY
(2023)
Review
Clinical Neurology
Abhijith Matur, Paolo Palmisciano, Henry O. Duah, Sai S. Chilakapati, Joseph S. Cheng, Owoicho Adogwa
Summary: A systematic review and meta-analysis showed that robotic and navigated pedicle screw placement techniques have higher accuracy and better safety profiles compared to fluoroscopic freehand techniques.
Article
Materials Science, Multidisciplinary
Viviana P. Ribeiro, Sandra Pina, Sabina Gheduzzi, Ana C. Araujo, Rui L. Reis, Joaquim M. Oliveira
FRONTIERS IN MATERIALS
(2020)
Review
Engineering, Biomedical
K. Hurle, J. M. Oliveira, R. L. Reis, S. Pina, F. Goetz-Neunhoeffer
Summary: Decades of research in orthopedics have led to the development of formidable yet resorbable biomaterials using bioactive materials. Brushite cements have high biocompatibility, bioresorbability, osteoconductivity, self-setting characteristics, handling, and injectability properties. Incorporating bioactive ions can improve the mechanical properties of such biomaterials. Ion-doped brushite cements have opened a new era in orthopedics, with applications in bone tissue repair and regeneration, enhanced by their bioresorbability and osteoconductive features. The role of ions in physicochemical and biological properties, as well as the potential use of ion-doped cements for drug delivery, are highlighted.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
George E. Stan, Teddy Tite, Adrian-Claudiu Popa, Iuliana Maria Chirica, Catalin C. Negrila, Cristina Besleaga, Irina Zgura, Any Cristina Sergentu, Gianina Popescu-Pelin, Daniel Cristea, Lucia E. Ionescu, Marius Necsulescu, Hugo R. Fernandes, Jose M. F. Ferreira
Review
Chemistry, Multidisciplinary
Maurice N. Collins, Guang Ren, Kieran Young, S. Pina, Rui L. Reis, J. Miguel Oliveira
Summary: Bone tissue engineering aims to create biofunctional tissue for treating diseases, with scaffold fabrication techniques and biomaterial selection being crucial. Vascularization and immunomodulation are major challenges in this field.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Lara Pierantoni, Viviana P. Ribeiro, Ligia Costa, Sandra Pina, Alain da Silva Morais, Joana Silva-Correia, Subhas C. Kundu, Antonella Motta, Rui L. Reis, Joaquim M. Oliveira
Summary: This study reports the generation of calcium-containing silk fibroin hydrogels using calcium peroxide as oxidizer, which exhibit potential for promoting tumor cell death and angiogenesis. In vivo evaluation shows the stability of the hydrogels up to 6 weeks after implantation, although an increased number of dead cells are present in the surrounding tissue.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
D. Bicho, R. F. Canadas, C. Goncalves, S. Pina, R. L. Reis, J. M. Oliveira
Summary: This study focuses on modulating the scaffold architecture to mimic bone structures and successfully develops scaffolds with controlled pore orientation, showing efficient scaffold integrity and morphology for future applications in clinical osteoregeneration and in vitro bone tissue modeling.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Physical
Ricardo Bento, Anuraag Gaddam, Jose M. F. Ferreira
Summary: Sol-gel synthesis is a promising method for preparing bioactive glass compositions at room temperature by controlling the kinetics of hydrolysis and condensation reactions. The quaternary silicate-based BG material showed amorphous structure and potential for biomedical applications in bone regeneration and tissue engineering, maintaining specific surface area and pore size distribution at different temperatures. The formation of an apatite layer on the BG particles in simulated body fluid further highlights its suitability for such applications.
Article
Chemistry, Physical
Ricardo Bento, Anuraag Gaddam, Parastu Oskoei, Helena Oliveira, Jose M. F. Ferreira
Summary: This study focuses on the sol-gel synthesis of an alkali-free bioactive glass and its application in robocasting for fabricating porous scaffolds. By adjusting milling procedures and heat treatment temperature, milling efficiency was improved and mesoporous powders' surface area was affected. Rheological tests were conducted on robocasting inks with 35 vol.% solids, and a customizable CAD scaffold geometry script was developed. The printing process was optimized for higher resolution, while the mechanical properties of the scaffolds were evaluated through compressive strength tests. The scaffolds showed good biomineralization activity and biocompatibility with human keratinocytes, indicating their potential for biomedical applications.
