Article
Materials Science, Biomaterials
Xiao Yue, Xuejuan Zhang, Chen Wang, Ying Huang, Ping Hu, Guanlin Wang, Yingtong Cui, Xiao Xia, Ziqiang Zhou, Xin Pan, Chuanbin Wu
Summary: A lyotropic liquid crystal-based bacteria-resistant and self-healing spray dressing loaded with epsilon-polylysine (PLL) was designed to effectively kill antibiotic-resistant bacteria and promote wound healing. The dressing demonstrated excellent antibacterial activity and mechanical properties, making it a promising candidate for therapy of infected post-operative wounds.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Multidisciplinary Sciences
Evi Sulastri, Ronny Lesmana, Muhammad Sulaiman Zubair, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Nasrul Wathoni
Summary: In this study, a new hydrogel film wound dressing composed of ulvan and silver nanoparticles (AgNP) was developed. The UHF-AgNP0.5 showed the highest antimicrobial activity and significantly accelerated the healing process of second-degree burns. Ulvan-silver nanoparticle hydrogel films have the potential to be ideal wound dressings.
Article
Chemistry, Physical
Maryam Azizi-Lalabadi, Farhad Garavand, Seid Mahdi Jafari
Summary: Developing novel composite systems using new strategies is a popular area of interest, with a focus on raising awareness of health and safety issues. Utilizing nanoparticles, particularly silver nanoparticles, within composite materials has shown to enhance their physical, mechanical, and antimicrobial characteristics, making them valuable in various applications. Safety precautions and evaluation techniques are crucial aspects in the implementation of nanocomposites containing silver nanoparticles.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Farah N. S. Raja, Tony Worthington, Richard A. Martin
Summary: With the development of nanotechnology, there is growing interest in the antimicrobial potential of metals. This study evaluated the antimicrobial efficacy of metallic copper, cobalt, silver, and zinc nanoparticles against various bacteria strains. The results showed that the metal nanoparticles exhibited broad-spectrum antimicrobial activity with varying degrees of sensitivity among different strains.
BIOMEDICAL MATERIALS
(2023)
Article
Polymer Science
Matheus Carlos Romeiro Miranda, Nicola Carlucci Sato, Giovana Sant'Ana Pegorin Brasil, Rodolfo Debone Piazza, Miguel Jafelicci Jr, Natan Roberto de Barros, Felipe Azevedo Borges, Augusto Batagin-Neto, William de Melo Silva, Rondinelli Donizetti Herculano, Nayrim Brizuela Guerra
Summary: The study utilized silver nanoparticles to reduce the toxic effects of metronidazole, demonstrating through release assays and molecular modeling that nanoparticles can interact more efficiently with metronidazole molecules. The similarities in reactivity between natural rubber latex and metronidazole suggest that some drug molecules may remain in the matrix during the release process.
Article
Chemistry, Applied
Hessah Alotaibi, Etelka Chung, Se Hun Chung, Guogang Ren, Vikramjeet Singh, Jie Huang
Summary: Nanosized CD-MOF was synthesized using triethylamine as a modulator, which showed unaffected crystal and chemical structure and a higher surface area compared to CD-MOF synthesized with bulky modulators. The improved CD-MOF supported the in-situ synthesis of silver nanoparticles, resulting in enhanced antimicrobial efficacy against bacteria and fungus. The minimum inhibitory concentration ranged from 31-15 μg/mL. Overall, the structural improvement in CD-MOF has great potential in the field of biomedicine.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Katarina Nesovic, Vesna Miskovic-Stankovic
Summary: This study aimed to analyze silver release from electrochemically synthesized antibacterial silver nanoparticles loaded poly(vinyl alcohol) hydrogels for wound dressing applications, showing potential in antibacterial activity assessment against Staphylococcus aureus and Escherichia coli bacterial strains.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Mukesh Saran, Ajit Kumar, Manas Mathur, Ashima Bagaria
Summary: This study reports the synthesis, characterization, and antibacterial efficacy of nanocomposites derived from carbon nanoparticles and silver nanoparticles. The CNP-AgNP nanocomposite showed efficient antibacterial properties against various strains, indicating its potential as an antibacterial agent.
