Article
Biochemistry & Molecular Biology
Ioanna Tsantzali, Fotini Boufidou, Eleni Sideri, Antonis Mavromatos, Myrto G. Papaioannou, Aikaterini Foska, Ioannis Tollos, Sotirios G. Paraskevas, Anastasios Bonakis, Konstantinos I. Voumvourakis, Georgios Tsivgoulis, Elisabeth Kapaki, George P. Paraskevas
Summary: Analysis of classical cerebrospinal fluid biomarkers, especially in the context of a diagnostic system like AT(N), can be a significant tool for diagnosing Alzheimer's disease accurately during a patient's lifetime. Despite atypical clinical presentations, the classical biomarker profile was consistent with Alzheimer's disease in four patients, demonstrating the potential usefulness of these biomarkers for identifying the biochemical fingerprints of the disease.
Article
Neurosciences
Soyeon Kim, Kiwon Kim, Kwangsik Nho, Woojae Myung, Hong-Hee Won
Summary: The study found a causal association between CSF biomarkers and the risk of LOAD, suggesting that the etiology of LOAD involves pathways of A beta and tau proteins. Further MR studies using large-scale data are needed to elucidate the pathophysiology of LOAD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Donovan A. McGrowder, Fabian Miller, Kurt Vaz, Chukwuemeka Nwokocha, Cameil Wilson-Clarke, Melisa Anderson-Cross, Jabari Brown, Lennox Anderson-Jackson, Lowen Williams, Lyndon Latore, Rory Thompson, Ruby Alexander-Lindo
Summary: This review presents the current evidence on CSF biomarkers for Alzheimer's disease, emphasizing the efficacy of existing core biomarkers and the need for further development of biomarkers reflecting other aspects of the disease mechanism. It also introduces new biomarkers that track Alzheimer's disease pathology and their potential in diagnosis and predicting cognitive decline.
Article
Clinical Neurology
Lei Liu, Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe, David A. Bennett, Celeste M. Karch, Tracy Young-Pearse, Dennis J. Selkoe
Summary: This study aims to identify biomarkers for Alzheimer's disease (AD) and finds that the A beta 37/42 ratio can be used to distinguish AD from normal aging. Experimental results show that this ratio outperforms the traditional ratio in differentiating physiological and pathological states in cell culture, brain tissue, and cerebrospinal fluid. The findings may provide a new indicator for early diagnosis of AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medical Laboratory Technology
Rosa Ferrer, Nuole Zhu, Javier Arranz, Inmaculada Porcel, Shaimaa El Bounasri, Oriol Sanchez, Soraya Torres, Josep Julve, Alberto Lleo, Francisco Blanco-Vaca, Daniel Alcolea, Mireia Tondo
Summary: This study aimed to investigate the potential influence of different storage conditions on the quantification of biomarkers related to Alzheimer's disease in cerebrospinal fluid. The results showed that temperature and storage days significantly impacted the concentrations of certain biomarkers. However, the use of a ratio between two biomarkers could partially compensate for this influence. Other biomarkers were not affected by the tested storage conditions. The findings suggest that specific correction factors can be applied for samples stored at 4 degrees C.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Chemistry, Analytical
Arezoo Mirzaie, Hassan Nasrollahpour, Balal Khalilzadeh, Ali Akbar Jamali, Raymond J. Spiteri, Hadi Youse, Ibrahim Isildak, Reza Rahbarghazi
Summary: Alzheimer's disease is a prevalent neurodegenerative disorder characterized by progressive deterioration, loss of neurons, and cognitive decline. Amyloid beta and Tau proteins are key biomarkers of the disease, and their abnormal levels in biofluids, particularly cerebrospinal fluid, are directly linked to the incidence and progression of Alzheimer's. Developing sensitive and reliable methods for screening and evaluating these biomarkers in cerebrospinal fluid can aid in early diagnosis and treatment. This article discusses the impact of Alzheimer's on cerebrospinal fluid and provides an overview of the latest biosensors for detecting amyloid beta and Tau in cerebrospinal fluid samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Clinical Neurology
