Article
Cardiac & Cardiovascular Systems
Mohamed F. Elsisy, Joseph A. Dearani, Juan A. Crestanello, Elena A. Ashikhmina, Charlotte S. Van Dorn, Elizabeth H. Stephens
Summary: This study found that delayed sternal closure (DSC) yielded better outcomes for hemodynamic instability and severe coagulopathy after complex congenital heart surgery compared to perioperative sternal reopening.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Juan A. Crestanello, Kevin Greason, Mohamed Elsisy, Brian Lahr, Gabor Bagameri, Richard Daly, John Stulak, Joseph Dearani, Hartzell Schaff
Summary: This study examined the indications and temporal trends for delayed sternal closure (DSC) after cardiac surgery, as well as factors associated with time to chest closure and its impact on short-term and long-term outcomes. Longer time to chest closure was associated with increased rates of operative complications and operative mortality, but did not have a statistically significant association with long-term survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Surgery
Adam S. Levy, Chloe L. Altchek, Elizabeth M. McMillen, Sarah J. Karinja, Jonathan R. Tiao, Craig R. Smith, Jeffrey A. Ascherman
Summary: For patients with sternal wound infection or dehiscence following cardiac surgery, performing sternal wound reconstruction within 30 days is recommended to reduce the risk of postoperative infection and wound complications.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed Asfari, Jeffrey P. Jacobs, Jonathan W. Byrnes, Santiago Borasino, Parthak Prodhan, Hayden Zaccagni, Robert J. Dabal, Robert A. Sorabella, James M. Hammel, Melissa Smith-Parrish, Wenying Zhang, Mousumi Banerjee, Kurt R. Schumacher, Sarah Tabbutt
Summary: In this retrospective study of neonates undergoing the Norwood operation, delayed sternal closure (DSC) was found in 74% of cases. There was no statistical difference in mortality rate and hospital postoperative stay between closed sternum and early sternal closure, while patients with intermediate sternal closure required longer mechanical ventilation and fewer subsequent sternotomies.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Faisal Mourad, Ihab Ali
Summary: The interlocking multi-twist sternal closure method is more effective in preventing sternal dehiscence compared to simple wire closure. There were no significant differences between the two groups in terms of wound infection, length of stay in the ICU, and duration of mechanical ventilation.
HEART SURGERY FORUM
(2021)
Article
Respiratory System
Audrey L. Khoury, Sapna Patel, Smith Ngeve, Kayla Doughty, Hadley K. Wilson, Thomas G. Caranasos
Summary: The traditional stainless steel wire cerclage for sternal closure after median sternotomy has various complications. The Figure 8 FlatWire Sternal Closure System is stronger and reduces sternum cut-through and postoperative pain significantly. The operative time is slightly longer but not significantly different.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Nanoscience & Nanotechnology
Sevgi Balcioglu, Samir Abbas Ali Noma, Ahmet Ulu, Merve Goksin Karaaslan-Tunc, Onural Ozhan, Suleyman Koytepe, Hakan Parlakpinar, Nigar Vardi, Mehmet Cengiz Colak, Burhan Ates
Summary: Wire cerclage is commonly used for sternal closure, but it has disadvantages such as tissue trauma and infection risk. To address these issues, a biocompatible and biodegradable tissue adhesive called PU-A was developed and tested. It showed high adhesion strength, biocompatibility, biodegradability, and antibacterial properties. When used for sternal closure in rats, it resulted in minimal inflammation compared to other methods. This adhesive shows promise for sternal fixation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cardiac & Cardiovascular Systems
Shigeto Tsuji, Akio Ikai, Kotaro Oyama, Hajime Kin, Junichi Koizumi
Summary: This study retrospectively analyzed the outcomes of debridement and primary sternal closure for postoperative mediastinitis in children, and found that primary sternal closure is an effective procedure with high survival rates and low reintervention rates. It significantly shortens treatment duration and reduces complications such as physical deformities and infection recurrence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Vishnu Vasanthan, Ali Fatehi Hassanabad, Sean Kang, Jameson Dundas, Darlene Ramadan, Daniel Holloway, Corey Adams, Muhammad Ahsan, Paul W. M. Fedak
Summary: Enhanced sternal closure improves and accelerates postoperative recovery, providing benefits in terms of functional recovery, quality of life, and hospital stay.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Ahmed M. A. Shafi, Eyad Abuelgasim, Biyaser Abuelgasim, Sashini Iddawela, Amer Harky
