Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Xiong, Tian Tian, Yang Fan, Shaolin Yang, Xiaoxiao Xiong, Qiang Zhang, Wenzhen Zhu
Summary: The global network organization and nodal efficiency in T2DM patients with cognitive impairment are significantly disrupted compared to those with normal cognition. Network analyses offer insights into the neuropathology of cognitive decline in T2DM patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Endocrinology & Metabolism
Cong Zhou, Jie Li, Man Dong, Liangliang Ping, Hao Lin, Yuxin Wang, Shuting Wang, Shuo Gao, Ge Yu, Yuqi Cheng, Xiufeng Xu
Summary: This meta-analysis examined white matter microstructural alterations in patients with type 2 diabetes mellitus and found reductions in fractional anisotropy in the left inferior network, corpus callosum, and left olfactory cortex. Additionally, a negative correlation was observed between fractional anisotropy in the corpus callosum and BMI in the patient group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyue Xia, Lisong Dai, Hongmei Zhou, Panpan Chen, Shuhua Liu, Wenzhong Yang, Zhentao Zuo, Xiangyang Xu
Summary: This study found that in diabetic patients, DTI parameters FA decreased and MD and RD increased compared to healthy controls. FA was positively correlated with MCV, while MD and RD were negatively correlated with MCV. FA displayed the best diagnostic accuracy and has good diagnostic value.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Wang, Lei Luo, Jianming Xing, Jianliang Wang, Bimin Shi, Yin-Min Li, Yong-Gang Li
Summary: The study demonstrated that DTI is effective in evaluating the diagnostic accuracy of diabetic peripheral neuropathy and can effectively differentiate between axonal injury and demyelination, showing correlations with electrophysiology parameters.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Geriatrics & Gerontology
Li Huang, Qingqing Zhang, Tong Tang, Minguang Yang, Cong Chen, Jing Tao, Shengxiang Liang
Summary: The meta-analysis revealed consistent reductions in fractional anisotropy in 10 white matter regions of patients with T2DM, indicating abnormalities in white matter integrity. This finding contributes to understanding the neuropathological and physiological mechanisms of T2DM and provides evidence for clinical diagnosis and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Abdulmajeed Alotaibi, Christopher Tench, Rebecca Stevenson, Ghadah Felmban, Amjad Altokhis, Ali Aldhebaib, Rob A. Dineen, Cris S. Constantinescu
Summary: Both type 1 and type 2 diabetes mellitus can impact the microstructural environment and cognitive functions of the brain. Diffusion Tensor Imaging (DTI) is a sensitive MRI-based technique that has been used to quantify brain microstructural abnormalities in patients with diabetes, demonstrating the potential affect on cognitive abilities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haoran Zhang, Peng Wang, Dafa Shi, Xiang Yao, Yanfei Li, Xuedan Liu, Yang Sun, Jie Ding, Siyuan Wang, Guangsong Wang, Ke Ren
Summary: This study aims to investigate the capabilities of DTI and IVIM in identifying early kidney function injury. The results suggest that IVIM-derived D and DTI-derived FA values are better indicators for evaluating early kidney impairment in diabetes.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Jun Wang, Laiyang Ma, Guangyao Liu, Wenjuan Bai, Kai Ai, Pengfei Zhang, Wanjun Hu, Jing Zhang
Summary: This study investigated the characteristics of white matter injury in patients with type 2 diabetes mellitus (T2DM) and its correlation with subjective memory complaints (SMC). The study found that white matter microstructure injury in T2DM may be associated with SMC, and these abnormalities identified by diffusion tensor imaging (DTI) can be used as an effective biomarker.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tijana Mrdanin, Olivera Nikolic, Una Molnar, Milena Mitrovic, Viktor Till
