Article
Neurosciences
Stephane Bugeon, Clara Haubold, Alexandre Ryzynski, Harold Cremer, Jean-Claude Platel
Summary: The study investigates the impact of neuronal activity on the migration of different interneuron subtypes, revealing a significant increase in intrinsic calcium activity in granule cell precursors during the switch from tangential to radial migration. Neuronal activity is found to be necessary for the positioning and survival of granule cell precursors in the olfactory bulb layers.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Nadina M. Ferroni, Mariela J. Chertoff, Carolina D. Alberca, Bruno G. Berardino, Octavio Gianatiempo, Martin Brahamian, Valeria Levi, Leandro Urrutia, German Falasco, Eduardo T. Canepa, Silvina V. Sonzogni
Summary: This study aimed to determine whether perinatal protein malnutrition predisposes to premature aging in a murine model and to assess the cellular and molecular mechanisms involved. The results showed that protein malnutrition impaired spatial memory, coinciding with higher levels of oxidative stress and altered sirtuin expression in the hippocampus. Additionally, protein malnutrition led to the upregulation of senescence markers and the interruption of neuronal maturation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Masato Sawada, Ayato Hamaguchi, Naomichi Mano, Yutaka Yoshida, Akiyoshi Uemura, Kazunobu Sawamoto
Summary: Newborn neurons exhibit an immature bipolar morphology and migrate towards their destinations. After migration, these neurons undergo controlled dendrite formation and acquire complex morphologies. The mechanisms underlying dendritic development in newborn neurons are not fully understood. This study reveals that the Sema3E-PlexinD1 signaling pathway regulates dendritic development in a domain-specific manner in the postnatal olfactory bulb (OB). The RhoJ protein, which directly interacts with PlexinD1, is also involved in the suppression of dendritic branching in the proximal domain of OB newborn granule cells.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Developmental Biology
Candida Tufo, Subathra Poopalasundaram, Ana Dorrego-Rivas, Marc C. Ford, Anthony Graham, Matthew S. Grubb
Summary: This review summarizes the development of the mammalian olfactory bulb, including prenatal, postnatal, and adult stages, focusing on the maturation, morphology, functions, and interactions of its diverse glutamatergic and GABAergic cell types. The review highlights the significant advances made in understanding olfactory bulb development in recent years, as well as the remaining gaps in knowledge that require urgent attention.
Review
Behavioral Sciences
Monserrat Silvas-Baltazar, Grecia Lopez-Oropeza, Pilar Duran, Alonso Martinez-Canabal
Summary: Olfactory bulb is the critical brain structure for receiving and processing olfactory information, and it plays a role in connecting olfaction with different types of memories. The addition of newborn neurons in the olfactory circuits may modulate olfactory fear memories, but the specific mechanisms are not yet clear.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Viacheslav E. Varentsov, Tatiana A. Rumyanceva, Anastasia D. Verzilina, Kirill K. Pshenisnov, Ekaterina E. Rudenko, Vladimir N. Nikolenko, Ivan V. Shevchuk, Mikhail Y. Sinelnikov
Summary: The study revealed that early administration of the neuropeptide TKPRPGP prolongs the expression of nestin and doublecortin in the olfactory bulbs of rats, but the effectiveness decreases with age.
Article
Neurosciences
Johanna K. Kostka, Sebastian H. Bitzenhofer
Summary: Processing in primary sensory areas is influenced by centrifugal inputs from higher brain areas, which are established during the postnatal period in an area-specific manner. The development of these centrifugal projections to the olfactory bulb varies in different regions.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Cell Biology
Katarzyna Bartkowska, Beata Tepper, Krzysztof Turlejski, Ruzanna Djavadian
Summary: This article evaluates the developmental neurogenesis that occurs after birth in both marsupials and eutherians, with a focus on the generation of granule cells during the formation of the olfactory bulb, dentate gyrus, and cerebellum. The importance of immature neurons in the piriform cortex of young mammals is discussed, and the knowledge of adult neurogenesis in the olfactory bulb and dentate gyrus of marsupials is synthesized to determine the essentiality of adult-born neurons in a given area.
