4.3 Article

Treatment of Clinical Solid Waste Using a Steam Autoclave as a Possible Alternative Technology to Incineration

出版社

MDPI AG
DOI: 10.3390/ijerph9030855

关键词

autoclave; clinical solid waste; clinical solid waste management; inactivation of bacteria; treatment technology

资金

  1. Institute for Post Graduate Studies, Universiti Sains Malaysia [USM-RU-PRGS-1001/PTEKIND/843010]

向作者/读者索取更多资源

A steam autoclave was used to sterilize bacteria in clinical solid waste in order to determine an alternative to incineration technology in clinical solid waste management. The influence of contact time (0, 5, 15, 30 and 60 min) and temperature (111 degrees C, 121 degrees C and 131 degrees C) at automated saturated steam pressure was investigated. Results showed that with increasing contact time and temperature, the number of surviving bacteria decreased. The optimum experimental conditions as measured by degree of inactivation of bacteria were 121 C for 15 minutes (min) for Gram negative bacteria, 121 degrees C and 131 degrees C for 60 and 30 min for Gram positive bacteria, respectively. The re-growth of bacteria in sterilized waste was also evaluated in the present study. It was found that bacterial re-growth started two days after the inactivation. The present study recommends that the steam autoclave cannot be considered as an alternative technology to incineration in clinical solid waste management.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Immunology

The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic

Sylvia Annabel Dass, Venugopal Balakrishnan, Norsyahida Arifin, Crystale Siew Ying Lim, Fazlina Nordin, Gee Jun Tye

Summary: This article discusses the importance of prioritizing tuberculosis during the COVID-19 pandemic, compares COVID-19 and tuberculosis in various aspects, and emphasizes the importance of antibody therapy. The article also presents how the lessons learned from the COVID-19 pandemic can be applied to enhance antibody-based immunotherapy for tuberculosis.

FRONTIERS IN IMMUNOLOGY (2022)

Article Food Science & Technology

Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy

Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Jun Jie Tan, Cindy Shuan-Ju Teh, Salina Sany, Svetoslav Dimitrov Todorov, Guoxia Liu, Yong-Ha Park, Min-Tze Liong

Summary: The aim of this study was to investigate the immunological and antimicrobial properties of breast milk in pregnant women with or without vaginal yeast infections. The study found that concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha were similar in both groups. However, breast milk from women in the W-group who were below 31 years old had a higher concentration of EGF compared to the WO-group. Additionally, breast milk from the WO-group exhibited higher anti-Candida properties. Correlation analysis showed that the concentration of TGF-alpha in breast milk positively correlated with the concentrations of IL-10 and IgA in the W-group. These findings suggest that while breast milk from women with vaginal infections during pregnancy may not hinder Candida growth, other immuno-modulatory bioactives may compensate for this protective effect.

FOOD SCIENCE AND BIOTECHNOLOGY (2023)

Article Genetics & Heredity

Gene expression profiling of HPV-associated cervical carcinogenesis in formalin-fixed paraffin-embedded (FFPE) tissues using the NanoString nCounterTM platform

Shandra Devi Balasubramaniam, Venugopal Balakrishnan, Chern Ein Oon, Gurjeet Kaur

Summary: By studying the various stages of cervical cancer development, we have identified the perturbed cellular pathways and changes in gene expression that contribute to the disease. These findings provide guidance for further investigation and validation of the molecular mechanisms involved in HPV-associated cervical cancer.
Article Polymer Science

Investigations of pectin nanostructures for enhanced percutaneous delivery of fusidic acid

Mohammad F. Bostanudin, Mosab Arafat, Suk Fei Tan, Md Zaidul I. Sarker

Summary: This study aimed to develop and characterize nanoformulations made from modified pectin to enhance drug permeation through the skin. The results showed that the spherical nanostructures produced from modified pectin had controlled drug release and efficient cellular absorption, suggesting their potential for percutaneous delivery of poorly penetrating drugs.

