Article
Clinical Neurology
Esraa M. Elnahas, Sally A. Abuelezz, Magda I. Mohamad, Mai M. Nabil, Sahar M. Abdelraouf, Nevine Bahaa, Ghada A. M. Hassan, Eman A. Ibrahim, Asmaa I. Ahmed, Sawsan Aboul-Fotouh
Summary: Despite the controversy on the timing of exposure to valproic acid (VPA) in inducing autism-like changes in male Wistar rats, this study found that both prenatal and postnatal VPA exposures showed similar effects on inducing autistic-like behaviors and neuropathological changes. The prenatal VPA exposure model demonstrated significant alterations in ASD core symptoms and histopathological changes compared to the postnatal model, with lower postnatal animal mortality.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Maryam Saadat, Abbas Ali Taherian, Mohammad Reza Aldaghi, Payman Raise-Abdullahi, Hamid Reza Sameni, Abbas Ali Vafaei
Summary: This study investigated the effect of Prangos ferulacea on behavioral alterations and neurochemical changes in a rat model of autism induced by prenatal exposure to valproic acid. The results showed that Prangos ferulacea extract reversed the behavioral changes caused by valproic acid and improved oxidative stress markers and apoptotic deficits in the hippocampus. This suggests that Prangos ferulacea may have the potential as an adjunct therapy for autism spectrum disorder.
BRAIN AND BEHAVIOR
(2023)
Article
Food Science & Technology
Ngoc Buu Tran, Haesung Lee, Sook-Jeong Lee
Summary: This study evaluated the effects of cricket and grasshopper extracts on a mouse model of autism spectrum disorder induced by valproic acid exposure. The extracts protected neurons in the brain, restored expression of apoptosis-associated proteins, prevented blood-brain barrier disruption and cerebral edema, and improved gut dysbiosis. These findings suggest a potential therapeutic role of insect extracts in ASD-induced BBB damage and gut microbiome composition alteration.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Integrative & Complementary Medicine
Fatemeh Amini, Hossein Amini-Khoei, Sara Haratizadeh, Mohammad Setayesh, Mohsen Basiri, Mahboobeh Raeiszadeh, Masoumeh Nozari
Summary: The hydroalcoholic extract of Passiflora incarnata can ameliorate behavioral aberrations induced by prenatal valproic acid (VPA) exposure and reduce oxidative stress markers. The results suggest that Passiflora extract may exert its effects through its antioxidant bioactive compounds.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Seyed Ali Seyedinia, Parnia Tarahomi, Davood Abbarin, Katayoun Sedaghat, Ali Rashidy-Pour, Habib Yaribeygi, Abbas Ali Vafaei, Payman Raise-Abdullahi
Summary: This study aimed to determine the effects of saffron extract and crocin on brain oxidative stress and behavioral, motor, and cognitive deficits in an animal model of autism. The results showed that saffron and crocin can alleviate behavioral abnormalities, reduce brain oxidative stress levels, and hold promise as herbal-based pharmacological treatments for individuals with autism.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sweety Mehra, Aitizaz Ul Ahsan, Madhu Sharma, Muskan Budhwar, Mani Chopra
Summary: Autism is a neurodevelopmental condition associated with oxidative stress and altered cellular homeostasis. This study found that fisetin, a bioflavonoid, showed neuroprotective potential in a rodent model of autism. Treatment with fisetin during gestation and post-weaning period improved behavioral impairments by reducing oxidative stress and restoring redox homeostasis.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Environmental Sciences
Shaista Chaudhary, Upasana Sahu, Suhel Parvez
Summary: This study investigates the cellular mechanisms underlying VPA-induced neuronal cell death and the neuroprotective role of exogenous melatonin. The results show that melatonin pre-treatment protects cells from VPA-induced toxicity by regulating apoptotic proteins and pro-inflammatory cytokines, emphasizing novel insights of melatonin as a supplement for preventing and treating neuronal dysfunction induced by VPA.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Plant Sciences
