Article
Behavioral Sciences
Marit Petzka, Ian Charest, George M. Balanos, Bernhard P. Staresina
Summary: Sleep plays a crucial role in stabilizing newly acquired memories through a process known as memory consolidation. Recent studies have shown that weaker memories may benefit more from post-learning sleep, while stronger memories may not show as significant consolidation effects. However, under certain testing conditions, the true effects of sleep-dependent consolidation may be masked.
Review
Psychology
Sabrina Berres, Edgar Erdfelder
Summary: Sleep has a moderate benefit on episodic memory, especially when stimuli are studied repeatedly, when using memory tests for verbal material without retrieval cues, and when employing pre-post difference measures of retention. The benefits are larger for natural sleep and nighttime naps.
PSYCHOLOGICAL BULLETIN
(2021)
Article
Neurosciences
Yufei Zhao, Avi J. H. Chanales, Brice A. Kuhl
Summary: The similarity between memories is a primary cause of interference and forgetting. Exaggerating subtle differences between memories could potentially reduce interference, as shown in this study. Competition between memories induces adaptive, feature-specific distortions in parietal representations and corresponding behavioral expressions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Experimental
Chi T. Ngo, Sebastian Michelmann, Ingrid R. Olson, Nora S. Newcombe
Summary: Although the overall accuracies for the two tasks correlated as expected, specific measures of individual variation in holistic retrieval and mnemonic discrimination did not correlate, suggesting that these two processes involve distinguishable properties of episodic memory.
MEMORY & COGNITION
(2021)
Article
Behavioral Sciences
Laura Garcia-Rueda, Claudia Poch, Pablo Campo
Summary: Two main explanations for memory loss are decay theories and interference theories. Decay theories suggest that memory fades away over time, while interference theories believe that similar memories are prone to confusion. The brain uses pattern separation to reduce interference and build detailed memory representations. The experiment results indicate that memory discrimination is influenced by the number of stored events, rather than the passage of time.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Sharon M. Noh, Umesh K. Singla, Ilana J. Bennett, Aaron M. Bornstein
Summary: This study investigates the impact of memory on decision-making and finds that memory precision is related to the contribution of memory sampling to choice, while age is negatively correlated with the influence of reinforcement learning.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Steven J. Granger, Joren G. Adams, Sarah M. Kark, Mithra T. Sathishkumar, Ivy Y. Chen, Ruth M. Benca, Liv McMillan, John T. Janecek, Michael A. Yassa
Summary: This study found that anxiety symptoms are associated with impaired recognition memory for negative stimuli, particularly with somatic and cognitive anxiety factors. This suggests the impact of anxiety symptoms on memory function.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
James W. Antony, Eitan Schechtman
Summary: Newly formed memories are spontaneously reactivated during sleep, and this process can be manipulated by providing learning-related stimuli during sleep. While previous studies have shown that cues delivered during sleep improve memory for simple associations, recent research has explored how targeted sleep reactivation affects memories within complex paradigms. The outcomes of sleep reactivation depend not only on the complexity of memory arrangements, but also on the interactions between memories during acquisition. The results suggest that the fate of reactivated stimuli within complex arrangements depends on how they were learned.
Review
Psychology, Mathematical
Pauline Palma, Debra Titone
Summary: Research suggests that sleep promotes the gradual transformation of initial memory traces into more stable representations, but there are various time courses for novel word lexicalization in different populations. Future studies need to focus on understanding sleep-related lexicalization patterns in diverse populations to fully comprehend this phenomenon.
PSYCHONOMIC BULLETIN & REVIEW
(2021)
Article
Neurosciences
Robert J. Molitor, Katherine R. Sherrill, Neal W. Morton, Alexandra A. Miller, Alison R. Preston
Summary: Reactivation of related memories during new learning leads to dissociable coding strategies in hippocampal subfields, with dentate gyrus and CA(2,3) biased towards differentiation and CA(1) towards integration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Mrinmayi Kulkarni, Deborah E. Hannula
Summary: The study finds that the impact of temporal regularity on memory is subtle and may be sensitive to minor changes in task parameters. Indirect upregulation of attention through imposed temporal structure may not be enough to have downstream effects on memory performance.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Hongshen He, Roman Boehringer, Arthur J. Y. Huang, Eric T. N. Overton, Denis Polygalov, Kazuo Okanoya, Thomas J. McHugh
Summary: Research suggests that CA2 activity plays a crucial role in the fidelity of experience-dependent hippocampal replay. By temporarily silencing CA2 pyramidal cells, it was observed that the reactivation of CA1 pyramidal cell ensembles within sharp-wave ripples events lost both temporal and informational precision.
