Article
Immunology
Xin-Jie Xu, Ji-Dong Lang, Jun Yang, Bo Long, Xu-Dong Liu, Xiao-Feng Zeng, Geng Tian, Xin You
Summary: This study found altered immune function and gut microbiota in children with Autism Spectrum Disorders (ASD), and the severity of autistic symptoms was higher in the high IFN-gamma group. Analysis of gut microbiota revealed overrepresentation of certain bacterial species and underrepresentation of others in the high IFN-gamma group. The results suggest that IFN-gamma level could serve as a potential biomarker to subtype ASD individuals and understanding the associations among immune function, gut microbiota, and metabolism abnormalities could lead to personalized biomedical treatment for ASD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychology, Developmental
Teresa Del Bianco, Georgia Lockwood Estrin, Julian Tillmann, Bethany F. Oakley, Daisy Crawley, Antonia San Jose Caceres, Hannah Hayward, Mandy Potter, Wendy Mackay, Petrusa Smit, Carlie du Plessis, Lucy Brink, Priscilla Springer, Hein Odendaal, Tony Charman, Tobias Banaschewski, Simon Baron-Cohen, Sven Boelte, Mark Johnson, Declan Murphy, Jan Buitelaar, Eva Loth, Emily J. H. Jones, EU-AIMS LEAP Team
Summary: Autistic individuals are more likely than non-autistic individuals to experience externalising and internalising symptoms, which may vary with environmental factors. This study analyzed data from European and South African cohorts and found that the "Family System" factor was associated with internalising and externalising symptoms in both cohorts, with different effects in individuals with high autistic traits.
Article
Chemistry, Medicinal
Claudia Cristiano, Floriana Volpicelli, Marianna Crispino, Enza Lacivita, Roberto Russo, Marcello Leopoldo, Antonio Calignano, Carla Perrone-Capano
Summary: Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by social deficits, repetitive behaviors, and altered inflammatory responses. This study found that ASD children have decreased levels of lipoxin A4 (LXA4), a mediator involved in inflammation resolution. Activation of the receptor FPR2 by a compound called MR-39 had positive effects on inflammation markers, LXA4 expression, and social behavior in validated animal models of ASD. These findings suggest that FPR2 could be a potential target for therapeutic approaches in ASD.
Article
Psychiatry
Bijun Shi, Weijia Wu, Meixia Dai, Jingjing Zeng, Jingyin Luo, Li Cai, Bin Wan, Jin Jing
Summary: Early comprehensive treatment models (CTMs) have shown positive effects on short-term and long-term outcomes for children with ASD, particularly in symptoms and language. The ESDM has a significant impact on IQ improvement, while EIBI is more effective in symptom reduction. Factors such as parent involvement, treatment intensity, and total treatment hours can positively affect the developmental gains of children with ASD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Giacomo Distefano, Sara Calderoni, Fabio Apicella, Angela Cosenza, Roberta Igliozzi, Giuseppina Palermo, Raffaella Tancredi, Giovanna Tritto, Francesco Craig, Filippo Muratori, Marco Turi
Summary: This study aims to identify sleep disorders in preschool children with ASD and explore their relationship with core symptoms, developmental level, and comorbidities. The results showed that sleep disorders were associated with emotional-behavioral problems and psychiatric comorbidities. Therefore, early screening and intervention for sleep problems should be part of the routine clinical practice for children with ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Katherine Pickard, Allison Meyer, Nuri Reyes, Tanea Tanda, Judy Reaven
Summary: The study indicated that training school providers to deliver cognitive behavioral therapy may help to have a broader impact on autistic students. The program is suitable for different types of students and has a positive effect on their school participation. The importance of flexibility in program implementation and task sharing is highlighted for public schools.