Article
Infectious Diseases
Sathit Malawong, Saengrawee Thammawithan, Pawinee Sirithongsuk, Sakda Daduang, Sompong Klaynongsruang, Pamela T. Wong, Rina Patramanon
Summary: The study demonstrated that combining antibiotics with silver nanoparticles can effectively enhance the antibacterial effects against Burkholderia pseudomallei, showing a synergistic antimicrobial effect, especially the combination of gentamicin sulfate with AgNPs exhibited the most significant enhancing effect.
Article
Biochemistry & Molecular Biology
Felipe Azevedo Borges, Bruno de Camargo Drago, Luis Otavio Baggio, Natan Roberto de Barros, Giovana Sant'Ana Pegorin Brasil, Mateus Scontri, Cassamo Ussemane Mussagy, Matheus Cicero da Silva Ribeiro, Debora Marcondes Bastos Pereira Milori, Carla Pereira de Morais, Bruno Spolon Marangoni, Gustavo Nicolodelli, Marvin Mecwan, Kalpana Mandal, Nayrim Brizuela Guerra, Carlos Renato Menegatti, Rondinelli Donizetti Herculano
Summary: Gold nanoparticles (AuNPs) and the antibiotic metronidazole (MET) can be effectively released using natural rubber latex (NRL) as a carrier, providing new opportunities for controlled release systems. The AuNP-MET-NRL wound dressing showed a second-order exponential release profile, with 64.70% released within 100 hours. The dressing also exhibited excellent biocompatibility and cell viability, making it a promising approach for dermal applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Ali Afzal, Mohammed Jalalah, Abid Noor, Zubair Khaliq, Muhammad Bilal Qadir, Rashid Masood, Ahsan Nazir, Sheraz Ahmad, Faheem Ahmad, Muhammad Irfan, Munazza Afzal, Mohd Faisal, Saeed A. Alsareii, Farid A. Harraz
Summary: Nowadays, synthetic polymers with special properties such as biodegradability, biocompatibility, hydrophilicity, and non-toxicity are widely used in medical applications. This study aims to develop and characterize PVA/PCL fibers containing a model drug for controlled drug release in wound dressing. The wet spinning technique was used to produce PVA/PCL fibers from a dope solution, and the fibers were tested for various properties related to wound healing. The results showed that the developed PVA/PCL fibers have respectable tensile properties, adequate liquid absorption, swelling behavior, degradation, and antimicrobial activity, as well as a controlled drug release profile.
Article
Biochemistry & Molecular Biology
Priyadarshani Choudhary, Baskaran Ramalingam, Sujoy K. Das
Summary: Wound dressings with poor antibacterial properties, adhesion to the wound site, weak mechanical strength, and lack of porosity and flexibility lead to blood loss, delayed wound repair, and sometimes death. In this study, a multifunctional graphene-based nanobiocomposite wound dressing was developed, which demonstrated hydrophilic properties, good mechanical strength, antibacterial activity, non-toxicity to cells, and pro-angiogenic potential. In in-vivo studies using a rat model, the nanobiocomposite dressing significantly enhanced wound healing compared to commercially available dressings, achieving complete wound closure in 14 days. Overall, the CGAPL nanobiocomposite dressing offers a novel and efficient solution for faster wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiangyan Chen, Hongjin Li, Xiaoni Qiao, Tianze Jiang, Xue Fu, Yue He, Xia Zhao
Summary: Marine agarose oligosaccharides and silver nanoparticles combined with antimicrobial peptides form a novel composite nanomaterial, which shows significant promoting effects on wound healing with strong antimicrobial activities and good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Pegah Sanjarnia, Jhamak Nourmohammadi, Saeed Hesaraki
Summary: This research introduces a new wound dressing made from chitosan and copper-containing Janus nanoparticles (JNPs) that have antibacterial and anti-inflammatory properties. The JNPs were synthesized by attaching copper to PDA nanospheres and were embedded in chitosan at different concentrations. The resulting JNPs showed successful adhesion of Cu2+ ions and increased pore size and porosity with higher JNPs concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Changchang Kong, Shijunyin Chen, Wenhao Ge, Yang Zhao, Xiaodong Xu, Shiming Wang, Jianfa Zhang
Summary: In this study, an antibacterial and anti-inflammatory wound dressing based on riclin and silver nanoparticles was developed. The results showed that the dressing had sustained release of silver nanoparticles, effectively suppressed pathogen growth, and had negligible toxicity to human cells. In addition, it promoted faster and smoother wound healing while reducing the expression of inflammatory mediators.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)