Article
Behavioral Sciences
Hanaa Malloul, Sara Bonzano, Mohammed Bennis, Silvia De Marchis, Saadia Ba-M'hamed
Summary: Exposure to volatile solvents can affect olfactory functioning and behavior in mice, but alterations in adult olfactory neurogenesis do not seem to be associated with impaired olfactory performances in chronically exposed animals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Ruilong Hu, Janam Shankar, Grant Z. Z. Dong, Pablo S. S. Villar, Ricardo C. C. Araneda
Summary: In the olfactory bulb (OB), noradrenaline (NA) modulates the hyperpolarization-activated currents (I-h) in adult-born granule cells (abGCs) through alpha(2)-adrenergic receptors (ARs), enhancing lateral inhibition onto mitral and tufted cells (MCs). This modulation also affects the subthreshold resonance in GCs, potentially impacting the temporal integration of abGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Yali Chen, Peng Ren, Xiongjie He, Fang Yan, Rou Gu, Jie Bai, Xianwen Zhang
Summary: Olfaction is a crucial sense that relies on the olfactory bulb (OB) as the relay station. The contribution of subventricular zone (SVZ) adult neurogenesis to OB neurogenesis is still not fully understood. Recent studies have focused on understanding the molecular and signaling pathways associated with OB neurogenesis dependent on SVZ function. This understanding is important for improving olfactory dysfunction and developing new therapies based on adult neural stem cells (aNSCs).
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Engineering, Environmental
Zhifang Shi, Lei Xi, Yan Wang, Xin Zhao
Summary: Ammonia exposure damages the olfactory system, leading to changes in behavior and inflammation. It affects the release of cytokines and compromises tissue function.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian
Summary: The study showed that aged female opossums took longer to find food using olfactory cues, and had lower levels of immature neurons marked by doublecortin in the olfactory bulb. Additionally, the protein HuD, associated with learning and memory, was higher in aged opossums compared to young opossums.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Kurowska-Rucinska, Jan Rucinski, Dorota Myslinska, Beata Grembecka, Danuta Wrona, Irena Majkutewicz
Summary: The disorder of adult neurogenesis is considered an important mechanism underlying the learning and memory impairment observed in Alzheimer's disease (AD). This study found that DMF therapy can ameliorate the disruption of adult neurogenesis and BDNF-related neuroprotection in an STZ-ICV rat model of sAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Etienne Puyoo, David Albertini
IEEE ELECTRON DEVICE LETTERS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Cell Biology
Patrick Sweeney, Michelle N. Bedenbaugh, Jose Maldonado, Pauline Pan, Katelyn Fowler, Savannah Y. Williams, Luis E. Gimenez, Masoud Ghamari-Langroudi, Griffin Downing, Yijun Gui, Colleen K. Hadley, Stephen T. Joy, Anna K. Mapp, Richard B. Simerly, Roger D. Cone
Summary: Research has shown that MC3R plays a crucial role in controlling feeding behavior, primarily through its impact on the AgRP circuitry. While there is sexual dimorphism in the expression of MC3R in different brain regions, there is no sexual dimorphism in AgRP neurons. MC3R is considered a potential therapeutic target for disorders such as anorexia.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Li Ma, Jing Wang, Jianlong Ge, Yuan Wang, Wei Zhang, Yuanning Du, Jun Luo, Yangping Li, Feng Wang, Guoping Fan, Rong Chen, Bing Yao, Zhen Zhao, Ming-Lei Guo, Woong-Ki Kim, Yang Chai, Jian-Fu Chen
Summary: This study demonstrates that ZIKV infection during pregnancy in mice leads to offspring displaying autistic-like behaviors, with abnormalities in neural circuits resulting in social memory deficits. The research highlights the importance of the vHIP-mPFC pathway in driving these behavioral abnormalities.
Article
Biochemistry & Molecular Biology
Denisa Jansova, Daria Aleshkina, Anna Jindrova, Rajan Iyyappan, Qin An, Guoping Fan, Andrej Susor
Summary: This study investigates the subcellular distribution and translation of specific RNAs in oocytes and embryos, revealing instances of localized translation with distinctive regulatory implications. The researchers found that translationally dormant and abundant mRNAs CyclinB1 and Mos are localized in the cytoplasm of fully grown GV oocytes, forming cloud-like structures with abundant translation at the center of MII oocytes. Coupling detection of specific mRNA localization with their translation at the subcellular level is a valuable tool for quantitatively studying temporal and spatial translation of target mRNAs in developing cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joseph R. Luchsinger, Tracy L. Fetterly, Kellie M. Williford, Gregory J. Salimando, Marie A. Doyle, Jose Maldonado, Richard B. Simerly, Danny G. Winder, Samuel W. Centanni
Summary: This study demonstrates the role of the insula(-> BNST) pathway in monitoring struggling activity and regulating affective behavior during active responses to stressors. The research reveals that struggling events are closely associated with neural activity in the insular cortex, indicating the involvement of a larger neural circuit.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Valentina Lodde, Alberto Maria Luciano, Giulia Musmeci, Ileana Miclea, Irene Tessaro, Mariella Aru, David F. Albertini, Federica Franciosi
Summary: Women's reproductive performance declines starting in midlife, with a very low possibility of pregnancy by age 40-45. Premature ovarian failure and early ovarian aging can lead to low-quality eggs, impacting fertility. Understanding cellular mechanisms is essential for finding solutions to reproductive aging issues.