JOURNAL OF APPLIED POLYMER SCIENCE (2022)

Article Food Science & Technology

Extraction and Evaluation of Bioactive Compounds from Date (Phoenix dactylifera) Seed Using Supercritical and Subcritical CO2 Techniques

Kashif Ghafoor, Md. Zaidul Islam Sarker, Fahad Y. Al-Juhaimi, Elfadil E. Babiker, Mohammed S. Alkaltham, Abdullah K. Almubarak

Summary: Date (Phoenix dactylifera) seed can be a potential source of natural antioxidants. Innovative green and low temperature antioxidant recovery techniques, such as supercritical fluid (SFE) and subcritical (SubCO(2)) extractions using CO2 as a solvent, can improve the yields and quality of antioxidant extracts. This study compared SFE, SubCO(2), and Soxhlet techniques for enriching antioxidants in extracts from different date seed varieties. The results showed that SFE and SubCO(2) methods extracted significantly higher levels of phenolics, flavonoids, anthocyanins, and carotenoids compared to Soxhlet. In vitro evaluation also demonstrated that SFE and SubCO(2) extracts had promising antioxidant properties, making them potential candidates for functional and nutraceutical applications.
Article Engineering, Chemical

Innovative and Green Extraction Techniques for the Optimal Recovery of Phytochemicals from Saudi Date Fruit Flesh

Kashif Ghafoor, Md Zaidul Islam Sarker, Fahad Y. Al-Juhaimi, Elfadil E. Babiker, Mohammed S. Alkaltham, Abdullah K. Almubarak, Isam A. Mohamed Ahmed

Summary: Supercritical and subcritical extraction techniques were used to produce flesh extracts from four Saudi date fruits. The subcritical CO(2) method showed significant extraction of phytochemicals, while the Majdool date variety exhibited the highest levels of both phytochemicals and biological properties.

PROCESSES (2022)

Article Chemistry, Organic

Evaluation of safe mixed solvents in N-phenylbenzamide synthesis for alteration of hazardous dipolar aprotic solvents in amide drug syntheses

Tariqul Islam, Md Zaidul Islam Sarker, A. B. M. Helal Uddin, Shah Samiur Rashid, Liew Kai Bin

Summary: In this study, N-phenylbenzamide (N-PBA) was synthesized using solvent-pair mixtures containing hydrogen bond donor and hydrogen bond acceptor to explore the replacement/limitation of hazardous dipolar aprotic solvents in amide drug synthesis. Different pure solvents and mixed solvents were selected based on their Kamlet-Taft parameters and GSK 2016 health-safety scores. The yields of N-PBA were evaluated using high-performance liquid chromatography (HPLC) under an amide coupling system at 25 degrees C. The results showed that safe solvent mixtures could be used to avoid/limit hazardous dipolar aprotic solvents and significantly improve the yield of N-PBA.

TETRAHEDRON (2023)

Article Environmental Sciences

Effectiveness of Booster Vaccinations on the Control of COVID-19 during the Spread of Omicron Variant in Malaysia

Matthew Tze Jian Wong, Satvinder Singh Dhaliwal, Venugopal Balakrishnan, Fazlina Nordin, Mohd Nor Norazmi, Gee Jun Tye

Summary: This study investigates the effectiveness of booster doses on the Omicron wave in Malaysia against COVID-19 infections and deaths, and the results show that boosters have high efficacy in reducing COVID-19 infections and deaths.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2023)

Article Biochemistry & Molecular Biology

In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the a-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa Fruit Subcritical CO2 Extract

Md Abdur Rashid Mia, Qamar Uddin Ahmed, Sahena Ferdosh, Abul Bashar Mohammed Helaluddin, Md Shihabul Awal, Murni Nazira Sarian, Md Zaidul Islam Sarker, Zainul Amiruddin Zakaria

Summary: This study evaluated the potential therapeutic effects of Phaleria macrocarpa fruit extracts on diabetes, specifically focusing on their antioxidant properties and their ability to inhibit the protein alpha-glucosidase. The study confirmed the presence of potent alpha-glucosidase inhibitors in the extracts and analyzed their mechanisms of action using molecular dynamic simulations and network pharmacology approaches. The findings suggest that these compounds have the potential to be developed as alternative alpha-glucosidase inhibitors for more effective diabetes management.

