Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

(2015) Timo Jan Oberstein et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation and � Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging

(2014) C. Hommet et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration

(2013) K. K. Leung et al.   NEUROLOGY

Role of glutaminyl cyclases in thyroid carcinomas

(2012) Astrid Kehlen et al.   ENDOCRINE-RELATED CANCER

Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis

(2012) Annelie Hellvard et al.   JOURNAL OF INFECTIOUS DISEASES

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease

(2012) Barbara Biscaro et al.   Neurodegenerative Diseases

CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease

(2012) Karin Westin et al.   PLoS One

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

(2011) Maike Hartlage-Rübsamen et al.   ACTA NEUROPATHOLOGICA

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

(2011) Holger Cynis et al.   EMBO Molecular Medicine

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-  and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

(2011) J. Maeda et al.   JOURNAL OF NEUROSCIENCE

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A  Is Induced by Pyroglutamate-A  Formation

(2011) A. Alexandru et al.   JOURNAL OF NEUROSCIENCE

Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

(2010) Markus Morawski et al.   ACTA NEUROPATHOLOGICA

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

(2009) Oliver Wirths et al.   ACTA NEUROPATHOLOGICA

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

N-terminal truncated pyroglutamyl β amyloid peptide Aβpy3-42 shows a faster aggregation kinetics than the full-length Aβ1-42

(2009) Cristina D'Arrigo et al.   BIOPOLYMERS

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

(2009) Anett Stephan et al.   FEBS Journal

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

(2009) Maike Hartlage-Rübsamen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

Immunodominant epitope and properties of pyroglutamate-modified Aβ-specific antibodies produced in rabbits

(2009) G. Acero et al.   JOURNAL OF NEUROIMMUNOLOGY

AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice

(2009) Tomomi Kiyota et al.   MOLECULAR THERAPY

CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

(2009) Tomomi Kiyota et al.   PLoS One

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007

(2008) Thomas G. Beach et al.   CELL AND TISSUE BANKING

Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

(2008) Yasmine Nadler et al.   GLIA

Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery

(2008) Holger Cynis et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ

(2008) Stephan Schilling et al.   JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE