期刊
G3-GENES GENOMES GENETICS
卷 3, 期 8, 页码 1241-1251出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.113.006700
关键词
additive genetic models; approximate Bayesian inference; heritability; quantitative genetics; AnimalINLA
资金
- Norwegian Research Council [191847, 221956]
Animal models are generalized linear mixed models used in evolutionary biology and animal breeding to identify the genetic part of traits. Integrated Nested Laplace Approximation (INLA) is a methodology for making fast, nonsampling-based Bayesian inference for hierarchical Gaussian Markov models. In this article, we demonstrate that the INLA methodology can be used for many versions of Bayesian animal models. We analyze animal models for both synthetic case studies and house sparrow (Passer domesticus) population case studies with Gaussian, binomial, and Poisson likelihoods using INLA. Inference results are compared with results using Markov Chain Monte Carlo methods. For model choice we use difference in deviance information criteria (DIC). We suggest and show how to evaluate differences in DIC by comparing them with sampling results from simulation studies. We also introduce an R package, AnimalINLA, for easy and fast inference for Bayesian Animal models using INLA.
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