Article
Endocrinology & Metabolism
Malgorzata Wamil, Ruth L. Coleman, Amanda Adler, John J. McMurray, Rury R. Holman
Summary: Insulin resistance in patients newly diagnosed with type 2 diabetes was found to be associated with an increased risk of developing heart failure or death compared to those who were more sensitive to insulin.
Article
Endocrinology & Metabolism
Katarzyna Dziopa, Folkert W. Asselbergs, Jasmine Gratton, Nishi Chaturvedi, Amand F. Schmidt
Summary: This study aimed to compare the performance of risk prediction scores for cardiovascular disease (CVD) in individuals with type 2 diabetes. The Systemic Coronary Risk Evaluation (SCORE) CVD rule derived in the general population performed best for both CVD and a broader definition of CVD. Simple recalibration considerably improved the performance of the scores.
Article
Public, Environmental & Occupational Health
Aayush Visaria, Sumaiya Islam, Pooja Polamarasetti, Joel James, Priyanka Raju, Akarsh Sharma, Karen K. Khangura, Rajat Thawani, Sunita Dodani
Summary: The study revealed that Asian Indians have a higher risk of hypertension and diabetes compared to non-Hispanic Whites, and are more likely to undergo fasting blood glucose testing. Factors such as older age, doctor's visit, higher education level, insurance coverage, and history of hypertension or diabetes were found to be predictors of testing among Asian Indians.
PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Han Rim Lee, Jungeun Shin, Kyungdo Han, Jiwon Chang, Su-Min Jeong, Seung Joo Chon, Soo Jung Choi, Dong Wook Shin
Summary: The association between obesity and diabetes mellitus was found to be stronger in premenopausal women than in postmenopausal women, especially in cases where BMI exceeded 30, indicating a higher risk of diabetes in obese premenopausal women.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Shilpa N. Bhupathiraju, Caleigh M. Sawicki, Shatabdi Goon, Unjali P. Gujral, Frank B. Hu, Namrulha R. Kandula, Alka M. Kanaya
Summary: This study evaluated the association between plant-based diet quality and cardiometabolic risks among participants of South Asian ancestry living in the United States. The results showed that a higher intake of healthful plant-based foods was associated with a lower cardiometabolic risk profile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Evan L. Reynolds, Gulcin Akinci, Mousumi Banerjee, Helen C. Looker, Adam Patterson, Robert G. Nelson, Eva L. Feldman, Brian C. Callaghan
Summary: In participants with longstanding diabetes, neuropathy and kidney disease worsened during follow-up, despite stable to improving MetS components. Early metabolic intervention is necessary to prevent complications in such patients. The number of MetS components was associated with an increased rate of neuropathy progression, and SBP was associated with each complication.
Article
Health Care Sciences & Services
Shruti Muralidharan, Harish Ranjani, Ranjit Mohan Anjana, Yashdeep Gupta, Samita Ambekar, Varsha Koppikar, N. Jagannathan, Sidhant Jena, Nikhil Tandon, Steven Allender, Viswanathan Mohan
Summary: This study examined the impact of a mobile health intervention on cardiometabolic risk factors, showing a slight reduction in waist circumference and systolic blood pressure in the intervention group, particularly among obese individuals. Overall, the improvements were modest, indicating that intensive engagement with participants may be necessary for more substantial effects.
Article
Endocrinology & Metabolism
Guanhong Miao, Ying Zhang, Zhiguang Huo, Wenjie Zeng, Jianhui Zhu, Jason G. Umans, Gert Wohlgemuth, Diego Pedrosa, Brian DeFelice, Shelley A. Cole, Amanda M. Fretts, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Jinying Zhao
Summary: The study found that alterations in plasma molecular lipids are closely associated with the risk of type 2 diabetes (T2D) in American Indians, with various lipid species showing significant impact on T2D risk both at baseline and over time. Aberrant lipid profiles were observed in prediabetes, and longitudinal changes in lipidome were significantly linked to changes in continuous measures of T2D. The findings suggest that lipid dysregulation occurs many years before the onset of T2D and may provide new therapeutic targets for early intervention tailored to American Indians.
