Article
Biochemical Research Methods
Aude Castel, Patrick M. Burns, Javier Benito, Hai L. Liu, Shikha Kuthiala, Lucien D. Durosier, Yael Frank, Mingju Cao, Marilene Paquet, Gilles Fecteau, Andre Desrochers, Martin G. Frasch
Summary: This study introduces a new surgical procedure for recording and manipulating fetal vagus nerve activity in an animal model of human pregnancy, providing insights into the physiological effects during pregnancy.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Business
John A. Clithero, Uma R. Karmarkar, Gideon Nave, Hilke Plassmann
Summary: Recent decades have seen significant progress in neuroscience research on consumer behavior, but the utilization of neural and physiological markers in consumer psychology has been limited. There has been an overly narrow use of neural data, and structural obstacles hinder the widespread adoption of these measures. Integration of physiological measures and overcoming these obstacles can lead to a more comprehensive understanding of consumers.
JOURNAL OF CONSUMER PSYCHOLOGY
(2023)
Article
Biology
Jamie C. S. McCoy, John I. Spicer, Simon D. Rundle, Oliver Tills
Summary: Phenomics provides a solution for quantifying developmental responses to elevated temperatures. Using energy proxy traits (EPTs), we assessed the thermal sensitivities of three species of freshwater snail. The results showed marked differences in thermal sensitivities between species, reflecting differences in embryonic physiology and behavior, as well as temperature-induced changes in physiological event timing.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Alberto Porta, Francesca Gelpi, Vlasta Bari, Beatrice Cairo, Beatrice De Maria, Davide Tonon, Gianluca Rossato, Marco Ranucci, Luca Faes
Summary: This study aims to investigate the impact of respiration on cardiovascular and cerebrovascular controls. The researchers propose a method to test whether respiration acts as a confounder or a suppressor, and validate its effectiveness in the study. The results show that respiration acts as a confounder in the regulation of cardiovascular and cerebrovascular controls. The significance of this study lies in the better understanding of the role of respiration in cardiovascular and cerebrovascular regulations through this testing method.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Neurosciences
Marta C. Antonelli, Martin G. Frasch, Mercedes Rumi, Ritika Sharma, Peter Zimmermann, Maria S. Molinet, Silvia M. Lobmaier
Summary: Exposure to stress during gestation and early childhood may increase the risk of functional developmental impairments. Non-invasively obtainable physiological signals and epigenetic biomarkers can predict neurodevelopmental outcomes and identify children who would benefit from early intervention programs. Early family-centered intervention programs can improve parental attachment and contribute to healthy socio-emotional adulthood. Biomarker-guided early intervention strategies are crucial in preventing future neuropsychiatric problems and reducing their impact.
CURRENT NEUROPHARMACOLOGY
(2022)
Letter
Physiology
Martin G. Frasch
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
M. G. Frasch
Summary: Sampling rate has an impact on the quality of HRV estimates. This article systematically examines the sensitivity of different HRV metrics to sampling rate errors and proposes a methodology for comprehensive validation of the effect of sampling rate on HRV.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Editorial Material
Immunology
Martin G. Frasch
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Peter Zimmermann, Marta C. Antonelli, Ritika Sharma, Alexander Mueller, Camilla Zelgert, Bibiana Fabre, Natasha Wenzel, Hau-Tieng Wu, Martin G. Frasch, Silvia M. Lobmaier
Summary: This study reveals the adverse effects of maternal prenatal stress on fetal iron homeostasis and neurodevelopment. Specifically, the study found lower transferrin saturation and a 15% decrease in fetal ferritin in stressed male neonates. Additionally, the study showed higher fetal stress index in the stressed group compared to the control group, suggesting the potential for early intervention strategies.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ritika Sharma, Martin G. Frasch, Camila Zelgert, Peter Zimmermann, Bibiana Fabre, Rory Wilson, Melanie Waldenberger, James W. MacDonald, Theo K. Bammler, Silvia M. Lobmaier, Marta C. Antonelli
Summary: Maternal stress before, during and after pregnancy has significant effects on the neurocognitive development of infants. This study aimed to find noninvasive epigenetic biomarkers of prenatal stress (PS) in newborns' saliva. Through DNA methylation analysis, significant associations were found between specific pregnancy worries and cortisol levels, and certain genes involved in secretion, transportation, signaling pathways, and neuronal signaling were identified. Early assessment of these noninvasive biomarkers can help detect at-risk babies and allocate resources for early intervention programs effectively.
CLINICAL EPIGENETICS
(2022)
Editorial Material
Pediatrics
Antoniya Georgieva, Patrice Abry, Ines Nunes, Martin G. Frasch
FRONTIERS IN PEDIATRICS
(2022)
Letter
Obstetrics & Gynecology
Martin G. Frasch
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biology
Martin G. Frasch, Byung-Jun Yoon, Dario Lucas Helbing, Gal Snir, Marta C. Antonelli, Reinhard Bauer
Summary: According to CDC data, ASD was diagnosed in one of every 36 children in the US in 2020. A model explaining the etiology of ASD based on common gene network features involving glial and neuronal cells during fetal development is proposed, with implications for understanding the causes of ASD, early detection, and new treatments. Fetal neuroinflammation and prenatal stress may contribute to lifelong neurological disabilities. Through genomic data analysis and statistical network analysis, the study supports the hypothesis of glial-neuronal interplay in ASD and discusses its implications for etiology, early detection, and therapeutic approaches. The proposed model is of interest for ASD research, treatment development, prevention, and policy-making.
Review
Biotechnology & Applied Microbiology
Martin Gerbert Frasch
Summary: A code, defined as a system of signals or symbols, has been found in heart rate variability (HRV) to reflect information flow and physiological responses. HRV shows features of time structure, phase space structure, specificity to organs and pathophysiological syndromes, and species independence universality. This code forms a spatiotemporal structure that is not fully understood. Physiological examples such as fetal systemic inflammatory response, organ-specific inflammatory responses, chronic hypoxia, allostatic load, and vagotomy provide evidence of the existence and utility of the HRV code.
BIOENGINEERING-BASEL
(2023)
Article
Obstetrics & Gynecology
Colin Wakefield, Lena Yao, Steve Self, Martin G. Frasch
Summary: This study evaluated the perception of women of child-bearing age towards remote fetal ECG monitoring technologies. The results of an online survey showed a high willingness among pregnant women to use wearable ECG devices for increased monitoring of maternal and fetal health.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, General & Internal
Colin Wakefield, Mingju Cao, Patrick Burns, Gilles Fecteau, Andre Desrochers, Martin G. Frasch
Summary: The experience level of the team was found to be the single variable determining the success of experiment outcomes using the CINAFS model.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Martin G. Frasch
Summary: NeuroKit2 is a Python Toolbox for Neurophysiological Signal Processing that simplifies and automates the computation of various mathematical estimates of heart rate variability (HRV) or similar time series. It can handle different types of input data and provides 124 HRV measures, including the estimation of temporal fluctuations of the HRV estimates themselves. The methodology is demonstrated in a sleep dataset, showcasing its potential applications in studying the dynamic relationships between sleep state architecture and multi-dimensional HRV metrics.
Meeting Abstract
Obstetrics & Gynecology
Moira Barbieri, Tamara Stampalija, Martin Gerbert Frasch, Roberto Sassi, Massimo Walter Rivolta
REPRODUCTIVE SCIENCES
(2022)
