Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Claudia Campana, Francesco Cocchiara, Giuliana Corica, Federica Nista, Marica Arvigo, Jessica Amaru, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Federico Gatto
Summary: Discordance between GH and IGF-1 levels in acromegaly patients is influenced by GH cutoff values. The use of GH(m) can mitigate the impact of GH cutoffs and improve predictive accuracy. Fasting GH levels (both GH(f) and GH(m)) are poor predictors of IGF-1 normalization in this cohort.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Denise Costa, Rosa Lauretta, Valeria Mercuri, Emilia Sbardella, Irene Samperi, Marialuisa Appetecchia, Antonio Bianchi, Antonella Giampietro, Patrizia Gargiulo, Andrea M. Isidori, Maurizio Poggi, Alfredo Pontecorvi, Laura De Marinis
Summary: This study investigated the treatment choices and outcomes for acromegaly patients resistant to first generation somatostatin analogues. The results showed that c-Peg-V and Pasi-Lar were chosen for the treatment of invasive tumors, and partial response to first gen-SSA seemed to be the main determinant for the choice of Pasi-Lar and positively predicted the treatment outcome.
Article
Endocrinology & Metabolism
Lukasz Mizera, Jowita Halupczok-Zyla, Katarzyna Kolackov, Agnieszka Zembska, Jedrzej Grzegrzolka, Diana Jedrzejuk, Marek Bolanowski, Jacek Daroszewski
Summary: The study found that irisin levels were significantly lower in acromegaly patients compared to controls, suggesting impaired hormonal muscle function contributing to metabolic complications in this disorder. On the other hand, myostatin does not appear to play a critical role in regulating muscle mass in acromegaly. Further studies are needed to better understand the relationship between myostatin and growth hormone in acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Malgorzata Rolla, Aleksandra Jawiarczyk-Przybylowska, Jowita Halupczok-Zyla, Marcin Kaluzny, Bogumil M. Konopka, Izabela Bloniecka, Grzegorz Zielinski, Marek Bolanowski
Summary: Acromegaly patients, predominantly female, commonly suffer from complications such as metabolic disorders, cardiovascular diseases, and endocrine disorders. A majority of patients demonstrate a coexistence of cardiac, metabolic, and endocrine disturbances, with a small percentage being disease-free in these main groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Christopher J. Unterberger, Vilena Maklakova, Michelle Lazar, Paige D. Arneson, Sean J. Mcilwain, Philippos K. Tsourkas, Rong Hu, John J. Kopchick, Steven M. Swanson, Paul C. Marker
Summary: This study investigates the species specificity of growth hormone (GH)-growth hormone receptor (GHR) activity in prostate cancer cells. In vitro experiments show that GH stimulates the growth of prostate cancer cells, while pegvisomant reduces cell proliferation. RNA sequencing reveals that pegvisomant regulates numerous genes implicated in cancer. Some genes show similar regulation by pegvisomant in both in vitro and in vivo settings, indicating direct regulation by GH via GHR activation in prostate cancer cells, while other genes respond to pegvisomant only in vivo, suggesting indirect regulation via its effects on the host endocrine environment.
Article
Endocrinology & Metabolism
Martina Romanisio, Rosa Pitino, Alice Ferrero, Francesca Pizzolitto, Samuele Costelli, Valentina Antoniotti, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam, Marina Caputo
Summary: This study evaluated metabolic comorbidities in surgically treated acromegalic patients and found that the discrepancy between GH and IGF-1 levels does not appear to be a risk factor for their presence or persistence. Further extended studies are needed to confirm these results in the long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
M. Parolin, F. Dassie, R. Vettor, R. P. Steeds, P. Maffei
Summary: Acromegaly is associated with specific cardiomyopathy, and while evidence of increased arrhythmia risk is limited, impaired preclinical markers of arrhythmia have been reported. Current position statements and guidelines recommend routine ECG and TTE in every acromegaly patient at diagnosis, with follow-up based on initial findings due to insufficient data on arrhythmia risk.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Luigi Maione, Cristina Albrici, Solange Grunenwald, Celine Mouly, Vincenzo Cimino, Anne-Lise Lecoq, Jean Claude Souberbielle, Philippe Caron, Philippe Chanson
Summary: This study compared the serum IGF-I dynamics and variability in patients treated with SRLs, surgically cured patients, and healthy controls. The results showed that IGF-I decreased significantly at Day 7 and Day 14 after injection in SRL-treated patients, but remained stable in cured patients and healthy controls. In addition, SRL-treated patients had higher IGF-I variability, especially in nonoptimally controlled patients. The measurement at the farthest distance from SRL injection was the best predictor of optimal disease control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Emmanuelle Kuhn, Philippe Caron, Brigitte Delemer, Isabelle Raingeard, Herve Lefebvre, Gerald Raverot, Christine Cortet-Rudelli, Rachel Desailloud, Clementine Geffroy, Robin Henocque, Yves Brault, Thierry Brue, Philippe Chanson
Summary: The study aimed to define the medical reasons for treating patients with Pegvisomant (PEG) as monotherapy or combined therapy with somatostatin analogs (SAs). Results showed different patterns of treatment based on patient characteristics and response to therapy, with a focus on tumor concern and ease of normalizing IGF-I levels. Overall, the prospect of reducing PEG injection frequency favored the choice of combined therapy in certain cases.
