Article
Behavioral Sciences
Sarah Kheloui, Silke Jacmin-Park, Ophelie Larocque, Philippe Kerr, Mathias Rossi, Louis Cartier, Robert-Paul Juster
Summary: Sex/gender differences in cognitive sciences are subject to conflicting perspectives, particularly in the clinical, social, and political domains. Evolutionary and biological perspectives often focus on "nature" arguments, while feminist and constructivist views center on "nurture" arguments regarding cognitive sex differences. This narrative review offers a comprehensive overview of the origins and historical development of these debates, along with a summary of the findings in the sexually polymorphic cognition field. It emphasizes the importance of transdisciplinary perspectives in bridging disciplines to gain a refined understanding of the specific factors that drive sex differences and gender diversity in cognitive abilities.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Behavioral Sciences
Susana Lima, Nuno Sousa, Patricia Patricio, Luisa Pinto
Summary: Major depression is a common psychiatric disorder affecting millions worldwide, with a complex etiology involving genetics and environmental factors. While depression is more prevalent in women, most preclinical studies are conducted in male rodents, highlighting the need for more research on female animal models of depression.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Christina J. Perry, Erin J. Campbell, Katherine D. Drummond, Jeremy S. Lum, Jee Hyun Kim
Summary: Traumatic events in early life can affect later psychopathology, and research shows that factors such as gender, type of stress, and timing of stress can influence neurochemical changes in the brain.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Tibor Stark, Serena Di Martino, Filippo Drago, Carsten T. Wotjak, Vincenzo Micale
Summary: The recent trend of liberalization in Cannabis use has raised concerns about its impact on vulnerable populations, such as adolescents. Increasing daily use of Cannabis among adolescents, along with a decline in perceived harms, may lead to compromised social and cognitive functioning in adulthood. Cannabis exerts its effects by altering signaling within the endocannabinoid system, potentially impacting neurodevelopment and leading to adult neurodevelopmental deficits.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Ryotaro Kubota, Ryo Okubo, Satoru Ikezawa, Makoto Matsui, Leona Adachi, Ayumu Wada, Chinatsu Fujimaki, Yuji Yamada, Koji Saeki, Chika Sumiyoshi, Akiko Kikuchi, Yoshie Omachi, Kazuyoshi Takeda, Ryota Hashimoto, Tomiki Sumiyoshi, Naoki Yoshimura
Summary: This study aimed to investigate the relationship between social cognition and neurocognition in early course schizophrenia, specifically focusing on whether there are sex differences in this association. The results showed that neurocognition associated with social cognition differed according to sex, suggesting that these differences should be considered for more effective treatment of social cognition.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Alyssa Johnson, Jennifer R. Rainville, G. Nicole Rivero-Ballon, Katerina Dhimitri, Georgia E. Hodes
Summary: Behavioral sex differences were detected in response to variable stress, with females being more susceptible to 6 days of stress and both sexes susceptible to 28 days of stress. Performance on behavioral tests varied between individuals and sexes, and not all stressed animals showed susceptibility to all behaviors tested.
Review
Biochemistry & Molecular Biology
Davide Decandia, Francesca Gelfo, Eugenia Landolfo, Francesca Balsamo, Laura Petrosini, Debora Cutuli
Summary: Alzheimer's disease (AD) is a growing epidemic with significant social and economic burden. Inflammation and neurodegeneration play a major role in AD pathogenesis. This review focuses on the effects of dietary supplementation in AD-like animal models, specifically in relation to neuroinflammation induced by lipopolysaccharide (LPS) injection. Various compounds, such as curcumin and krill oil, have been found to counteract cognitive decline and neuroinflammatory responses in rodents. Overall, dietary interventions offer potential neuroprotection and immune regulation in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Heather E. Dark, Nathaniel G. Harnett, Danielle R. Hurst, Muriah D. Wheelock, Kimberly H. Wood, Adam M. Goodman, Sylvie Mrug, Marc N. Elliott, Susan Tortolero Emery, Mark A. Schuster, David C. Knight
Summary: The prefrontal cortex (PFC), hippocampus, and amygdala play crucial roles in emotional health. Women are more susceptible to depression and anxiety compared to men, possibly due to sex differences in neural processes involved in emotion expression and regulation. This study found sex differences in threat-related brain and psychophysiological activity, suggesting their implications for mental health.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Biagio D'Aniello, Barbara Fierro, Anna Scandurra, Claudia Pinelli, Massimo Aria, Gun R. Semin
Summary: The study showed that when exposed to fear chemosignals, dogs exhibited longer behavior towards their owners and stress signals, while in the happy odor condition, females showed a stronger tendency to interact with strangers.