Article
Polymer Science
Ana S. Neto, Patricia Pereira, Ana C. Fonseca, Carla Dias, Mariana C. Almeida, Ines Barros, Catarina O. Miranda, Luis P. de Almeida, Paula V. Morais, Jorge F. J. Coelho, Jose M. F. Ferreira
Summary: The study focused on developing multifunctional biphasic calcium phosphate scaffolds coated with biopolymers loaded with antibiotic drug Rifampicin. The drug release profiles were different between PCL and PEU-coated scaffolds, with PCL showing a faster burst release. The effectiveness of the scaffolds in inhibiting bacterial growth depends on the specific bacterial strain and the type of polymer coating, influencing the drug release behavior.
Article
Engineering, Biomedical
K. Hurle, F. R. Maia, V. P. Ribeiro, S. Pina, J. M. Oliveira, F. Goetz-Neunhoeffer, R. L. Reis
Summary: This study investigated the osteogenic performance of Li+-doped brushite cements for bone regeneration. The results showed that Li+ favored the formation of monetite and increased in vivo bone density. In addition, Li+ exhibited an accelerating effect on the setting time of the cement. This study provides a promising strategy for further research on bone defect repair.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bruna L. Correia, Ana T. P. C. Gomes, Rita Noites, Jose M. F. Ferreira, Ana S. Duarte
Summary: Endodontic treatment aims to preserve teeth by removing infected tissue, disinfecting, and filling/sealing the root canal. The removal of microorganisms is crucial to prevent reinfection and tooth loss. Due to drug resistance, alternative procedures are needed. This study suggests using bioactive glass as an intracanal medication, which has been found to inhibit the growth of oral pathogens and greatly impact the success of endodontic treatments.
Article
Pharmacology & Pharmacy
Viviana P. Ribeiro, Joao B. Costa, Sofia M. Carneiro, Sandra Pina, Ana C. A. Veloso, Rui L. Reis, Joaquim M. Oliveira
Summary: This study introduces a biomimetic composite tubular graft (CTG) made of silk fibroin hydrogels containing ZnSr-doped beta-tricalcium phosphate particles as a promising bone tunnel filler for ACL grafts. The CTG exhibits superior mechanical properties and good swelling properties, supporting bone tissue regeneration and osteogenic activity of cells.
Article
Biochemistry & Molecular Biology
Helena Salgado, Ana T. P. C. Gomes, Ana S. Duarte, Jose M. F. Ferreira, Carlos Fernandes, Maria Helena Figueiral, Pedro Mesquita
Summary: This study tested the antimicrobial activity and surface roughness of a graphene-enhanced dental resin against Candida albicans and Streptococcus mutans. The increase in graphene concentration resulted in increased surface roughness. Graphene was effective in inhibiting the growth and adhesion of C. albicans and S. mutans.
Article
Chemistry, Physical
Liviu Nedelcu, Jose M. F. Ferreira, Adrian-Claudiu Popa, Luminita Amarande, Bo Nan, Liliana-Marinela Balescu, Cezar Dragos Geambasu, Marius-Cristian Cioangher, Lucia Leonat, Mihai Grigoroscuta, Daniel Cristea, Hermine Stroescu, Robert Catalin Ciocoiu, George E. Stan
Summary: This study conducted a comparative analysis of various sintered piezoceramic materials using multi-parametric unitary methods. The aim was to identify the most promising biocompatible piezoelectric material for use in 3D printed macro-porous ceramic scaffolds. The results showed that the BCTZ solid solution had the best combination of functional properties and compatibility with osteoblast cell cultures. Using the selected piezoceramic as a base material, 3D macro-porous scaffolds with promising compressive strength and excellent cell colonization capability were fabricated.
Article
Engineering, Biomedical
Cristina Besleaga, Bo Nan, Adrian-Claudiu Popa, Liliana Marinela Balescu, Liviu Nedelcu, Ana Sofia Neto, Iuliana Pasuk, Lucia Leonat, Gianina Popescu-Pelin, Jose M. F. Ferreira, George E. Stan
Summary: Bi-phasic calcium phosphates (BCPs) are promising materials for bone graft substitutes. This study investigates the structural role of supplemental cation-doping in BCPs and its influence on biological effects. The results show that double Mg-Sr doping in BCPs leads to the highest β-TCP/hydroxyapatite mass concentration ratio.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)