Mishra Abhishek, Singla Rubal, Kumar Rohit, Joshi Rupa, Sarma Phulen, Kaur Gurjeet, Sharma Amit Raj, Prajapat Manisha, Bhatia Alka, Pallola Ramprasad, Medhi Bikash
Summary: This study evaluated the neuroprotective effect and mechanism of action of Bacopa monnieri in a rat model of autism spectrum disorder. The results showed that Bacopa monnieri improved abnormal behavior and had antioxidant and anti-inflammatory properties, possibly through modulating the expression of AMPA receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Summary: This study summarizes the anti-inflammatory efficacy of astaxanthin in various chronic and acute disorders, as well as the pathways through which it mediates its effects. Further experimental and clinical studies are needed to confirm the anti-inflammatory and protective effects of astaxanthin in humans. The review suggests that astaxanthin, with its demonstrated anti-inflammatory properties, may be a suitable candidate for drug design with novel technology.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian
Summary: Astaxanthin (ATX) is a red pigment carotenoid found in shrimp, salmon, crab, and asteroidean, with proven antioxidant efficacy. Nrf2 plays a crucial role in mediating the various protective effects of ATX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Yuyang Peng, Min Li, Yong Huang, Bo Cheng, Zigang Cao, Xinjun Liao, Guanghua Xiong, Fasheng Liu, Chengyu Hu, Huiqiang Lu
Summary: Exposure to bifenazate has immunotoxicity and oxidative stress effects on zebrafish larvae, affecting growth and development, decreasing immune cells, and inhibiting antioxidant activity. Astaxanthin can effectively alleviate this developmental toxicity.
Article
Anatomy & Morphology
Omer Faruk Koroglu, Mehmet Gunata, Nigar Vardi, Azibe Yildiz, Burhan Ates, Cemil Colak, Lokman Hekim Tanriverdi, Hakan Parlakpinar
Summary: Despite the multiple beneficial biological activities of NRG in protecting the liver, the study found that NRG could not effectively prevent histopathological changes in the VPA-induced hepatotoxicity model.
Article
Neurosciences
Arushi Sandhu, Kajal Rawat, Vipasha Gautam, Antika Sharma, Anil Kumar, Lekha Saha
Summary: This study investigated the pharmacological effects of ibudilast in a prenatal valproic acid (VPA) model of autism spectrum disorder (ASD) in Wistar rats. The results showed that ibudilast significantly improved social interaction, spatial learning, anxiety, hyperactivity, and decreased nociceptive threshold, as well as reduced oxidative stress, inflammation, glial cell activation, and neuronal damage in the brain. In conclusion, ibudilast treatment restored crucial ASD-related behavioral abnormalities, potentially through neuroprotection.
Article
Biochemistry & Molecular Biology
Mohammad Javad Khodayar, Heibatullah Kalantari, Layasadat Khorsandi, Nematollah Ahangar, Azin Samimi, Hadis Alidadi
Summary: The study shows that Taurine (Tau) protects liver tissue against Valproic acid (VPA) toxicity by inhibiting the necroptosis signaling pathway and reducing oxidative stress.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Nutrition & Dietetics
Luchuanyang Sun, Nobuyuki Miyaji, Min Yang, Edward M. Mills, Shigeto Taniyama, Takayuki Uchida, Takeshi Nikawa, Jifeng Li, Jie Shi, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: The study demonstrated that astaxanthin (AX) has protective effects on muscle atrophy by preventing loss of muscle weight and suppressing muscle fiber size decrease, hydrogen peroxide production increase, and downregulation of mitochondrial respiratory chain complexes. AX also promoted mitochondrial biogenesis and inhibited mitochondrial reactive oxygen species production and apoptosis, ultimately preventing muscle atrophy.
