Article
Oncology
Carla S. Walti, Andrea N. Loes, Kiel Shuey, Elizabeth M. Krantz, Jim Boonyaratanakornkit, Jacob Keane-Candib, Tillie Loeffelholz, Caitlin R. Wolf, Justin J. Taylor, Rebecca A. Gardner, Damian J. Green, Andrew J. Cowan, David G. Maloney, Cameron J. Turtle, Steven A. Pergam, Helen Y. Chu, Jesse D. Bloom, Joshua A. Hill
Summary: CAR-T cell therapy recipients for B cell malignancies have impaired humoral vaccine immunogenicity compared to non-immunocompromised adults, with seroprotection less frequent. However, even individuals with low immunoglobulin and cellular immunodeficiencies show evidence of immunogenicity to vaccination. Additional infection-prevention strategies may be needed for this population.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Endocrinology & Metabolism
Neil E. Wrigley Kelly, Grace Kenny, Fearon C. Cassidy, Alejandro A. Garcia-Leon, Conor De Barra, Patrick W. G. Mallon, Andrew E. Hogan, Donal O'Shea
Summary: Obesity is a major risk factor for severe COVID-19, and it is associated with impaired immune response to vaccines. This study found that individuals with obesity who have recovered from COVID-19 generate robust and durable SARS-CoV-2-specific T cell immunity, equivalent to that seen in individuals without obesity.
Article
Immunology
Esther Dawen Yu, Alba Grifoni, Aaron Sutherland, Hannah Voic, Eric Wang, April Frazier, Natalia Jimenez-Truque, Sandra Yoder, Sabrina Welsh, Stacey Wooden, Wayne Koff, Buddy Creech, Alessandro Sette, Ricardo da Silva Antunes
Summary: The study found that the Flucelvax (R) quadrivalent influenza vaccine has a significant impact on T cell immunity, with increased CD4 and CD8 cell responses to different influenza antigens post-vaccination, maintaining a Th1 polarized profile. No vaccine interference was detected, with balanced responses across all four included viral strains for both CD4 and CD8 T cells targeting HA and multiple additional viral antigens.
Article
Immunology
Sarah Begue, Gwenn Waerlop, Bruno Salaun, Michel Janssens, Duncan Bellamy, Rebecca Jane Cox, Richard Davies, Elena Gianchecchi, Donata Medaglini, Emanuele Montomoli, Elena Pettini, Geert Leroux-Roels, Frederic Clement, Anke Pagnon
Summary: This study describes the development of a consensus protocol to reduce inter-laboratory variability in measuring influenza-specific T cell responses. The protocol allows for quantitative and qualitative evaluation of vaccine-induced T cell responses, facilitating comparisons of different influenza vaccines and potential assessments of protection correlates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marit J. van Elsas, Johan M. S. van der Schoot, Alexander Bartels, Kas Steuten, Duco van Dalen, Zacharias Wijfjes, Carl G. Figdor, Thorbald van Hall, Sjoerd H. van der Burg, Martijn Verdoes, Ferenc A. Scheeren
Summary: Regulatory T cells play a crucial role in immune suppression and pose challenges in cancer therapy. By optimizing the Fc domain of an antibody, efficient depletion of tumor-resident regulatory T cells can be achieved. Using a genome engineering strategy, a stable cell line producing optimized antibodies was generated, leading to effective depletion of tumor-resident regulatory T cells and enhanced tumor eradication when combined with other antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Federica Zavaglio, Irene Cassaniti, Jose Camilla Sammartino, Stelvio Tonello, Pier Paolo Sainaghi, Viola Novelli, Federica Meloni, Daniele Lilleri, Fausto Baldanti
Summary: By comparing the development and persistence of antibody and T-cell responses, we found that the mRNA BNT162b2 vaccine and SARS-CoV-2 infection can induce strong immune responses. Vaccinated subjects and patients with pneumonia had higher levels of antibodies and T-cell responses, while mild COVID-19 patients had weaker immune responses. The antibody response declined over time in vaccinated subjects but could be restored with a booster dose, while the proliferative CD4(+) T-cell response persisted.
Article
Chemistry, Multidisciplinary
Keegan Braz Gomes, Yi-Nan Zhang, Yi-Zong Lee, Mor Eldad, Alexander Lim, Garrett Ward, Sarah Auclair, Linling He, Jiang Zhu
Summary: In this study, the researchers designed and evaluated a cross-protective pan-influenza A vaccine using self-assembling protein nanoparticles. The vaccine demonstrated high efficacy in protecting against lethal challenges of H1N1 and H3N2 in mice.