Ziqi Fan, Zheyu Li, Shuai Zhao, Yanxing Chen, Yujie Su, Guoping Peng, Benyan Luo
Summary: This study conducted a meta-analysis on salivary biomarkers in Alzheimer's disease (AD) and found that salivary β-amyloid 1-42 (Aβ(1-42)) showed higher sensitivity in early AD diagnosis. However, larger studies are needed to confirm the sensitivity and specificity of salivary Aβ(1-42) in AD diagnosis.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Constance Delaby, Teresa Estelles, Nuole Zhu, Javier Arranz, Isabel Barroeta, Maria Carmona-Iragui, Ignacio Illan-Gala, Miguel Angel Santos-Santos, Miren Altuna, Isabel Sala, M. Belen Sanchez-Saudinos, Laura Videla, Silvia Valldeneu, Andrea Subirana, Mireia Tondo, Francisco Blanco-Vaca, Sylvain Lehmann, Olivia Belbin, Rafael Blesa, Juan Fortea, Alberto Lleo, Daniel Alcolea
Summary: This study compared the differences in CSF A beta 1-42 and A beta 1-42/A beta 1-40 ratio in different neurodegenerative disorders and found that the A beta 1-42/A beta 1-40 ratio was strongly correlated with tTau and pTau181. Patients with a low A beta 1-42/A beta 1-40 ratio showed higher levels of tTau and pTau181 and worse cognitive and functional prognosis, regardless of A beta 1-42 positivity.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M. Shaw, Sanjay Asthana, Cynthia M. Carlsson, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin, Qiongshi Lu, Corinne D. Engelman
Summary: APOE epsilon 4-carrier status and epsilon 4 allele count are not sufficient to fully account for the effects of APOE on Alzheimer's disease. A weighted risk score (APOE-npscore) was developed to better explain the genetic effect on neuropathology and provide an improved method for analyzing APOE in relation to AD. This approach outperformed the traditional APOE epsilon 4-carrier status and epsilon 4 allele count in predicting CSF biomarker changes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Summary: This study aimed to compare the ability of Aβ(42) and amyR to detect AD pathology. The results showed that patients with decreased CSF Aβ(42) levels may have pathological p-tau/Aβ(42) and typical FDG hypometabolism of AD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
George P. P. Paraskevas, Vasilios C. C. Constantinides, Fotini Boufidou, Ioanna Tsantzali, Efstratios-Stylianos Pyrgelis, Georgios Liakakis, Elisabeth Kapaki
Summary: In addition to typical symptoms, Alzheimer's disease (AD) can also present with atypical clinical manifestations. A study of patients with AD cerebrospinal fluid (CSF) biomarker profile found that 46% had typical symptoms, while 23.5% had mixed presentations and 15.3% had atypical presentations. Some of these atypical presentations may need to be included in diagnostic criteria.
Review
Medicine, General & Internal
Efstratios-Stylianos Pyrgelis, Fotini Boufidou, Vasilios C. C. Constantinides, Myrto Papaioannou, Sokratis G. G. Papageorgiou, Leonidas Stefanis, George P. P. Paraskevas, Elisabeth Kapaki
Summary: Idiopathic normal pressure hydrocephalus (iNPH) is a neurological syndrome characterized by gait disorder, cognitive impairment, and urinary incontinence. CSF biomarker studies show differences in concentration of A beta 42 and tau proteins (t-tau and p-tau) between iNPH patients, healthy individuals, and patients with AD and vascular dementia. This could be helpful for diagnosis and prognosis of iNPH.
Article
Neuroimaging
Lauren E. McCollum, Sandhitsu R. Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X. Xie, Laura E. M. Wisse, Paul A. Yushkevich, David A. Wolk
Summary: The study compared cognitive and neuroimaging characteristics between mismatch MCI, prodromal AD, and neurodegeneration-only MCI groups, finding that mismatch MCI had fewer AD-like features compared to prodromal AD and resembled neurodegeneration-only MCI more closely. This suggests that considering beta-amyloid status alone may not accurately identify the underlying driver of symptoms in MCI patients.