Article
Behavioral Sciences
Aleksandra Kosza Koszalka, Klaudia Lustyk, Karolina Pytka
Summary: This review discusses the recent progress in understanding the biological sex differences in cognition and highlights the challenges encountered in such research. It focuses on spatial, recognition, and emotional memory, as well as executive functions such as attention, cognitive flexibility, and working memory.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
Tyrone Lucon-Xiccato
Summary: Cognitive sex differences have been found in various vertebrate species, including spatial abilities and general cognitive functions such as cognitive flexibility and inhibitory control. The direction and magnitude of these differences vary greatly among species, potentially due to the reproductive systems and roles of males and females. These differences in executive functions may provide males and females with distinct cognitive phenotypes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Jessica K. Bone, Gemma Lewis, Jonathan P. Roiser, Sarah-Jayne Blakemore, Glyn Lewis
Summary: The study found that adolescents who recalled more self-referential negative words had more severe depressive symptoms, and this association was stronger in females.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Shen He, Yange Li, Tian Li, Feikang Xu, Duan Zeng, Yue Shi, Nan Zhao, Lei Zhang, Yin Zhu Ma, Qiang Wang, Wenjuan Yu, Yifeng Shen, Jingjing Huang, Huafang Li
Summary: Lower serum TBIL levels may be associated with cognitive impairment in male SCZ patients, while there was no significant association found in female patients. Further multiple regression analysis and propensity score matching methods supported this conclusion.
Article
Behavioral Sciences
Biagio D'Aniello, Anna Scandurra, Claudia Pinelli, Lieta Marinelli, Paolo Mongillo
Summary: The study explored sex differences in the behavioral responses of Labrador Retriever dogs in the Strange Situation Test. Females were found to be more social but also more affected by the owner's absence, showing differences in distress, sociability, and separation-distress compared to males. The results suggest parallels with sex differences in adult human romantic attachment and highlight unique characteristics of the dog-owner bond.
Article
Neurosciences
Annesha Sil, Arina Erfani, Nicola Lamb, Rachel Copland, Gernot Riedel, Bettina Platt
Summary: The prevalence of Alzheimer's disease (AD) is higher in women compared to men, and this study found that female 5XFAD mice had higher levels of human APP and amyloid-beta and heightened inflammation compared to males. Male animals had higher expression of stress markers and neurotrophic factors. These findings provide important insights into the impact of sex on AD and potential protective mechanisms and treatment strategies.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Cell Biology
P. Darrell Neufer, Marcas M. Bamman, Deborah M. Muoio, Claude Bouchard, Dan M. Cooper, Bret H. Goodpaster, Frank W. Booth, Wendy M. Kohrt, Robert E. Gerszten, Mark P. Mattson, Russell T. Hepple, William E. Kraus, Michael B. Reid, Sue C. Bodine, John M. Jakicic, Jerome L. Fleg, John P. Williams, Lyndon Joseph, Mary Evans, Padma Maruvada, Mary Rodgers, Mary Roary, Amanda T. Boyce, Jonelle K. Drugan, James I. Koenig, Richard H. Ingraham, Danuta Krotoski, Mary Garcia-Cazarin, Joan A. McGowan, Maren R. Laughlin
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, James M. Gold, Kathryn L. Ossenfort, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, Sara K. Sullivan, James M. Gold, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, James M. Gold, Katherine H. Frost, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Review
Cell Biology