Article
Immunology
Giuliana X. Medeiros, Greyce Luri Sasahara, Jhosiene Y. Magawa, Joao Paulo S. Nunes, Fernanda R. Bruno, Andreia C. Kuramoto, Rafael R. Almeida, Marcelo A. Ferreira, Guilherme P. Scagion, Erika D. Candido, Fabyano B. Leal, Danielle B. L. Oliveira, Edison L. Durigon, Roberto Carlos V. Silva, Daniela S. Rosa, Silvia B. Boscardin, Veronica Coelho, Jorge Kalil, Keity S. Santos, Edecio Cunha-Neto
Summary: The study found that CoronaVac vaccination induced T cell and/or antibody responses in 96% of individuals, comparable to the response in convalescent patients. However, men and individuals aged 55 years or older who received CoronaVac had significantly lower responses to the Wuhan strain and antigen-induced IL-2 production. The neutralizing antibody responses for the Gamma variant were even lower than for the Wuhan strain. Therefore, individuals above 55 years old who received CoronaVac may benefit from a heterologous third dose/booster vaccine to enhance immune response and protection, considering the emergence of novel variants of concern.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Anna Schmidt, Dennis Lapuente
Summary: Current flu vaccines mainly rely on strain-specific antibodies which may not protect against drifted or newly emerged strains. Therefore, research on universal flu vaccines that target conserved parts of the virus is a top priority. Tissue-resident memory T cells in the respiratory tract play a crucial role in providing efficient heterologous immunity, making them key components of universal flu vaccines. Recent studies on T cell-based flu immunity, along with preclinical and clinical trials of T cell-evoking vaccines, are crucial for the development of effective flu vaccine policies.
Article
Immunology
Weijia Xiong, Tim K. Tsang, Ranawaka A. P. M. Perera, Nancy H. L. Leung, Vicky J. Fang, Ian G. Barr, J. S. Malik Peiris, Benjamin J. Cowling
Summary: We explored the biphasic pattern of antibody titers waning after influenza vaccination in children. Using blood samples, we found evidence for a faster waning in the first 1-2 years, followed by a slower decline in the longer term. Children with higher postvaccination titers showed faster antibody decay.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Yo Han Jang, Baik L. Seong
Summary: Influenza virus infection poses a major public health challenge, with current vaccines potentially compromised by viral antigenic changes. Efforts are underway to develop a universal influenza vaccine that provides long-lasting and broad protection. Immune responses induced by live attenuated influenza vaccines (LAIVs), including neutralizing antibodies, T cell responses, and mucosal immunity, show promising potential for serving as attractive platforms for a universal influenza vaccine.
Article
Health Care Sciences & Services
Amanda J. Eakin, Tahanver Ahmed, Cathy M. McGeough, Stephen Drain, H. Denis Alexander, Gary D. Wright, Philip Gardiner, Dawn Small, Anthony J. Bjourson, David S. Gibson
Summary: This study investigates the relationship between disease activity in rheumatoid arthritis (RA) and the numbers and phenotypes of circulating regulatory T cells (Tregs) and monocytes. It also explores the potential sialic acid link between Tregs and monocytes and the effects of sialic acid on Treg activation and cytokine release.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Molly Javier Uyeda, Robert A. A. Freeborn, Brandon Cieniewicz, Rosa Romano, Ping (Pauline) Chen, Jeffrey Mao-Hwa Liu, Benjamin Thomas, Esmond Lee, Alma-Martina Cepika, Rosa Bacchetta, Maria Grazia Roncarolo
Summary: This study reveals that BHLHE40 is highly expressed in human Tr1 cells and regulates CD4(+) T cells by inhibiting IL-10 and promoting IFN-gamma secretion. Although BHLHE40 is not essential for differentiation of CD4(+) T cells into Tr1 cells, its overexpression induces the expression of specific surface markers. These findings highlight a novel mechanism for BHLHE40 as a regulator of IL-10 and IFN-gamma in human T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Rajeka Lazarus, Sarah Baos, Heike Cappel-Porter, Andrew Carson-Stevens, Madeleine Clout, Lucy Culliford, Stevan R. Emmett, Jonathan Garstang, Lukuman Gbadamoshi, Bassam Hallis, Rosie A. Harris, David Hutton, Nick Jacobsen, Katherine Joyce, Rachel Kaminski, Vincenzo Libri, Alex Middleditch, Liz McCullagh, Ed Moran, Adrian Phillipson, Elizabeth Price, John Ryan, Russell Thirard, Rachel Todd, Matthew D. Snape, David Tucker, Rachel Lauren Williams, Jonathan S. Nguyen-Van-Tam, Adam Finn, Chris A. Rogers
Summary: This study assessed the safety of concomitant administration of COVID-19 and influenza vaccines. The results showed that simultaneous vaccination with ChAdOx1 or BNT162b2 and an age-appropriate influenza vaccine raised no safety concerns and did not adversely affect immune responses.