Article
Pharmacology & Pharmacy
Mithun Saha, Diti Rani Saha, Tahamina Ulhosna, Shazid Md Sharker, Md Hasanuzzaman Shohag, Muhammad Saiful Islam, Swapan K. Ray, G. M. Sayedur Rahman, Hasan Mahmud Reza
Summary: The study successfully developed resveratrol-loaded mucoadhesive lecithin/chitosan nanoparticles to improve drug retention in the eye. Through risk assessments and optimized designs, the formulated nanoparticles had optimal characteristics such as 163.3 nm particle size, 97.03% entrapment efficiency, and zero-order release kinetics with an R2 value of 0.9897.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Md. Ashrafur Rahman, Yeasna Shanjana, Md. Ismail Tushar, Tarif Mahmud, Ghazi Muhammad Sayedur Rahman, Zahid Hossain Milan, Tamanna Sultana, Ali Mohammed Lutful Hoq Chowdhury, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam, Hasan Mahmud Reza
Summary: This study aimed to assess the correlations between hematological parameters and the severity of COVID-19. Among the 306 hospitalized COVID-19 patients, alterations of several hematological parameters were observed between severe and non-severe patients. Levels of CRP, d-dimer, and ferritin at admission were indicative factors for COVID-19 severity.
Article
Pharmacology & Pharmacy
Mithun Saha, Pallabi Sikder, Aditi Saha, Sharha Shah, Sharmin Sultana, Tushar Emran, Ananna Banik, Zahidul Islam, Muhammad Saiful Islam, Shazid Md Sharker, Hasan Mahmud Reza
Summary: This study developed a drug delivery system using piperine to inhibit liver damage caused by flutamide. By utilizing a quality by design approach, an optimized formulation was successfully developed with high payloads, significantly reducing flutamide-induced hepatotoxicity.
Review
Multidisciplinary Sciences
Jason Abaluck, Laura H. Kwong, Ashley Styczynski, Ashraful Haque, Md Alamgir Kabir, Ellen Bates-Jefferys, Emily Crawford, Jade Benjamin-Chung, Shabib Raihan, Shadman Rahman, Salim Benhachmi, Neeti Zaman Bintee, Peter J. Winch, Maqsud Hossain, Hasan Mahmud Reza, Abdullah All Jaber, Shawkee Gulshan Momen, Aura Rahman, Faika Laz Banti, Tahrima Saiha Huq, Stephen P. Luby, Ahmed Mushfiq Mobarak
Summary: A cluster-randomized trial in rural Bangladesh found that distributing masks and promoting their use can effectively reduce symptomatic SARS-CoV-2 infections, with a significant increase in proper mask-wearing and a decrease in the prevalence of infection, especially among adults aged 60 and above.
Review
Biology
Chio Oka, Razwa Saleh, Yasumasa Bessho, Hasan Mahmud Reza
Summary: This review provides a detailed overview of the role of high temperature requirement factor Al (HTRA1) in cellular processes and its association with various diseases, including preeclampsia, age-related macular degeneration (AMD), small vessel disease, and cancer. Additionally, possible therapeutic avenues utilizing HTRA1 are discussed.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Fariha Chowdhury, Sakiba Ahmed, Muntasir Rahman, Md Alomgir Ahmed, Md Delower Hossain, Hasan Mahmud Reza, Sung Young Park, Shazid Md Sharker
Summary: Natural or synthetic polymeric films have gained interest in biomedical research due to their biocompatibility. A nanocomposite film using the chitosan-tannic acid (CT) crosslinking process has been developed, showing antibacterial activity and pH-responsive drug release both in vitro and in vivo.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Asim Kumar Bepari, Hirohide Takebayashi, Jannatun Nayem Namme, Ghazi Muhammad Sayedur Rahman, Hasan Mahmud Reza
Summary: In this study, a computational approach was used to identify a blood-brain-barrier-permeable potent RIPK1 ligand with a novel chemotype. Molecular dynamics simulations validated the binding stability between the ligand and RIPK1. Therefore, this ligand may be a potential drug for inhibiting necroptosis in central nervous system inflammatory disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Md Ashrafur Rahman, Arif Anzum Shuvo, Asim Kumar Bepari, Mehedi Hasan Apu, Manik Chandra Shill, Murad Hossain, Mohammed Uddin, Md Rabiul Islam, Monjurul Kader Bakshi, Javed Hasan, Atiqur Rahman, Ghazi Mohammad Sayedur Rahman, Hasan Mahmud Reza
Summary: Curcumin improves memory impairment in D-Gal and nature-induced aging mice by interacting with multiple proteins and inhibiting oxidative stress and damage.
