期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2018.00279
关键词
cerebral perfusion; arterial spin labeling; cognition; neuropsychology; vascular risk factors; ethnicity
资金
- British Heart Foundation [CS/13/1//30327, SP/07/001/23603]
- Wellcome Trust [082464/Z/07/Z]
- UK Medical Research Council [MC_UU_12019/3]
- Diabetes UK
- National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre
- NIHR Clinical Research Network
- The Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation [CVON 2012-06]
- NIH Biomedical Research Center at University College London Hospital
- Wellcome Trust [082464/Z/07/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_12019/3] Funding Source: UKRI
Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 +/- 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized beta [st beta] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (st beta = 0.14; p < 0.05 and st beta = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline.
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