期刊
JOURNAL OF DIABETES
卷 7, 期 1, 页码 10-15出版社
WILEY-BLACKWELL
DOI: 10.1111/1753-0407.12138
关键词
children; glucose tolerance; insulin sensitivity; sleep architecture; sleep stage
资金
- Research Grant Committee [CUHK4465/06M]
- Chinese University of Hong Kong
BackgroundShort sleep duration is a contributing factor for decreased insulin sensitivity and hyperglycemia. Sleep architecture represents a cyclical pattern of sleep that shifts between sleep Stages N1, N2, N3 (slow wave sleep) and Stage R (rapid eye movement sleep). The aim of the present study was to examine the association between sleep architecture and glucose and insulin metabolism in both normal weight and overweight/obese children and adolescents. MethodsA total of 118 subjects participated in the study. Subjects underwent overnight polysomnography (PSG) when the percentage of total sleep time (% TST) spent at each sleep stage was recorded and an oral glucose tolerance test together was performed the next morning. We assessed glucose tolerance, insulin sensitivity and pancreatic -cell function using 2-h glucose levels, the Matsuda index (ISOGTT), and insulin secretion-sensitivity index-2 (ISSI-2), respectively. ResultsAfter adjustment for age, gender, body mass index z-score, pubertal status, and obstructive apnea hypopnea index, Stage N3 (% TST) was positively associated with ISOGTT, whereas Stage N1 (%TST) exerted an opposite effect on ISOGTT. Higher sleep efficiency and longer TST were independently associated with lower 2-h glucose levels, higher ISSI-2 and/or higher ISOGTT. ConclusionsStage N3, sleep efficiency and TST were protective factors in maintaining glucose and insulin homeostasis; however, Stage N1 functioned in the opposite direction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据