Article
Polymer Science
Syed Abul Layes Gausuzzaman, Mithun Saha, Shahid Jaman Dip, Shaiful Alam, Arup Kumar, Harinarayan Das, Shazid Md Sharker, Md Abdur Rashid, Mohsin Kazi, Hasan Mahmud Reza
Summary: An optimal self-emulsifying formulation can significantly increase the bioavailability of resveratrol through lymphatic transport to achieve the desired pharmacological effects.
Article
Food Science & Technology
Anika Tabassum Bristy, Tairin Islam, Rezwana Ahmed, Jumana Hossain, Hasan Mahmud Reza, Preeti Jain
Summary: This study investigated the phenolic and flavonoid content as well as the antioxidant properties of ethanolic extracts from three different varieties of mushrooms grown in Bangladesh. The results showed that the extract from G. lucidum had the highest antioxidant potential and phenolic content, while the extracts from the other two mushrooms also exhibited significant antioxidant properties. Additionally, G. lucidum demonstrated alpha-amylase inhibitory and antibacterial activities.
INTERNATIONAL JOURNAL OF FOOD SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Satyajit Kundu, Subarna Kundu, Md. Ashfikur Rahman, Humayun Kabir, Md. Hasan Al Banna, Saurav Basu, Hasan Mahmud Reza, Ahmed Hossain
Summary: This study investigated the prevalence and factors associated with contraceptive methods use in Bangladesh. The results showed that older women, women with living children, and husbands/partners' decision were related to the use of both modern and traditional contraceptive methods. Rural participants were less likely to use modern methods. The study highlights the importance of male partners' decision-making regarding women's contraceptive use.
Article
Multidisciplinary Sciences
Manik Chandra Shill, Md Nurul Absar Bin Mohsin, Usha Showdagor, Sharif Nahid Hasan, Md Zahidul Islam Zahid, Sabrin Islam Khan, Murad Hossain, Ghazi Mohammad Sayedur Rahman, Hasan Mahmud Reza
Summary: This study compared the antibiotic sensitivity in urinary tract infection (UTI) patients with and without diabetes, and found that patients with diabetes had lower sensitivity to certain antibiotics.
Article
Biochemistry & Molecular Biology
Jannatun Nayem Namme, Hasan Mahmud Reza, Asim Kumar Bepari
Summary: Polymorphisms of ADAM10 are associated with various pathophysiological changes. This study analyzed the pathogenicity of ADAM10 non-synonymous single nucleotide polymorphisms (nsSNPs) using bioinformatics tools. Thirteen nsSNPs were predicted to be deleterious by all ten tools and C222G, G361E, and C639Y were identified as the most pathogenic mutations. Further analysis confirmed the stability of these variants. These findings suggest that ADAM10 nsSNPs could be potential candidates for genetic screening and therapeutic targeting.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Md Hasanuzzaman Shohag, Syed Abdul Kuddus, Esfat M. Saim Brishty, Salman Sakir Chowdhury, Md Tofazzal Hossain, Maruf Hasan, Sabrin Islam Khan, Murad Hossain, Hasan Mahmud Reza
Summary: Antibiotic resistance is a growing public health threat, with increasing mortality rates. This study evaluated the quality attributes of commonly prescribed brands of ciprofloxacin tablets in Bangladesh, finding that most brands met potency and dissolution test specifications. However, some brands exhibited differences in dissolution profiles and one brand failed potency standards. All brands showed good antimicrobial sensitivity in minimum inhibitory concentration tests.
Article
Multidisciplinary Sciences
Md. Ashrafur Rahman, Arif Anzum Shuvo, Md. Mehedi Hasan Apu, Monisha Rani Bhakta, Farzana Islam, Md. Atiqur Rahman, Md. Rabiul Islam, Hasan Mahmud Reza
Summary: Previously, it was observed that curcumin can improve aging-associated memory impairment, and this study further discovered that the combination of curcumin and EGCG can effectively improve memory problems caused by aging, while reducing oxidative stress through multiple pathways.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)