Article
Immunology
Vanessa Rocha Ribeiro, Mariana Romao-Veiga, Priscila Rezeck Nunes, Mariana Leticia Matias, Jose Carlos Peracoli, Maria Terezinha Serrao Peracoli
Summary: The study found that pregnant women with preeclampsia have significantly lower levels of Vitamin D. Vitamin D treatment in these women led to a decrease in inflammatory gene expression and an increase in anti-inflammatory and regulatory gene expression. This indicates that Vitamin D has an immunomodulatory effect on T cell subsets in pregnant women with preeclampsia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Virology
Jia-Horung Hung, Chang-Yao Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Jen-Ren Wang, Kung-Chao Chang, Fu-Chin Huang
JOURNAL OF CLINICAL VIROLOGY
(2015)
Article
Virology
Sheng-Wen Huang, Ching-Hui Tai, Judith M. Fonville, Chin-Hui Lin, Shih-Min Wang, Ching-Chung Liu, Ih-Jen Su, Derek J. Smith, Jen-Ren Wang
JOURNAL OF VIROLOGY
(2015)
Article
Virology
Pei-Yi Su, Ya-Fang Wang, Sheng-Wen Huang, Yu-Chih Lo, Ya-Hui Wang, Shang-Rung Wu, Dar-Bin Shieh, Shun-Hua Chen, Jen-Ren Wang, Ming-Der Lai, Chuan-Fa Chang
JOURNAL OF VIROLOGY
(2015)
Article
Medicine, General & Internal
Hsin-I Shih, Hsuan-Chen Wang, Ih-Jen Su, Hsiang-Chin Hsu, Jen-Ren Wang, Hsiao Fang Sunny Sun, Chien-Hsuan Chou, Wen-Chien Ko, Ming-I Hsieh, Chi-Jung Wu
Article
Pharmacology & Pharmacy
Chia-Chyi Liu, Meng-Shin Guo, Shang-Rung Wu, Hsiao-Yu Lin, Ya-Ting Yang, Wei-Chih Liu, Yen-Hung Chow, Dar-Bin Shieh, Jen-Ren Wang, Pele Chong
ANTIVIRAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Yu-Tzu Chang, Jen-Ren Wang, Meng-Te Lin, Chi-Jung Wu, Ming-Song Tsai, Chiang Lin Wen-Chi, Te-En Shih, Te-Hui Kuo, Eing-Ju Song, Junne-Ming Sung
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Kuo-Feng Weng, Chuan-Tien Hung, Po-Ting Hsieh, Mei-Ling Li, Guang-Wu Chen, Yu-An Kung, Peng-Nien Huang, Rei-Lin Kuo, Li-Lien Chen, Jing-Yi Lin, Robert Yung-Liang Wang, Shu-Jen Chen, Petrus Tang, Jim-Tong Horng, Hsing-I Huang, Jen-Ren Wang, David M. Ojcius, Gary Brewer, Shin-Ru Shih
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Chia-Chyi Liu, Chyi-Sing Hwang, Wun-Syue Yang, Dan-Chin Tsai, Sze-Hsien Wu, Ai-Hsiang Chou, Yen-Hung Chow, Suh-Chin Wu, Jen-Ren Wang, Jen-Ron Chiang, Chin-Cheng Huang, Chien-Hsiung Pan, Pele Chong
Article
Multidisciplinary Sciences
Yu-Ting Liao, Shih-Min Wang, Jen-Ren Wang, Chun-Keung Yu, Ching-Chuan Liu
Article
Multidisciplinary Sciences
Matthew C. Y. Lim, Ya-Fang Wang, Sheng-Wen Huang, Jyh-Yuan Yang, Jen-Ren Wang
Article
Virology
Yu-Hsuan Yang, Ching-Hui Tai, Dayna Cheng, Ya-Fang Wang, Jen-Ren Wang
Summary: In this study, H5N6 virus-like particles (VLPs) were generated and tested for their potential as a broad-spectrum vaccine candidate against H5Nx avian influenza viruses. The results showed that H5N6 VLPs induced higher neutralizing antibody titers and increased production of immune-related cytokines compared to H5+N6 proteins, suggesting that H5N6 VLPs may be a potential vaccine candidate.
Article
Virology
Dayna Cheng, Yo-Wei Chiu, Sheng-Wen Huang, Yun-Yin Lien, Chia-Lun Chang, Huey-Pin Tsai, Ya-Fang Wang, Jen-Ren Wang
Summary: This study analyzed the epidemiology and genetic variations of CVA16 in Taiwan from 1998 to 2021, finding that CVA16 infections were more prevalent in patients aged 1 to 3 years, with subgenotype B1 being dominant and a potential candidate for a CVA16 vaccine.
Article
Cell Biology
Ying-Ray Lee, Po-Shun Wang, Jen-Ren Wang, Hsiao-Sheng Liu
JOURNAL OF BIOMEDICAL SCIENCE
(2014)
Article
Cell Biology
Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su, Jen-Ren Wang
JOURNAL OF BIOMEDICAL SCIENCE
(2014)
Article
Cell Biology
Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang, Yong Poovorawan
JOURNAL OF BIOMEDICAL SCIENCE
(2014)