Summary: The study compared different sternal closure techniques in obese patients undergoing cardiac surgery, finding that double or figure-of-8 wire closure techniques were more effective in reducing sternal instability compared to single wire closure. Further large-scale comparative studies are needed to provide solid evidence for selecting the optimal sternal closure technique in this high-risk patient population.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Andrea Dell'Amore, Martin Kalab, Archibald Sandford Miller, Giampiero Dolci, Valeria Liparulo, Farahnaz Sadegh Beigee, Lorenzo Rosso, Pia Ferrigno, Alessandro Pangoni, Marco Schiavon, Tommaso Bottio, Francesco Puma, Vladimir Lonsky, Federico Rea
Summary: The study reviewed the clinical indications and outcomes of sternal chondral allograft transplantation in 58 patients, demonstrating that it is a safe and effective method for reconstructing the anterior chest wall after sternectomy, with a 74% survival rate at 5 years.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Paul Philipp Heinisch, Maria Nucera, Maris Bartkevics, Gabor Erdoes, Damian Hutter, Martin Gloeckler, Alexander Kadner
Summary: The study showed that the novel absorbable, knotless suture technique led to excellent results in sternal closure in pediatric cardiac surgical procedures, significantly reducing the rate of sternal wound infection and promoting healing.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Thais Pittet, Stephane Cook, Gregory Khatchatourov, Nicolas Theumann
Summary: Sternal pseudarthrosis after cardiac surgery can be treated with percutaneous cementoplasty, which effectively reduces pain and improves patients' quality of life.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Seyedreza Kashef Tabrizian, Seppe Terryn, Aleix Costa Cornella, Joost Brancart, Julie Legrand, Guy Van Assche, Bram Vanderborght
Summary: This paper introduces a new type of self-healing soft robot, using a shape memory alloy reinforced soft bending actuator, which can recover from large incisions through shape memory assisted healing. This healing method is achieved by the contraction of alloy wires to bring the fracture surfaces into contact and promote healing. Mechanical and ultrasound tests on the specimen level, as well as bending characterization of the pneumatic robot in multiple damage healing cycles, are conducted to study this novel healing approach.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Abdullah Dogan, Elif Tekin Ada, Riza Turkoz
Summary: Delayed sternal closure is used to promote postoperative recovery in complex pediatric cardiac surgeries. Introducing a new instrument, similar to an adult eye speculum, has shown potential in keeping the sternum open in neonates and infants, improving outcomes in this patient population.
JOURNAL OF CARDIAC SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Friederike I. Schoettler, Payam Akhyari, Paul W. M. Fedak
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Maximilian Luehr, Carolyn Weber, Martin Misfeld, Artur Lichtenberg, Sems-Malte Tugtekin, Mahmoud Diab, Shekhar Saha, Yupeng Li, Klaus Matsche, Torsten Doenst, Michael A. Borger, Thorsten Wahlers, Payam Akhyari, Christian Hagl
Summary: This study aimed to explore the virulence of Staphylococcus species in infectious endocarditis (IE) compared to other commonly causative bacteria in terms of short-term and long-term mortality. The results showed that patients with Staphylococcus IE had significantly higher mortality rates than those with IE caused by other bacteria. It is recommended to make an early diagnosis and refer patients with Staphylococcus infection to specialized centers for surgical treatment to reduce the risk of septic embolism and stroke.
Article
Engineering, Biomedical
Moritz Benjamin Immohr, Fabio Dos Santos Adrego, Helena Lauren Teichert, Vera Schmidt, Yukiharu Sugimura, Sebastian Bauer, Mareike Barth, Artur Lichtenberg, Payam Akhyari
Summary: Calcific aortic valve disease (CAVD) is a common cardiac pathology in the aging society, and the mechanisms behind it are not fully understood. 3D-bioprinting can be used to develop tissue-engineered cellular models to investigate the underlying mechanisms of CAVD.
BIOMEDICAL MATERIALS
(2023)
Article
Surgery
Moritz Benjamin Immohr, Christina Ballazs, Vincent Hettlich, Daniel Scheiber, Florian Boenner, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Udo Boeken
Summary: The COVID-19 pandemic has had a significant impact on heart transplantation, affecting both donors and recipients. The pandemic has led to changes in the etiology of heart failure in recipients, a decrease in high urgency status and the use of left ventricular assist devices, and a shorter waiting time. Donors are more likely to have heart disease and marginal donors are being accepted. Surprisingly, the postoperative outcome has not been affected.