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Summary: A personalized approach to acromegaly treatment, utilizing novel clinical and molecular biomarkers, has shown promising results in predicting responsiveness to second-line medical treatments. Integrating these findings into existing guidelines may significantly improve the management of difficult acromegaly patients.
Review
Endocrinology & Metabolism
S. Camerini, A. Wennberg, M. Adriani, B. Martin, R. Vettor, P. Maffei, F. Dassie
Summary: This review provides a description of disease-specific tools for acromegaly, including both patient-reported and clinician-reported outcome tools. These tools are flexible and widely adopted by endocrinologists to assist in evaluating patients' symptoms and disease activity.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, Research & Experimental
Jacobo Kerbel, Amayrani Cano-Zaragoza, Rodrigo Espinosa-Dorado, Keren-Enid Garcia de la Torre, Moises Mercado
Summary: National registries are valuable tools to investigate rare conditions like acromegaly, providing insights into epidemiology, clinical presentation, diagnosis, treatment outcomes, and mortality. While single-center studies are more homogeneous, they are often limited by small sample sizes and lack statistical power.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Rosaria Maddalena Ruggeri, Salvatore Giovinazzo, Maria Cristina Barbalace, Mariateresa Cristani, Angela Alibrandi, Teresa M. Vicchio, Giuseppe Giuffrida, Mohamed H. Aguennouz, Marco Malaguti, Cristina Angeloni, Francesco Trimarchi, Silvana Hrelia, Alfredo Campenni, Salvatore Cannavo
Summary: The study found that individuals with Hashimoto's thyroiditis had higher intake frequencies of animal foods compared to controls, while controls reported higher intake frequencies of plant foods. Meat consumption was associated with increased odds of developing thyroid autoimmunity, while adherence to Mediterranean diet traits was protective. In Hashimoto's thyroiditis subjects, markers of oxidative stress were significantly higher and antioxidant activity was lower, indicating a condition of oxidative stress.
Article
Endocrinology & Metabolism
C. Bona, N. Prencipe, M. L. Jaffrain-Rea, G. Carosi, R. Lanzi, M. R. Ambrosio, D. Pasquali, R. Vettor, S. Cannavo, E. Ghigo, S. Grottoli
Summary: The study aimed to evaluate the somatotroph axis in patients with prolactinoma to confirm the prevalence of silent acromegaly in the population. High IGF-I levels were observed in a small percentage of patients, with only one case of silent acromegaly diagnosed. It was suggested that evaluation of the somatotroph axis at diagnosis should be conducted in all cases rather than systematically during follow-up.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
S. Puglisi, A. Rossini, I Tabaro, S. Cannavo, F. Ferrau', M. Ragonese, G. Borretta, M. Pellegrino, F. Dughera, A. Parisi, A. Latina, A. Pia, M. Terzolo, G. Reimondo
Summary: This study found that the etiology of adrenal insufficiency impacts the choice of glucocorticoids used, with weight-based individualization in secondary AI, the possibility of initial glucocorticoid overdosage in primary AI women, and successful increases in fludrocortisone acetate doses to avoid glucocorticoid over-treatment.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
F. Ferrau, F. Ceccato, S. Cannavo, C. Scaroni
Summary: Glucocorticoids (GCs), when used in SARS-CoV-2 patients, can lead to symptoms of hypercortisolism or hypoadrenalism, impacting mortality risk. Additionally, coadministration of antiretroviral drugs and corticosteroids may enhance drug-drug interaction and impact HPA axis function, emphasizing the need for appropriate tapering of GC dose and awareness of potential interactions.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Valeria Barresi, Michele Simbolo, Marco Gessi, Sabrina Rossi, Maria Caffo, Albino Eccher, Filippo Flavio Angileri, Salvatore Cannavo, Matteo Brunelli, Aldo Scarpa
Summary: Posterior pituitary tumors, including spindle cell oncocytomas (SCOs), pituicytomas, and granular cell tumors, exhibit differences in clinical-pathological, immunohistochemical, and genetic features. Common genetic alterations may be shared among these tumors, suggesting the possibility of including SMARCA4/SMARCB1-deficiency in the differential diagnosis.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Salvatore Giovinazzo, Soraya Puglisi, Oana R. Cotta, Angela Alibrandi, Tommaso Aversa, Laura Cannavo, Francesco Ferrau, Salvatore Cannavo
Summary: The study found an increased prevalence of overweight/obesity only in pediatric and adolescent patients with GH- or ACTH-secreting pituitary adenomas. Additionally, the study suggests a careful metabolic management for patients during treatment, as there was no correlation found between pituitary tumor size and BMI in the study.
