Article
Infectious Diseases
Damien Friel, Mary Co, Thierry Ollinger, Bruno Salaun, Anne Schuind, Ping Li, Karl Walravens, Francis A. Ennis, David W. Vaughn
Summary: This study found broadly comparable non-neutralizing immune responses following vaccination with non-adjuvanted and AS03-adjuvanted A(H1N1)pdm09 formulations, including increased activity against a related vaccine strain.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Tatiana Sofia Rodriguez-Reyna, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Diana Lizzeth Hernandez-Garcia, Eduardo M. Choreno-Parra, Yalbi I. Balderas-Martinez, Mariana Esther Martinez-Sanchez, Eduardo Marquez-Garcia, Edda Sciutto, Jose Moreno-Rodriguez, Jose Omar Barreto-Rodriguez, Hazel Vazquez-Rojas, Gustavo Ivan Centeno-Saenz, Nestor Alvarado-Pena, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, David Galeana-Cadena, Gabriela Hernandez, Criselda Mendoza-Milla, Andrea Dominguez, Julio Granados, Lula Mena-Hernandez, Luis Angel Perez-Buenfil, Guillermo Dominguez-Cheritt, Carlos Cabello-Gutierrez, Cesar Luna-Rivero, Jorge Salas-Hernandez, Patricio Santillan-Doherty, Justino Regalado, Angelica Hernandez-Martinez, Lorena Orozco, Federico Avila-Moreno, Ethel A. Garcia-Latorre, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: By comparing patients with COVID-19 and pandemic influenza A(H1N1), it was found that influenza patients had more severe respiratory symptoms, while COVID-19 patients more often experienced dry cough and gastrointestinal symptoms. The immune responses also differed between the two diseases, with pandemic influenza A(H1N1) characterized by higher levels of certain cytokines and COVID-19 displaying a distinct immune profile with increased Th1 and Th2 cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Immunology
Jakob N. Nissen, Sophie J. George, Charlotte K. Hjulsager, Jesper S. Krog, Xiaohui C. Nielsen, Tina V. Madsen, Klara M. Andersen, Tyra G. Krause, Lasse S. Vestergaard, Lars E. Larsen, Ramona Trebbien
Summary: In January 2021, a case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine influenza virus was detected in Denmark. The clinical case and testing results of the genetic and antigenic characterizations of the virus were described.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Immunology
Justin R. Ortiz, Paul W. Spearman, Paul A. Goepfert, Kaitlyn Cross, C. Buddy Creech, Wilbur H. Chen, Susan Parker, Edgar T. Overton, Michelle Dickey, Heather L. Logan, Ashley Wegel, Kathleen M. Neuzil
Summary: This study evaluated the immunogenicity and safety of the AS03-adjuvanted H7N9 influenza vaccine in healthy adults. The results showed that the vaccine had low immunogenicity when administered simultaneously or sequentially with the seasonal influenza vaccine. Immunoprotection declined after 180 days of vaccination with the H7N9 vaccine. However, the seasonal influenza vaccine was immunogenic regardless of the schedule.
Review
Immunology
Celine H. Lemoine, Reviany V. Nidom, Roland Ventura, Setyarina Indrasari, Irine Normalina, Kuncoro Puguh Santoso, Francis Derouet, Christophe Barnier-Quer, Gerrit Borchard, Nicolas Collin, Chairul A. Nidom
Summary: Adequate global vaccine coverage is crucial during an influenza pandemic to mitigate morbidity, mortality, and economic impact. Adjuvant technologies can help increase vaccine doses, extend protection, and potentially enable single-dose vaccination. International cooperation is necessary to meet global vaccine demand.
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Chemistry, Physical
Yongbo Qiao, YaXin Zhang, Jie Chen, Shenghui Jin, Yaming Shan
Summary: This study reports a biepitope nanovaccine for universal influenza vaccine development by incorporating multiple epitopes. The vaccine provides complete protection against H3N2 virus and partial protection against H1N1 virus. Subcutaneous immunization with the vaccine induces robust immune responses.
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Alfredo Cruz-Lagunas, Mahima Thapa, Luis Alejandro Fernandez-Lopez, Martha Carnalla-Cortes, Eduardo M. Choreno-Parra, Lourdes Mena-Hernandez, Montserrat Sandoval-Vega, Erika Mariana Hernandez-Montiel, Diana Lizzeth Hernandez-Garcia, Jazmin Ariadna Ramirez-Noyola, Cynthia Estefania Reyes-Lopez, Andrea Dominguez-Faure, Guillermo Yamil Zamudio-Lopez, Eduardo Marquez-Garcia, Angelica Moncada-Morales, Criselda Mendoza-Milla, Diana Cervantes-Rosete, Marcela Munoz-Torrico, Cesar Luna-Rivero, Ethel A. Garcia-Latorre, Parmenides Guadarrama-Ortiz, Federico Avila-Moreno, Guillermo Dominguez-Cherit, Tatiana Sofia Rodriguez-Reyna, Philip A. Mudd, Carmen Margarita Hernandez-Cardenas, Shabaana A. Khader, Joaquin Zuniga
Summary: Surfactant protein D (SP-D) may help differentiate severe pandemic influenza from COVID-19, with high serum SP-D levels possibly associated with death and renal failure in severe pandemic influenza cases. However, SP-D levels do not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease.
JOURNAL OF INFECTIOUS DISEASES
(2021)