METABOLITES (2022)

Article Food Science & Technology

Bioactive Compounds Extracted from Saudi Dates Using Green Methods and Utilization of These Extracts in Functional Yogurt

Kashif Ghafoor, Md. Zaidul Islam Sarker, Fahad Y. Al-Juhaimi, Isam A. Mohamed Ahmed, Elfadil E. Babiker, Mohammed S. Alkaltham, Abdullah K. Almubarak

Summary: The bioactive compounds of four Saudi date flesh extracts were evaluated using different extraction methods. Both the date variety and extraction method affected the phenolic profile of the extracts. The incorporation of date flesh extracts into yogurt increased the total phenolic content, antiradical activity, viscosity, and redness of the product.
Review Chemistry, Analytical

A Review of Detection Methods for Vancomycin-Resistant Enterococci (VRE) Genes: From Conventional Approaches to Potentially Electrochemical DNA Biosensors

Nor Dyana Zakaria, Hairul Hisham Hamzah, Ibrahim Luqman Salih, Venugopal Balakrishnan, Khairunisak Abdul Razak

Summary: Vancomycin-resistant Enterococci (VRE) genes are bacteria strains that are resistant to the antibiotic vancomycin. They exhibit phenotypic and genotypic variations and pose significant issues for hospitalized patients. This review summarizes methods for detecting VRE strains and explores the potential use of electrochemical DNA biosensors for detecting VRE genes. However, no information was found on the development of electrochemical biosensors for VRE genes, only for vancomycin-susceptible bacteria.

BIOSENSORS-BASEL (2023)

Article Food Science & Technology

Vaginal Infections during Pregnancy Increase Breast Milk Microbiome Alpha Diversity and Alter Taxonomic Composition

Azka Ainun Nisaa, Chern-Ein Oon, Sasidharan Sreenivasan, Venugopal Balakrishnan, Deepa Rajendran, Jun-Jie Tan, Fatin Fazrina Roslan, Svetoslav Dimitrov Todorov, Woo-Sik Jeong, Feiyan Zhao, Nur Syafiqah Mohamad Nasir, Zakuan Zainy Deris, Heping Zhang, Yong-Ha Park, Guoxia Liu, Min-Tze Liong

Summary: We compared the microbiota profiles of breast milk from women with and without vaginal yeast infection during pregnancy. Breast milk from women with vaginal yeast infection exhibited higher alpha diversity across different taxonomic levels. The composition of breast milk from the two groups showed marginal differences at certain taxonomic levels. Our findings suggest that vaginal infection during pregnancy may affect breast milk composition, but it may not pose a threat to infant growth and development.

PREVENTIVE NUTRITION AND FOOD SCIENCE (2023)

Article Horticulture

Effects of Functional Edible Coatings and Storage on Bioactive Compounds, Antioxidant Properties and Sugars in Barhi Dates

Kashif Ghafoor, Fahad Y. Al-Juhaimi, Elfadil E. Babiker, Md. Zaidul Islam Sarker, Isam A. Mohamed Ahmed

Summary: In this study, functional coatings developed using chitosan, olive-cake, and orange-peel extracts were applied to preserve Barhi dates. The coatings significantly improved the functional properties and phytochemical content of the dates, and slowed down the ripening process.

HORTICULTURAE (2022)

Review Polymer Science

Insights into the Role of Biopolymer-Based Xerogels in Biomedical Applications

H. P. S. Abdul Khalil, Esam Bashir Yahya, Husnul Azan Tajarudin, Venugopal Balakrishnan, Halimatuddahliana Nasution

Summary: This article introduces the fabrication approach and properties of biopolymeric xerogels for the first time, and discusses their latest applications in drug delivery, wound healing and dressing, tissue scaffolding, and biosensing.
Review Pharmacology & Pharmacy

A short review on cervical cancer cell lines characterization and their corresponding human leukocyte antigen (HLA) type expression

R. S. Rajan, S. A. Dass, G. J. Tye, V. Balakrishnan

Summary: Cervical cancer is a major cause of death in women worldwide, and extensive research is being conducted to develop efficient diagnostics and treatments. The characterization of cervical cell lines is essential for these studies, as it ensures the suitability of the cells and enables accurate therapy.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES (2022)

暂无数据