Article
Immunology
Rong Lin, Yu-Wei Lin, Mei-Hsiu Chen
Summary: This article reports a 39-year-old woman who developed fulminant type 1 diabetes following SARS-CoV-2 vaccination. The patient had low glycohemoglobin levels, hyperglycemia, and diabetic ketoacidosis. Initial misdiagnosis as type 2 diabetes led to a second episode of ketoacidosis. This case highlights the importance of recognizing vaccine-related fulminant T1DM for clinicians.
Article
Endocrinology & Metabolism
Einas H. Alkhatib, Jody B. Grundman, Anna M. Adamusiak, Melena D. Bellin, Joel P. Brooks, Kevin S. Buckley, Erin M. Janssen, Maleewan Kitcharoensakkul, Kyle P. Mcnerney, Thea L. Pfeifer, Brooke I. Polk, Brynn E. Marks
Summary: Insulin hypersensitivity reactions are rare but serious complications of T1D treatment, negatively affecting glycemic control and quality of life.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Cuiping Lin, Xuan Li, Yu Qiu, Zheng Chen, Jianping Liu
Summary: PD-1 inhibitor-associated type 1 diabetes progresses rapidly, leading to islet failure and endangering patients' lives. Patients receiving PD-1 inhibitors should closely monitor their blood glucose levels.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Anne M. Kerola, Markus Juonala, Antti Palomaki, Anne Grete Semb, Paivi Rautava, Ville Kyto
Summary: This study found that patients with type 1 diabetes have a higher case fatality rate after myocardial infarction compared to patients without diabetes. Younger age, heart failure, peripheral vascular disease, and no revascularization were associated with the highest risk.
Article
Multidisciplinary Sciences
Hasim Tekin, Knud Josefsen, Lars Krogvold, Knut Dahl-Jorgensen, Ivan Gerling, Flemming Pociot, Karsten Buschard
Summary: The incidence of type 1 diabetes in children under 18 years of age increases after COVID-19 infection. Decreased expression of PDE12 is associated with T1D development, while rare PDE12 SNPs may increase the risk of T1D.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Giulia Dallagiacoma, Agnese Allora, Stefano Salvati, Giulia Cocciolo, Michele Capraro, Anna Lamberti, Sabrina Senatore, Leandro Gentile, Vincenza Gianfredi, Andrea Laurenzi, Chiara Molinari, Amelia Caretto, Marino Faccini, Carlo Signorelli, Marina Scavini, Anna Odone
Summary: The study found that seasonal influenza vaccination coverage was low among patients with type 1 diabetes, with different attitudes and practices towards vaccination. Diabetes specialists were considered the most trusted source of information on vaccines and should be more actively involved in preventive interventions.
Article
Multidisciplinary Sciences
A. Vuorela, T. L. Freitag, K. Leskinen, H. Pessa, T. Harkonen, I Stracenski, T. Kirjavainen, P. Olsen, O. Saarenpaa-Heikkila, J. Ilonen, M. Knip, A. Vaheri, M. Partinen, P. Saavalainen, S. Meri, O. Vaarala
Summary: NT1, a severe sleep disorder, is strongly associated with the HLA type DQB1*0602 and its incidence increases among children vaccinated with Pandemrix. Children vaccinated with Pandemrix develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 through cross-reactivity, suggesting POMT1 as a potential autoantigen in NT1.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Lingling Zhou, Huanjia Qu, Qiuling Zhang, Jinhua Hu, Lan Shou
Summary: A pregnant woman developed acute diabetes after SARS-CoV-2 infection, with improvement following insulin therapy but without recovery of beta cell function. This report highlights the occurrence of acute diabetes after SARS-CoV-2 infection and emphasizes the importance of early recognition and management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Wei Fang, Yang Gao, Xiaoyan Shi, Xiaoran Zhang, Shan Zhou, Hongxia Zhu, Wei Yan, Huanping Wang
Summary: The co-occurrence of ICIs-related pancreatitis with diabetes is rare but often severe or fatal. This article presents a case of acute pancreatitis and fulminant type 1 diabetes mellitus in a patient treated with the PD-L1 inhibitor toripalimab and reviews the literature on ICIs-related pancreatitis with diabetes. The study suggests that ICIs can affect endocrine and exocrine functions of the pancreas, providing new perspectives for early identification and effective management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Eriko Totsune, Tomohiro Nakano, Kunihiko Moriya, Daichi Sato, Dai Suzuki, Akinobu Miura, Saori Katayama, Hidetaka Niizuma, Junko Kanno, Menno C. van Zelm, Kohsuke Imai, Hirokazu Kanegane, Yoji Sasahara, Shigeo Kure
Summary: LRBA deficiency is a monogenic disease related to CVID, causing immune dysregulation, enteropathy, and recurrent infections. Patients may present with fulminant autoimmune diseases and require genetic testing and evaluation of markers of immunodeficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Min Gu, Kaibiao Chen, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: This study investigated the genetic and biologic characteristics of two Eurasian avian-like H1N1 swine influenza viruses from pigs in China. One swine isolate showed high similarity to contemporary human Eurasian avian-like H1N1 isolates, had a preference for binding to human-type receptors, and demonstrated vigorous replication in mice without the need for adaptation.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Ladislav Kocan, Jozef Firment, Ingrid Pirnikova, SilviaFarkasova Iannaccone, Dusan Rybar, Juliana Gnorikova, Jan Korcek, Hana Kocanova, Pavol Toeroek, Simona Rapcanova, Janka Vaskova
Summary: In the last decades, viral pneumonia cases, such as H1N1, MERS-CoV, and SARS-COVID-19, have posed significant challenges to global healthcare. The impact of viral infections on lung structure, function, and mortality is a major concern. This study presents the course and treatment of severe H1N1 pneumonia in a 30-year-old patient. The patient was included in a selenium therapy study with long-term follow-up and documented lung examinations. The outcomes showed a healing trend with full recovery of lung tissue.
