Review
Biochemistry & Molecular Biology
Pierandrea Vinci, Emiliano Panizon, Letizia Maria Tosoni, Carla Cerrato, Federica Pellicori, Filippo Mearelli, Chiara Biasinutto, Nicola Fiotti, Filippo Giorgio Di Girolamo, Gianni Biolo
Summary: Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality, and statins are the first-choice therapy for dyslipidemias. However, patient compliance is poor and statin-associated muscle symptoms are the most common side effect leading to treatment discontinuation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giulia Maria Camerino, Nancy Tarantino, Ileana Canfora, Michela De Bellis, Olimpia Musumeci, Sabata Pierno
Summary: Statins are effective drugs for treating cardiovascular diseases, but can lead to skeletal muscle toxicity which needs risk assessment and study of new biomarkers. Identifying a marker of toxicity is important to prevent or to cure statin induced myopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Maryam Nemati, Meena Srai, Rajani Rudrangi
Summary: This case report describes a 56-year-old female with statin-induced autoimmune myopathy. Despite discontinuation of statin therapy and treatment with high-dose steroids, her symptoms gradually improved as evidenced by normalization of creatine phosphokinase levels. Diagnosis was confirmed by positive anti-HMG-CoA reductase autoantibody and muscle biopsy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhang, Xiaolong Xu, Yaru Wang, Yingli Wang, Xindi Zhou, Lifeng Pan
Summary: HOIL-1L and SHARPIN are regulatory subunits of the linear ubiquitin chain assembly complex (LUBAC) and play crucial roles in various cellular processes. This study reveals that HOIL-1L and SHARPIN can form homo-dimers through their LTM motifs, and the A18P mutation in HOIL-1L disrupts its structural folding and dimer formation. These findings provide mechanistic insights into the functions of HOIL-1L and SHARPIN, as well as the etiology of human diseases associated with defective HOIL-1L.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Brian Lu, Laura Sun, Manuel Seraydarian, Thomas J. Hoffmann, Marisa W. Medina, Neil Risch, Carlos Iribarren, Ronald M. Krauss, Akinyemi Oni-Orisan
Summary: The study identified an association between the c.521T>C variant allele in the SLCO1B1 gene and statin-induced myotoxicity. Homozygous carriers of the C allele had increased risk of myopathy with simvastatin and lovastatin. The association with atorvastatin users was less clear and further research is needed to confirm this relationship.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Clinical Neurology
Elie Naddaf, Pritikanta Paul, Omar F. AbouEzzeddine
Summary: Long-term exposure to CQ and HCQ can lead to myopathy with a wide range of clinical presentations, affecting swallowing, respiratory, and cardiac muscles. Discontinuation of the medication can result in improvement in most patients, but often with residual weakness.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Kelly M. Tomcsanyi, Kelvin A. Tran, Jill Bates, Francesca E. Cunningham, Robert Silverman, Amy K. Norris, Von R. Moore, Deepak Voora
Summary: This study aims to describe the implementation of clinical decision support tools for alerting prescribers about actionable drug-gene interactions in the Veterans Health Administration (VHA). The VHA implemented the Pharmacogenomic Testing for Veterans (PHASER) program in 2019 to offer panel-based, preemptive pharmacogenomic testing and interpretation, focusing on the SLCO1B1 gene. The program aims to reduce adverse drug reactions and improve medication efficacy by alerting practitioners of actionable drug-gene interactions.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2023)
Article
Medicine, General & Internal
M. Casula, M. Gazzotti, F. Bonaiti, E. OImastroni, M. Arca, M. Averna, A. Zambon, A. L. Catapano
Summary: The PROSISA study found that 9.6% of dyslipidaemic patients reported statin-associated muscle symptoms (SAMS), with only one third of patients still reporting SAMS after dechallenge/rechallenge.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Food Science & Technology
Yulong Zhang, Mingyuan Huang, Xuefei Shao, Feiyu Zhang, Zhen Li, Yun Bai, Xinglian Xu, Peng Wang, Tinghui Zhao
Summary: Wooden breast myopathy (WBM) is a meat abnormality in fast-growing broiler chickens, characterized by varied meat qualities with increasing WBM severity. This study investigated the structure and properties of connective tissue and collagen in WBM-affected pectoralis major muscles. The results showed that WBM led to thickened organization, tightly packed collagen fibrils, increased mechanical strength, thermal temperature, particle size, surface hydrophobicity, and intrinsic fluorescence of proteins. These changes were more pronounced in severe cases of WBM.