CLINICAL TRANSPLANTATION
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Yingfei Xue, Payam Akhyari, Bin Duan, Hooi Hooi Ng, Zongmin Zhao
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Moritz Benjamin Immohr, Arash Mehdiani, Daniel Oehler, Vincent Hendrik Hettlich, Freya Sophie Jenkins, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Udo Boeken, Artur Lichtenberg, Payam Akhyari
Summary: This study investigated the impact of circadian rhythm and daytime variation on heart transplantation outcomes. The results showed that the timing of the surgery in the morning, afternoon, or night did not significantly affect postoperative adverse events and survival rates. Therefore, the current practice of scheduling surgery can continue.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Arash Mehdiani, Sebastian Johannes Bauer, Hayato Ise, Yukiharu Sugimura, Artur Lichtenberg, Payam Akhyari
Summary: This study explored the application of AMDS in patients requiring additional aortic root surgery and found that although the surgery time was prolonged, the postoperative complications and mortality rate during hospitalization were comparable to conventional surgical methods.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Vincent Hendrik Hettlich, Detlef Kindgen-Milles, Timo Brandenburger, Torsten Feldt, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Hannan Dalyanoglu, Udo Boeken
Summary: This study analyzed the effectiveness and changes in vv-ECMO therapy for COVID-19-related acute respiratory distress syndrome patients in Germany. The study found that during the second wave, there were changes in cannulation technique and the implementation of awake ECMO. The duration of ECMO support increased significantly and there were improvements in the weaning rate and in-hospital mortality.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Engineering, Biomedical
Alicia Fernandez-Colino, Fabian Kiessling, Ioana Slabu, Laura De Laporte, Payam Akhyari, Saskia K. Nagel, Julia Stingl, Stefanie Reese, Stefan Jockenhoevel
Summary: By studying the construction rules of living organisms, it is possible to develop biomimetic materials and biomedical systems. The article highlights recent advances in transformative biohybrid systems for tissue regeneration and biomedicine, as well as the progress in computational simulations and data-driven predictions. The ongoing development of imaging methods is also essential for validating computational models and enabling longitudinal monitoring. The challenges and future prospects of lifelike biohybrid materials are discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Jose L. Gerardo-Nava, Jitske Jansen, Daniel Guenther, Laura Klasen, Anja Lena Thiebes, Bastian Niessing, Cedric Bergerbit, Anna A. Meyer, John Linkhorst, Mareike Barth, Payam Akhyari, Julia Stingl, Saskia Nagel, Thomas Stiehl, Angelika Lampert, Rudolf Leube, Matthias Wessling, Francesca Santoro, Sven Ingebrandt, Stefan Jockenhoevel, Andreas Herrmann, Horst Fischer, Wolfgang Wagner, Robert H. Schmitt, Fabian Kiessling, Rafael Kramann, Laura De Laporte
Summary: Recreating human tissues and organs in the petri dish to establish models as tools in biomedical sciences has gained momentum. Transformative materials play an important role in this evolution, as they can be programmed to direct cell behavior and fate. This paper illustrates state-of-the-art developments in in vitro tissue engineering and the challenges related to the design, production, and translation of transformative materials, emphasizing the need for convergence of different technologies to generate functional human tissue models.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Payam Akhyari, Moritz Benjamin Immohr, Florian Boenner, Petra Reinecke, Artur Lichtenberg, Udo Boeken
Summary: The incidence of SARS-CoV-2 remains high in the population, leading to an increasing number of organ donors testing positive for the virus. However, heart transplants from SARS-CoV-2 positive donors have traditionally been rejected due to potential unnoticed cardiovascular effects. This study presents three consecutive patients who underwent heart transplants from SARS-CoV-2 positive donors and showed good outcomes without rejection, viral myocarditis, or SARS-CoV-2 infection.
Article
Cardiac & Cardiovascular Systems
Anna Kathrin Assmann, Artur Lichtenberg, Alexander Assmann, Payam Akhyari
Summary: This study used a microsurgical small animal model to investigate the effects of pioglitazone, a PPAR-γ agonist, on the degeneration of cardiovascular grafts. It was found that pioglitazone administration significantly reduced inflammatory and calcifying degeneration of the grafts, and improved their functional outcome.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Oehler, Hannah Oehler, Dennis Sigetti, Moritz Benjamin Immohr, Charlotte Boettger, Raphael Romano Bruno, Jafer Haschemi, Hug Aubin, Patrick Horn, Ralf Westenfeld, Florian Boenner, Payam Akhyari, Malte Kelm, Artur Lichtenberg, Udo Boeken
Summary: This study aimed to investigate the association between neurologic events during hospitalization and the outcome and survival of heart transplant recipients. The results showed that neurologic events after heart transplant were strongly associated with worse postoperative outcomes and reduced survival up to 5 years after transplant.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Biology
Daniel Oehler, Charlotte Boettger, Moritz Benjamin Immohr, Raphael Romano Bruno, Jafer Haschemi, Daniel Scheiber, Patrick Horn, Hug Aubin, Igor Tudorache, Ralf Westenfeld, Payam Akhyari, Malte Kelm, Artur Lichtenberg, Udo Boeken
Correction
Surgery
Moritz Benjamin Immohr, Christina Ballazs, Vincent Hettlich, Dennis Sigetti, Daniel Scheiber, Florian Boenner, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Udo Boeken
CLINICAL TRANSPLANTATION
(2023)