期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2013.00102
关键词
anxiety disorders; obsessive compulsive disorder; prefrontal cortex; amygdala; Fos; high-frequency stimulation; fear expression
资金
- NIH [R01MH058883, P50 MH086400]
- University of Puerto Rico President's Office
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) reduces the symptoms of treatment resistant obsessive compulsive disorder (OCD), and improves response to extinction based therapies. We recently reported that DBS-like stimulation of a rat homologue of VC/VS, the dorsal-VS, reduced conditioned fear and enhanced extinction memory (Rodriguez-Romaguera et al., 2012). In contrast, DBS of the ventral VS had the opposite effects. To examine possible mechanisms of these effects, we assessed the effects of VS DBS on the expression of the neural activity marker Fos and brain derived neurotrophic factor (BDNF), a key mediator of extinction plasticity in prefrontal amygdala circuits. Consistent with decreased fear expression, DBS of dorsal VS increased Fos expression in prelimbic and infralimbic prefrontal cortices and in the lateral division of the central nucleus of amygdala, an area that inhibits amygdala output. Consistent with improved extinction memory, we found that DBS of dorsal-VS, but not ventral VS, increased neuronal BDNF expression in prelimbic and infralimbic prefrontal cortices. These rodent findings are consistent with the idea that clinical DBS of VC/VS may augment fear extinction through an increase in BDNF expression.
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