期刊
INTERNATIONAL JOURNAL OF POLYMER SCIENCE
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/340121
关键词
-
资金
- Ministry of Higher Education (MOHE) through Fundamental Research Grant Scheme (FRGS) [01(17)746/2010(32)]
- MyBrain15 (MyMaster) Programme
Curcumin was loaded onto starch nanoparticles by using in situ nanoprecipitation method and water-in-oil microemulsion system. Curcumin loaded starch nanoparticles exhibited enhanced solubility in aqueous solution as compared to free curcumin. Effects of formulation parameters such as types of reaction medium, types of surfactant, surfactant concentrations, oil/ethanol ratios, loading time, and initial curcumin concentration were found to affect the particle size and loading efficiency (LF) of the curcumin loaded starch nanoparticles. Under optimum conditions, curcumin loaded starch nanoparticles with mean particles size of 87 nm and maximum loading efficiency of 78% were achieved. Curcumin was observed to release out from starch nanoparticles in a sustained way under physiological pH over a period of 10 days.
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