Article
Psychology, Multidisciplinary
Arit Glicksohn, Ladan Shams, Aaron R. Seitz
Summary: Memory involves encoding, consolidating, and retrieving information. Targeted memory reactivation is an experimental method that reactivates sensory components to enhance memory retrieval. In this study, participants were presented with everyday objects, some of which were tagged with sounds. Unusual objects and sounds were created as "oddballs". During a reactivation phase, participants listened to a replay of normal and oddball sounds. The results showed that participants had better memory for oddball objects, especially when their sounds were reactivated.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Hao Wang, Na Sun, Xinyue Wang, Jinyuan Han, Yongxiang Zhang, Yan Huang, Wenxia Zhou
Summary: The accuracy of memory involves the processes of pattern separation and pattern completion. This study designed a new experimental method to evaluate pattern separation and pattern completion using images with varying degrees of similarity. The results showed that the similarity of images affected the evaluation of memory accuracy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
A. Surget, C. Belzung
Summary: Adult hippocampal neurogenesis plays a crucial role in shaping adaptation to environmental demands and enhancing conjunctive encoding and pattern separation in the hippocampus, reducing proactive interference and generalization of stressful experiences. This process ultimately enables more accurate and contextualized information to be transmitted to downstream brain areas, facilitating appropriate setting of the stress response in specific contexts.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Christopher N. Wahlheim, Alexander P. Christensen, Zachariah M. Reagh, Brittany S. Cassidy
Summary: The ability to distinguish between existing memories and similar perceptual experiences is a core feature of episodic memory. This study found that resting-state functional connectivity in the default mode network (DMN) can predict mnemonic discrimination outside the MRI scanner, particularly in prefrontal and temporal regions as well as several hippocampal regions. Additionally, the study suggests that age-related disruptions in network connectivity can impact the extent to which the DMN supports mnemonic discrimination.
Article
Neurosciences
Natalie D. DiProspero, David B. Keator, Michael Phelan, Theo G. M. van Erp, Eric Doran, David K. Powell, Kathryn L. Van Pelt, Frederick A. Schmitt, Elizabeth Head, Ira T. Lott, Michael A. Yassa
Summary: Lower long-range functional connectivity within the default mode network predicts Alzheimer's disease diagnosis and cognitive decline in individuals with Down syndrome. Amyloid-beta accumulation in the inferior parietal cortex is associated with reduced regional DMN functional connectivity, indicating a potential biomarker for Alzheimer's disease in this population.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Miranda G. Chappel-Farley, Bryce A. Mander, Ariel B. Neikrug, Annamarie Stehli, Bin Nan, Joshua D. Grill, Michael A. Yassa, Ruth M. Benca
Summary: The study aimed to investigate the relationship between subjective measures of exercise and sleep with cognitive complaints and examine whether sleep mediates the effects of exercise. The results showed that exercise frequency and sleep quality were associated with cognitive complaints. Sleep mediated the association between exercise and cognitive complaints, particularly symptoms suggestive of obstructive sleep apnea.