Review
Endocrinology & Metabolism
Matthias Blueher, Mohini Aras, Louis J. Aronne, Rachel L. Batterham, Francesco Giorgino, Linong Ji, Kirsi H. Pietilainen, Oliver Schnell, Elena Tonchevska, John P. H. Wilding
Summary: Obesity is a chronic disease with increasing prevalence worldwide and is associated with various health risks. The treatment of obesity includes behavioral interventions, pharmacotherapy, and bariatric surgery, but long-term weight maintenance is challenging. Recent advances in understanding the pathophysiology of obesity have led to the development of novel and effective therapies, such as semaglutide and tirzepatide, which have shown promising weight loss effects and improvement in cardiometabolic risk factors. These new agents may bridge the gap between traditional treatments and achieve better outcomes in obesity management.
DIABETES OBESITY & METABOLISM
(2023)
Article
Mathematical & Computational Biology
Yueyue Shen, Ying Xiang, Xiaolong Huang, Youhua Zhang, Zhenyu Yue
Summary: In this study, the consistency of drug responses between lung cell lines and NSCLC tumors was evaluated, and it was found that some commonly used lung cell lines were not clustered with their matched tumor subtypes. Furthermore, lung cell lines and tumors in the same sub-cluster had similar responses to certain drugs but were also inconsistent in some cases.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang, Kelong Ai
Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.
Review
Pharmacology & Pharmacy
Therdpong Tempark, Shobana John, Pawinee Rerknimitr, Patompong Satapornpong, Chonlaphat Sukasem
Summary: SCARs are rare and life-threatening hypersensitivity reactions with different clinical and morphological features. Genetic polymorphism of the HLA genes may be associated with drug-induced severe cutaneous reactions, but there may also be other immune pathogenesis involved. This review discusses various aspects of SCARs, including clinical morphology, immune pathogenesis models, diagnostic criteria, treatments, and the application of pharmacogenomics in the prevention of SCARs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Ryan M. Close, Laura M. Close, Patrick Galdun, Stefanie Gerstberger, Matthew Rydberg, Lisa Christopher-Stine
Summary: Statin-associated autoimmune myopathy is a rare condition in American Indians, with potential risk factors requiring further investigation. Healthcare providers need to be aware of this possibility and familiarize themselves with its presentation for effective treatment.
Review
Cardiac & Cardiovascular Systems
Maryam Mahjoubin-Tehran, Vasily N. Sukhorukov, Tannaz Jmaialahmadi, Amirhossein Sahebkar
Summary: In this study, we used microarray profiles obtained from the GEO database to identify key genes associated with primary metabolic processes. Through gene ontology analysis and protein-protein interaction analysis, we found 11 differentially expressed genes, including 8 genes involved in these processes, with RORA, NR1D2, PIK3R1, CKAP4, and GZMK identified as central players in the network.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Allergy
Mahmoud Abdel-Aziz, Paul Brinkman, Susanne J. H. Vijverberg, Anne H. Neerincx, John H. Riley, Stewart Bates, Simone Hashimoto, Nazanin Zounemat Kermani, Kian Fan Chung, Ratko Djukanovic, Sven-Erik Dahlen, Ian M. Adcock, Peter H. Howarth, Peter J. Sterk, Aletta D. Kraneveld, Anke H. Maitland-van der Zee
Summary: Two distinct severe asthma phenotypes were identified based on sputum microbiome profiles, showing relative stability over 12 to 18 months. Further validation with an independent cohort of patients with mild-to-moderate asthma confirmed the robustness and consistency of the clustering assignments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Stefania Principe, Celeste Porsbjerg, Sisse Bolm Ditlev, Ditte Kjaersgaard Klein, Korneliusz Golebski, Nanna Dyhre-Petersen, Yoni E. van Dijk, Job J. M. H. van Bragt, Lente L. H. Dankelman, Sven-Erik Dahlen, Christopher E. Brightling, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee
Summary: Severe asthma is heterogeneous, with the eosinophilic phenotype being effectively treated by monoclonal antibodies targeting the eosinophilic inflammatory pathways. Apart from the eosinophil threshold, markers like improved asthma symptoms, lung function, and decreased exacerbations are indicative of treatment response.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Review
Oncology
Hedy Maagdenberg, Natanja Oosterom, Jolanda Zanen, Donato Gemmati, Rachael E. Windsor, Sandra G. Heil, Patricia Esperon, Shakila Jabeen, Guillermo J. Ruiz-Arguelles, Oliver Zolk, Susanne Hoerning, Charlotte Sleurs, Elixabet Lopez-Lopez, Monica Moreno-Galvan, Marry M. van den Heuvel-Eibrink, Anke H. van der Zee, Bruce C. Carleton