Article
Endocrinology & Metabolism
Rosario Licitra, Devid Damiani, Valentina Naef, Baldassare Fronte, Stefania Della Vecchia, Chiara Sangiacomo, Maria Marchese, Filippo M. Santorelli
Summary: This study evaluated the embryotoxic effect of Valproic acid (VPA) using the zebrafish model and investigated the potential of cannabidiol as an alternative drug to mitigate the adverse effects of VPA. The results showed that zebrafish simultaneously treated with VPA and cannabidiol displayed similar survival rates and heart rates compared to the untreated control group.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Psychiatry
Liliana Dell'Osso, Giulia Amatori, Barbara Carpita, Gabriele Massimetti, Benedetta Nardi, Davide Gravina, Francesca Benedetti, Chiara Bonelli, Danila Casagrande, Mario Luciano, Isabella Berardelli, Natascia Brondino, Marianna De Gregorio, Giacomo Deste, Marta Nola, Antonino Reitano, Maria Rosaria Anna Muscatello, Maurizio Pompili, Pierluigi Politi, Antonio Vita, Mario Maj
Summary: Several studies have found a correlation between autism spectrum disorder (ASD) and catatonia, both of which are also associated with mood disorders. This study aimed to investigate the relationship between autistic traits and catatonic symptoms, as well as the potential mediating role of mood disorder spectrum. The results showed strong positive correlations, with the strongest coefficient observed between AdAS Spectrum total score and CS total score. Mediation analysis revealed that the mood disorder spectrum had a significant indirect effect on the relationship between autistic traits and catatonic symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Education, Special
Carrie Cuffman, Kimberly Burkhart
Summary: Children with autism spectrum disorder (ASD) may have a higher likelihood of constipation and medication use compared to children with other developmental-behavioral disorders. Providers should ask thorough questions to identify constipation and gather information from both caregivers and children if possible. Clinicians should tailor behavioral treatment recommendations to address caregiver concerns.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2021)
Review
Psychology, Developmental
Thelma E. Uzonyi, Alaina C. Grissom, Ranita Anderson, Helen Lee, Sarah Towner-Wright, Elizabeth R. Crais, Linda R. Watson, Rebecca J. Landa
Summary: Various methods have been used to measure parent responsiveness to children with autism or elevated likelihood of autism, leading to difficulties in comparing results across studies. This scoping review analyzed 101 articles to summarize the behavioral coding methods used, highlight strengths and weaknesses in reporting, and propose a best practice model for coding and reporting standards. The review revealed variations in procedures, measurement forms, and aspects of responsiveness measured, and emphasized the need for clear definitions and replicable research protocols.
Review
Psychiatry
V Nezgovorova, C. J. Ferretti, B. P. Taylor, E. Shanahan, G. Uzunova, K. Hong, O. Devinsky, E. Hollander
Summary: Current treatments for ASD are limited in efficacy, leading to the need for novel experimental therapeutics. The endocannabinoid system may play a role in the pathogenesis of ASD, making phytocannabinoids a potential effective treatment for core symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Behavioral Sciences
Anne Masi, Mohammod Ali Moni, Syeda Ishra Azim, Byungkuk Choi, Helen Heussler, Ping- Lin, Antonio Mendoza Diaz, Valsamma Eapen
Summary: Sleep disorders are common in children with autism spectrum disorder (autism), but the relationship between clinical features of autism and sleep disorders is unclear. This study examined this relationship and found that lower adaptive behaviors and sensory issues were associated with more severe sleep problems in autistic children. The findings highlight the importance of a holistic assessment and appropriate sleep intervention for autistic children.
Article
Neurosciences
Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Chiara Scuoppo, Chiara Padovano, Valentina Vivenzio, Ilaria Pistola, Gilda Belfiore, Rosetta Rinaldi, Valeria de Simone, Giangennaro Coppola
Summary: The study found that children with higher severity levels of ASD symptoms had lower adaptive functioning, and parental stress levels were related to the severity of ASD symptoms, fewer adaptive skills, and a greater presence of internalizing and externalizing problems.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Sophia R. D'Agostino, Ana D. Duenas, Alice Bravo, Kelsie Tyson, Diondra Straiton, Giovanna L. Salvatore, Cressida Pacia, Melanie Pellecchia
Summary: Despite having strong evidence, Naturalistic Developmental Behavioral Interventions (NDBIs) are not widely implemented in early intervention programs for children with autism. The slow adoption may be due to different theoretical orientations and a lack of training and support. Efforts should be made to clarify the features, address misconceptions, and provide recommendations to promote wide-scale implementation.