Article
Health Care Sciences & Services
Sigan L. Hartley, Victoria Fleming, Brianna Piro-Gambetti, Annie Cohen, Beau M. Ances, Michael A. Yassa, Adam M. Brickman, Benjamin L. Handen, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Ira T. Lott, Eric Doran, Shahid Zaman, Sharon Krinsky-McHale, Fredrick A. Schmitt, Christy Hom, Nicole Schupf
Summary: The COVID-19 pandemic has had widespread effects on the daily life and mood and behavior of adults with Down syndrome, including changes in residence, employment, and mood. The majority of changes were reported to be of modest severity. In the short term, caregivers and providers should be prepared to assist individuals with Down syndrome in adapting to these changes.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Neurosciences
Jenna N. Adams, Soyun Kim, Batool Rizvi, Mithra Sathishkumar, Lisa Taylor, Alyssa L. Harris, Abanoub Mikhail, David B. Keator, Liv McMillan, Michael A. Yassa
Summary: This study examined the relationship between functional connectivity (FC) within the entorhinal-hippocampal circuit, mnemonic discrimination, and amyloid-P (AP) pathology. The findings suggest that low object mnemonic discrimination performance is associated with increased FC between the anterior-lateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, which is related to AP pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination is not associated with altered FC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Ilana J. Bennett, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The perforant path, connecting the entorhinal cortex with the hippocampal formation, deteriorates with age-related cognitive decline. Diffusion-weighted MRI has limitations in quantifying the perforant path integrity, so this study used ultra-high resolution diffusion imaging to investigate its structural connectivity and found that older age and poorer delayed recall are associated with reduced connectivity of the path. The findings suggest that intra-MTL connectivity may serve as new candidate biomarkers for age-related cognitive decline.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Feng-Tzu Chen, Hideaki Soya, Michael A. Yassa, Ruei-Hong Li, Chien-Heng Chu, Ai-Guo Chen, Chiao-Ling Hung, Yu-Kai Chang
Summary: Aerobic exercise during late midlife is associated with improved white matter microstructure. Both Tai Chi and walking can facilitate white matter changes in adults during this period. These findings may guide the development and application of prevention and intervention strategies for age-related cognitive impairments in late midlife.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Weizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem A. Zaghloul, Weiwei Zhang, Floris P. de Lange
Summary: Classic models consider working memory and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Recent evidence suggests that the medial temporal lobe may be involved in working memory, but the specific role of the entorhinal-DG/CA3 pathway in supporting precise item-specific working memory remains unclear.
Article
Clinical Neurology
Jenna N. Adams, Freddie Marquez, Myra S. Larson, John T. Janecek, Blake A. Miranda, Jessica A. Noche, Lisa Taylor, Martina K. Hollearn, Liv McMillan, David B. Keator, Elizabeth Head, Robert A. Rissman, Michael A. Yassa
Summary: This study examined the relationship between Alzheimer's disease (AD) pathology and memory deficits in non-demented older adults through the effects on medial temporal lobe (MTL) subregional volume. The results showed that biomarkers of AD pathology were related to retroactive interference (RI), with dentate gyrus (DG) and CA3 volume uniquely associated with RI. AD pathology was also associated with reduced volume in BA35, CA1, and subiculum, and CA1 volume mediated the relationship between AD pathology and RI.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Geriatrics & Gerontology
Georgia M. Parkin, Soyun Kim, Abanoub Mikhail, Rond Malhas, Liv McMillan, Martina Hollearn, Douglas A. Granger, Mark Mapstone, Michael A. Yassa, Elizabeth A. Thomas
Summary: This study found that inflammatory markers in saliva are associated with those found in circulation, suggesting shared inflammatory mechanisms between these two fluids. The higher levels of cytokines measured in saliva suggest that it might represent a better peripheral fluid to gauge inflammatory processes. Additionally, the research revealed robust sex differences in several salivary cytokines, indicating potential implications for their use as disease biomarkers in the elderly and their association with sex differences in the prevalence of age-related conditions.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Neurosciences
Jennifer Blackford, Marisa Silveri, Danny Winder, Tallie Z. Baram, Michael Yassa, Mohammed Milad, Ned Kalin, Daniel Pine, Kerry Ressler, William Carlezon, Isabelle Rosso, Jennifer Blackford
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Bianca Leonard, Steven Granger, Joren Adams, Liv McMillan, Michael Yassa
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Nazek Queder, Michael J. Phelan, Lisa Taylor, Nicholas Tustison, Eric Doran, Christy Hom, Dana Nguyen, Florence Lai, Margaret Pulsifer, Julie Price, William C. Kreisl, Herminia D. Rosas, Sharon Krinsky-McHale, Adam M. Brickman, Michael A. Yassa, Nicole Schupf, Wayne Silverman, Ira T. Lott, Elizabeth Head, Mark Mapstone, David B. Keator
Summary: Research suggests a link between Alzheimer's Disease in Down Syndrome (DS) and the overproduction of amyloid plaques. PET technology can be used to assess the amyloid load in specific brain regions. Creating disorder-specific atlases for DS provides more accurate quantification of PET signals compared to using atlases derived from neurotypical populations.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Meeting Abstract
Clinical Neurology
D. E. Berisha, M. G. Chappel-Farley, R. Malhas, T. J. Gross, I. Y. Chen, A. Dave, K. K. Lui, A. B. Neikrug, M. A. Yassa, R. M. Benca, M. Mapstone, B. A. Mander
Meeting Abstract
Clinical Neurology
M. G. Chappel-Farley, B. A. Mander, A. B. Neikrug, A. Dave, K. K. Lui, I. Y. Chen, M. A. Yassa, R. M. Benca