Article
Geriatrics & Gerontology
Matti Hyvarinen, Juha Karvanen, Hanna-Kaarina Juppi, Jari E. Karppinen, Tuija H. Tammelin, Vuokko Kovanen, Pauliina Aukee, Sarianna Sipila, Timo Rantalainen, Eija K. Laakkonen
Summary: The objective of this study was to examine the associations between menopausal symptoms and cardiometabolic risk factors. The authors conducted a cross-sectional and longitudinal study on a representative population sample of women aged 47-55 years. The results showed modest positive associations between menopausal symptoms and cholesterol and fat mass measures, but these associations disappeared after adjusting for confounders. Menopausal symptoms did not predict changes in risk factors during the follow-up period.
Article
Geriatrics & Gerontology
Aysegul Gulbahar, Gamze Sinem Caglar, Tufan Arslanca
Summary: The study aimed to investigate the predictive value of Visceral Adiposity Index (VAI) for cardiovascular disease (CVD) and its relationship with electrolytes. The results showed a significant correlation between VAI and patients with Metabolic Syndrome (MetS), but VAI was not predictive of 10-year CVD risk.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Endocrinology & Metabolism
Mostafa Salama, Babu Balagopal, Ilene Fennoy, Seema Kumar
Summary: This mini-review provides a brief summary of the pathophysiology of childhood obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk. It also reviews recent data on lifestyle interventions, medications, and metabolic surgery for obesity, T2DM, and CVD risk factors. Childhood obesity is influenced by genetic, physiological, environmental, and socioeconomic factors. There is a need for a comprehensive approach to detecting, monitoring, and managing childhood obesity and its metabolic consequences.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Nilay S. Shah, Cecily Luncheon, Namratha R. Kandula, Pyone Cho, Fleetwood Loustalot, Jing Fang
Summary: The study found that the self-reported diabetes prevalence is higher in non-Hispanic Asian Americans compared to non-Hispanic Whites, with significant differences in prevalence rates among different Asian American subgroups, particularly highest in Filipino and Asian Indian Americans, especially in the age group of 65 and above.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Ramatu Wuni, Evelyn Adela Nathania, Ashok K. Ayyappa, Nagarajan Lakshmipriya, Kandaswamy Ramya, Rajagopal Gayathri, Gunasekaran Geetha, Ranjit Mohan Anjana, Gunter G. C. Kuhnle, Venkatesan Radha, Viswanathan Mohan, Vasudevan Sudha, Karani Santhanakrishnan Vimaleswaran
Summary: Using a nutrigenetic approach, researchers found a link between abnormalities in lipid metabolism and obesity in Asian Indians. It was observed that a diet low in saturated fatty acids can reduce the genetic risk of central obesity, while a high intake of saturated fatty acids increases the genetic risk of central obesity in Asian Indians.
Article
Nutrition & Dietetics
Sooad Alsulami, Dhanasekaran Bodhini, Vasudevan Sudha, Coimbatore Subramanian Shanthi Rani, Rajendra Pradeepa, Ranjit Mohan Anjana, Venkatesan Radha, Julie A. Lovegrove, Rajagopal Gayathri, Viswanathan Mohan, Karani Santhanakrishnan Vimaleswaran
Summary: The study examined how dietary and genetic factors impact metabolic traits and the risk of type 2 diabetes among Asian Indians. It found that genetic risk scores were associated with a higher risk of developing type 2 diabetes and certain metabolic traits. Additionally, there were significant interactions between genetic risk scores and protein intake, suggesting that lower plant protein intake may contribute to increased susceptibility to diabetes in this population.
Article
Multidisciplinary Sciences
Claudia Fernandez Perez, Kevin Xi, Aditya Simha, Nilay Shah, Robert Huang, Latha Palaniappan, Sukyung Chung, Tim Au, Nora Sharp, Nathaniel Islas, Malathi Srinivasan
Summary: Heart disease and cancer are the leading causes of death among Asian Indians in the US. Foreign-born Asian Indians have higher all-cause mortality rates compared to US-born, while Asian Indians overall have lower mortality rates than NHWs. Mortality rates for heart disease and cancer are higher for foreign-born Asian Indians.