Article
Behavioral Sciences
Xiaolei Yang, Lin Li, Xuejiao Chai, Jicheng Liu
Summary: This study examines the correlation between the ST8SIA2 gene and autistic behavioral symptoms. It finds that the ST8SIA2 gene expression levels are lower in ASD children compared to the control group, and that these expression levels are negatively associated with stereotyped behaviors. Methylation levels of specific gene sites are also higher in ASD children and positively correlated with stereotyped behaviors. This provides a scientific basis to understand the relationship between the ST8SIA2 gene and behavioral phenotypes of ASD.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Marie-Rachelle Narcisse, Holly Felix, Christopher R. Long, Teresa Hudson, Nalin Payakachat, Zoran Bursac, Pearl A. McElfish
BMC HEALTH SERVICES RESEARCH
(2018)
Article
Health Care Sciences & Services
Corey J. Hayes, Xiaocong Li, Chenghui Li, Anuj Shah, Niranjan Kathe, Naleen Raj Bhandari, Nalin Payakachat
HEALTH SERVICES RESEARCH
(2018)
Article
Health Care Sciences & Services
Pearl A. McElfish, Christopher R. Long, Nalin Payakachat, Holly Felix, Zoran Bursac, Brett Rowland, Jonell S. Hudson, Marie-Rachelle Narcisse
Article
Health Policy & Services
Nalin Payakachat, J. Mick Tilford, Karen A. Kuhlthau
PSYCHIATRIC SERVICES
(2018)
Article
Health Care Sciences & Services
Corey J. Hayes, Nalin Payakachat, Chenghui Li
QUALITY OF LIFE RESEARCH
(2018)
Article
Economics
Clare C. Brown, J. Mick Tilford, Nalin Payakachat, D. Keith Williams, Karen A. Kuhlthau, Jeffrey M. Pyne, Renske J. Hoefman, Werner B. F. Brouwer
Article
Urology & Nephrology
Mahmoud I. Khalil, Joel Ubeda, Thomas Soehner, Naleen Raj Bhandari, Nalin Payakachat, Rodney Davis, Omer A. Raheem, Mohamed H. Kamel
JOURNAL OF ENDOUROLOGY
(2019)
Article
Oncology
Mahmoud Khalil, Naleen Raj Bhandari, Nalin Payakachat, Rodney Davis, Omer A. Raheem, Mohamed H. Kamel
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2020)
Article
Pharmacology & Pharmacy
Michelle Hernandez, Amy M. Franks, Nalin Payakachat
Summary: This study examined changes in attitudes towards medical cannabis regulation and pharmacist involvement in dispensing after the availability of medical cannabis products in Arkansas. The findings showed an increase in preference for less regulation and a decrease in agreement with the pharmacist's role in improving safety. Pharmacists need to promote their role in public health safety and demonstrate their knowledge of medical cannabis.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Oncology
Ambrish A. Pandit, Laura E. Gressler, Michael T. Halpern, Mohamed Kamel, Nalin Payakachat, Chenghui Li
Summary: This study evaluates racial/ethnic disparities in patient care experiences among prostate cancer survivors. The findings suggest that Hispanics and non-Hispanic Asians report worse experiences in several aspects of patient care compared to non-Hispanic Whites, while non-Hispanic Blacks have lower scores in one aspect but higher scores in another.
Article
Health Care Sciences & Services
Naleen Raj Bhandari, Mohamed H. Kamel, Erin E. Kent, Carrie McAdam-Marx, Songthip T. Ounpraseuth, J. Mick Tilford, Nalin Payakachat
Summary: A study on kidney cancer patients in the US found that lower health-related quality of life is associated with worse overall survival, with the post-diagnosis physical component summary score showing the strongest impact on survival. The results highlight the importance of monitoring HRQoL for evaluating kidney cancer prognosis.
Article
Andrology
Mahmoud Khalil, Austin K. Bramwell, Naleen Raj Bhandari, Nalin Payakachat, Bruno Machado, Rodney Davis, Mohamed H. Kamel, Ahmed Safaan, Omer A. Raheem
Summary: This study aimed to compare the 30-day morbidity in patients undergoing combined insertion of penile prosthesis with artificial urinary sphincter vs. penile prosthesis with male sling. The results showed that 30-day morbidity was recorded in the PP+AUS group and none in the PP+MS group. Complication and readmission rates were comparable to previous reports in both groups.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Education, Special
Nalin Payakachat, Christopher R. Long, Pearl A. McElfish, Marie-Rachelle Narcisse, Holly C. Felix, Zoran Bursac, Teresa J. Hudson
AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
(2019)
Correction
Public, Environmental & Occupational Health
Pratik Doshi, J. Mick Tilford, Songthip Ounpraseuth, Dennis Z. Kuo, Nalin Payakachat
MATERNAL AND CHILD HEALTH JOURNAL
(2019)
Article
Public, Environmental & Occupational Health
Naleen Raj Bhandari, Kanesha D. Day, Nalin Payakachat, Amy M. Franks, Keith R. McCain, Denise Ragland
WOMENS HEALTH ISSUES
(2018)