Roderick A. Corriveau, Francesca Bosetti, Marian Emr, Jordan T. Gladman, James I. Koenig, Claudia S. Moy, Katherine Pahigiannis, Salina P. Waddy, Walter Koroshetz
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Francesca Bosetti, Zorina S. Galis, Margaret S. Bynoe, Marc Charette, Marilyn J. Cipolla, Gregory J. del Zoppo, Douglas Gould, Thomas S. Hatsukami, Teresa L. Z. Jones, James I. Koenig, Gerard A. Lutty, Christine Maric-Bilkan, Troy Stevens, H. Eser Tolunay, Walter Koroshetz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Article
Clinical Neurology
Francesca Bosetti, James I. Koenig, Cenk Ayata, Stephen A. Back, Kyra Becker, Joseph P. Broderick, S. Thomas Carmichael, Sunghee Cho, Marilyn J. Cipolla, Dale Corbett, Roderick A. Corriveau, Steven C. Cramer, Adam R. Ferguson, Seth P. Finklestein, Byron D. Ford, Karen L. Furie, Thomas M. Hemmen, Costantino Iadecola, Lyn B. Jakeman, Scott Janis, Edward C. Jauch, Karen C. Johnston, Patrick M. Kochanek, Harold Kohn, Eng H. Lo, Patrick D. Lyden, Carina Mallard, Louise D. McCullough, Linda M. McGavern, James F. Meschia, Claudia S. Moy, Miguel A. Perez-Pinzon, Ipolia Ramadan, Sean I. Savitz, Lee H. Schwamm, Gary K. Steinberg, Mary P. Stenzel-Poore, Michael Tymianski, Steven Warach, Lawrence R. Wechsler, John H. Zhang, Walter Koroshetz
Review
Clinical Neurology
Veronica Schiariti, Eileen Fowler, Joline E. Brandenburg, Eric Levey, Sarah Mcintyre, Theresa Sukal-Moulton, Sharon L. Ramey, Jessica Rose, Susan Sienko, Elaine Stashinko, Laura Vogtle, Robin S. Feldman, James I. Koenig
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2018)
Article
Clinical Neurology
Christina A. Wilson, James I. Koenig
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Clinical Neurology
Alyssa M. Day, Adrienne M. Hammill, Csaba Juhasz, Anna L. Pinto, E. Steve Roach, Charles E. McCulloch, Anne M. Comi, Karen L. Ball, Brian J. Fisher, Jim Koenig, Michael T. Lawton, Warren D. Lo, Douglas A. Marchuk, Daniel K. Miles, Marsha A. Moses, Angus A. Wilfong
PEDIATRIC NEUROLOGY
(2019)
Article
Psychiatry
Gregory P. Strauss, Hannah C. Chapman, William R. Keller, James I. Koenig, James M. Gold, William T. Carpenter, Robert W. Buchanan
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Editorial Material
Clinical Neurology
Francesca Bosetti, James Koenig, L. Scott Janis, Clinton B. Wright
Article
Clinical Neurology
Patrick D. Lyden, Francesca Bosetti, Marcio A. Diniz, Andre Rogatko, James Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S. B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh
Summary: Cerebral ischemia and reperfusion lead to neurological disabilities, and developing successful stroke treatments has been challenging. The Stroke Preclinical Assessment Network (SPAN) aims to reduce bias in treatment selection for clinical studies by rigorously assessing candidate treatments across multiple research laboratories. The first stage of SPAN successfully implemented standardized procedures, randomization, and blinded assessment. Subsequent stages will evaluate candidate treatments using aged animals and animals with comorbid conditions.
Article
Clinical Neurology
Andreia Morais, Joseph J. J. Locascio, Lauren H. H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, SPAN Investigators
Summary: The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform that uses rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In this study, we report the heterogeneity introduced by allowing variations in biological and experimental model variables among the 6 SPAN laboratories and its impact on middle cerebral artery occlusion (MCAo) performance.
Editorial Material
Clinical Neurology
Clinton B. Wright, Francesca Bosetti, James I. Koenig, L. Scott Janis