Summary: Methotrexate-induced mucositis varies greatly among individuals, and genetic variants such as MTHFR c.677C > T and MTRR c.66A > G have been found to have statistically significant associations with the occurrence of mucositis. Further research in this area may help in predicting and managing this common side effect of MTX treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Renate Kos, Paul Brinkman, Anne H. Neerincx, Tamara Paff, Marije G. Gerritsen, Ariana Lammers, Aletta D. Kraneveld, Harry G. M. Heijerman, Hettie M. Janssens, Jane C. Davies, Christof J. Majoor, Els J. Weersink, Peter J. Sterk, Eric G. Haarman, Lieuwe D. Bos, Anke H. Maitland-van der Zee
Summary: Targeted analysis of volatile organic compounds in exhaled breath can non-invasively identify patients with Pseudomonas aeruginosa in cystic fibrosis, with high accuracy. This provides a new approach for simplifying the diagnosis and monitoring of respiratory infections.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Dominic Fenn, Mahmoud Abdel-Aziz, Paul Brinkman, Renate Kos, Anne H. Neerincx, Josje Altenburg, E. Weersink, Eric G. Haarman, Suzanne W. J. Terheggen-Lagro, Anke H. Maitland-van der Zee, Lieuwe D. J. Bos
Summary: Culture-independent analysis of cough swabs provides an inaccurate diagnosis of lower respiratory tract colonisation and should not be used as a diagnostic test in patients with CF.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Letter
Allergy
Niels Rutjes, Ivo van den Bongaardt, Simone Hashimoto, Peter Sterk, Wim Van Aalderen, Suzanne Terheggen-Lagro, Paul Brinkman, Anke-Hilse Maitland - van der Zee, Marc van der Schee, Eric Haarman
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Job J. M. H. van Bragt, Stefania Principe, Simone Hashimoto, D. Naomi Versteeg, Paul Brinkman, Susanne J. H. Vijverberg, Els J. M. Weersink, Nicola Scichilone, Anke H. van der Zee
Summary: Exhaled breath analysis using eNose can accurately identify asthma patients who recently had exacerbations, indicating a specific exhaled breath pattern associated with asthma exacerbations.
Article
Health Care Sciences & Services
Zulfan Zazuli, Corine de Jong, Wei Xu, Susanne J. H. Vijverberg, Rosalinde Masereeuw, Devalben Patel, Maryam Mirshams, Khaleeq Khan, Dangxiao Cheng, Bayardo Ordonez-Perez, Shao Hui Huang, Anna Spreafico, Aaron R. Hansen, David P. Goldstein, John R. de Almeida, Scott V. Bratman, Andrew Hope, Jennifer J. Knox, Rebecca K. S. Wong, Gail E. Darling, Abhijat Kitchlu, Simone W. A. van Haarlem, Femke van der Meer, Anne S. R. van Lindert, Alexandra ten Heuvel, Jan Brouwer, Colin J. D. Ross, Bruce C. Carleton, Toine C. G. Egberts, Gerarda J. M. Herder, Vera H. M. Deneer, Anke H. Maitland-van der Zee, Geoffrey Liu
Summary: This study identified a specific variant of the BACH2 gene that may play an important role in cisplatin-induced nephrotoxicity, suggesting opportunities for mechanistic research, tailored therapy, and preventive strategies related to this pathology.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Letter
Allergy
Abena S. Amoah, Maria Prins, Elisabeth H. D. Bel, Wytske J. Fokkens, Aeilko H. Zwinderman, Maria Yazdanbakhsh, Anke H. Maitland-van der Zee, Ronald van Ree
Review
Health Care Sciences & Services
Somayeh Bazdar, Anastasia K. A. L. Kwee, Laura Houweling, Yolanda de Wit-van Wijck, Firdaus A. A. Mohamed Hoesein, George S. Downward, Esther J. Nossent, Anke H. Maitland-van der Zee
Summary: Long COVID refers to the persistence of COVID-19 symptoms after the initial infection, and it is associated with lung damage. This systematic review focuses on lung imaging and its findings in patients with long COVID. The study identified 31 articles that reported imaging findings of 342 long COVID patients, with computed tomography (CT) being the most common modality used. Various types of lung abnormalities were observed, but a significant proportion of patients had normal CT findings. Further research is needed to understand the role of lung and organ damage in long COVID.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Feiko J. M. de Jong, Thijs T. Wingelaar, Paul Brinkman, Pieter-Jan A. M. van Ooij, Anke H. van der Zee, Markus W. Hollmann, Rob A. van Hulst
Summary: The study assessed whether VOCs in exhaled breath after COMEX-30 treatment are early markers of hyperoxic stress and/or POT. Results showed that the identified VOCs are associated with inflammatory responses or pulmonary diseases and most subjects reported pulmonary symptoms reflecting early-stage POT. Therefore, these VOCs are likely markers of POT, not just indicators of hyperbaric hyperoxic exposure.