Article
Neurosciences
Michelle N. Bedenbaugh, Samantha C. Brener, Jose Maldonado, Rachel N. Lippert, Patrick Sweeney, Roger D. Cone, Richard B. Simerly
Summary: This study provides a comprehensive mapping of MC3R neural circuits, revealing their connections with multiple brain regions and their sexual dimorphism. The findings suggest that MC3R plays an important role in controlling various complex behaviors.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Xili Ding, Qin An, Weikang Zhao, Yang Song, Xiaokai Tang, Jing Wang, Chih-Chiang Chang, Gexin Zhao, Tzung Hsiai, Guoping Fan, Yubo Fan, Song Li
Summary: This study provides insights at the single-cell level on the distinct patterns of endothelial cells and smooth muscle cells (SMCs) responses to vascular injury. Less than 30% of SMCs responded to the injury, forming proinflammatory SMCs and stress-responsive SMCs clusters. Proinflammatory SMCs were enriched with inflammatory markers while stress-responsive SMCs overexpressed heat shock proteins. The interaction between macrophages and proinflammatory SMCs was found to be the major cell-cell communication among all cell types in the injured arteries.
Article
Medicine, Research & Experimental
Ryan P. Ceddia, Zack Zurawski, Analisa Thompson Gray, Feyisayo Adegboye, Ainsley McDonald-Boyer, Fubiao Shi, Dianxin Liu, Jose Maldonado, Jiesi Feng, Yulong Li, Simon Alford, Julio E. Ayala, Owen P. Mcguinness, Sheila Collins, Heidi E. Hamm
Summary: By inhibiting the interaction between G beta gamma subunit and SNARE complex, metabolic protection can be enhanced in mice, improving insulin sensitivity and promoting browning of white fat cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Tengfei Wang, Shuxiang Shi, Yuanyuan Shi, Peipei Jiang, Ganlu Hu, Qinying Ye, Zhan Shi, Kexin Yu, Chenguang Wang, Guoping Fan, Suwen Zhao, Hanhui Ma, Alex C. Y. Chang, Zhi Li, Qian Bian, Chao-Po Lin
Summary: Chemotherapeutic drug adriamycin induces visible local condensation and global conformational change of chromatin, leading to weakened chromatin interaction, lower chromatin accessibility, and transcriptomic changes. Mechanistically, adriamycin complexes with histone H1 and induces phase transition of H1. This study reveals a phase separation-driven mechanism for the chemotherapeutic drug.
NATURE COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
D. H. Barad, D. F. Albertini, E. Molinari, N. Gleicher
Summary: This study aimed to investigate the effects of intraovarian injection of platelet-rich plasma (PRP) on ovarian function in patients with extremely low functional ovarian reserve (LFOR). The results showed that PRP treatment did not have clinically significant effects on ovarian function over a 1-year follow-up period. However, two patients with poor prognosis achieved pregnancy after PRP treatment. The study suggests that sporadic pregnancies are possible even in extremely poor prognosis patients due to LFOR, but further research is needed to determine the role of PRP treatments in these pregnancies.
HUMAN REPRODUCTION OPEN
(2022)
Article
Biochemistry & Molecular Biology
Di He, Di Wang, Ping Lu, Nan Yang, Zhigang Xue, Xianmin Zhu, Peng Zhang, Guoping Fan
Summary: The study revealed significant heterogeneity within early-stage LUAD carrying EGFR mutations, indicating complex interactions among tumor cells, stromal cells and immune infiltrates in the TME.
Article
Endocrinology & Metabolism
Norbert Gleicher, Sarah Darmon, Emanuela Molinari, Lin Zhang, Jianjun Hu, David F. Albertini, David H. Barad
Summary: This study found that young women under the age of 41 with adrenal hypoandrogenism may actually suffer from secondary ovarian insufficiency (SOI) rather than primary ovarian insufficiency (POI). In some cases, this condition could be treated with androgen supplementation.
Meeting Abstract
Obstetrics & Gynecology
Jianjun Hu, Min Yang, Lin Zhang, David F. Albertini, Emanuela Molinari, David H. Barad, Norbert Gleicher
FERTILITY AND STERILITY
(2020)