Summary: The study investigated the role of functional MRI in detecting diabetic nephropathy in type 2 diabetes patients, finding that ADC and FA values are significant parameters in the diagnosis of this condition, with medullary FA being particularly sensitive for early detection of renal damage. Further research is needed to refine recommendations and improve diagnostic accuracy.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2021)
Article
Geriatrics & Gerontology
Chang Li, Jingna Zhang, Mingguo Qiu, Kaijun Liu, Yang Li, Zhiwei Zuo, Xuntao Yin, Yuqi Lai, Jingqin Fang, Haipeng Tong, Yu Guo, Jian Wang, Xiao Chen, Kunlin Xiong
Summary: This study investigates white matter structural network changes in T2DM patients with MCI and finds disruptions in both global and regional levels, particularly in regions like the limbic system, basal ganglia, and several cortical structures. Cognitive impairment in T2DM-MCI patients is significantly correlated with altered global and nodal parameters, suggesting potential biomarkers for detecting T2DM-associated MCI.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Yoshiaki Tamura, Keigo Shimoji, Joji Ishikawa, Aya Tachibana, Remi Kodera, Kazuhito Oba, Kenji Toyoshima, Yuko Chiba, Aya M. Tokumaru, Atsushi Araki
Summary: White matter alterations in the left anterior thalamic radiations and right inferior fronto-occipital fasciculus are associated with sarcopenia prevalence in patients with diabetes, indicating that specific changes in these tracts may play a critical role in the occurrence of sarcopenia in this population.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Neurosciences
Dongsheng Zhang, Yang Huang, Jie Gao, Yumeng Lei, Kai Ai, Min Tang, Xuejiao Yan, Xiaoyan Lei, Zhen Yang, Zhirong Shao, Xiaoling Zhang
Summary: This study found that patients with type 2 diabetes mellitus (T2DM) and microvascular complications displayed more extensive changes in different network topology scales, with the visual network and cerebellar being potentially central vulnerable regions for these patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Neurosciences
Jie Tang, Qian Su, Xue Zhang, Wen Qin, Huaigui Liu, Meng Liang, Chunshui Yu
Summary: This study identified genes preferentially correlated to painful and tactile activation patterns at the cortical level, revealing differential genetic architectures involved in these specific brain activation patterns. Genes correlated to painful activation were enriched for neuron and opioid- and addiction-related pathways, showing overlapping with pain-related genes identified in previous studies, indicating a new approach to studying pain- and touch-related genes from the perspective of neural responses in the human brain.
Article
Neurosciences
Qingqing Yang, Xinxin Zhang, Yingchao Song, Feng Liu, Wen Qin, Chunshui Yu, Meng Liang
Summary: Canonical correlation analysis (CCA) is a multivariate approach increasingly used in neuroimaging studies to identify correlations between two sets of variables related to brain-behavior relationships. This study systematically assessed the stability of CCA and found that both the subject-to-variable ratio (SVR) and correlation strength greatly influence the stability of CCA. The results provide a practical guideline for interpreting CCA results and applying CCA in neuroimaging studies.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Xinjun Suo, Hao Ding, Xi Li, Yaodan Zhang, Meng Liang, Yongqiang Zhang, Chunshui Yu, Wen Qin
Summary: The functional connector hubs anatomically bridge the DAN and VAN, with unique connectivity patterns resembling their functional connectivity, and the strength of anatomical connectivity is positively associated with functional connectivity at group- and individual-levels.