NEUROIMAGE-CLINICAL
(2021)
Article
Biochemistry & Molecular Biology
Ming-Jang Chiu, Shieh-Yueh Yang, Ta-Fu Chen, Chin-Hsien Lin, Fu-Chi Yang, Wen-Ping Chen, Henrik Zetterberg, Kaj Blennow
Summary: In Alzheimer's disease (AD), phosphorylated tau (p-tau) is significantly associated with plasma A beta(1-42) levels, which explains a large portion of the plasma p-tau levels in AD participants. The relationship between p-tau and A beta(1-42) is specific to AD and frontotemporal dementia, suggesting a synergic effect in the genesis of these pathological proteins. Plasma p-tau is also correlated with clinical severity in AD patients.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Katherine W. Turk, Alexandra Geada, Victor E. Alvarez, Weiming Xia, Jonathan D. Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R. Huber, Andrew E. Budson, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein
Summary: CSF levels of p-tau(231) were higher in CTE patients, indicating it may be a potential biomarker for CTE diagnosis. Additionally, A beta(1-42) levels were lower in CTE patients, suggesting further investigation is needed for its role in CTE. The study highlights the differences in CSF analytes between CTE and AD patients.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Clinical Neurology
Jon B. Toledo, Carla Abdelnour, Rimona S. Weil, Daniel Ferreira, Federico Rodriguez-Porcel, Andrea Pilotto, Kathryn A. Wyman-Chick, Michel J. Grothe, Joseph P. M. Kane, Angela Taylor, Arvid Rongve, Sonja Scholz, James B. Leverenz, Bradley F. Boeve, Dag Aarsland, Ian G. McKeith, Simon Lewis, Iracema Leroi, John P. Taylor
Summary: Dementia with Le bodies (DLB) is clinically characterized by visual hallucinations, fluctuations, rapid eye movement (REM) sleep behavioral disorder, and parkinsonism. However, neuropathological studies have shown the coexistence of Alzheimer's disease, TAR DNA-binding protein 43 (TDP-43), and cerebrovascular pathologies in DLB cases. These co-pathologies should be taken into consideration in clinical trials for DLB individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Review
Clinical Neurology
Annegret Habich, Lars-Olof Wahlund, Eric Westman, Thomas Dierks, Daniel Ferreira
Summary: This systematic review summarizes findings on the structural and functional brain connectivity in patients with dementia with Lewy bodies (DLB). DLB patients show widespread abnormalities within and across brain networks, which are associated with core clinical features and cognitive impairments. Graph theoretical measures reveal disease-related decreases in local and global network efficiency. These connectivity characteristics may be particularly valuable at early stages of DLB and can help improve diagnosis, prognosis, and identify targets for future treatment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Anna Marseglia, Gregoria Kalpouzos, Erika J. Laukka, Jane Maddock, Praveetha Patalay, Hui-Xin Wang, Lars Backman, Eric Westman, Anna-Karin Welmer, Serhiy Dekhtyar
Summary: This study investigates the interplay between social health and brain structural properties in relation to cognitive change in older adults. The findings suggest that both good social health and larger brain volume are associated with slower cognitive decline. Furthermore, good social health is related to higher cognitive levels in individuals with larger brain volume.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Jingru Fu, Antonios Tzortzakakis, Jose Barroso, Eric Westman, Daniel Ferreira, Rodrigo Moreno
Summary: Predicting brain aging is important for early detection and prognosis of neurodegenerative diseases. This paper proposes a methodology to fill missing data in longitudinal cohorts with anatomically plausible images. The proposed methodology uses deep learning-based diffeomorphic registration to simulate the aging process and rearrange the generated images to specific age ranges. The experimental results show that this methodology can produce anatomically plausible aging predictions and enhance longitudinal datasets.
HUMAN BRAIN MAPPING
(2023)
Article
Genetics & Heredity
Antonio Sarria-Santamera, Kymbat Mukhtarova, Ardak Baizhaxynova, Kaznagul Kanatova, Saule Zhumambayeva, Ainur Akilzhanova, Azliyati Azizan
Summary: This study aimed to investigate the association between vitamin D metabolism pathway gene polymorphisms and asymptomatic COVID-19 susceptibility in Kazakhstan. The results showed that a dominant mutation in rs6127099 (CYP24A1) was protective against asymptomatic COVID-19. Additionally, the G allele of rs731236 TaqI (VDR), dominant mutation in rs10877012 (CYP27B1), recessive rs1544410 BsmI (VDR), and rs7041 (GC) were statistically significant in bivariate analysis, although their independent effects were not found in the adjusted multivariate logistic regression model.