Article
Biochemistry & Molecular Biology
Mario Martin-Almeida, Javier Perez-Garcia, Esther Herrera-Luis, Carlos Rosa-Baez, Mario Gorenjak, Anne H. Neerincx, Olaia Sardon-Prado, Antoaneta A. Toncheva, Susanne Harner, Christine Wolff, Susanne Brandstetter, Elisa Valletta, Mahmoud Abdel-Aziz, Simone Hashimoto, Vojko Berce, Paula Corcuera-Elosegui, Javier Korta-Murua, Heike Buntrock-Doepke, Susanne J. H. Vijverberg, Joris C. Verster, Nikki Kerssemakers, Anna M. Hedman, Catarina Almqvist, Jesus Villar, Aletta D. Kraneveld, Uros Potocnik, Michael Kabesch, Anke H. Maitland-van der Zee, Maria Pino-Yanes
Summary: Asthma is a common chronic disease in children, but the influence of DNA methylation on bronchodilator drug response and fractional exhaled nitric oxide is understudied. In this study, we identified DNA methylation markers associated with fractional exhaled nitric oxide in blood samples and bronchodilator drug response in pediatric asthma patients.
Article
Allergy
Korneliusz Golebski, Rik Johannes Leonardus van Der Lans, Danielle van Egmond, Esther de Groot, Hergen Spits, Anke-Hilse Maitland-van Der Zee, Cornelis Maria van Drunen, Wytske Johanna Fokkens, Sietze Reitsma
Article
Health Care Sciences & Services
Nadia Baalbaki, Jelle M. Blankestijn, Mahmoud I. Abdel-Aziz, Jan de Backer, Somayeh Bazdar, Ines Beekers, Rosanne J. H. C. G. Beijers, Joop P. van den Bergh, Lizan D. Bloemsma, Harm Jan Bogaard, Job J. M. H. van Bragt, Vera van den Brink, Jean Paul Charbonnier, Merel E. B. Cornelissen, Yennece Dagelet, Elin Haf Davies, Anne M. van der Does, George S. Downward, Cornelis M. van Drunen, Debbie Gach, J. J. Miranda Geelhoed, Jorrit Glastra, Kornel Golebski, Irene H. Heijink, Judith C. S. Holtjer, Sebastiaan Holverda, Laura Houweling, John J. L. Jacobs, Renee Jonker, Renate Kos, Ramon C. J. Langen, Ivo van der Lee, Asabi Leliveld, Firdaus A. A. Mohamed Hoesein, Anne H. Neerincx, Lieke Noij, Johan Olsson, Marianne van de Pol, Simon D. Pouwels, Emiel Rolink, Michael Rutgers, Havva Sahin, Daphne Schaminee, Annemie M. W. J. Schols, Lisanne Schuurman, Gitte Slingers, Olie Smeenk, Brigitte Sondermeijer, Paul J. Skipp, Marisca Tamarit, Inge Verkouter, Roel Vermeulen, Rianne de Vries, Els J. M. Weersink, Marco van de Werken, Yolanda de Wit-van Wijck, Stewart Young, Esther J. Nossent, Anke H. van der Zee
Summary: The P4O2 COVID-19 study aims to identify long COVID patients at risk for developing chronic lung disease and to find personalized therapeutic strategies. The study showed persistent symptoms and abnormalities in post-COVID patients, with the most commonly reported symptoms being respiratory and neurological symptoms.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