Article
Neuroimaging
Jiahui Zhang, Ling Wang, Hao Ding, Ke Fan, Qin Tian, Meng Liang, Zhihua Sun, Dapeng Shi, Wen Qin
Summary: This study aimed to investigate structural abnormalities in LHON patients with DTI, revealing abnormal rich club organization in both acute and chronic LHON and the coexistence of primary and secondary connectivity damage in LHON.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Xiaoxi He, Xi Li, Jilian Fu, Jiayuan Xu, Huaigui Liu, Peng Zhang, Wei Li, Chunshui Yu, Zhaoxiang Ye, Wen Qin
Summary: This study investigated the genetic variants, brain morphometry, and working memory performance, finding a significant correlation between the left cuneus volume and 2-back accuracy.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Jiahe Guo, Kai Zhang, Jianyu Zhang, Rui Zhao, Yibo Liang, Yu Lin, Shengping Yu, Wen Qin, Xuejun Yang
Summary: Our study aimed to investigate how spatial memory retrieval is represented in the brain. Through the use of both univariate analysis and multivariate pattern analysis, we discovered that spatial memory retrieval involves widespread brain regions, including the hippocampus, frontal and parietal lobes, occipital lobes, and cerebellum. The activation amplitude in the left hippocampus was negatively correlated with task completions, while the classification accuracies based on signal patterns of the right middle temporal gyrus showed a significant positive correlation with retrieval accuracy. This underscores the importance of understanding the separation between navigational and non-navigational states and the utility of multivariate pattern analysis in studying brain functions.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Clinical Neurology
Ling Wang, Hao Ding, Bihong T. Chen, Ke Fan, Qin Tian, Miaomiao Long, Meng Liang, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: LHON patients show occult brain white matter impairment, which may not be correlated with disease duration or retinal nerve fiber layer thickness.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weimin Zheng, Ling Wang, Qian Chen, Xuejing Li, Xin Chen, Wen Qin, Kuncheng Li, Jie Lu, Nan Chen
Summary: The study found that CTSCI patients exhibit altered neural function in the right lingual gyrus and right middle frontal gyrus, as well as changes in functional connectivity between these regions and Vermis_3. These changes are associated with clinical manifestations such as visual analog scale scores, indicating a potential theoretical basis for rehabilitation techniques targeting visual, emotion, and cognition in CTSCI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Yingchao Song, Qian Su, Qingqing Yang, Rui Zhao, Guotao Yin, Wen Qin, Gian Domenico Iannetti, Chunshui Yu, Meng Liang
Summary: The study using dynamic causal modeling and high-temporal-resolution fMRI revealed a parallel structure for nociceptive and tactile information processing in the 'thalamus-S1-S2' network, with distinct corticothalamic feedback regulations from S1 and S2.
Article
Psychology, Biological
Jiayuan Xu, Xiaoxuan Liu, Qiaojun Li, Ran Goldblatt, Wen Qin, Feng Liu, Congying Chu, Qiang Luo, Alex Ing, Lining Guo, Nana Liu, Huaigui Liu, Conghong Huang, Jingliang Cheng, Meiyun Wang, Zuojun Geng, Wenzhen Zhu, Bing Zhang, Weihua Liao, Shijun Qiu, Hui Zhang, Xiaojun Xu, Yongqiang Yu, Bo Gao, Tong Han, Guangbin Cui, Feng Chen, Junfang Xian, Jiance Li, Jing Zhang, Xi-Nian Zuo, Dawei Wang, Wen Shen, Yanwei Miao, Fei Yuan, Su Lui, Xiaochu Zhang, Kai Xu, Longjiang Zhang, Zhaoxiang Ye, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Lauren Robinson, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Jeanne Winterer, Kevin Patrick, Vince Calhoun, Mulin Jun Li, Meng Liang, Peng Gong, Edward D. Barker, Nicholas Clinton, Andre Marquand, Le Yu, Chunshui Yu, Gunter Schumann
Summary: Research shows correlations between urbanization and brain function, neuropsychology, and mental illness symptoms, with the most pronounced effects on the cerebellum and prefrontal cortex. Urbanization impacts brain structure and function, perspective-taking, and depression symptoms, with neural variables acting as mediators.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neuroimaging
Zirui Wang, Yuan Ji, Yumeng Fu, Feng Liu, Xin Du, Huaigui Liu, Wenshuang Zhu, Kaizhong Xue, Wen Qin, Quan Zhang
Summary: Using transcriptome-neuroimaging spatial association analysis, this study identified 371 genes significantly associated with facial expression recognition-related brain activations. Enrichment analysis revealed the importance of these genes in regulating nervous system development, cell junction organization, and synaptic functions, as well as their higher enrichment in psychiatric diseases with emotion impairments.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Jingchun Liu, Caihong Wang, Wen Qin, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical stroke leads to structural changes in multiple areas of the cerebral cortex. The location of the lesion affects the pattern of cortical thickness changes. Motor outcomes and impairment of the corticospinal tract are correlated with cortical thickness in specific gyri. The longitudinal dataset shows gradual changes in cortical thickness and area in regions with structural reorganization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