Article
Public, Environmental & Occupational Health
Sauran Yerdessov, Assel Zhunussova, Aliya Imanova, Arnur Gusmanov, Yesbolat Sakko, Gulnur Zhakhina, Kamilla Mussina, Dmitriy Syssoyev, Aidar Alimbayev, Anara Abbay, Antonio Sarria-Santamera, Abduzhappar Gaipov
Summary: A total of 10,251 patients with viral meningitis were admitted to hospitals in Kazakhstan from 2014 to 2019. Enteroviral meningitis was the main cause of VM in children. The incidence rate of VM increased from 13 to 18 cases per 100,000 population. The climatic indicators, such as temperature and humidity, influenced the incidence rate of VM.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Jessica Samuelsson, Anna Marseglia, Olof Lindberg, Eric Westman, Joana B. Pereira, Sara Shams, Silke Kern, Felicia Ahlner, Elisabet Rothenberg, Ingmar Skoog, Anna Zettergren
Summary: This study found associations between dietary patterns and dementia-related neuroimaging markers. Specifically, a high-protein and alcohol pattern was negatively associated with cortical thickness, while a Mediterranean-like pattern was positively associated with white matter microstructural integrity. No associations were found with a Western-like pattern.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Mans Gyllenhammar, Anna Rennie, Daniel Ferreira Padilla, John Wallert, Anders Rydstrom, Lars-Olof Wahlund, Maria Eriksdotter, Eric Westman, Urban Ekman
Summary: Education level is associated with atrophy in the medial temporal lobe and memory, with education moderating the effect of atrophy on memory.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Patricia Diaz-Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Martensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Summary: This study investigated the differential response of mild cognitive impaired (MCI) individuals with different magnetic resonance imaging (MRI) subtypes to donepezil treatment. Results showed that only MCI patients with minimal atrophy or hippocampal-sparing subtypes benefited from donepezil, as the drug slowed down the atrophy rate in these subtypes. The continuous subtyping approach, rather than the conventional categorical approach, captured this differential response.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
Summary: This study investigated the relationship between tau pathology and atrophy in Alzheimer's disease (AD) using tau-PET and structural MRI. The results showed that tau-PET patterns were associated with longitudinal atrophy in the AD continuum. Heterogeneity was also characterized as a continuous phenomenon, offering new insights into disease progression.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Correction
Clinical Neurology
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Sarria-Santamera, Alexandr Petrov, Dinara Yessimova, Miguel A. Ortega, Saule Zhumambayeva, Angel Asunsolo
Summary: The delay of coronary revascularizations due to the COVID-19 pandemic had different effects on patients undergoing PCI and CABG procedures in Spain. The risk profile of CABG patients increased, while PCI patients did not experience a change in risk profile. Furthermore, the risk profile of both procedures showed a temporal trend of increasing risk even before the pandemic. Further research is needed to validate these findings in other databases, regions, or countries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Geriatrics & Gerontology
Mariola Zapater-Fajari, Patricia Diaz-Galvan, Nira Cedres, Therese Rydberg Sterner, Lina Ryden, Simona Sacuiu, Margda Waern, Anna Zettergren, Henrik Zetterberg, Kaj Blennow, Silke Kern, Vanesa Hidalgo, Alicia Salvador, Eric Westman, Ingmar Skoog, Daniel Ferreira
Summary: This study found a significant association between depressive symptomatology and SCD-memory and SCD-concentration. Depressive symptomatology was not associated with AD and CVD biomarkers. The phosphorylated tau biomarker and depressive symptomatology predicted SCD-memory, while the A beta 42/40 ratio and depressive symptomatology predicted SCD-concentration.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio Sarria-Santamera, Yerden Yemenkhan, Milan Terzic, Miguel A. Ortega, Angel Asunsolo del Barco
Summary: Endometriosis is a complex and challenging disease with variability in classification and effectiveness of therapies. This study identifies six clusters of women with endometriosis based on comorbidity, providing insight into the multidimensionality of the disease and its association with specific molecular mechanisms.
