期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 9, 期 8, 页码 1679-1684出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.24844
关键词
hepatitis B; vaccine; challenge dose; persistence; hepatitis B virus
资金
- Thailand Research Fund [DPG5480002]
- CU Centenary Academic Development Project
- National Research University Project of Thailand [HR1155A-55]
- GlaxoSmithKline group of companies
- GlaxoSmithKline Biologicals SA
- Center of Excellence in Clinical Virology, Chulalongkorn University [CU56-HR01]
- National Research University Fund [HR1155A]
Hepatitis B vaccine has been available worldwide since the mid-1980s. This vaccine was evaluated in a clinical trial in Thailand, conducted on subjects born to hepatitis B surface antigen positive and hepatitis B e-antigen positive mothers and vaccinated according to a 4-dose schedule at 0, 1, 2 and 12 mo of age and a single dose of hepatitis B immunoglobulin concomitantly at birth. All enrolled subjects seroconverted and were followed for 20 y to assess the persistence of antibody to the hepatitis B surface antigen (anti-HBs) (NCT00240539). At year 20, 64% of subjects had anti-HBs antibody concentrations 10 milli-international units per milli liter (mIU/ml) and 92% of subjects had detectable levels ( 3.3 mIU/ml) of anti-HBs antibodies. At year 20, subjects with anti-HBs antibody titer < 100 mIU/ml were offered an additional dose of hepatitis B virus (HBV) vaccine to assess immune memory (NCT00657657). Anamnestic response to the challenge dose was observed in 96.6% of subjects with an 82-fold (13.2 to 1082.4 mIU/ml) increase in anti-HBs antibody geometric mean concentrations. This study confirms the long-term immunogenicity of the 4-dose regimen of the HBV vaccine eliciting long-term persistence of antibodies and immune memory against hepatitis B for up to at least 20 y after vaccination.
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