Article
Biochemistry & Molecular Biology
Susanne Kohl, Britta Baumann, Francesca Dassie, Anja K. Mayer, Maria Solaki, Peggy Reuter, Laura Kuehlewein, Bernd Wissinger, Pietro Maffei
Summary: This study identified a homozygous variant in the CNGA3 gene in a patient with ACHM, with the variant being detected in a heterozygous state in the father but not in the mother. The homozygosity of the CNGA3 variant in the patient was found to be due to partial or complete paternal uniparental isodisomy. In addition to the ACHM phenotype, the patient was clinically unsuspicious and healthy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Endocrinology & Metabolism
Giuseppe Giuffrida, Alfredo Campenni, Salvatore Cannavo, Rosaria M. Ruggeri
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Marta Ragonese, Gianluca Di Bella, Federica Spagnolo, Loredana Grasso, Angela Alibrandi, Guiseppe Giuffrida, Mariacarla Moleti, Francesco Ferrau, Salvatore Cannavo
Summary: High NT-pro-BNP levels are associated with an increased risk of fatal or non-fatal CV events in acromegaly patients; a cut-off value of 91.55 pg/mL can predict the occurrence of CV events according to ROC analysis; surgically treated patients have a lower CV risk.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Endocrinology & Metabolism
Mirko Parasiliti-Caprino, Fabio Bioletto, Tommaso Frigerio, Valentina D'Angelo, Filippo Ceccato, Francesco Ferrau, Rosario Ferrigno, Marianna Minnetti, Carla Scaroni, Salvatore Cannavo, Rosario Pivonello, Andrea Isidori, Fabio Broglio, Roberta Giordano, Maurizio Spinello, Silvia Grottoli, Emanuela Arvat
Summary: A clinical model, the Cushing score, was developed and validated to estimate the pre-test probability of hypercortisolism in high-risk population, showing remarkable predictive power for discriminating between patients with and without Cushing's syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Giuseppe Giuffrida, Francesco Ferrau, Ylenia Alessi, Salvatore Cannavo
Summary: This is the first reported case of a patient with pituitary metastasis from melanoma responding effectively to treatment with immune checkpoint inhibitors.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Endocrinology & Metabolism
S. Cannavo, M. Cappa, D. Ferone, A. M. Isidori, S. Loche, M. Salerno, M. Maghnie
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Nutrition & Dietetics
Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Laura Croce, Marco Malaguti, Alfredo Campenni, Mario Rotondi, Salvatore Cannavo, Silvana Hrelia
Summary: Autoimmune thyroid diseases are increasing rapidly worldwide due to environmental factors related to changed lifestyles. Unhealthy high-energy diets negatively affect autoimmunity, while the Mediterranean diet positively influences immune system function, gut microbiota composition, and redox homeostasis.
Article
Health Care Sciences & Services
Agata Zirilli, Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Silvana Hrelia, Luca Giovanella, Alfredo Campenni, Salvatore Cannavo, Angela Alibrandi
Summary: This study aimed to assess the differences in oxidative stress markers between omnivorous and semi-vegetarian dietary regimes. The findings indicate that semi-vegetarians have higher levels of antioxidant parameters (GPx and TRxR) and lower levels of AGE and AOPP markers compared to omnivorous individuals, particularly in females, different age groups, those with normal weight, and those not affected by Hashimoto's thyroiditis.
Article
Endocrinology & Metabolism
Tommaso Aversa, Rosaria Maddalena Ruggeri, Domenico Corica, Maria Teresa Cristani, Giorgia Pepe, Teresa Manuela Vicchio, Angela Alibrandi, Francesco Trimarchi, Salvatore Cannavo, Giovanni Battista Pajno, Malgorzata Gabriela Wasniewska
Summary: This study found that serum sRAGE levels were significantly decreased in euthyroid children with HT, while no significant differences were observed in AGEs and AOPPs levels. This suggests that children with HT may have increased susceptibility to oxidative damage even when their thyroid function is normal.
HORMONE RESEARCH IN PAEDIATRICS
(2021)